Article
Clinical Neurology
Nadinda A. M. van der Ende, Femke C. C. Kremers, Wouter van der Steen, Esmee Venema, Manon Kappelhof, Charles B. L. M. Majoie, Alida A. A. Postma, Jelis Boiten, Ido R. R. van den Wijngaard, Aad van der Lugt, Diederik W. J. Dippel, Bob Roozenbeek, MR CLEAN Registry Investigators
Summary: This study investigated multiple models for predicting symptomatic intracranial hemorrhage (sICH) after reperfusion therapy and evaluated their performance in clinical practice. The results showed that these models poorly discriminate between patients at low and high risk of sICH after endovascular treatment, indicating limited clinical utility for this patient population.
Article
Multidisciplinary Sciences
Chutithep Teekaput, Kitti Thiankhaw, Surat Tanprawate, Kanokkarn Teekaput, Chatree Chai-Adisaksopha
Summary: This study investigated the incidence, risk factors, characteristics, management, and clinical outcome of rtPA-associated asymptomatic intracranial hemorrhage (aICH) in acute ischemic stroke patients treated with rtPA. The results showed that aICH was associated with poorer clinical outcomes at 90 days and an increased risk of 90-day mortality compared to non-ICH patients.
Article
Virology
Emin Ediz Tutuncu, Didem Ozgur, Murat Karamese
Summary: The study found that saliva specimens can be considered as a reliable and less resource-intensive alternative to nasopharyngeal specimens for screening asymptomatic SARS-CoV-2 infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Clinical Neurology
Laura Venditti, Olivier Chassin, Claire Ancelet, Nicolas Legris, Mariana Sarov, Bertrand Lapergue, Cristian Mihalea, Augustin Ozanne, Sophie Gallas, Jonathan Cortese, Vanessa Chalumeau, Leon Ikka, Jildaz Caroff, Julien Labreuche, Laurent Spelle, Christian Denier
Summary: The study identified predictive factors of symptomatic intracerebral hemorrhage (sICH) in patients with acute ischemic stroke (AIS) following mechanical thrombectomy (MT). Pre-procedural predictors of sICH included prior use of antiplatelet therapies, high C-reactive protein and hyperglycemia at baseline, elevated mean arterial blood pressure, and low ASPECTS score.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Paul Janvier, Basile Kerleroux, Guillaume Turc, Marco Pasi, Wassim Farhat, Nicolas Bricout, Joseph Benzakoun, Laurence Legrand, Frederic Clarencon, Serge Bracard, Catherine Oppenheim, Gregoire Boulouis, Hilde Henon, Olivier Naggara, Wagih Ben Hassen
Summary: This study aims to determine if early venous filling (EVF) after mechanical thrombectomy is an independent predictor of symptomatic intracranial hemorrhage (sICH) and integrate EVF into a risk score for sICH prediction. The results showed that the presence of EVF, time from onset-to-successful recanalization >270 minutes, low Alberta Stroke Program Early CT Score, and high glucose blood level were independent predictors of sICH and constituted the Time-Alberta Stroke Program Early CT-Glycemia-EVF score. This score demonstrated good performance in predicting sICH after mechanical thrombectomy.
Article
Clinical Neurology
Yu Cui, Xin-Hong Wang, Yong Zhao, Shao-Yuan Chen, Bao-Ying Sheng, Li-Hua Wang, Hui-Sheng Chen
Summary: This study investigated the association between biomarker changes and symptomatic intracranial hemorrhage (sICH) in patients after intravenous thrombolysis (IVT). The results identified 9 biomarkers that significantly changed before vs. after thrombolysis in patients with sICH, including 6 neuroinflammatory and 3 neuroprotective biomarkers.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mate Elod Maros, Caspar Brekenfeld, Gabriel Broocks, Hannes Leischner, Rosalie McDonough, Milani Deb-Chatterji, Anna Alegiani, Gotz Thomalla, Jens Fiehler, Fabian Flottmann
Summary: This study indicates that in endovascular therapy for acute large-vessel occlusion in stroke patients, more than 3 retrieval attempts are significantly associated with an increased risk of symptomatic intracranial hemorrhage, while baseline Alberta Stroke Program Early CT Score of around 8-9 or 10 serves as important protective factors against intracranial hemorrhage.
Article
Biology
Simon Amaral, Gauthier Duloquin, Yannick Bejot
Summary: This study aimed to determine the frequency and factors contributing to symptomatic intracranial hemorrhage (sICH) in patients with ischemic stroke treated with bridging therapy. Results showed that 1 in 12 patients suffered sICH, which resulted in poor outcomes. Further studies are needed to identify high-risk patients and guide therapeutic strategies.
