Review
Immunology
Edward L. G. Pryzdial, Alexander Leatherdale, Edward M. Conway
Summary: This article is a review on the interactions between coagulation and complement and how they work together to protect the body from injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yang Du, Zhiqiang Hu, Yien Luo, Helen Y. Wang, Xiao Yu, Rong-Fu Wang
Summary: The DNA-sensing receptor cGAS and its downstream signaling adaptor STING play crucial roles in immune defense against infectious pathogens, and the interplay between the cGAS-STING pathway and pathogens provides insight into the development of pharmacological approaches for treating infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Behazine Combadiere, Lucille Adam, Noelline Guillou, Paul Quentric, Pierre Rosenbaum, Karim Dorgham, Olivia Bonduelle, Christophe Parizot, Delphine Sauce, Julien Mayaux, Charles-Edouard Luyt, Alexandre Boissonnas, Zahir Amoura, Valerie Pourcher, Makoto Miyara, Guy Gorochov, Amelie Guihot, Christophe Combadiere
Summary: Neutrophil subsets in COVID-19 patients have prognostic value in predicting disease severity and thrombosis complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong, Chao Yang
Summary: This article provides an up-to-date overview of the strategies and applications of nanocarrier-assisted innate immune modulation for the management of infections and their associated complications. It discusses the importance of innate immunity in defending against pathogens and the role of immunomodulators in treating infectious diseases. The use of nanocarriers as a promising tool to overcome challenges in immunomodulator therapy is also explored.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Microbiology
Aritra Bhattacharyya, Toni Herta, Claudia Conrad, Doris Frey, Pedro Garcia, Norbert Suttorp, Stefan Hippenstiel, Janine Zahlten
Summary: The induction of KLF4 expression in PMNs by Streptococcus pneumoniae is found to play a crucial role in regulating PMN activation and contributing to the immune response during bacterial infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Hematology
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M. Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M. Verhamme, Owen J. T. McCarty, Ruby H. P. Law, David Gailani
Summary: Factor XII (FXII) is a plasma protease that contributes to bradykinin generation. Its conversion to FXIIa enhances when it binds to negatively charged surfaces. The heavy chain of FXII plays a key role in surface binding and activation, while also restricting activation when not bound to a surface. Different domains within the heavy chain have varying importance in FXII function, such as EGF1 being required for surface-dependent activation and KNG and FN2 influencing activation in the absence of a surface.
Article
Hematology
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M. Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M. Verhamme, Owen J. T. McCarty, Ruby H. P. Law, David Gailani
Summary: Factor XII (FXII) is a plasma zymogen that contributes to bradykinin production. The activation of FXII is enhanced when it binds to negatively charged surfaces such as polymeric orthophosphate. The heavy chain of FXII promotes surface-binding and activation, while restricting activation in the absence of a surface. EGF1, KNG, and FN2 domains play important roles in FXII function.
Review
Allergy
Steven de Maat, Kusumam Joseph, Coen Maas, Allen P. Kaplan
Summary: The plasma contact system quickly activates upon exposure to a negatively charged surface, initiating the intrinsic pathway of coagulation and producing the inflammatory peptide bradykinin. While naturally occurring negatively charged surfaces play a role in thrombosis, their specific involvement in the pathophysiology of hereditary angioedema remains unclear.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Review
Hematology
Karsten Engseth Kluge, Ingebjorg Seljeflot, Harald Arnesen, Torstein Jensen, Sigrun Halvorsen, Ragnhild Helseth
Summary: In this review, observational and experimental studies on factors XI and XII as potential targets for anticoagulant therapy are discussed. Low concentrations of FXI are found to be protective against ischemic stroke and venous thrombosis, indicating its potential as a target for antithrombotic therapy. The potential of targeting FXII for preventing thrombosis is still unclear, with conflicting results from different studies.
