Article
Food Science & Technology
Wei Sun, Wenjie He, Danjun Guo, Wei Xu
Summary: This study aimed to investigate the effect mechanism of capsaicin on the structure and function of myofibrillar proteins in duck meat. The results showed that capsaicin could decrease the carbonyl content and increase the sulfhydryl content of the proteins, and enhance the antioxidant properties of the meat.
Article
Biochemistry & Molecular Biology
Sung-Sook Choi, Hye-Ryung Park, Kyung-Ae Lee
Summary: The effects of rutin and rutin glycoside were compared in terms of antioxidant activity, anti-inflammatory effects, platelet aggregation, and blood coagulation. While rutin and rutin glycoside showed differences in antioxidant activities in vitro, they were similar in reducing inflammatory markers and had similar effects on platelet aggregation and blood coagulation both in vitro and in vivo.
Article
Biochemical Research Methods
Kaushik N. Shankar, Yiyuan Zhang, Talid Sinno, Scott L. Diamond
Summary: Modeling thrombus growth in pathological flows using a 3D multiscale framework allows evaluation of risk under patient-specific conditions. The framework includes modules for platelet signaling, platelet position tracking, agonist release and transport, and blood flow computation. The model accurately predicts the evolution and morphology of growing thrombi and enables simulations of important clinical situations.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Agronomy
Naleene Balakrishnan, Salma Mohamad Yusop, Irman Abdul Rahman, Eqbal Dauqan, Aminah Abdullah
Summary: This study investigated the effects of gamma radiation and storage time on microbial and physicochemical properties of dried Byadgi chili. The results showed that as the radiation dose and storage time increased, water activity and moisture also increased. Gamma radiation did not affect the surface color, but it did not help retain the initial color value during storage. Mold growth was observed in both the control and radiated samples, but no aflatoxin was found. Increasing radiation dose and storage time had a negative effect on capsaicin and dihydrocapsaicin, but 10.0 kGy of radiation had an excellent response to the microbial profile.
Article
Agronomy
Teodor Stan, Neculai Munteanu, Gabriel-Ciprian Teliban, Alexandru Cojocaru, Vasile Stoleru
Summary: This study investigated the impact of different fertilizers on the production and accumulation of capsaicin and dihydrocapsaicin in six varieties of chili pepper. The results showed that mixed treatments yielded the highest production in all cultivars, with significant differences observed in capsaicinoid content depending on fertilizer type and chili pepper variety.
Article
Biochemistry & Molecular Biology
Martin Lalic, Ana Soldic, Andrija Lalic, Zdenka Lalic, Miranda Sertic
Summary: A reverse-phase high-performance liquid chromatography method was developed for the determination and quantification of capsaicin, dihydrocapsaicin, and camphor. The method is applicable for the analysis of over-the-counter medications and raw materials such as chili pepper oleoresin. Various validation parameters were evaluated, demonstrating good selectivity, accuracy, repeatability, and intermediate precision.
Review
Nutrition & Dietetics
Betul Sukan-Karacagil, Gamze Akbulut, Yasemin Acar, Meleknur Demirkoparan
Summary: Capsaicinoids and capsinoids, bioactive compounds found in peppers, have positive effects on exercise performance, especially in resistance training, possibly due to the correlation between capsaicin and TRPV1 and insulin-like growth factor-1.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Immunology
Bartlomiej Kalaska, Joanna Miklosz, Justyna Swieton, Aleksandra Jakimczuk, Dariusz Pawlak, Andrzej Mogielnicki
Summary: In this study, it was found that ChAdOx1 nCoV-19 vaccine does not increase the risk of arterial thrombosis development in female rats. Vaccinated rats developed SARS-CoV-2-specific neutralizing antibodies, and there were slight luminal narrowing and extravasation of blood in the blood vessel/thrombus area. However, there were no significant differences in thrombus weight and composition, and only a slight increase in platelet aggregation was observed.
