期刊
THROMBOSIS RESEARCH
卷 128, 期 5, 页码 410-416出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2011.08.001
关键词
activated protein C; endothelial protein C receptor; factor VII; venous thrombosis; myocardial infarction
资金
- Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria [PN de I + D + I 2008-20011]
- FEDER (Red Tematica de Investigacion RECAVA) [PS09/00610, PI10/01432, RD06/0014/0004, RD06/0014/0008]
- Conselleria de Educacion-Generalitat Valenciana [Prometeo/2011/027]
- Fundacion para la Investigacion del Hospital Universitario La Fe, Spain [2007-0185]
The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated protein C generation and modulate the risk of thrombosis. This review highlights the role of the endothelial protein C receptor in disease and discusses the association of its mutations with the risk of thrombosis. (C) 2011 Elsevier Ltd. All rights reserved.
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