THROMBOSIS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Luis A. Arteaga-Blanco, Dumith Chequer Bou-Habib
Summary: The nanosized EVs released by cells play a crucial role in intercellular communication, regulating cellular homeostasis and potentially spreading pathogen-derived molecules. Studying EVs shed by human macrophages can provide insights into modulating host immune responses and developing innovative therapeutic strategies against infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Amy Dagenais, Carlos Villalba-Guerrero, Martin Olivier
Summary: Innate immune cells can enhance the response to reinfection through trained immunity, a form of immunological memory. The potential of trained immunity in prophylaxis and therapy has attracted great interest in the field of infectious diseases. In the context of antimicrobial resistance and climate change, harnessing the advantages of trained immunity could be game-changing. This article presents recent research linking trained immunity and infectious diseases, highlighting important discoveries, questions, concerns, and novel avenues for its modulation in practice, with a focus on problematic and understudied pathogens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Paul N. Zivich, Will Huang, Ali Walsh, Prabal Dutta, Marisa Eisenberg, Allison E. Aiello
Summary: The study investigated person-to-person contacts and hand hygiene in office-based workplaces using two different sensors. It found that face-to-face contacts and proximity contacts have different characteristics, and there are differences in interactions between supervisors and non-supervisors. The study demonstrates the feasibility of implementing sensor technologies in offices to track interactions and behaviors, providing new insights into real-world social networks and hygiene practices.
Review
Immunology
Junjie Gu, Chongying Su, Fei Huang, Yuwei Zhao, Jing Li
Summary: This article discusses the roles of circRNAs in immune-related diseases, including their expression profile analysis, potential biomarker research, impact on phenotypes, and applications and prospects in therapeutic target seeking.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Brian J. Laight, Natasha A. Jawa, Kathrin Tyryshkin, David M. Maslove, J. Gordon Boyd, Peter A. Greer
Summary: Sepsis is caused by initial over-activation of the immune system in response to an infection or trauma, followed by suppression of the immune system. Enhancing FES in early sepsis and inhibiting it in late sepsis may improve the severity and outcome of septic illness.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Infectious Diseases
Francesca Conti, Antonio Marzollo, Mattia Moratti, Lorenzo Lodi, Silvia Ricci
Summary: This article summarizes the inborn errors of immunity that result in a high risk of severe pyogenic infections, including deficiencies in major components of the immune system and novel monogenic disorders leading to specific susceptibility to pyogenic infections.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Gastroenterology & Hepatology
Thorben Fruendt, Niko Schroeder, Angelique Hoelzemer, Hans Pinnschmidt, Jocelyn de Heer, Berit C. Behrends, Thomas Renne, Anne Lautenbach, Ansgar W. Lohse, Joerg Schrader
Summary: Background: Diabetes mellitus is a major risk factor for chronic kidney injury or cardiovascular disease, but little is known about the prevalence of undiagnosed diabetes in gastroenterology inpatients. Objective: To improve detection of undiagnosed diabetes, a routine screening procedure for gastroenterology inpatients was established. Results: The prevalence of undiagnosed diabetes in gastroenterology inpatients is markedly elevated, with a substantial number of patients in a prediabetic status, and PSC-related liver cirrhosis is an independent risk factor for undiagnosed diabetes.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Review
Biochemistry & Molecular Biology