Article
Agriculture, Multidisciplinary
Leeseul Jang, Jungwon Choi, Sullim Lee, Sanghyun Lee
Summary: This study found that red pepper and Shishito pepper have significant protective effects on skin damage, including antioxidant stress, anti-inflammatory reactions, and reduction of collagen. Capsaicinoids CAP and DHC were proved to be the active constituents responsible for these protective effects. This research provides important basic data for developing Capsicum fruits as ingredients for improving skin damage.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Di Wu, Ran Duan, Lan Tang, Dian Zhou, Zhen Zeng, Wen Wu, Jie Hu, Qiaomei Sun
Summary: This study explored the binding mechanism and inhibitory effect of capsaicin on lipase, demonstrating that capsaicin has a moderate affinity to lipase and can disturb the secondary structure of the enzyme. The research also showed that capsaicin inhibits lipase activity, potentially affecting the development of weight-loss related functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Hematology
Zachary A. Matthay, Alexander T. Fields, Brenda Nunez-Garcia, John J. Park, Chayse Jones, Aleksandra Leligdowicz, Carolyn M. Hendrickson, Rachael A. Callcut, Michael A. Matthay, Lucy Z. Kornblith
Summary: This study aimed to determine the relationship between catecholamines and platelet-dependent hemostasis after injury, as well as to model catecholamine-induced functional platelet exhaustion in healthy donor platelets. The study found that epinephrine and norepinephrine were associated with impaired platelet aggregation in trauma patients. In healthy donors, short incubation with epinephrine enhanced platelet aggregation, platelet adhesion, and glycoprotein IIb/IIIa activation, while longer incubation resulted in decreased platelet adhesion, aggregation, and surface expression of glycoprotein IIb/IIIa.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Food Science & Technology
Naleene Balakrishnan, Salma Mohamad Yusop, Irman Abdul Rahman, Eqbal Dauqan, Aminah Abdullah
Summary: Dried chilli is a highly traded spice known for its natural flavor and color, rich nutrients, and medicinal benefits. However, the proliferation of unwanted microorganisms during dehydration and storage is a concern. Food irradiation, particularly using gamma radiation, is gaining attention as an effective sanitation treatment to eliminate pathogens and preserve the quality and safety of dried chilli.
Article
Pharmacology & Pharmacy
Ricardo Lorenzoni, Renata Vidor Contri, Cleverton Kleiton Freitas de Lima, Fabiano Barreto, Bibiana Verlindo de Araujo, Adriana Raffin Pohlmann, Ana Luisa Palhares de Miranda, Teresa Dalla Costa, Silvia Staniscuaski Guterres
Summary: The study found that the chitosan hydrogel containing capsaicinoids-loaded nanocapsules (CHNC caps) demonstrated good skin penetration and pharmacological efficacy for treating peripheral neuropathic pain. This formulation showed superior performance compared to other tested options, with sustained antiallodynic and antihyperalgesic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Marija Milic, Barbara Vukovic, Rinea Barbir, Barbara Pem, Mirta Milic, Vatroslav Seric, Eleonore Frohlich, Ivana Vinkovic Vrcek
Summary: This study evaluated the hemostatic effects of differently stabilized silver nanoparticles on human blood. The results showed that different AgNPs have varying effects on blood coagulation, emphasizing the need for standardized assessment methods.
