Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chung-Ze Wu, Li-Chien Chang, Chao-Wen Cheng, Te-Chao Fang, Yuh-Feng Lin, Dee Pei, Jin-Shuen Chen
Summary: The study investigated the relationship between urokinase plasminogen activator (uPA), metabolic disorders, glomerular filtration rate, and adipose tissues using obese mouse models. Results showed that triglyceride levels, insulin resistance, and body weight increased with duration on a high fat diet (HFD), while the expression of uPA decreased in brown adipose tissue (BAT) in obese mice fed a HFD. These findings suggest a potential association between BAT fibrosis and dysfunction in obese models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Hematology
Matilde Kanstrup Andersen, Isabella Hangaard Rudiger, Anna Louise Vestergaard, Yaseelan Palarasah, Pinar Bor, Agnete Larsen, Mustafa Vakur Bor
Summary: Vitamin D deficiency is associated with an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women, which may increase thrombotic risk and lead to pregnancy complications. Further research is needed to determine the optimal vitamin D supplementation in pregnancy.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. Pamuk, M. Lutfioglu, T. Paksoy, C. Z. Koyuncuoglu, N. G. Polat, E. Cifcibasi, S. Yildirim, A. Kantarci
Summary: The study found that low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment can modulate the plasminogen-activating system in severe periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Biochemistry & Molecular Biology
Max Liu, Khalequz Zaman, Yolanda M. Fortenberry
Summary: Aptamers are single-stranded DNA or RNA sequences that exhibit high specificity and affinity in binding target molecules. They are non-immunogenic, easier to synthesize and modify, and can bind targets with greater affinity, making them a promising therapeutic candidate for treating various conditions. Active research is ongoing in developing aptamers to target blood coagulation factors, with potential applications in treating cardiovascular diseases, blood disorders, and cancers. Although no aptamers targeting blood coagulation factors have been approved for clinical use, several have shown promise in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Eleni Syrimi, Eanna Fennell, Alex Richter, Pavle Vrljicak, Richard Stark, Sascha Ott, Paul G. Murray, Eslam Al-Abadi, Ashish Chikermane, Pamela Dawson, Scott Hackett, Deepthi Jyothish, Hari Krishnan Kanthimathinathan, Sean Monaghan, Prasad Nagakumar, Barnaby R. Scholefield, Steven Welch, Naeem Khan, Sian Faustini, Kate Davies, Wioleta M. Zelek, Pamela Kearns, Graham S. Taylor
Summary: Children with Multisystem Inflammatory Syndrome in Children (MIS-C) show highly activated immune cells during acute phase, which changes as they recover with increased levels of certain immune markers. Plasma profiling suggests potential treatment options and mechanisms of action, such as inhibition of IL-6 and complement activation.
Review
Environmental Sciences
Kai Wang, Wanzhou Wang, Lei Lei, Yang Lan, Qisijing Liu, Lihua Ren, Shaowei Wu
Summary: This study conducted a systematic review and meta-analysis of existing epidemiological research to examine the associations between ambient air pollution and coagulation biomarkers. The results showed that short-term exposures to PM2.5 and O3 were associated with significant increases in coagulation biomarkers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Immunology
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng -Chao Ruan, Ping-Jin Gao
Summary: Obesity-induced adipose tissue-derived factors play a key role in cardiac damage, with the newly identified adipokine PDGF-D potentially regulating cardiac remodeling in obese mice. The study demonstrates that uPA activates PDGF-D and accelerates AngII-induced cardiac remodeling in obese mice by a new interaction pattern between macrophage and adipocyte.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Rolf Jorde, Monica Sneve, Moira Hutchinson, Nina Emaus, Yngve Figenschau, Guri Grimnes
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Rolf Jorde, Monica Sneve, Peter A. Torjesen, Yngve Figenschau, Lasse G. Goransson, Roald Omdal
Article
Biochemistry & Molecular Biology
Julia Beilfuss, Vivian Berg, Monica Sneve, Rolf Jorde, Elena Kamycheva
Article
Endocrinology & Metabolism
Monica Sneve, Nina Emaus, Ragnar Martin Joakimsen, Rolf Jorde
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2008)
Article
Endocrinology & Metabolism
M. Sneve, Y. Figenschau, R. Jorde
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2008)
Article
Endocrinology & Metabolism
Guri Grimnes, Bjorg Almaas, Anne Elise Eggen, Nina Emaus, Yngve Figenschau, Laila Arnesdatter Hopstock, Moira Strand Hutchinson, Paal Methlie, Albena Mihailova, Monica Sneve, Peter Torjesen, Tom Wilsgaard, Rolf Jorde
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2010)
Article
Public, Environmental & Occupational Health
Nina Emaus, Tone K. Omsland, Luai Awad Ahmed, Guri Grimnes, Monica Sneve, Gro K. Berntsen
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2009)
Article
Nutrition & Dietetics
Rolf Jorde, Monica Sneve, Nina Emaus, Yngve Figenschau, Guri Grimnes
EUROPEAN JOURNAL OF NUTRITION
(2010)
Article
Medicine, General & Internal
R. Jorde, M. Sneve, Y. Figenschau, J. Svartberg, K. Waterloo
JOURNAL OF INTERNAL MEDICINE
(2008)
Article
Medicine, General & Internal
R. Jorde, M. Sneve, P. Torjesen, Y. Figenschau
JOURNAL OF INTERNAL MEDICINE
(2010)
Article
Nutrition & Dietetics
Rolf Jorde, Monica Sneve, Peter A. Torjesen, Yngve Figenschau, John-Bjarne Hansen, Guri Grimnes
Article
Public, Environmental & Occupational Health
M. Sneve, R. Jorde
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2008)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)