Review
Biochemistry & Molecular Biology
Salvatore Ulisse, Enke Baldini, Daniele Pironi, Federica Gagliardi, Domenico Tripodi, Augusto Lauro, Sabino Carbotta, Danilo Tarroni, Matteo D'Armiento, Aldo Morrone, Flavio Forte, Flaminia Frattaroli, Severino Persechino, Teresa Odorisio, Vito D'Andrea, Eleonora Lori, Salvatore Sorrenti
Summary: There is evidence suggesting a relationship between thyroid diseases and melanoma, with hypothyroidism potentially promoting melanoma spread and thyroid hormones playing a protective role. Other hormonal factors in the hypothalamic-pituitary-thyroid (HPT) axis may also affect melanoma cell behavior. Further research is needed to understand the precise action of HPT hormones on melanoma cells, which could lead to improved and personalized clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Uttariya Pal, Mohan C. Manjegowda, Neha Singh, Snigdha Saikia, Betty S. Philip, Deep Jyoti Kalita, Avdhesh Kumar Rai, Anupam Sarma, Vandana Raphael, Deepak Modi, Amal Chandra Kataki, Anil Mukund Limaye
Summary: This study demonstrated the positive association between GPER and ERα in breast tumors, and revealed that GPER expression is induced by estrogen-ERα signaling axis. These findings have implications in understanding the interplay between GPER and ERα in breast tumor development, progression, and treatment.
Article
Biochemistry & Molecular Biology
Khaoula Talbi, Ines Cabrita, Rainer Schreiber, Karl Kunzelmann
Summary: ADPKD is caused by loss of function of PKD1 or PKD2, with TMEM16A playing a central role. Expression and function of TMEM16A is upregulated in ADPKD, leading to enhanced intracellular Ca2+ signaling, cell proliferation, and ion secretion. The more severe cystic phenotype in males may be due to enhanced cell proliferation, possibly caused by elevated intracellular Ca2+ levels and increased TMEM16A currents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Joshua Stokar, Irina Gurt, Einav Cohen-Kfir, Oran Yakubovsky, Noa Hallak, Hadar Benyamini, Natan Lishinsky, Neta Offir, Joseph Tam, Rivka Dresner-Pollak
Summary: Menopause is associated with visceral adiposity, hepatic steatosis, and increased risk for cardiovascular disease. This study found that ovariectomy-induced metabolic derangement in adult female mice, and hepatic adropin, regulated by estrogen, was negatively correlated with adverse post-menopausal metabolic phenotypes, which were partially reversed with adropin treatment.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Petr Lapcik, Petr Sulc, Lucia Janacova, Katerina Jilkova, David Potesil, Pavla Bouchalova, Petr Mueller, Pavel Bouchal
Summary: This study found that DSC1 is involved in cell cycle regulation in luminal A breast cancer cells and can be effectively modulated using parthenolide.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Aristides Lopez-Marquez, Carlos Carrasco-Lopez, Andrea Martinez-Cano, Pascale Lemoine, Christophe E. Pierreux, Pilar Santisteban
Summary: This study investigates the role of the transcription factor Sox9 in the differentiation of thyroid follicular cells. The results show that TSH and TGF beta signals regulate the expression of Sox9, and the thyroid transcription factor Pax8 also plays a role in the transcription of Sox9.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi, Gianluigi Giannelli
Summary: CD90 is associated with Notch pathway in iCCA, and its overexpression is related to poor prognosis. Inhibition of the Notch pathway may be beneficial for treating iCCA.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Wei Chen, Shihyun Park, Chrishma Patel, Yuxin Bai, Karim Henary, Arjun Raha, Saeed Mohammadi, Lidan You, Fei Geng
Summary: Matrix stiffness influences the proliferation and migration ability of breast cancer cells, with YAP playing a significant role in this process. As matrix stiffness increases, highly metastatic breast cancer cells exhibit a different migratory potential compared to non-metastatic cells, and this process is YAP-dependent.
