Article
Biochemistry & Molecular Biology
Isabel Legaz, Jose Miguel Bolarin, Jose Antonio Campillo, Maria R. Moya-Quiles, Manuel Miras, Manuel Muro, Alfredo Minguela, Maria R. Alvarez-Lopez
Summary: This study reveals that the combination of activating killer cell immunoglobulin-like receptor (KIR) genes and European human leukocyte antigen 2 (HLA-C2) genotypes in recipients is associated with chronic liver rejection (CR). The presence of inhibitory KIR genes significantly increases the incidence of chronic rejection. In addition, KIR2DL3 and the absence of donor HLA-C2 ligand also have an impact on chronic rejection. These findings have important clinical implications for understanding the mechanism of chronic liver rejection and improving treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Galen F. Gao, Dajiang Liu, Xiaowei Zhan, Bo Li
Summary: In this study, a method for identifying KIR allele variants from whole exome sequencing data was developed. The researchers discovered novel associations between these variants and various molecular and clinical correlates.
Article
Immunology
Chao Shen, Zhijun Ge, Chen Dong, Chunhui Wang, Jianguo Shao, Weihua Cai, Peng Huang, Haozhi Fan, Jun Li, Yun Zhang, Ming Yue
Summary: The study revealed that KIR2DS4/KIR2DS1/KIR2DL1 rs35440472-A and HLA-C rs1130838-A variants are associated with increased susceptibility to HCV infection in a high-risk Chinese population.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Nicholas R. Pollock, Genelle F. Harrison, Paul J. Norman
Summary: Interactions between killer cell immunoglobin-like receptors (KIR) and human leukocyte antigens (HLA) class I play crucial roles in regulating the effector functions of key cytotoxic cells in innate and adaptive immunity. The extreme diversity of this interaction is genetically determined and has evolved in response to the ever-changing environment of pathogen exposure. The independent segregation of KIR and HLA genes on separate chromosomes further contributes to the diversity. Specific combinations of inherited receptors and ligands may predispose individuals to certain immune-mediated diseases, including autoimmunity. The combinatorial diversity of KIR and HLA class I also affects the success rates of immunotherapy for these diseases. Detailed characterization of the extent and consequences of the combinatorial diversity is helping in understanding the etiopathology and predicting response to therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Hematology
Falk Heidenreich, Bose Falk, Henning Baldauf, Carolin Massalski, Gesine Schaefer, Elke Ruecker-Braun, Heidi Altmann, Juergen Sauter, Ute V. Solloch, Vinzenz Lange, Friedrich Stoelzel, Christoph Roellig, Jan M. Middeke, Malte von Bonin, Christian Thiede, Kerstin Schaefer-Eckart, Carsten Mueller-Tidow, Stefan W. Krause, Sabrina Kraus, Martin Kaufmann, Mathias Haenel, Hubert Serve, Andreas Neubauer, Martin Bornhaeuser, Alexander H. Schmidt, Johannes Schetelig
Summary: Immunogenetic association studies were conducted to investigate the relationship between killer immunoglobulin-like receptor (KIR) and HLA genotypes and natural killer (NK) cell immunity against acute myeloid leukemia (AML). The study analyzed the genotypes of AML patients and compared them with that of a control group. However, no significant differences were found between the two groups in terms of KIR genotype or receptor-ligand models.
Article
Oncology
Takeji Umemura, Satoru Joshita, Hiromi Saito, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Masao Ota
Summary: Natural killer cells, mediated through KIR-HLA interactions, play a role in hepatocellular carcinoma (HCC) development. In patients with hepatitis C virus-associated cirrhosis, the presence of HLA-Bw4 and the KIR3DL1 + HLA-Bw4 pair was significantly associated with HCC onset, suggesting a potential risk factor for HCC development in HCV cirrhosis.