Review
Biochemistry & Molecular Biology
Stephani Stamboroski, Arundhati Joshi, Paul-Ludwig Michael Noeske, Susan Koeppen, Dorothea Brueggemann
Summary: This review summarizes the current state of research on fibrinogen fibrillogenesis in vitro, categorizing the manifold factors leading to the assembly of fibrinogen molecules into fibers into three main groups: substrate interactions, denaturing and non-denaturing buffer conditions. Based on the meta-analysis, it is concluded that the assembly of fibrinogen is driven by several mechanisms across different length scales.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
Summary: In this study, the effect of capsaicin and zinc on glucose metabolism signalling pathways was evaluated. The results showed that both compounds activated calcium signalling, leading to increased glucose uptake in skeletal muscle cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Y. C. Ho, S. J. Brake, K. D. K. Ahuja, N. Acott, J. Tiao, R. Baker, M. J. Adams
Summary: Anti-beta-2 glycoprotein 1 (anti-beta 2GP1) is an antiphospholipid antibody commonly found in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). This study investigated the effects of patient-derived IgG fractions on collagen-mediated platelet aggregation and the binding of IgG to platelets before and after activation by collagen. The results suggest that patient-derived IgG fractions may sensitize non-activated platelets, increasing platelet reactivity and thrombotic risk in patients.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Sisitha Jayasinghe, Robert Soward, Timothy P. Holloway, Kira A. E. Patterson, Kiran D. K. Ahuja, Roger Hughes, Nuala M. Byrne, Andrew P. Hills
Summary: This study aimed to explore and evaluate the public's perception of the physical activity environment and assess the quantity, variety, and quality of existing physical activity infrastructure in regional Northwest Tasmania. The results showed a wide array of high-quality physical activity infrastructure in the region, which was highly appreciated by the public. However, there is a need to implement place-based interventions to address barriers and increase awareness and utilization of the infrastructure.
Review
Biochemistry & Molecular Biology
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. M. Beckett, Stephen Myers
Summary: The global burden of type 2 diabetes (T2DM) has prompted research on finding new therapeutic targets for this chronic disorder. Bioactive food components, such as capsaicin and zinc, have shown the potential to improve glucose metabolism by activating specific pathways. Capsaicin and zinc stimulate glucose uptake through different pathways (AMPK and AKT), but both involve calcium signal transduction. Investigating the molecular pathways activated by capsaicin and zinc could lead to the discovery of new therapeutic targets for T2DM. This literature review aims to provide an overview of the main signaling pathways triggered by capsaicin and zinc in glucose metabolism.
Review
Endocrinology & Metabolism
Chitra Sharma, Kiran D. K. Ahuja, Bharati Kulkarni, Nuala N. M. Byrne, Andrew P. P. Hills
Summary: Current global trends in physical activity levels indicate the lack of progress towards achieving the 2030 target set by the Global Action Plan. Compositional data analysis and life course epidemiology provide potential frameworks for understanding the complexity of physical activity and its relationship with life course factors. Combining these fields represents a paradigm shift in physical activity research with potential impacts on policy and both advantages and challenges. The implications of maintaining the disconnect between these fields versus consolidating them should be carefully considered.
Review
Nutrition & Dietetics
Timothy P. Holloway, Lisa Dalton, Roger Hughes, Sisitha Jayasinghe, Kira A. E. Patterson, Sandra Murray, Robert Soward, Nuala M. Byrne, Andrew P. Hills, Kiran D. K. Ahuja
Summary: School environments can create a healthy setting for children's health and well-being. School gardening interventions have shown positive outcomes in terms of healthier eating and increased physical activity. This study found that embedding nutrition and garden-based education in the curriculum, experiential learning opportunities, family and authority figure engagement, cultural context, and the use of multi-prong approaches contribute to the improvement of children's health and well-being through school gardening programs.
Article
Health Care Sciences & Services
Sisitha Jayasinghe, Timothy P. Holloway, Robert Soward, Kira A. E. Patterson, Kiran D. K. Ahuja, Lisa Dalton, Sandra Murray, Roger Hughes, Nuala M. Byrne, Andrew P. Hills
Summary: This study aims to reduce the incidence of obesity and related diseases through social prescribing, peer education, and health screening, increase service and workforce connectivity and collaboration, and enhance health and well-being by improving food literacy, physical literacy, mental health, and community connectedness.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Public, Environmental & Occupational Health
Roger Hughes, Kiran D. K. Ahuja, Kira A. E. Patterson, Timothy P. P. Holloway, Robert Soward, Sisitha Jayasinghe, Nuala M. M. Byrne, Andrew P. P. Hills
Summary: This study aimed to determine the determinants, needs, strategic priorities, and capacity to act on overweight and obesity prevention in North-West Tasmania by engaging and consulting local community stakeholders. The results showed that mental health and obesity were major concerns and shared similar determinants. The study identified health promotion capacity assets and deficits, highlighting the need for stakeholder consultations in future programs for obesity prevention and health promotion.
