Review
Nutrition & Dietetics
Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton, Andreas M. Grabrucker, Ronan Lordan, Ioannis Zabetakis
Summary: This review discusses the role of platelet-activating factor (PAF) and its receptor in inflammatory diseases and atherosclerotic cardiovascular diseases, with a focus on how inhibiting PAF-R can reduce cardiovascular disease risk. Research suggests that dietary factors may modulate PAF metabolism and PAF-R function to regulate disease development.
Review
Cell Biology
Pu Rong, Jie-Li Wang, Angelina Angelova, Zakaria A. Almsherqi, Yuru Deng
Summary: This article explores the relationship between plasmalogens and Platelet-Activating Factor (PAF), suggesting the potential role of plasmalogenic analogs of PAF as modulators and PAF antagonists. The metabolic interconversion of these lipids is discussed as an important factor in preventing and relieving PAF-mediated inflammation, and the possibility of plasmalogen analogs as a new class of bioactive anti-inflammatory drugs is proposed. Additionally, the competition between PAF and its natural plasmalogenic analogs for binding to the PAF receptor is proposed as a mechanistic model and potential therapeutic perspective.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xin Chen, Jiajun Yan, Yingying Jiang, Yunshan Fan, Zhengran Ying, Shuo Tan, Zhi Zhou, Junjian Liu, Feng Chen, Shisheng He
Summary: This study presents a biomimetic strategy for developing an injectable biomaterial composed of platelets, fibrins, and biominerals to repair bone defects. The biomaterial showed high biocompatibility and promoted the osteogenic differentiation of bone marrow stem cells. In vivo studies demonstrated that the biomaterial induced the formation of new collagen and blood vessels, leading to faster bone defect regeneration. This research provides a strategy for designing new biomimetic materials and holds significant importance for the treatment of refractory bone fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Kai Yang, Bin Wu, Wu Wei, Cuiyu Li, Lu Li, Zhukai Cong, Qian Xiang
Summary: This study investigated the effects of curdione, an active ingredient of Curcuma zedoary, on sepsis-induced lung injury. The results showed that curdione can alleviate tissue pathological changes, reduce inflammatory factors and protein concentrations, decrease oxidative stress responses, inhibit platelet activation, and reduce neutrophil infiltration and NET formation. Curdione has great therapeutic potential in sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Justine Brodard, Johanna A. Kremer Hovinga, Pierre Fontana, Jan-Dirk Studt, Yves Gruel, Andreas Greinacher
Summary: In COVID-19 patients, a serum-derived factor does not seem to interfere with heparin-induced platelet activation tests, leading to false negative antibody test results. This is crucial for accurate diagnosis of HIT to avoid overdiagnosis and overtreatment.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Jing Wang, Yongxiang Gao, Lan Chen, Yugang Guo, Siyi Hu, Liansheng Cheng, Weihua Xiao, Jiyuan Ke, Zhongliang Zhu, Liwen Niu
Summary: Agkisacucetin, a novel antithrombotic drug candidate isolated from the venom of Deinagkistrodon acutus, specifically recognizes the platelet surface receptor to block thrombosis. The crystal structure reveals that Agkisacucetin primarily contacts GPIb alpha at specific regions to inhibit platelet function.
Article
Immunology
Stefan Hug, Stefan Bernhard, Alexander Elias Paul Stratmann, Maike Erber, Lisa Wohlgemuth, Christiane Leonie Knapp, Jonas Martin Bauer, Laura Vidoni, Michael Fauler, Karl Josef Foehr, Peter Radermacher, Andrea Hoffmann, Markus Huber-Lang, David Alexander Christian Messerer
Summary: Platelet-activating factor (PAF) plays a crucial role in the systemic inflammatory response, particularly in sepsis. This study investigates the changes in neutrophil cellular responses induced by PAF during sepsis, focusing on membrane potential, intracellular pH, and cellular swelling. The study found that in a pathological environment, the response of neutrophils to PAF was altered, with exposure to lipopolysaccharide leading to diminished intracellular alkalization and neutrophil size changes. These findings suggest that an impaired physiological response of neutrophils to PAF stimulation may contribute to the development of neutrophil dysfunction in sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Ziqi Yan, Wanling Zhang, Pengcheng Xu, Wenting Zheng, Xinyi Lin, Jian Zhou, Jianwu Chen, Qing-Yu He, Jingxiang Zhong, Jiahui Guo, Biao Cheng, Tong Wang
Summary: Through phosphoproteome analysis, we found aberrant phospho-signaling changes in keloid fibroblasts, including disrupted calcium homeostasis and induced platelet aggregation. Additionally, some phosphoproteins were identified to predict activation of upstream regulators relevant to keloid. Importantly, phosphorylated FLNA was confirmed as a key phosphoprotein associated with keloid phenotype.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Engineering, Biomedical
Meredith A. Jackson, Shrusti S. Patel, Fang Yu, Matthew A. Cottam, Evan B. Glass, Ella N. Hoogenboezem, R. Brock Fletcher, Bryan R. Dollinger, Prarthana Patil, Danielle D. Liu, Isom B. Kelly, Sean K. Bedingfield, Allyson R. King, Rachel E. Miles, Alyssa M. Hasty, Todd D. Giorgio, Craig L. Duvall
Summary: The study demonstrates that Kupffer cell release of plate activating factor (PAF) is a key determinant of siRNA nanocarrier toxicity, and inhibiting PAFR can increase the tolerated dose of siRNA nanocarriers.
Article
Biochemistry & Molecular Biology
Paresh P. Kulkarni, Mohammad Ekhlak, Vipin Singh, Vikas Kailashiya, Nitesh Singh, Debabrata Dash
Summary: A comprehensive analysis showed that beta-oxidation of fatty acids is crucial for maintaining ATP levels and plays a critical role in activated platelet responses. Therefore, targeting fatty acid oxidation may be a promising strategy for developing novel antiplatelet agents.
Article
Cell Biology
Mary A. Smal, Brian A. Baldo
Summary: Experiments identified a fatty acid inhibitor in human saliva that can effectively inhibit PAF-induced platelet aggregation. The cis-unsaturated fatty acids showed strong inhibitory effects, especially on ADP-induced PA, suggesting a potential regulatory role in certain diseases.
Article
Allergy
Bo Youn Choi, Eun-Mi Yang, Hae-Won Jung, Min-Kyoung Shin, Junghyun Jo, Hyun-Young Cha, Hae-Sim Park, Ho-Chul Kang, Young-Min Ye
Summary: The study found a new autoantibody called anti-HSP10 IgG in patients with CSU, which showed a significant correlation with the severity of the disease. CSU patients had lower levels of HSP10 and higher levels of miR-101-5p compared to normal controls. MiR-101-5p promoted mast cell degranulation through upregulation of IL-4 and PAF, while HSP10 provided protection against it.
Article
Hematology
Hem Kumar Tamang, Ruey-Bing Yang, Zong-Han Song, Shao-Chun Hsu, Chien-Chung Peng, Yi-Chung Tung, Bing-Hsiean Tzeng, Chien-Chang Chen
Summary: This study explores the expression and role of Ca(v)3.2 in platelet function, revealing its importance for optimal platelet activation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Endocrinology & Metabolism
Jeffrey B. Travers, Joyce G. Rohan, Ravi P. Sahu
Summary: PAF, a glycerophosphocholine lipid mediator, plays a crucial role in pathologic processes and can be transmitted through MVP to activate the PAF receptor and generate more PAF. Studying the PAF family of lipid mediators is essential for understanding the relationship among diverse cutaneous, cancerous, neurologic, and systemic pathologic processes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)