Article
Virology
Zepei Feng, Peng Huang, Jinwei Zhang, Xueshan Xia, A-mei Zhang, Tian Zeng, Qiong Chen, Chuanlong Zhu, Weilong Tan, Yun Zhang, Ming Yue
Summary: The genetic variants of KIR2DL4 and HLA-G are associated with susceptibility to hepatitis C virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Fadwa Albalawi, Fadwa M. Alkhulaifi, Jameel Al-Tamimi, Lamjed Mansour, Yusra Tashkandy, Suliman Yousef Alomar
Summary: The study aimed to investigate the association of 16 KIR complexes and HLA-C1 and C2 ligands with the genetic predisposition and development of Acute Lymphoblastic Leukemia (AML) in Saudi Arabian patients. The results showed significant differences in KIR genotype frequency between AML patients and healthy controls. KIR2DL1, KIR2DL5, and KIR2DS2 were significantly increased in patients, while KIR 2DL3, KIR2DS4, and KIR2DL2 were elevated in healthy controls.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Immunology
Xin Zhang, Yi Li, Xinyu Han, Yiyun Xu, Haili Wang, Tianye Wang, Tiejun Zhang
Summary: This study identified several variants of human leukocyte antigen (HLA-I) and killer cell immunoglobulin-like receptors (KIRs) associated with KSHV infection. It highlighted the role of KSHV-susceptible HLA-I variants and KSHV replication caused by specific KIR genotype, and revealed the potential mechanism of KIR-mediated natural killer cell activation in anti-KSHV infection.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Hanan M. Alharbi, Afrah F. Alkhuriji, Suliman Y. Alomar, Zainb A. Babay, Alaa A. Alnafjan, Hussah M. Alobaid, Wazirah G. Allharbi, Lamjed A. Mansour
Summary: The aim of this study was to investigate the genetic polymorphisms of the KIR and HLA-C genes and their association with PCO and RSA. The results showed a significant decrease in the recurrences of KIR3DL1, 2DS4ins, 2DL2, and KIR2DS2 in RSA-PCO women compared to healthy controls. The study also found a preventive effect of certain KIR-HLA-C combinations in both PCO and RSA-PCO groups. However, KIR2DL1 was identified as a risk factor for PCO and RSA in the presence of HLA-C2 ligand.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Immunology
Vlad Andrei Cianga, Lydia Campos Catafal, Petru Cianga, Mariana Pavel Tanasa, Mohamad Cherry, Phillipe Collet, Emmanuelle Tavernier, Denis Guyotat, Cristina Rusu, Carmen Mariana Aanei
Summary: The study investigated NK cell maturation in bone marrow under different conditions and found impaired NK cell antitumor response and phenotypic shift in MDS and AML settings. The results suggest immune response failure during myeloid malignancy pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Alok K. Tembhurne, Amita Maheshwari, Himangi Warke, Hemangi Chaudhari, Shilpa C. Kerkar, Kedar Deodhar, Bharat Rekhi, Jayanti Mania-Pramanik
Summary: This study investigates the role of killer cell immunoglobulin-like receptors (KIRs) in cervical cancer among Indian women. The findings suggest that KIR2DS5, the C4T4 subset, and activating KIR genes are susceptible factors or positively associated with cervical cancer. Additionally, KIR2DL5B may have a protective association against cervical cancer, while KIR2DL1 and KIR2DL3 frequencies have important implications in healthy controls and HPV-infected women, respectively.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Young Eun Lee, Ga-Yeon Go, Eun-Young Koh, Han-Na Yoon, Minkoo Seo, Seung-Mo Hong, Ji Hye Jeong, Jin-Chul Kim, Duck Cho, Tae Sung Kim, Song Cheol Kim, Eunsung Jun, Mihue Jang
Summary: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) impair the functionality of natural killer (NK) cells, which are considered as a promising therapeutic modality. Targeted therapies against CAFs may enhance NK-mediated cancer killing.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Editorial Material
Gastroenterology & Hepatology
Manuel Muro, Isabel Legaz
