Article
Endocrinology & Metabolism
Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin
Summary: This study evaluated the frequency and type of androgen receptor (AR) gene variants in a large cohort of infertile males. The study found that patients with AR gene variants had lower sperm count, higher testosterone concentration, and higher androgen sensitivity index compared to patients without variants. Two novel potentially pathogenic AR variants were identified. Based on these findings, AR sequencing is suggested as a routine genetic test in cases of idiopathic oligozoospermia with high testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Arthi Thirumalai, Fiona Yuen, John K. Amory, Andrew N. Hoofnagle, Ronald S. Swerdloff, Peter Y. Liu, Jill E. Long, Diana L. Blithe, Christina Wang, Stephanie T. Page
Summary: Oral administration of DMAU for 28 days suppresses serum testosterone and estradiol in healthy men, while increasing the bone formation marker P1NP. Longer-term studies are needed to understand DMAU's impact on bone health in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Andrology
Rosario Lopez-Rodriguez, Javier Ruiz-Hornillos, Marta Corton, Berta Almoguera, Pablo Minguez, Maria Elena Perez-Tomas, Maria Barreda-Sanchez, Esther Mancebo, Lorena Ondo, Andrea Martinez-Ramas, Lidia Fernandez-Caballero, Juan Carlos Taracido-Fernandez, Antonio Herrero-Gonzalez, Ignacio Mahillo, Estela Paz-Artal, Encarna Guillen-Navarro, Carmen Ayuso
Summary: There is no association between the androgen receptor polyQ polymorphism and the severity of COVID-19 in male patients.
Article
Biochemistry & Molecular Biology
Ludmila Osadchuk, Gennady Vasiliev, Maxim Kleshchev, Alexander Osadchuk
Summary: Male infertility is a complex disorder influenced by multiple factors and genetic variations. This study investigated the association between the length of CAG repeats in the androgen receptor (AR) gene and semen quality and reproductive hormone levels in a population-based cohort of young men. The findings revealed that longer CAG repeats were associated with impaired semen quality, with variations observed among different ethnic subgroups. These results highlight the importance of genetic factors in male fertility and provide insights for potential risk assessment and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Arianna Ventura-Bahena, Jesus Gibran Hernandez-Perez, Luisa Torres-Sanchez, Adolfo Sierra-Santoyo, Derly Constanza Escobar-Wilches, Consuelo Escamilla-Nunez, Rocio Gomez, Francisco Rodriguez-Covarrubias, Ma de Lourdes Lopez-Gonzalez, Mario Figueroa
Summary: This study investigated the association between androgen levels in urine and prostate cancer, finding three distinct patterns of androgen excretion. One pattern was associated with higher prostate cancer risk in individuals with certain genetic variations, while another pattern was marginally associated with lower risk of poorly differentiated prostate cancer. The results suggest the importance of the C11-oxy backdoor pathway in prostatic carcinogenesis.
ENDOCRINE-RELATED CANCER
(2021)
Article
Biology
Alessandra Buonacquisto, Anna Chiara Conflitti, Francesco Pallotti, Antonella Anzuini, Serena Bianchini, Luisa Caponecchia, Anna Carraro, Maria Rosa Ciardi, Fabiana Faja, Cristina Fiori, Daniele Gianfrilli, Andrea Lenzi, Miriam Lichtner, Claudio Maria Mastroianni, Patrizia Pasculli, Flavio Rizzo, Pietro Salacone, Annalisa Sebastianelli, Francesco Lombardo, Donatella Paoli
Summary: Male patients are more prone to develop severe forms of COVID-19. Genetic predisposition, including CAG repeat polymorphism, low testosterone levels, and reduced androgen receptor activity, may play a role in this susceptibility. Disease severity is associated with an increase in CAG repeat number and lower testosterone levels.
