期刊
TISSUE ANTIGENS
卷 73, 期 1, 页码 1-8出版社
WILEY
DOI: 10.1111/j.1399-0039.2008.01167.x
关键词
ankylosing spondilitis; celiac disease; genetic predisposition; human leukocyte antigen association; narcolepsy; peptide binding; type 1 diabetes
The association of human leukocyte antigen (HLA) molecules with many autoimmune diseases has been long known. Yet, the molecular basis for these associations remains unclear for most of these diseases because of the lack of identification of a primary target autoantigen or autoantigens. In two frequent autoimmune disorders, however, celiac disease and type 1 diabetes, recent progress in the identification of immunogenic antigen epitopes and analysis of crystal structure of particular HLA molecules in complex with disease-specific epitopes has allowed for a better understanding of the molecular mechanisms underlying disease association. In this review, these two diseases will be analyzed in detail to show how HLA polymorphisms may directly contribute to susceptibility to, or protection from, disease. Such analyses have significant interest in clinical practice to identify at-risk individuals and elaborate new therapeutic strategies aiming at inhibiting or preventing the autoimmune process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据