Article
Clinical Neurology
Zhiming Kang, Chuang Nie, Keni Ouyang, Xiangbo Wu, Jiaqi Yin, Dong Sun, Bin Mei
Summary: This study aimed to develop and validate a nomogram for predicting symptomatic intracranial hemorrhage (sICH) in patients with large vessel occlusion (LVO) in the anterior circulation. The model showed good discriminative ability and calibration, and was internally validated. Further external validation is warranted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Review
Clinical Neurology
Guoyi Tang, Zhixin Cao, Yuting Luo, Shaoqing Wu, Xunsha Sun
Summary: This meta-analysis explores the association between asymptomatic intracranial hemorrhage (aICH) and poor neurological outcomes after acute ischemic stroke. The findings suggest that patients with aICH during the acute stage of ischemic stroke have an increased risk of worse outcomes, especially in those receiving endovascular therapy.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Hongquan Guo, Wei Xu, Xiaohao Zhang, Shuai Zhang, Zheng Dai, Shun Li, Yi Xie, Yingle Li, Jianzhong Xue, Xinfeng Liu
Summary: This study aimed to develop a nomogram for predicting the risk of sICH after IVT in Chinese acute ischemic stroke patients, and found that atrial fibrillation, baseline glucose level, neutrophil to lymphocyte ratio, and NIHSS score were independent predictors for sICH. The nomogram had good discrimination and calibration in predicting sICH risk.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Neuroimaging
Guo-Can Chang, Thanh N. Nguyen, Jing Qiu, Wei Li, Yong-Gang Zhao, Xian-Hui Sun, Xin Liu, Zi-Ai Zhao, Liang Liu, Mohamad Abdalkader, Hui-Sheng Chen
Summary: This study aimed to establish a reliable scoring tool to predict the probability of symptomatic intracranial hemorrhage (sICH) in patients with anterior circulation stroke who had contrast enhancement (CE) on non-contrast CT (NCCT) after endovascular thrombectomy (EVT). The CE-age-glucose-AF (CAGA) score, which included age, atrial fibrillation, serum glucose level, CE-ASPECTS score, and location of CE, demonstrated good discrimination and calibration in predicting sICH in patients with CE on NCCT after EVT treatment.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Huixin Shen, Qingfeng Ma, Liqun Jiao, Fei Chen, Sufang Xue, Jingya Li, Zhengping Li, Haiqing Song, Xiaoqin Huang
Summary: This study aimed to evaluate the predictors of symptomatic intracranial hemorrhage (sICH) after endovascular treatment (EVT) in patients with large vessel occlusion (LVO)-induced acute ischemic stroke (AIS). The results showed that diabetes, initial stroke score, post-operation stroke scale score, fasting blood glucose, neutrophil to lymphocyte ratio, platelets, and thrombin time were significantly associated with sICH. Higher levels of fasting blood glucose, neutrophil to lymphocyte ratio, thrombin time, and post-operation stroke scale score were independent predictors of sICH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Wouter van der Steen, Nadinda A. M. van der Ende, Katinka R. van Kranendonk, Vicky Chalos, Josje Brouwer, Robert J. van Oostenbrugge, Wim H. van Zwam, Pieter J. van Doormaal, Adriaan C. G. M. van Es, Charles B. L. M. Majoie, Aad van der Lugt, Diederik W. J. Dippel, Bob Roozenbeek
Summary: This study aimed to investigate the timing of symptomatic intracranial hemorrhage (sICH) after endovascular therapy (EVT) for acute ischemic stroke and identify factors associated with its timing. The results showed that the majority of sICH occurred within a few hours after EVT, with a lower incidence after 24 hours. Factors such as baseline NIHSS, intravenous alteplase treatment, and poor reperfusion at the end of the procedure were not associated with the timing of sICH.
EUROPEAN STROKE JOURNAL
(2022)
Article
Clinical Neurology
P. Constant Dit Beaufils, C. Preterre, S. De Gaalon, J. Labreuche, M. Mazighi, F. Di Maria, I. Sibon, G. Marnat, F. Gariel, R. Blanc, B. Gory, A. Consoli, F. Zhu, S. Richard, R. Fahed, H. Desal, B. Lapergue, B. Guillon, R. Bourcier
Summary: After EVT for AIS, patients with aICH had a worse functional outcome at 3 months compared to those without ICH. Male sex, diabetes, coronary artery disease, baseline National Institutes of Health Stroke Scale score, Alberta Stroke Program Early Computed Tomography Score, number of passes, and onset to groin puncture time were independently associated with aICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)