Article
Urology & Nephrology
Kajal Khodamoradi, Alexandra Dullea, Katherine Campbell, Christian Ramsoomair, Roei Golan, Ranjith Ramasamy
Summary: This study aimed to measure androgen receptor (AR) signaling levels in corpus cavernosal tissue of males with different serum testosterone (T) levels. The results showed no significant difference in VEGF expression above a serum T level of 200 ng/dl. Therefore, there may be a saturation level of approximately 200 ng/dl that fully saturates tissue androgen receptors and results in optimal male function.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Hematology
Nadira Vadaq, Melanie Schirmer, Rahajeng N. Tunjungputri, Hera Vlamakis, Cecilia Chiriac, Edwin Ardiansyah, M. Hussein Gasem, Leo A. B. Joosten, Philip G. de Groot, Ramnik J. Xavier, Mihai G. Netea, Andre J. van der Ven, Quirijn de Mast
Summary: Platelet reactivity is influenced by plasma metabolome, with a focus on lipid metabolites and dietary polyphenols. Functional microbial profiles revealed two key metabolic pathways associated with platelet reactivity, offering insights into the regulation of platelet function and the potential role of gut microbiota.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Andrology
Fiona Yuen, Arthi Thirumalai, Frances A. Fernando, Ronald S. Swerdloff, Peter Y. Liu, Youngju Pak, Laura Hull, Rachelle Bross, Diana L. Blithe, Jill E. Long, Stephanie T. Page, Christina Wang
Summary: The metabolic effects of DMAU and 11β-MNTDC were similar in terms of lipid profile and weight, but there may be subtle differences in adiponectin and LDL-C levels. Neither compound had significant effects on insulin resistance after 28 days of administration, suggesting further exploration of their metabolic impacts in future studies is warranted.
Article
Biochemistry & Molecular Biology
Swathi Ramakrishnan, Rick A. Kittles, Wendy J. Huss, Jianmin Wang, Kristopher Attwood, Anna Woloszynska
Summary: Dihydrotestosterone (DHT) and testosterone (T) play crucial roles in the proliferation and survival of prostate cancer cells. This study found significant differences in the serum levels of metabolites involved in DHT/T biosynthesis between African American (AA) and European American (EA) men with prostate cancer. The study also revealed higher frequencies of gene polymorphisms related to corticosterone-aldosterone conversion in AA men. Additionally, higher levels of T and pregnenolone were associated with a lower risk of progression-free survival only in AA men.
Article
Cell Biology
Ichiro Wakabayashi, Yoko Sotoda, Ryoji Eguchi
Summary: Platelets are a major source of microRNAs in blood. Relationships between circulating platelet-derived miRNAs were investigated in this study to elucidate their significance as biomarkers. Six miRNAs were identified as potentially useful biomarkers reflecting platelet condition and function.
Review
Biochemistry & Molecular Biology
Mu Lv, Juanjuan Yu, Yan Huang, Jie Ma, Jun Xiang, Yanqiu Wang, Linxia Li, Zhenbo Zhang, Hong Liao
Summary: Uterine diseases, such as endometriosis and uterine fibroids, have a significant impact on women's health. Androgens, primarily synthesized in the ovaries and adrenal glands, play a crucial role in the development of these diseases. However, further research is needed to understand the signaling pathways involved and develop targeted therapeutic strategies.
Article
Geriatrics & Gerontology
Liming Peng, Thiago Gagliano-Juca, Karol M. Pencina, Srinivasan Krishnan, Zhuoying Li, Russell P. Tracy, Ravi Jasuja, Shalender Bhasin
Summary: A LC-MS/MS method for measuring circulating GDF-8 and GDF-11 was developed. The levels of GDF-8 and GDF-11 were not related to age or body composition in healthy men. Testosterone treatment increased GDF-8 levels, but not GDF-11 levels.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Review
Biochemistry & Molecular Biology
Katarzyna Balon, Adam Sheriff, Joanna Jackow, Lukasz Laczmanski
Summary: This article describes recent advancements in cancer-selective treatments based on the CRISPR/Cas9 system, including strategies for targeted delivery of the CRISPR/Cas9 machinery to affected cells, controlling Cas9 expression in tissues of interest, and disrupting cancer-specific genes to result in selective death of malignant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Marcin Choroszy, Beata Sobieszczanska, Kamil Litwinowicz, Lukasz Laczmanski, Mateusz Chmielarz, Urszula Walczuk, Tomasz Roleder, Jadwiga Radziejewska, Magdalena Wawrzynska
Summary: This study investigated the role of gut dysbiosis in coronary arterial disease (CAD) development. The results showed that CAD patients exhibited gut dysbiosis, as well as elevated levels of bacterial metabolites LPS and indoxyl sulfate in their blood. Furthermore, LPS and indoxyl sulfate were found to have co-toxicity on endothelial cells and promote thrombogenicity. These findings suggest that increased intestinal permeability caused by gut dysbiosis may contribute to endothelial inflammation and atherosclerosis progression.
