Review
Nutrition & Dietetics
Elif Ulug, Reyhan Nergiz-Unal
Summary: The CD36 receptor plays a crucial role in cholesterol homeostasis, with dietary fatty acids influencing its levels and cholesterol metabolism. The effects of saturated fatty acids and trans-fatty acids on CD36-mediated cholesterol homeostasis may be detrimental, while monounsaturated fatty acids could be beneficial. The role of polyunsaturated fatty acids in CD36-mediated cholesterol homeostasis is controversial and depends on the ratio of n-3 to n-6 PUFA.
NUTRITION RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Junhui Zhang, Huilin Yu, Qianqian Wang, Haiying Cai, Fei Shen, Shengyue Ruan, Yue Wu, Tao Liu, Fengqin Feng, Minjie Zhao
Summary: This study found that octyl and decyl glycerate (ODG), a medium-chain triglyceride (MCT), can alter the composition of the gut microbiota and have an impact on glucose and lipid metabolism and inflammation. The effects of ODG on lipid metabolism differ under different dietary patterns. Moreover, ODG supplementation also leads to changes in the gut microbiota, which may contribute to the alterations in metabolism and inflammation and may be influenced by dietary patterns.
Article
Cardiac & Cardiovascular Systems
Umar R. Rekhi, Mohamed Omar, Maria Alexiou, Cole Delyea, Linnet Immaraj, Shokrollah Elahi, Maria Febbraio
Summary: Research indicates that endothelial cell CD36 plays a significant role in systemic metabolism and has a sex-specific impact on atherosclerosis and energy substrate use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wenxiang Li, Guangyi Huang, Ningning Tang, Peng Lu, Li Jiang, Jian Lv, Yuanjun Qin, Yunru Lin, Fan Xu, Daizai Lei
Summary: This cross-sectional study examined the association between dietary components and abdominal aortic calcification (AAC) using data from NHANES. The study found that total protein, total fiber, vitamin A, and β-cryptoxanthin were negatively associated with AAC. A plant-based dietary pattern was associated with a lower risk of AAC, while a caffeine and theobromine pattern was associated with a higher risk.
Article
Hematology
Jenni Maatta, Raisa Serpi, Sohvi Horkko, Valerio Izzi, Johanna Myllyharju, Elitsa Y. Dimova, Peppi Koivunen
Summary: The genetic ablation of P4H-TM was shown to protect against atherosclerosis by potentially modulating immuno-metabolic interactions, including the presence of IgM antibodies to Ox-LDL and increased lipoprotein lipase levels. This mechanism could provide a novel approach for intervention in atherosclerosis pathology by targeting hypertriglyceridemia and promoting protective immune responses.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Nutrition & Dietetics
Wei Zeng, Qingzhe Jin, Xingguo Wang
Summary: There is a significant correlation between dietary fat consumption and cardiovascular disease in China over the past 30 years. Changes in fat intake have been closely related to the incidence of cardiovascular disease. Therefore, it is important for the government to raise awareness about dietary fat intake and educate the public to avoid high-fat diets.
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Ashish Gupta, Mohammad Alkhalil
Summary: Omega-3 polyunsaturated fatty acids (PUFAs) have been established as a therapeutic option for patients with high triglyceride levels. They have effects on lipoprotein particles and can be incorporated within the cellular membrane, leading to plaque stability and anti-inflammatory effects. However, recent clinical trials have shown inconsistent results regarding the cardioprotective effects of omega-3 fatty acids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Mohsen Mazidi, Andre P. Kengne, Mario Siervo, Richard Kirwan
Summary: The study suggests that higher dietary intake of polyunsaturated fatty acids (PUFAs) is associated with improved renal function and lower risk of chronic kidney disease (CKD), while there is no significant association between monounsaturated fatty acids (MUFAs) intake and renal function or CKD risk. Genetically determined serum levels of PUFAs and MUFAs also do not show significant association with renal function and CKD risk.
