Article
Infectious Diseases
Xiaoxue Liang, Ping Chen, Baoguo Deng, Feng-Hui Sun, Yongqiang Yang, Yanxian Yang, Ruowen He, Mingyang Qin, Yiping Wu, Fan Yang, Guo-Bao Tian, Min Dai
Summary: This study compared the antimicrobial resistance, virulence, clinical characteristics, and risk factors between carbapenem-resistant K. pneumoniae (CRKP) and carbapenem-susceptible K. pneumoniae (CSKP) isolates from patients with bloodstream infections (BSIs) in China. The results demonstrated that CRKP isolates were more drug-resistant, more virulent, and associated with poorer outcomes compared to CSKP isolates.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Mykhailo Savin, Gabriele Bierbaum, Nico T. Mutters, Ricarda Maria Schmithausen, Judith Kreyenschmidt, Isidro Garcia-Menino, Silvia Schmoger, Annemarie Kaesbohrer, Jens Andre Hammerl
Summary: This study characterizes carbapenem-resistant Klebsiella spp. in wastewater and surface water in Germany. The isolates showed resistance to multiple antibiotics and a high diversity of antibiotic-resistance genes. Virulence factors were also present in most isolates. The findings suggest the possible dissemination of resistant bacteria in the environment and the risk of colonization and infection in humans, livestock, and wildlife.
Article
Immunology
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
Summary: The study found that patients coinfected with CRKP and another carbapenem-resistant pathogen have more significant morbidity and require longer hospital stays compared to those with CRKP monoinfection. Empiric therapy targeting both CRKP and carbapenem-resistant Pseudomonas aeruginosa may be beneficial for at-risk patients with pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Cuiyun Wu, Lin Zheng, Jie Yao
Summary: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection is associated with higher in-hospital mortality in patients. The independent risk factors for death from Klebsiella pneumoniae (KP) infection include CRKP isolation, lower total protein levels, antibiotic therapy duration more than 15 days, and prolonged length of stay. Intensive care unit (ICU) stay and previous carbapenem exposure are independent risk factors for CRKP infection.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Theodoros Karampatakis, Charalampos Zarras, Styliani Pappa, Eleni Vagdatli, Elias Iosifidis, Emmanuel Roilides, Anna Papa
Summary: This study genetically characterized four ST39 CRKP isolates simultaneously producing VIM-1 and KPC-2, obtained in a Greek tertiary hospital. The isolates were pandrug-resistant or extensively drug-resistant, and carried multiple antimicrobial resistance genes and plasmids. The analysis revealed a close clonal relatedness among the isolates.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Po-Han Huang, Wen-Yin Chen, Sheng-Hua Chou, Fu-Der Wang, Yi-Tsung Lin
Summary: Treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections is challenging due to limited antibiotic options. The development of colistin resistance during treatment poses a major challenge. This study found that the addition of tigecycline to colistin treatment reduced the risk of acquiring colistin resistance, providing hope for the treatment of CRKP infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Health Care Sciences & Services
Keh-Sen Liu, Yao-Shen Tong, Ming-Tsung Lee, Hung-Yu Lin, Min-Chi Lu
Summary: This study identified risk factors of 30-day all-cause mortality in patients with CRKP BSI, including microbiologic eradication > 7 days, lower platelet count, and a higher Pitt bacteremia score. These findings provide new insights into the clinical landscape of CRKP BSI.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Immunology
Ning Liu, Gengxia Yang, Yan Dang, Xin Liu, Ming Chen, Fangfang Dai, Xiurong Ding, Wenlei Li, Guangming Li, Jinli Lou, Dexi Chen, Yanhua Yu
Summary: This study retrospectively analyzed the infection characteristics and related factors of liver transplant recipients in our hospital and found a significant correlation between CRKP infection and mortality in the early stage post-liver transplantation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jozef Ficik, Michal Andrezal, Hana Drahovska, Miroslav Bohmer, Tomas Szemes, Adriana Liptakova, Livia Slobodnikova
Summary: The COVID-19 era has significantly increased the incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitals. It is vital to monitor the global and local incidence of CRKP and its antimicrobial resistance. The study highlighted the importance of rational antibiotic policy and strict anti-epidemic precautions.
Article
Infectious Diseases
Athira Pattolath, Prabha Adhikari, Vidya Pai
Summary: The purpose of this study was to detect the presence of Carbapenemase-producing genes in Klebsiella pneumoniae, identify the risk factors for acquiring them, and understand their impact on clinical outcomes. The study found a high prevalence of Carbapenem-resistant K. pneumoniae (CRKP), with surgery and parenteral nutrition significantly associated with the infection. Patients with CRKP had a higher risk of mortality and poor clinical outcomes.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Infectious Diseases
Theodoros Karampatakis, Katerina Tsergouli, Payam Behzadi
Summary: Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for various infections. Carbapenem-resistant K. pneumoniae (CRKP) pose a major threat to public health, with high mortality rates in immunocompromised and critically ill patients. Understanding the virulence factors, molecular epidemiology, and treatment options for CRKP is crucial.
Article
Microbiology
Xiong Liu, Kaiying Wang, Jiali Chen, Jingwen Lyu, Jinhui Li, Qichao Chen, Yanfeng Lin, Benshun Tian, Hongbin Song, Peng Li, Bing Gu
Summary: We report a nosocomial outbreak among pediatric patients caused by clonal dissemination of KPC-2-producing ST11 Klebsiella pneumoniae. Our findings highlight the value of whole-genome sequencing during outbreak investigations and illustrate that transmission chains can be identified during hospital stays.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Jingxuan Zhu, Ye Chen, Xuejing Yang
Summary: This study investigated the antibiotic resistance and molecular characteristics of CRKP strains isolated in Zhejiang Province, China, revealing that CRKP isolates in ICU showed significantly higher resistance rates than those in general ward patients, 50 strains carried the blaKPC gene, and pulmonary disease may affect the prognosis of CRKP infection.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Feiyang Zhang, Qin Li, Jiawei Bai, Manlin Ding, Xiangjin Yan, Guangxi Wang, Baoli Zhu, Yingshun Zhou
Summary: This study revealed that 8.39% of Klebsiella pneumoniae strains were amikacin-heteroresistant, with potential association with increased expression of aminoglycoside resistance genes. The majority of heteroresistant phenotypes were unstable, with partial or full reversion of minimal inhibitory concentrations to the level of susceptibility.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Gabriel Mendes, Maria Leonor Santos, Joao F. Ramalho, Aida Duarte, Catia Caneiras
Summary: Hypervirulent and carbapenem-resistant pathotypes of Klebsiella pneumoniae have emerged as distinct evolutionary types with significant impact on public health. However, there is concern over the convergence of high-risk clones that pose a challenge to available therapeutic options. This review aims to describe the worldwide distribution of virulence factors among carbapenem-resistant highly virulent or hypervirulent K. pneumoniae strains and their interactions with carbapenemase production and sequence types. Urgent understanding of these strains is necessary for effective response as they increasingly replace classical strains in healthcare settings.
FRONTIERS IN MICROBIOLOGY
(2023)