Article
Food Science & Technology
Beata Nowak, Agnieszka Matuszewska, Adam Szelag, Maciej Danielewski, Wojciech Dziewiszek, Anna Nikodem, Jaroslaw Filipiak, Diana Jedrzejuk, Marek Bolanowski, Alicja Z. Kucharska, Narcyz Piorecki, Tomasz Piasecki, Tomasz Sozanski
Summary: The aim of this study was to investigate the effects of cornelian cherry extract on metabolic changes induced by ovary removal, including bone loss, obesity development, adipokine imbalance, and oxidative stress. The results showed that cornelian cherry extract could improve weight gain, reduce visceral fat accumulation, restore adipokine balance, reduce oxidative stress, and prevent bone loss caused by ovary removal. This study is the first to demonstrate the bone-protective properties of cornelian cherry and its potential benefits for preventing cardiovascular diseases.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Radoslaw Andrzej Konieczny, Ewa Zurawska-Plaksej, Konrad Kaaz, Hanna Czapor-Irzabek, Wojciech Bombala, Andrzej Mysiak, Wiktor Kuliczkowski
Summary: This study found that decreased citrulline levels were not predictive of long-term mortality in hospitalized patients with CVD, and were not associated with TMAO levels in these patients. Citrulline levels may be associated with long-term mortality in patients with ACS.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Monika Stepien, Malgorzata Zalewska, Brygida Knysz, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska, Lukasz Laczmanski, Agnieszka Piwowar, Amadeusz Kuzniarski
Summary: The aim of this study was to evaluate and compare the effectiveness of different vaccines in Poland's mass vaccination program and investigate the most common side effects. The study found that 100% of patients responded to the vaccines, with convalescents having higher antibody levels after the first dose but a decrease after the second dose. Moderna vaccine generated the highest antibody titers after both doses, and fever was identified as a significant factor in higher antibody levels.
Article
Oncology
Bartosz Malkiewicz, Blazej Bugla, Maciej Czarnecki, Jakub Karwacki, Paulina Dlugosz, Adam Gurwin, Pawel Kielb, Artur Leminski, Wojciech Krajewski, Diana Jedrzejuk, Marek Bolanowski, Agnieszka Halon, Tomasz Szydelko
Summary: Radio-guided sentinel lymph node detection techniques have low specificity and relatively high sensitivity in nodal staging of prostate cancer patients. This study evaluated the efficacy of single-photon emission computed tomography (SPECT-CT) and gamma-probe in SLN detection and mapped lymphatic drainage patterns of the prostate. The results showed that SLN detection techniques had low specificity and were not reliable for nodal staging in prostate cancer.
Review
Biochemistry & Molecular Biology
Mikolaj Blaziak, Szymon Urban, Weronika Wietrzyk, Maksym Jura, Gracjan Iwanek, Bartlomiej Stanczykiewicz, Wiktor Kuliczkowski, Robert Zymlinski, Maciej Pondel, Petr Berka, Dariusz Danel, Jan Biegus, Agnieszka Siennicka
Summary: Heart failure is a major cause of mortality and hospitalization worldwide. Machine learning models have shown higher accuracy in predicting outcomes in heart failure patients and may play an important role in management.
Article
Pharmacology & Pharmacy
Beata Weber-Dabrowska, Maciej Zaczek, Malgorzata Lobocka, Marzanna Lusiak-Szelachowska, Barbara Owczarek, Filip Orwat, Norbert Lodej, Aneta Skaradzinska, Lukasz Laczmanski, Dariusz Martynowski, Marta Kaszowska, Andrzej Gorski
Summary: In recent years, multidrug-resistant strains of Klebsiella pneumoniae have become a global concern and bacteriophage therapy may provide a potential solution. This study evaluated the properties and effectiveness of bacteriophages against Klebsiella strains, identifying promising candidates for therapeutic purposes. Additionally, historical phages were examined, including one with lytic activity that has been maintained for nearly 60 years.
Article
Biochemistry & Molecular Biology
Diana Jedrzejuk, Pawel Poznanski, Pawel Szewczyk, Oktawia Mazanowska, Marek Bolanowski, Magdalena Krajewska, Dorota Kaminska
Summary: The popularity of living-donor organ donation has increased recently due to the growing need for organs and a shortage of deceased-donor organs. This procedure requires a comprehensive health assessment of candidates, who must be in good physical and mental health. We present a case of a potential living-kidney donor who was withdrawn from donation due to Paget's disease of bone, and various imaging and assessment techniques were used to thoroughly evaluate the affected vertebra.
