Review
Obstetrics & Gynecology
Stefan Verlohren, Lisa-Antonia Droege
Summary: The definition of preeclampsia is changing to include organ symptoms alongside hypertension in pregnancy, rather than relying solely on proteinuria. Angiogenic and antiangiogenic factors have emerged as important tools for predicting and diagnosing preeclampsia with high accuracy. This review highlights their central role in the differential diagnosis of high-risk women and their ability to predict preeclampsia-associated adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Courtney Lynn Schubert, Kamran Yusuf
Summary: This study compared the serum levels of related factors in smoking and non-smoking pregnant women and found that TGF-β1 levels were significantly higher in smoking mothers, which may help explain the lower risk of preeclampsia in smoking mothers.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cristina Trilla, Cristina Luna, Silvia De Leon Socorro, Leire Rodriguez, Aina Ruiz-Romero, Josefina Mora Brugues, Taysa Benitez Delgado, Marta Fabre, Alicia Martin Martinez, Sara Ruiz-Martinez, Elisa Llurba, Daniel Oros
Summary: This study aims to determine the predictive and preventive capacity of a universal first-trimester screening model for preeclampsia by determining PlGF levels in intermediate-risk patients. The screening model is expected to achieve similar diagnostic performance as universal determination of PlGF but at a lower economic cost.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Carlos Jose Molina-Perez, Ana Graciela Nolasco-Leanos, Reyes Ismael Carrillo-Juarez, Alfredo Leanos-Miranda
Summary: This study evaluated the clinical characteristics and outcomes of pregnant women with chronic kidney disease (CKD) and suspected superimposed preeclampsia. The degree of angiogenic imbalance was found to be associated with disease severity and prognosis.
JOURNAL OF NEPHROLOGY
(2022)
Article
Obstetrics & Gynecology
Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan
Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Immunology
Marco Scioscia, Monika Siwetz, Pierre-Yves Robillard, Agostino Brizzi, Berthold Huppertz
Summary: The cause of preeclampsia is still unclear, but it is believed that alterations in placental metabolism can have negative effects on the placental syncytiotrophoblast and subsequently disrupt the glycocalyx. This disruption may lead to changes in signaling pathways and the release of certain molecules, which can affect the maternal endothelium and cause typical symptoms of preeclampsia.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Peripheral Vascular Disease
Juilee S. Deshpande, Deepali P. Sundrani, Akriti S. Sahay, Sanjay A. Gupte, Sadhana R. Joshi
Summary: Preeclampsia is a dangerous disorder for pregnant women and neonates that requires specific and reliable biomarkers for early prediction. The imbalance of angiogenic factors contributes to the pathophysiology. Applying a multivariable model from the start of pregnancy throughout gestation is essential for early and specific prediction of preeclampsia.
HYPERTENSION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jaskiran Kaur, Kajal Kamboj, Ashok Kumar Yadav, Prabhjot Kaur, Vivek Kumar, Vivekanand Jha
Summary: Cholecalciferol supplementation has a significant effect on the levels of angiogenic markers in non-diabetic CKD patients, and also improves brachial artery flow-mediated dilatation.
Article
Physiology
Shunping Gui, Shengping Zhou, Min Liu, Yanping Zhang, Linbo Gao, Tao Wang, Rong Zhou
Summary: In patients with severe preeclampsia (sPE), the upregulation of soluble Axl (sAxl) in maternal plasma is positively correlated with elevated levels of sFlt-1 and negatively correlated with placental NO synthase (eNOS). Elevated sAxl levels suppress proliferation and tube formation of endothelial cells, and promote cytotoxicity. The study also demonstrates that sAxl plays a role in systemic vascular injury through the regulation of key molecules of angiogenesis, contributing to the development of sPE.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Obstetrics & Gynecology
Grzegorz Szewczyk, Michal Pyzlak, Katarzyna Pankiewicz, Ewa Szczerba, Aleksandra Stangret, Dariusz Szukiewicz, Marta Skoda, Joanna Bierla, Bozena Cukrowska, Anna Fijalkowska
Summary: Impaired angiogenesis is a common finding in preeclamptic placentas, with a new angiogenetic role of fractalkine (CX3CL1) being recognized. Higher levels of CX3CL1 and sFlt-1, and lower levels of PlGF were observed in preeclampsia cases. The underdevelopment of placental vascular network in preeclampsia is associated with changes in the CX3CL1/CX3CR1 system, especially in cases complicated with fetal growth restriction (FGR).