Summary: HLA compatibility, viral infections, and HLA-C/KIR combinations are all related to liver transplant rejection and survival. Presence of DSAs in the recipient may lead to increased risk of acute and chronic rejection, faster graft fibrosis, biliary problems, poorer survival, and even de novo autoimmune hepatitis. High-risk patients with preformed DSAs and higher MFI values should be considered for selecting the graft placed and desensitization methods. In cases of combined kidney-liver transplant, DSAs resistant to treatment may result in antibody-mediated rejection and loss of the renal graft.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Lohith Madireddy, Niklaos A. Patsopoulos, Chris Cotsapas, Steffan D. Bos, Ashley Beecham, Jacob McCauley, Kicheol Kim, Xiaoming Jia, Adam Santaniello, Stacy J. Caillier, Till F. M. Andlauer, Lisa F. Barcellos, Tone Berge, Luisa Bernardinelli, Filippo Martinelli-Boneschi, David R. Booth, Farren Briggs, Elisabeth G. Celius, Manuel Comabella, Giancarlo Comi, Bruce A. C. Cree, Sandra D'Alfonso, Katrina Dedham, Pierre Duquette, Dardiotis Efthimios, Federica Esposito, Bertrand Fontaine, Christiane Gasperi, An Goris, Benedicte Dubois, Pierre-Antoine Gourraud, Georgios Hadjigeorgiou, Jonathan Haines, Clive Hawkins, Bernhard Hemmer, Rogier Hintzen, Dana Horakova, Noriko Isobe, Seema Kalra, Jun-ichi Kira, Michael Khalil, Ingrid Kockum, Christina M. Lill, Matthew R. Lincoln, Felix Luessi, Roland Martin, Annette Oturai, Aarno Palotie, Margaret A. Pericak-Vance, Roland Henry, Janna Saarela, Adrian Ivinson, Tomas Olsson, Bruce V. Taylor, Graeme J. Stewart, Hanne F. Harbo, Alastair Compston, Stephen L. Hauser, David A. Hafler, Frauke Zipp, Philip De Jager, Stephen Sawcer, Jorge R. Oksenberg, Sergio E. Baranzini
NATURE COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Lennox Din, Mohammad Sheikh, Nikitha Kosaraju, Karin Ekstrom Smedby, Sasha Bernatsky, Sonja Berndt, Christine F. Skibola, Alexandra Nieters, Sophia Wang, James D. McKay, Pierluigi Cocco, Marc Maynadie, Lenka Foretova, Anthony Staines, Thomas M. Mack, Silvia de Sanjose, Timothy J. Vyse, Leonid Padyukov, Alain Monnereau, Alan A. Arslan, Amy Moore, Angela R. Brooks-Wilson, Anne J. Novak, Bengt Glimelius, Brenda M. Birmann, Brian K. Link, Carolyn Stewart, Claire M. Vajdic, Corinne Haioun, Corrado Magnani, David Conti, David G. Cox, Delphine Casabonne, Demetrius Albanes, Eleanor Kane, Eve Roman, Giacomo Muzi, Gilles Salles, Graham G. Giles, Hans-Olov Adami, Herve Ghesquieres, Immaculata De Vivo, Jacqueline Clavel, James R. Cerhan, John J. Spinelli, Jonathan Hofmann, Joseph Vijai, Karen Curtin, Karen H. Costenbader, Kenan Onel, Kenneth Offit, Lauren R. Teras, Lindsay Morton, Lucia Conde, Lucia Miligi, Mads Melbye, Maria Grazia Ennas, Mark Liebow, Mark P. Purdue, Martha Glenn, Melissa C. Southey, Morris Din, Nathaniel Rothman, Nicola J. Camp, Nicole Wong Doo, Nikolaus Becker, Nisha Pradhan, Paige M. Bracci, Paolo Boffetta, Paolo Vineis, Paul Brennan, Peter Kraft, Qing Lan, Richard K. Severson, Roel C. H. Vermeulen, Roger L. Milne, Rudolph Kaaks, Ruth C. Travis, Stephanie J. Weinstein, Stephen J. Chanock, Stephen M. Ansell, Susan L. Slager, Tongzhang Zheng, Yawei Zhang, Yolanda Benavente, Zachary Taub, Lohith Madireddy, Pierre-Antoine Gourraud, Jorge R. Oksenberg, Wendy Cozen, Henrik Hjalgrim, Pouya Khankhanian
GENETIC EPIDEMIOLOGY
(2019)
Article
Biochemical Research Methods
Estelle Geffard, Sophie Limou, Alexandre Walencik, Michelle Daya, Harold Watson, Dara Torgerson, Kathleen C. Barnes, Anne Cesbron Gautier, Pierre-Antoine Gourraud, Nicolas Vince
Article
Allergy
Nicolas Vince, Sophie Limou, Michelle Daya, Wataru Morii, Nicholas Rafaels, Estelle Geffard, Venceslas Douillard, Alexandre Walencik, Meher Preethi Boorgula, Sameer Chavan, Candelaria Vergara, Victor E. Ortega, James G. Wilson, Leslie A. Lange, Harold Watson, Dan L. Nicolae, Deborah A. Meyers, Nadia N. Hansel, Jean G. Ford, Mezbah U. Faruque, Eugene R. Bleecker, Monica Campbell, Terri H. Beaty, Ingo Ruczinski, Rasika A. Mathias, Margaret A. Taub, Carole Ober, Emiko Noguchi, Kathleen C. Barnes, Dara Torgerson, Pierre-Antoine Gourraud
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Guillaume Guimbretiere, Simon Nusinovici, Antoine Monnot, Jonathan Sobocinski, Thomas Senage, Pascal Delsart, Pierre-Antoine Gourraud, Blandine Maurel
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Emmanuel Montassier, Gabriel A. Al-Ghalith, Camille Mathe, Quentin Le Bastard, Venceslas Douillard, Abel Garnier, Remi Guimon, Bastien Raimondeau, Yann Touchefeu, Emilie Duchalais, Nicolas Vince, Sophie Limou, Pierre-Antoine Gourraud, David A. Laplaud, Arnaud B. Nicot, Jean-Paul Soulillou, Laureline Berthelot