Reiner K. Mailer, Chandini Rangaswamy, Sandra Konrath, Jonas Emsley, Thomas Renne
Summary: The plasma protein factor XII, as the liver-derived zymogen of serine protease FXIIa, plays a key role in thrombosis and inflammation. Growing evidence suggests that FXIIa-mediated thrombo-inflammation is crucial in various pathological states, and increased FXIIa levels are associated with hypercholestemlemia and hypertriglyceridemia.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Letter
Cell Biology
Martin Zickler, Stephanie Stanelle-Bertram, Sandra Ehret, Fabian Heinrich, Philine Lange, Berfin Schaumburg, Nancy Mounogou Kouassi, Sebastian Beck, Michelle Y. Jaeckstein, Oliver Mann, Susanne Krasemann, Maria Schroeder, Dominik Jarczak, Axel Nierhaus, Stefan Kluge, Manuela Peschka, Hartmut Schlueter, Thomas Renne, Klaus Pueschel, Andreas Kloetgen, Ludger Scheja, Benjamin Ondruschka, Joerg Heeren, Guelsah Gabriel
Article
Cardiac & Cardiovascular Systems
Elina Larissa Petersen, Alina Gossling, Gerhard Adam, Martin Aepfelbacher, Christian-Alexander Behrendt, Ersin Cavus, Bastian Cheng, Nicole Fischer, Juergen Gallinat, Simone Kuehn, Christian Gerloff, Uwe Koch-Gromus, Martin Haerter, Uta Hanning, Tobias B. Huber, Stefan Kluge, Johannes K. Knobloch, Piotr Kuta, Christian Schmidt-Lauber, Marc Luetgehetmann, Christina Magnussen, Carola Mayer, Kai Muellerleile, Julia Muench, Felix Leonard Naegele, Marvin Petersen, Thomas Renne, Katharina Alina Riedl, David Leander Rimmele, Ines Schaefer, Holger Schulz, Enver Tahir, Benjamin Waschki, Jan-Per Wenzel, Tanja Zeller, Andreas Ziegler, Goetz Thomalla, Raphael Twerenbold, Stefan Blankenberg
Summary: This study comprehensively assessed organ-specific functions in individuals after mild to moderate SARS-CoV-2 infection and found subclinical multi-organ affection related to pulmonary, cardiac, thrombotic, and renal function. However, there were no signs of structural brain damage, neurocognitive impairment, or quality-of-life impairment.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Hematology
Andreas Greinacher, Florian Langer, Linda Schoenborn, Thomas Thiele, Munif Haddad, Thomas Renne, Jerome Rollin, Yves Gruel, Theodore E. Warkentin
Review
Hematology
Reiner K. Mailer, Piotr Kuta, Thomas Renne
Summary: Blood coagulation is essential for maintaining the integrity of the circulatory system, but it can also lead to thrombosis. Existing anticoagulant treatments increase the risk of bleeding, necessitating the development of drugs targeting novel mechanisms. Recent studies have shown that intervention in contact system proteins can provide effective and safe thromboprotection without increasing bleeding risk.
Article
Endocrinology & Metabolism
Lena Rass, Amir-Hossein Rahvar, Jakob Matschke, Wolfgang Saeger, Thomas Renne, Jens Aberle, Joerg Flitsch, Roman Rotermund
Summary: The study aimed to analyze the expression of SSTR2a and 5 in somatotrophic pituitary adenomas and associate it with tumor size, clinical, biochemical, and histological parameters, as well as response to SA therapy. The results showed no significant relationship between receptor subtype expression rates and the parameters analyzed.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Medicine, General & Internal
Bastian F. J. Plochg, Hanna Englert, Chandini Rangaswamy, Sandra Konrath, Mandy Malle, Sibylle Lampalzer, Claudia Beisel, Salma Wollin, Maike Frye, Jens Aberle, Johannes Kluwe, Thomas Renne, Reiner K. Mailer
Summary: Our study reveals that liver damage promotes pro-inflammatory ApoB100-specific T-cell populations, providing a cellular mechanism for increased CVD risk in liver disease patients.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Genetics & Heredity
Mojgan Masoodi, Manuela Peschka, Stefan Schmiedel, Munif Haddad, Maike Frye, Coen Maas, Ansgar Lohse, Samuel Huber, Paulus Kirchhof, Jerzy-Roch Nofer, Thomas Renne