Article
Medicine, Research & Experimental
Qing He, Peng Hao, Gang He, Hantao Mai, Wenzhou Liu, Weiqiong Zhang, Kelin Zhang, Guifang Zhong, Ruilian Guo, Changzhi Yu, Yang Li, Chipiu Wong, Qian Chen, Yantao Chen
Summary: Doxorubicin (Dox) is the standard treatment for osteosarcoma (OS), but drug resistance limits its effectiveness. This study investigated metabolic reprogramming and its regulation in Dox-resistant OS cells. The results showed increased ATP levels and altered metabolic profiles in Dox-resistant cells, which was associated with elevated expression of estrogen-related receptor alpha (ERR alpha). Mechanistic analysis revealed increased mRNA stability in chemoresistant cells, possibly due to methylation of the 3' untranslated region of ERR alpha mRNA by N-6-methyladenine, leading to recruitment of IGF2BP1 and increased mRNA stability. Knockdown of IGF2BP1 reversed the metabolic alterations and downregulated ERR alpha, indicating the oncogenic role of the IGF2BP1/ERR alpha axis in Dox-resistant OS cells. Clinical analysis also showed correlation between IGF2BP1 and ERR alpha expression with OS progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Huijin Kim, Jinwoo Jang, Subhin Seomun, Youngdae Yoon, Geupil Jang
Summary: The root cortex is responsible for transporting water and nutrients and storing substances, while also determining the fate of epidermal cells. Research has shown that cortical cells do not divide during root apical meristem (RAM) development, but they can be induced to divide by auxin. This finding highlights the crucial role of auxin in determining root cortical cell division.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Ivanka Jimenez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martinez, Carmen G. Feijoo, Cristobal Aravena, Alejandra Gonzalez-Canacer, Simon Correa, Diego Varela, Claudio Cabello-Verrugio, Felipe Simon
Summary: This study found that TRPM7 in endothelial cells regulates coagulation during sepsis, contributing to inflammation and increased mortality. Additionally, TRPM7 expression in circulating endothelial cells accurately predicts mortality in septic shock patients, making it a potential prognostic biomarker and target for treating sepsis-related coagulation disorders.
BIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yee Ming Khaw, Shehata Anwar, Jinyan Zhou, Tasuku Kawano, Po-Ching Lin, Ashley Otero, Radwa Barakat, Jenny Drnevich, Tomoko Takahashi, CheMyong Jay Ko, Makoto Inoue
Summary: Estrogen through estrogen receptor alpha (ER alpha) is involved in disease modification in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, the exact mechanisms of ER alpha signaling in disease pathogenesis remain unclear. Our study shows that deletion of ER alpha in dendritic cells (DCs) leads to severe neurodegeneration in a mouse EAE model and resistance to interferon beta (IFN beta), a first-line treatment for MS. Estrogen derived from extragonadal sources plays a crucial role in controlling disease phenotypes.
Article
Oncology
Emily Smart, Svetlana E. Semina, Luis H. Alejo, Nidhi S. Kansara, Jonna Frasor
Summary: This study identifies two specific gene signatures in estrogen receptor (ER)-positive breast cancer that are associated with invasion and poor patient outcome. The findings reveal the complex role of ER in promoting invasion and metastasis and provide insights into potential targeted therapies.
Article
Cell Biology
Sara Uhan, Nina Hauptman
Summary: Epithelial-mesenchymal transition (EMT) is a fundamental physiological process in embryonic and organ development. In cancer, EMT is hijacked by cancer cells to promote uncontrolled metastatic dissemination. The competing endogenous RNA (ceRNA) hypothesis suggests that gene expression alterations, both coding and non-coding, contribute to EMT progression in cancer through a large-scale regulatory network. This regulatory diversity is exerted through various epigenetic factors beyond transcriptional control. This review aims to uncover the competitive relationships between ceRNA transcripts that share miRNA-200 family, which play a crucial role in EMT associated with cancer dissemination. Understanding the non-genetic factors influencing neoplasia and modulating the expression levels of various ceRNAs could lead to the development of novel prognostic/diagnostic markers and potential targets for disrupting cancer-related EMT.
Article
Biochemistry & Molecular Biology
Snigdha Saikia, Uttariya Pal, Deep Jyoti Kalita, Avdhesh Kumar Rai, Anupam Sarma, Amal Chandra Kataki, Anil Mukund Limaye
Summary: High expression of RUNX1T1 in breast tumors is associated with a favorable prognosis and is positively associated with overall survival, relapse-free survival, and distant metastasis-free survival in breast cancer patients. RUNX1T1 expression influences the overall survival of patients with ER alpha-positive and ER alpha-negative breast tumors. In ER alpha-positive breast tumors, estrogen downmodulates the expression of RUNX1T1 mRNA through ER alpha signaling, suggesting a potential role in breast cancer progression.
MOLECULAR BIOLOGY REPORTS
(2021)
