Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Medicine, General & Internal
Hanyang Lin, Zhaohui Bai, Fanjun Meng, Yanyan Wu, Li Luo, Akash Shukla, Eric M. Yoshida, Xiaozhong Guo, Xingshun Qi
Summary: Patients with inflammatory bowel disease (IBD) have a higher risk of developing portal venous system thrombosis (PVST) after colorectal surgery. Preoperative corticosteroids therapy and urgent surgery are significant risk factors for PVST in these patients. Screening for PVST by imaging examinations and considering antithrombotic prophylaxis in high-risk patients can effectively reduce the risk.
FRONTIERS IN MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Luca Massimino, Luigi Antonio Lamparelli, Yashar Houshyar, Silvia D'Alessio, Laurent Peyrin-Biroulet, Stefania Vetrano, Silvio Danese, Federica Ungaro
Summary: Massimino et al. propose the Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework, an open-source platform for expediting the investigation of IBD-specific transcriptomics and metatranscriptomics signatures.
NATURE COMPUTATIONAL SCIENCE
(2021)
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Hematology
Beate Luxembourg, Franziska Henke, Anette Kirsch-Altena, Ulrich Sachs, Bettina Kemkes-Matthes
Summary: Double heterozygotes for Factor V Leiden and Prothrombin G20210A exhibit a higher risk of venous thromboembolism in female patients compared to other genotype groups, developing VTE at a younger age. However, there is no significant difference in spontaneous VTE and arterial thromboembolic events compared to other genotypes. Deep vein thrombosis in the lower limb is the predominant VTE location in double heterozygotes.
THROMBOSIS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Aleksandra Kubas, Ewa Malecka-Wojciesko
Summary: Vaccination against COVID-19 is considered safe and effective for patients with IBD, although further research is needed to understand its safety in special populations. The willingness to receive the vaccine among IBD patients is conflicting, with concerns about effectiveness and safety being the most common reasons for hesitancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Anouk M. Wijnands, Michiel E. de Jong, Maurice W. M. D. Lutgens, Frank Hoentjen, Sjoerd G. Elias, Bas Oldenburg
Summary: A systematic review and meta-analysis identified 13 risk factors and 5 protective factors for advanced colorectal neoplasia in IBD patients. These findings could contribute to an improved surveillance based on CRC risk stratification in IBD.
Article
Medicine, General & Internal
Cosmin Adrian Teodoru, Mihnea Munteanu, Nadina Mercea, Alina Moatar, Horia Stanca, Florina Georgeta Popescu, Horatiu Dura, Adrian Hasegan, Doina Ileana Giurgiu, Maria-Emilia Cerghedean-Florea
Summary: This article presents a rare case of Superior Ophthalmic Vein Thrombosis (SOVT) that may be associated with hypercoagulable status. A 77-year-old female patient presented with eye ptosis, chemosis, and conjunctival congestion in the right eye (RE) and was found to have hypertrophy of the right ophthalmic vein and inferior rectus muscle. Further investigations revealed positive results for Factor V Leiden (heterozygous mutation) and methyl-enetetrahydrofolate reductase (MTHFR-C677T homozygous mutations). Immediate systemic treatment with steroids and anticoagulants led to gradual resolution of symptoms and improved visual acuity at follow-up.
Article
Cardiac & Cardiovascular Systems
Bakhtawar K. Mahmoodi, Niclas Eriksson, Gerrit J. A. Vos, Karina Meijer, Agneta Siegbahn, Stefan James, Lars Wallentin, Jurrien M. ten Berg
Summary: In patients with acute coronary syndrome, factor V Leiden mutation does not increase the risk of ST-segment-elevation myocardial infarction (STEMI) or affect peak cardiac necrosis markers levels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Multidisciplinary Sciences
Kelly A. Baker, Timothy D. Miller, Frank E. Marino, Tegan E. Hartmann
Summary: This study examined the effects of acute and chronic exercise on inflammatory responses in individuals with inflammatory bowel disease (IBD) through a systematic review and meta-analysis. The results showed that exercise did not significantly affect inflammatory markers in IBD patients, but regular moderate exercise improved bowel symptoms.
Review
Geriatrics & Gerontology
Nanyang Liu, Yi Wang, Lanye He, Jiahui Sun, Xing Wang, Hao Li
Summary: The study found that a previous diagnosis of inflammatory bowel disease (IBD) does not seem to increase the risk of subsequent all-cause dementia and AD-dementia. Cohort studies show a positive association between IBD patients and all-cause dementia, but it is not related to age and gender.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Mengsi Liu, Dongxiu Li, Xia Hong, Zhen Sun
Summary: This study found a unidirectional association between inflammatory bowel disease (IBD) and dementia, with patients with IBD having an increased risk of dementia. However, the current evidence is insufficient to establish a causal relationship.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Jeremy Lagrange, Patrick Lacolley, Denis Wahl, Laurent Peyrin-Biroulet, Veronique Regnault
Summary: Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, with reasons including increased platelet reactivity and continuous coagulation activation. Additionally, fibrinogen levels are increased and fibrin clots are denser in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)