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Clinical Neurology
Alireza Akhbardeh, Jennifer K. Arjona, Kristen M. Krysko, Bardia Nourbakhsh, Pierre Antoine Gourraud, Jennifer S. Graves
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2020)
Article
Cell Biology
Paloma Gomez-Fernandez, Aitzkoa Lopez de Lapuente Portilla, Ianire Astobiza, Jorge Mena, Andoni Urtasun, Vivian Altmann, Fuencisla Matesanz, David Otaegui, Elena Urcelay, Alfredo Antiguedad, Sunny Malhotra, Xavier Montalban, Tamara Castillo-Trivino, Laura Espino-Paisan, Orhan Aktas, Mathias Buttmann, Andrew Chan, Bertrand Fontaine, Pierre-Antoine Gourraud, Michael Hecker, Sabine Hoffjan, Christian Kubisch, Tania Kuempfel, Felix Luessi, Uwe K. Zettl, Frauke Zipp, Iraide Alloza, Manuel Comabella, Christina M. Lill, Koen Vandenbroeck
Article
Gastroenterology & Hepatology
C. Le Berre, A. Bourreille, M. Flamant, G. Bouguen, L. Siproudhis, M. Dewitte, N. Dib, E. Cesbron-Metivier, T. Goronflot, M. Hanf, P. -A. Gourraud, E. Kerdreux, A. Poinas, C. Trang-Poisson
BMC GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Catherine Le Berre, Mathurin Flamant, Guillaume Bouguen, Laurent Siproudhis, Marie Dewitte, Nina Dib, Elodie Cesbron-Metivier, Thomas Goronflot, Matthieu Hanf, Pierre-Antoine Gourraud, Elise Kerdreux, Alexandra Poinas, Arnaud Bourreille, Caroline Trang-Poisson
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Genetics & Heredity
Nicolas Vince, Venceslas Douillard, Estelle Geffard, Diogo Meyer, Erick C. Castelli, Steven J. Mack, Sophie Limou, Pierre-Antoine Gourraud
GENETIC EPIDEMIOLOGY
(2020)
Article
Clinical Neurology
Olivia Rousseau, Matilde Karakachoff, Alban Gaignard, Lise Bellanger, Philippe Bijlenga, Pacome Constant Dit Beaufils, Vincent L'Allinec, Olivier Levrier, Pierre Aguettaz, Jean-Philippe Desilles, Caterina Michelozzi, Gaultier Marnat, Anne-Clemence Vion, Gervaise Loirand, Hubert Desal, Richard Redon, Pierre-Antoine Gourraud, Romain Bourcier
Summary: Through analyzing a large amount of patient data, it was found that the location of intracranial aneurysms is the most significant factor associated with the risk of rupture, while size and treatment intake are less relevant. The use of machine-learning methods can help predict rupture risks more accurately.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Genetics & Heredity
D. S. Goodin, P. Khankhanian, P. A. Gourraud, N. Vince
Summary: The study found that different combinations of risk haplotypes result in MS risk closer to an additive model, indicating that the individual combination of risk haplotypes is crucial for the development of MS, and this interaction plays a key role in determining whether MS develops or not.
BMC MEDICAL GENOMICS
(2021)
Article
Clinical Neurology
Stanislas Demuth, Joris Mueller, Veronique Quenardelle, Valerie Lauer, Roxana Gheoca, Malwina Trzeciak, Irene Pierre-Paul, Jerome De Seze, Pierre-Antoine Gourraud, Valerie Wolff
Summary: Strokecopilot is a literature-based clinical decision support system developed to assist neurologists in managing the acute phase of AIS. By providing information and outcomes of reference populations that match patient characteristics, the system helps neurologists make evidence-based medical reasoning to determine the indications of intravenous thrombolysis and endovascular treatments.
JOURNAL OF NEUROLOGY
(2023)
Article
Cell Biology
Venceslas Douillard, Nayane dos Santos Brito Silva, Sonia Bourguiba-Hachemi, Michel S. Naslavsky, Marilia O. Scliar, Yeda A. O. Duarte, Mayana Zatz, Maria Rita Passos-Bueno, Sophie Limou, Pierre-Antoine Gourraud, Elise Launay, Erick C. Castelli, Nicolas Vince
Summary: Human genomics has advanced rapidly, driving genome-wide association studies (GWASs). However, SNP-based GWASs are limited in capturing the polymorphism of HLA genes. This study evaluated the accuracy of using the 1000 Genomes data as a reference panel to impute HLA genotypes in admixed individuals and highlighted the importance of using genetically specific models for imputation.