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Review
Engineering, Environmental
Matej Zula, Miha Grilc, Blaz Likozar
Summary: This article provides a review of the mechanisms, kinetics, and effects of process conditions on the conversion, selectivity, and catalyst stability in the hydrogenation, hydrocracking, and hydro-deoxygenation reactions of biomass-derived fatty acids. It discusses various steps in the reactions and focuses on non-equilibrium thermodynamic energetics and characteristic modeling approaches.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Agricultural Engineering
Vanessa Ferreira Caldeira, Ana Flavia Freitas de Carvalho, Jose Marcos Teixeira de Alencar Filho, Amanda Leite Guimaraes, Silvio Alan Gonsalves Bomfim Reis, Edigenia Cavalcante da Cruz Araujo
Summary: This study aims to determine the chemical composition of fixed oils extracted from the seeds of two species of Cenostigma and develop emulsions. The evaluation of the chemical composition showed that linoleic acid is the majority fatty acid in both oils. The physicochemical characterization indicated that the oils meet the quality standard and are suitable for application in cosmetic emulsions. Stable emulsions with pseudoplastic behavior and cosmetic potential were successfully developed.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Nutrition & Dietetics
Alexander Folwaczny, Elisa Waldmann, Julia Altenhofer, Kerstin Henze, Klaus G. Parhofer
Summary: Fasting and postprandial hypertriglyceridemia are risk factors for atherosclerosis. Dietary interventions may impact postprandial triglyceride metabolism in mildly to moderately hypertriglyceridemic patients. Replacing saturated fatty acids with medium-chain fatty acids could be a treatment option for preventing postprandial hypertriglyceridemia in these patients.
Article
Biochemistry & Molecular Biology
C. J. Urso, Heping Zhou
Summary: The study revealed that CD36 plays a crucial role in fatty acid uptake and palmitic acid (PA) lipotoxicity in N2a neuroblastoma cells, suggesting that CD36 may represent a regulatory target against pathologies caused by excess fatty acids.
Editorial Material
Biochemistry & Molecular Biology
Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Kerstin Jurk
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Stefan Loroch, Dominik Kopczynski, Adriana C. Schneider, Cornelia Schumbrutzki, Ingo Feldmann, Eleftherios Panagiotidis, Yvonne Reinders, Roman Sakson, Fiorella A. Solari, Alicia Vening, Frauke Swieringa, Johan W. M. Heemskerk, Maria Grandoch, Thomas Dandekar, Albert Sickmann
Summary: This study introduces a novel strategy for positive-pressure 96-well filter-aided sample preparation (PF96), which significantly increases throughput and demonstrates high reproducibility. The study confirms the excellent reproducibility and stability of PF96 at the protein level, as well as its compatibility with nanoLC-MS instrumentation. This method has promising applications in biomedical and clinical research.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Cell Biology
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W. M. Heemskerk, Angel Garcia, Steve P. Watson
Summary: Src tyrosine kinases and spleen tyrosine kinase (Syk) play a role in sustained platelet aggregation under minimal shear following activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2). Aggregation and tyrosine phosphorylation were monitored by light transmission aggregometry (LTA) and fluorescence-labeled antibody. Src contributes to sustained aggregation through a Syk-independent pathway that inhibits outside-in signaling from glycoprotein IIb-IIia (GPIIIb-IIIa) to the cytoskeleton.
Article
Biochemistry & Molecular Biology
Linsey J. F. Peters, Constance C. F. M. J. Baaten, Sanne L. Maas, Chang Lu, Magdolna Nagy, Natalie J. Jooss, Kiril Bidzhekov, Donato Santovito, Daniel Moreno-Andres, Joachim Jankowski, Erik A. L. Biessen, Yvonne Doering, Johan W. M. Heemskerk, Christian Weber, Marijke J. E. Kuijpers, Emiel P. C. van der Vorst
Summary: This study demonstrates for the first time that miR-26b attenuates platelet adhesion and aggregation, possibly through Src and EGFR signaling.
Review
Nutrition & Dietetics
Mariska Dotsch-Klerk, Maaike J. Bruins, Patrick Detzel, Janne Martikainen, Reyhan Nergiz-Unal, Annet J. C. Roodenburg, Ayla Gulden Pekcan
Summary: This review evaluates existing models to estimate the health and/or economic impact of nutrition interventions. The study finds that the complexity of these models and the challenges of data availability require more guidance and standardization to compare results across studies.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Guido R. M. M. Haenen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
James R. R. Bayrer, Joel Castro, Archana Venkataraman, Kouki K. K. Touhara, Nathan D. D. Rossen, Ryan D. D. Morrie, Jessica Maddern, Aenea Hendry, Kristina N. N. Braverman, Sonia Garcia-Caraballo, Gudrun Schober, Mariana Brizuela, Fernanda M. M. Castro Navarro, Carla Bueno-Silva, Holly A. A. Ingraham, Stuart M. M. Brierley, David Julius
Summary: Gastrointestinal discomfort is a common symptom of gut disorders and chronic visceral pain, especially in patients with irritable bowel syndrome. Enterochromaffin (EC) cells, which are rare serotonergic neuroendocrine cells in the gut epithelium, play a crucial role in detecting and transmitting noxious stimuli to nerve endings. The activation and dysfunction of EC cells are associated with hypersensitivity to gut distension and the inflammatory effects of certain fatty acids. Additionally, prolonged EC cell activation leads to persistent visceral hypersensitivity and anxiety-like behaviors. Furthermore, there are notable sex differences in the involvement of the EC cell-mucosal afferent circuit.