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2023)
Review
Rehabilitation
E. Jovic, K. D. K. Ahuja, K. Lawler, S. Hardcastle, M. L. Bird
Summary: This study reviewed the literature on carer-supported home-based exercise programs for people after stroke. The research found that there is significant variation in the training carers receive, and these exercise programs have positive effects on the physical activity levels and functional mobility of stroke patients.
DISABILITY AND REHABILITATION
(2023)
Article
Nutrition & Dietetics
Rebecca Kuriyan, Andrew P. Hills, Alexia Murphy-Alford, Ramya Padmanabha, Lukhanyo H. Nyati, Nuala M. Byrne, Anura V. Kurpad, Shane Norris
Summary: 3C-model estimates of body composition in infants differed between countries; further studies are needed to confirm these findings and investigate the causes for the differences.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Ina S. Santos, Caroline S. Costa, Andrew P. Hills, Shabina Ariff, V. Pujitha Wickramasinghe, Shane Norris, Alexia J. Murphy-Alford, Christine Slater, Nishani Lucas, Lukhanyo H. Nyati, Anura V. Kurpad, Kiran D. K. Ahuja, Rebecca Kuriyan
Summary: This study aimed to investigate factors associated with infant body composition and found that birth weight and breastfeeding are independent predictors of body composition in early life, regardless of sex.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Endocrinology & Metabolism
Seonad K. Madden, Kiran D. K. Ahuja, Claire Blewitt, Briony Hill, Andrew P. Hills, Helen Skouteris
Summary: This paper examines the complex link between work and health outcomes for preconception, pregnant, and postpartum women, proposing a systems-thinking approach to understand the pathways between paid work and health for individual women and improve their health outcomes.
Article
Public, Environmental & Occupational Health
Manoja P. Herath, Andrew P. Hills, Jeffrey M. Beckett, Sisitha Jayasinghe, Nuala M. Byrne, Kiran D. K. Ahuja
Summary: This study aimed to investigate the trends and associations of maternal characteristics and birthweight among Indigenous and non-Indigenous infants. The study used retrospective population-based data from Tasmania to assess the trends and associations between maternal characteristics and infant birthweight. The results showed that Indigenous mothers had a higher prevalence of risk factors compared to non-Indigenous mothers, and there were significant differences in the rates of increase in certain risk factors between the two groups.
Article
Nutrition & Dietetics
Manoja P. Herath, Sandra Murray, Meron Lewis, Timothy P. Holloway, Roger Hughes, Sisitha Jayasinghe, Robert Soward, Kira A. E. Patterson, Nuala M. Byrne, Amanda J. Lee, Andrew P. Hills, Kiran D. K. Ahuja
Summary: Understanding food prices and affordability is crucial for promoting healthy dietary habits and informing policy actions. A study in Northwest Tasmania found that the recommended healthy diet was cheaper and had slower cost growth compared to the habitual unhealthy diet. The habitual diet was unaffordable for low-income households while the recommended diet posed a risk of food stress for some groups. Interventions such as financial support, nutrition education, and price regulation can help address food insecurity in the region.
Meeting Abstract
Clinical Neurology
C. A. Honan, J. A. Turner, C. Padgett, S. McDonald, I. Van der Mei, K. D. K. Ahuja, H. M. Francis, L. Tan, C. K. Lim
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