Summary: This study found significant differences in plasma metabolic signatures between COVID-19 patients and control group, primarily in lipid and amino acid metabolism. Protein systems biology analysis revealed that COVID-19 mainly impacted sphingolipid, tryptophan, tyrosine, glutamine, arginine, and arachidonic acid metabolism pathways. Additionally, decreased levels of GABA could serve as a potential biomarker and therapeutic target for COVID-19 patients.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Hematology
Wariya Sanrattana, Simone Smits, Arjan D. Barendrecht, Nadine D. van Kleef, Hinde El Otmani, Minka Zivkovic, Mark Roest, Thomas Renne, Chantal C. Clark, Steven de Maat, Coen Maas
Summary: TaSER fusion protein has antithrombotic properties by interfering with platelet-driven thrombin formation, inhibiting thrombin activity on platelet surface, blocking VWF binding, and disassembling platelet agglutinates. It delays tissue factor-triggered thrombin generation in a targeted manner. TaSER limits platelet adhesion and aggregate formation, as well as thrombus formation, through targeted inhibition of platelet-dependent thrombin activity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Stuart Wallis, Nina Wolska, Hanna Englert, Mareike Posner, Abhishek Upadhyay, Thomas Renne, Ian Eggleston, Stefan Bagby, Giordano Pula
Summary: In this study, Efb(68-87) was identified as a novel selective platelet-binding peptide that directly binds to P-selectin and inhibits interactions between platelets and leukocytes leading to PLAs and NETs formation. This peptide has the potential to become a selective inhibitor of the proinflammatory activity of platelets, which play a key role in thromboinflammation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Anesthesiology
Karim Kouz, Alina Bergholz, Oliver Diener, Maximilian Leistenschneider, Christina Thompson, Friederike Pichotka, Constantin Trepte, Edzard Schwedhelm, Thomas Renne, Linda Krause, Julia Y. Nicklas, Bernd Saugel
Summary: Intraoperative personalized goal-directed hemodynamic management reduces the incidence of acute myocardial injury in high-risk patients undergoing major abdominal surgery.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Hematology
Reiner K. Mailer, Sandra Konrath, Lydia Zhan, Hanna Thode, Manu Beerens, Maike Frye, Daniel F. J. Ketelhuth, Thomas Renne, Goeran K. Hansson
Summary: Inflammation caused by LDL deposition in the arterial wall leads to atherosclerosis. Regulatory T cells inhibit vascular inflammation by inducing immune tolerance towards LDL-related antigens. However, the mechanisms that promote the generation of LDL-specific regulatory T cells in vivo are still unclear.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cell Biology
Peter M. Benz, Timo Froemel, Hebatullah Laban, Joana Zink, Lea Ulrich, Dieter Groneberg, Reinier A. Boon, Philip Poley, Thomas Renne, Cor de Wit, Ingrid Fleming
Summary: Actin binding proteins are crucial for the regulation of actin cytoskeletal dynamics and play a role in various cellular processes. The Ena/VASP family of proteins enhance actin filament assembly and link kinase signaling pathways to actin organization. They are involved in processes such as membrane protrusions, cell adhesions, and mechanical tension. This review provides an overview of the functions and molecular mechanisms of Ena/VASP proteins in cardiovascular cells.
Article
Hematology
Steven de Maat, Chantal C. Clark, Arjan D. Barendrecht, Simone Smits, Nadine D. van Kleef, Hinde El Otmani, Manon Waning, Marc van Moorsel, Michael Szardenings, Nicolas Delaroque, Kristof Vercruysse, Rolf T. Urbanus, Silvie Sebastian, Peter J. Lenting, Christoph Hagemeyer, Thomas Renne, Karen Vanhoorelbeke, Claudia Tersteeg, Coen Maas
Summary: Thrombotic microangiopathies are characterized by attacks of disseminated microvascular thrombosis. This study developed a fusion protein called Microlyse that can target and activate plasminogen on microthrombi, showing greater efficacy for the treatment of TTP compared to current methods.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