Article
Hematology
Claudia Schoenichen, Samantha J. Montague, Sanne L. N. Brouns, James J. Burston, Judith M. E. M. Cosemans, Kerstin Jurk, Beate E. Kehrel, Rory R. Koenen, Fionnuala Ni Ainle, Valerie B. O'Donnell, Oliver Soehnlein, Steve P. Watson, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Magdolna Nagy
Summary: This study reveals the key interaction mechanisms between platelets and neutrophils in arterial thrombus formation. Activated platelet integrin αIIbβ3 plays a role in preventing leukocyte adhesion, while platelet-released substances promote neutrophil activation. These findings provide insights for potential pharmacological intervention.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaping Xu, Zhengwen Li, Yue Wang, Chujie Li, Ming Zhang, Haiming Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Weijun Chen, Guido R. M. M. Haenen, Mohamed Moalin
Summary: It has been found that 2R,3R-DHQ does not convert into quercetin in an oxidative environment, but forms an unstable oxidation product. The addition of glutathione leads to the formation of a 2R,3R-DHQ-GSH adduct, indicating oxidation of the B-ring. Ascorbate can reduce the quinone back to 2R,3R-DHQ. This suggests that the redox-modulating activity of 2R,3R-DHQ quinone resides in its B-ring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Isabella Provenzale, Ilaria De Simone, Jonathan M. Gibbins, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Chris I. Jones
Summary: This study investigated the roles of different extracellular matrix proteoglycans in platelet responses and thrombus formation. It was found that one proteoglycan (perlecan) enhanced platelet activation and promoted thrombus formation, but also reduced platelet adhesion under flow. This suggests that proteoglycans play an important role in platelet activation and thrombus formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
QingQing Wang, Sonia Garcia Caraballo, Grigori Rychkov, Alice E. McGovern, Stuart B. Mazzone, Stuart M. Brierley, Andrea M. Harrington
Summary: This study compared the central circuits of vagal and spinal afferent pathways in the transmission of colorectal nociceptive information. The results showed differences in the projections and activation of neurons between the two pathways, as well as differences in their response to pressure intensity.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Hematology
Alexandra Yakusheva, Alexandre Slater, Bernard Payrastre, Cedric Garcia, Giorgia D'Italia, Harriet Allan, Judith M. E. M. Cosemans, Matthew Harper, Meinrad Gawaz, Paul Armstrong, Sara Troitino, Silvia Maria Grazia Trivigno, Ulhas P. Naik, Yotis A. Senis
Summary: This article presents the talks and original investigations conducted at the 5th European Platelet Network International Conference, covering recent advances in platelet and megakaryocyte biology.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Sanne L. N. Brouns, Bibian M. E. Tullemans, Cristiana Bulato, Gina Perrella, Elena Campello, Luca Spiezia, Johanna P. van Geffen, Marijke J. E. Kuijpers, Rene van Oerle, Henri M. H. Spronk, Paola E. J. van der Meijden, Paolo Simioni, Johan W. M. Heemskerk
Summary: This study assessed the role of platelets in thrombus and fibrin formation in patients with protein C or protein S deficiency under high-shear flow conditions. The results showed that these patients had impaired platelet activation, thrombus phenotype, and fibrin formation, but unchanged platelet adhesion. The defect may be caused by negative platelet priming.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Herm Jan M. Brinkman, Frauke Swieringa, Marleen Zuurveld, Alicia Veninga, Sanne L. N. Brouns, Johan W. M. Heemskerk, Joost C. M. Meijers
Summary: The study demonstrates the beneficial effect of combined use of PCC and FVC in reversing DOAC-induced coagulopathy by increasing thrombin generation, improving clot formation, enhancing clot strength and resistance to lysis.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Public, Environmental & Occupational Health
Derya Dikmen, Ezgi Bellikci-Koyu, Kubra Isgin-Atici, Elif Inan-Eroglu, Asli Akyol, Aylin Ayaz, Reyhan Nergiz-Unal, Zehra Buyuktuncer
Summary: This study examined the food and beverages purchased by Turkish adolescents under the influence of television advertisements and evaluated the products using the WHO nutrient profiling model. Results showed that unhealthy foods, such as cakes, confectionery, savory snacks, and soft drinks, were heavily advertised and purchased by the adolescents. Only a small proportion of the advertised products were deemed healthy according to the WHO nutrient profile model.
JOURNAL OF RESEARCH IN HEALTH SCIENCES
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
