Article
Hematology
Sang-A Kim, Ju Hyun Lee, Ji Yun Lee, Hun-Gyu Hwang, Yang-Ki Kim, Ho-Young Yhim, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
Summary: This study found that DOACs have become the most prescribed anticoagulant in Korea after five years, but bleeding complications occurred more frequently in CT patients, especially in those treated with DOACs.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Surgery
Alexandre Tran, Shannon M. Fernando, Marc Carrier, Deborah M. Siegal, Kenji Inaba, Kelly Vogt, Paul T. Engels, Shane W. English, Salmaan Kanji, Kwadwo Kyeremanteng, Jacinthe Lampron, Dennis Kim, Bram Rochwerg
Summary: This study summarizes the efficacy and safety of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) for the prevention of venous thromboembolism (VTE) in trauma patients. The results showed that LMWH is more effective than UFH in reducing the risk of deep vein thrombosis and VTE, and may also reduce the risk of pulmonary embolism and mortality. However, the impact on adverse events and heparin induced thrombocytopenia is uncertain.
Article
Oncology
Jasmin Jo, Joseph Donahue, Guneet Sarai, Gina Petroni, David Schiff
Summary: This study aimed to assess the risk of intracranial hemorrhage (ICH) in high-grade glioma (HGG) patients with venous thromboembolism (VTE) on low molecular weight heparin (LMWH). The retrospective matched cohort study found that therapeutic LMWH is not associated with a substantially increased risk of ICH in HGG patients, and the median survival was similar among all three cohorts.
Review
Pharmacology & Pharmacy
Adham Makarem, Rana Zareef, Joseph Abourjeili, Joseph E. Nassar, Fadi Bitar, Mariam Arabi
Summary: Since the emergence of the COVID-19 pandemic, it has had a dramatic impact on public health worldwide and has affected various aspects of life. Despite the development of vaccines, severe cases of SARS-CoV-2 infection with life-threatening complications still occur. Researchers are exploring different approaches to prevent infection and minimize its severity. Low molecular weight heparin (LMWH) has been shown to play an important role in addressing the sequelae of COVID-19.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Surgery
Alexandre Tran, Shannon M. Fernando, Rebecca S. Gates, Jacob R. Gillen, Molly E. Droege, Marc Carrier, Kenji Inaba, Elliott R. Haut, Bryan Cotton, Amanda Teichman, Paul T. Engels, Rakesh V. Patel, Jacinthe Lampron, Bram Rochwerg
Summary: This study compared anti-Xa-guided dosing with fixed dosing of low molecular weight heparin (LMWH) for VTE prevention in adult trauma patients. The findings suggest that anti-Xa-guided dosing may reduce the risk of deep vein thrombosis, pulmonary embolism, and any VTE, although the certainty of evidence is low. The impact on mortality and bleeding events remains uncertain. Overall rating: 8 out of 10.
Article
Hematology
Angela Lee, Frank Oley, Mimi Lo, Richard Fong, Mary McGann, Ila Saunders, Shanna Block, Anjlee Mahajan, Tiffany K. Pon
Summary: This study found no significant differences in safety and efficacy between DOACs and LMWH for the treatment of cancer-associated VTE. This suggests that DOACs may be a safe and effective option for VTE treatment in patients with primary or secondary brain tumors.
THROMBOSIS RESEARCH
(2021)
Review
Hematology
Joao Presume, Jorge Ferreira, Regina Ribeiras, Miguel Mendes
Summary: This study systematically evaluated the use of FXI inhibitors in major orthopedic surgery and found that FXI inhibitors significantly reduced the incidence of venous thromboembolism and bleeding events among patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Agriculture, Dairy & Animal Science
Athanasia Mitropoulou, Esther Hassdenteufel, Joanna Lin, Natali Bauer, Gabriel Wurtinger, Claudia Vollmar, Estelle Henrich, Nicolai Hildebrandt, Matthias Schneider
Summary: Feline arterial thromboembolism is a painful disease that can be induced by feline heart diseases, hyperthyroidism, or neoplasia. This retrospective study reports the clinical data of 36 affected cats treated with intravenous enoxaparin and oral clopidogrel, showing that this combination therapy is effective in treating the disease.
Article
Cardiac & Cardiovascular Systems
Paul D. Stein, Fadi Matta, Mary J. Hughes
Summary: The study found that the selection of hospitalization for acute DVT patients is related to the site of DVT and age, with a conservative approach still prevalent in the use of home treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jacqueline G. Gerhart, Fernando O. Carreno, Matthew Shane Loop, Craig R. Lee, Andrea N. Edginton, Jaydeep Sinha, Karan R. Kumar, Carl M. Kirkpatrick, Christoph P. Hornik, Daniel Gonzalez
Summary: Dosing guidance for children with obesity is often unknown and it remains unclear whether children with and without obesity experience equivalent enoxaparin exposure. A physiologically-based pharmacokinetic model was developed to explore the differences in anti-Xa concentration between children with and without obesity. The model showed that weight-normalized clearance was reduced in children with obesity, leading to higher anti-Xa concentrations under weight-based dosing. Fat-free mass weight-based dosing improved enoxaparin exposure across different age groups and obesity status.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Anna Matyjek, Aleksandra Rymarz, Zuzanna Nowicka, Slawomir Literacki, Tomasz Rozmyslowicz, Stanislaw Niemczyk
Summary: The study found that the efficacy of enoxaparin is reduced in severe nephrotic syndrome patients, and the dose should be adjusted based on ideal body weight to achieve target anti-FXa activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
William Knoll, Nathan Fergusson, Victoria Ivankovic, Tzu-Fei Wang, Lucia Caiano, Rebecca Auer, Marc Carrier
Summary: Postoperative venous thromboembolism is a significant concern for cancer patients undergoing major abdominopelvic surgery. Extended duration thromboprophylaxis with LMWH was found to significantly reduce the incidence of clinical VTE without increasing the risk of clinically-relevant bleeding.
THROMBOSIS RESEARCH
(2021)
Article
Clinical Neurology
Peter Wood, Giovanni Boyer, Elie Mehanna, Daniel Cagney, Nayan Lamba, Paul Catalano, Jean M. Connors, Liangge Hsu, Mallika Mendu, Shyam Tanguturi, Brian Alexander, Daphne Haas-Kogan, Ayal Aizer
Summary: Anticoagulation therapy in patients with brain metastases may increase the risk of intracerebral hemorrhage, especially in those with melanoma or a history of prior intracerebral hemorrhage. Individualized assessment of the indication for anticoagulation and risk of bleeding should be considered in such patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Surgery
Rachel Bigos, Edmond Solomon, Jon D. Dorfman, Michael Ha
Summary: The study evaluated a weight-based and anti-Xa-guided enoxaparin dosing protocol in ICU trauma patients. The protocol was safe and effective in achieving initial anti-Xa levels within goal, but monitoring may be beneficial for patients over 100 kg to prevent sub-prophylactic levels.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tessa Corrine Catherina Jaspers, A. Keyany, B. Maat, K. Meijer, P. M. L. A. van den Bemt, N. Khorsand
Summary: There is substantial diversity in the treatment policies of therapeutically dosed LMWHs in renally impaired patients in Dutch hospitals. The most commonly used treatment regimen is a regular dose reduction if eGFR is < 50 ml/min, without routine monitoring of anti-Xa levels.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)