Article
Genetics & Heredity
Anna Andrzejczak, Agata Witkowicz, Dorota Kujawa, Damian Skrypnik, Monika Szulinska, Pawel Bogdanski, Lukasz Laczmanski, Lidia Karabon
Summary: The number of people suffering from metabolic syndrome (MetS), including type 2 diabetes (T2DM), hypertension, and obesity, has increased over 10 times in the last 30 years, posing a severe public health concern worldwide. Uncoupling protein 1 (UCP1) is a mitochondrial carrier protein found in brown adipose tissue and is involved in thermogenesis and energy expenditure. This study aimed to identify new UCP1 gene variants potentially associated with MetS and/or T2DM risk by performing NGS sequencing of the entire UCP1 gene. The results revealed 12 new variants, including rs3811787 which has been previously studied, that may have implications for MetS and/or T2DM risk in the Polish population.
Editorial Material
Cardiac & Cardiovascular Systems
Jacek Kubica, Piotr Adamski, Robert Gajda, Mariusz Gasior, Marek Gierlotka, Robert Gil, Milosz Jaguszewski, Aldona Kubica, Wiktor Kuliczkowski, Krzysztof Kurek, Jerzy Robert Ladny, Piotr Michalski, Eliano Pio Navarese, Piotr Niezgoda, Malgorzata Ostrowska, Agnieszka Tycinska
CARDIOLOGY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Arkadiusz Pietrasik, Aleksandra Gasecka, Tomasz Pawlowski, Jerzy Sacha, Marek Grygier, Gabriel Bielawski, Wojciech Balak, Adam Sukiennik, Paulina Burzynska, Adam Witkowski, Mateusz Warniello, Lukasz Rzeszutko, Stanislaw Bartus, Artur Pawlik, Mateusz Kaczynski, Robert Gil, Wiktor Kuliczkowski, Krzysztof Reczuch, Marcin Protasiewicz, Pawel Kleczynski, Piotr Wanczura, Sebastian Gurba, Anna Kochanowska, Michal Lomiak, Andrzej Cacko, Wlodzimierz Skorupski, Maciej Zarebinski, Piotr Pawluczuk, Szymon Wlodarczak, Adrian Wlodarczak, Krzysztof Sciborski, Artur Telichowski, Mieszko Plucinski, Jaroslaw Hiczkiewicz, Karolina Konsek, Michal Hawranek, Mariusz Gasior, Jan Peruga, Marcin Fiutowski, Robert Romanek, Piotr Kasprzyk, Dariusz Ciecwierz, Andrzej Ochala, Wojciech Wojakowski, Jacek Legutko, Janusz Kochman
Summary: This study analyzed real-world data from a Polish registry to assess the efficacy and safety of Impella in high-risk percutaneous coronary interventions (HR-PCI) and cardiogenic shock (CS). The results showed that Impella was safe and effective in HR-PCI, but CS patients had higher risk and mortality rates compared to other registries, indicating the need for further investigation of the potential benefits of Impella in CS.
KARDIOLOGIA POLSKA
(2023)
Article
Environmental Sciences
Maciej Antkiewicz, Wiktor Kuliczkowski, Marcin Protasiewicz, Tomasz Zubilewicz, Piotr Terlecki, Magdalena Kobielarz, Dariusz Janczak
Summary: This study compared the difference in aneurysm sac pressure (ASP) between patients undergoing branched endovascular aneurysm repair (BEVAR) and multilayer flow modulator (MFM) implantation for thoracoabdominal aortic aneurysm (TAAA). The results showed that the systolic pressure index (SPI) and pulse pressure index (PPI) were lower in the BEVAR group compared to the MFM group, with a decrease in SPI and PPI observed during the procedure in the BEVAR group. This indicates that BEVAR, but not MFM, is associated with a reduction in systolic and pulse pressure in the aneurysm sac in TAAA patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Dorota Pawelka, Izabela Laczmanska, Pawel Karpinski, Stanislaw Supplitt, Wojciech Witkiewicz, Barlomiej Knychalski, Joanna Pelak, Paulina Zebrowska, Lukasz Laczmanski
Summary: Our research suggests the potential role of overexpressed miRNAs as diagnostic or prognostic biomarkers among CRC patients. Such clustering of miRNAs may be a potential direction for discovering new diagnostic panels of cancer (including CRC), especially using machine learning. The low correspondence between deregulation of miRNAs in serum and tumour tissue revealed in our study confirms previously published reports.
CANCER GENOMICS & PROTEOMICS
(2022)
Article
Medicine, General & Internal
Lukasz Kozera, Wiktor Kuliczkowski, Elzbieta Gocek
Summary: This study found that biochemical changes associated with cardiovascular diseases may already occur in individuals aged 30 and above. The positive correlation between these changes and age suggests the progression of metabolic changes that may lead to fatal outcomes such as heart attack or stroke. Therefore, screening programs for cardiovascular diseases should target a wider population, especially younger individuals, to prevent fatal outcomes.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