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Peripheral Vascular Disease
Marlies Penning, Jamie S. Chua, Cees van Kooten, Malu Zandbergen, Aletta Buurma, Joke Schutte, Jan Anthonie Bruijn, Eliyahu V. Khankin, Kitty Bloemenkamp, S. Ananth Karumanchi, Hans Baelde
Article
Peripheral Vascular Disease
Dafina Pruthi, Eliyahu V. Khankin, Robert M. Blanton, Mark Aronovitz, Suzanne D. Burke, Amy McCurley, S. Ananth Karumanchi, Iris Z. Jaffe
Editorial Material
Peripheral Vascular Disease
Eliyahu V. Khankin, Zoltan Arany
Article
Medicine, Research & Experimental
Suzanne D. Burke, Zsuzsanna K. Zsengeller, Eliyahu V. Khankin, Agnes S. Lo, Augustine Rajakumar, Jennifer J. DuPont, Amy McCurley, Mary E. Moss, Dongsheng Zhang, Christopher D. Clark, Alice Wang, Ellen W. Seely, Peter M. Kang, Isaac E. Stillman, Iris Z. Jaffe, S. Ananth Karumanchi
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Multidisciplinary Sciences
Mei T. Tran, Zsuzsanna K. Zsengeller, Anders H. Berg, Eliyahu V. Khankin, Manoj K. Bhasin, Wondong Kim, Clary B. Clish, Isaac E. Stillman, S. Ananth Karumanchi, Eugene P. Rhee, Samir M. Parikh
Article
Physiology
Sascha David, Chandra C. Ghosh, Philipp Kuempers, Nelli Shushakova, Paul Van Slyke, Eliyahu V. Khankin, S. Ananth Karumanchi, Dan Dumont, Samir M. Parikh
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2011)
Article
Reproductive Biology
Eliyahu V. Khankin, Maurizio Mandala, Ilsley Colton, S. Ananth Karumanchi, George Osol
BIOLOGY OF REPRODUCTION
(2012)
Article
Critical Care Medicine
Sascha David, Aditi Mukherjee, Chandra C. Ghosh, Midori Yano, Eliyahu V. Khankin, Julia B. Wenger, S. Ananth Karumanchi, Nathan I. Shapiro, Samir M. Parikh
CRITICAL CARE MEDICINE
(2012)
Article
Endocrinology & Metabolism
Carine Gennari-Moser, Eliyahu V. Khankin, Simone Schuller, Genevieve Escher, Brigitte M. Frey, C. -Bettina Portmann, Marc U. Baumann, Andrea D. Lehmann, Daniel Surbek, S. Ananth Karumanchi, Felix J. Frey, Markus G. Mohaupt
Article
Peripheral Vascular Disease
Carine Gennari-Moser, Eliyahu V. Khankin, Genevieve Escher, Fiona Burkhard, Brigitte M. Frey, S. Ananth Karumanchi, Felix J. Frey, Markus G. Mohaupt
Letter
Peripheral Vascular Disease
Carine Gennari-Moser, Eliyahu V. Khankin, Genevieve Escher, Fiona Burkhard, Brigitte M. Frey, S. Ananth Karumanchi, Felix J. Frey, Markus G. Mohaupt
Article
Medicine, Research & Experimental
Mei Tran, Denise Tam, Amit Bardia, Manoj Bhasin, Glenn C. Rowe, Ajay Kher, Zsuzsanna K. Zsengeller, M. Reza Akhavan-Sharif, Eliyahu V. Khankin, Magali Saintgeniez, Sascha David, Deborah Burstein, S. Ananth Karumanchi, Isaac E. Stillman, Zoltan Arany, Samir M. Parikh
JOURNAL OF CLINICAL INVESTIGATION
(2011)
Article
Multidisciplinary Sciences
Ian S. Patten, Sarosh Rana, Sajid Shahul, Glenn C. Rowe, Cholsoon Jang, Laura Liu, Michele R. Hacker, Julie S. Rhee, John Mitchell, Feroze Mahmood, Philip Hess, Caitlin Farrell, Nicole Koulisis, Eliyahu V. Khankin, Suzanne D. Burke, Igor Tudorache, Johann Bauersachs, Federica del Monte, Denise Hilfiker-Kleiner, S. Ananth Karumanchi, Zoltan Arany
Article
Developmental Biology
S. D. Burke, V. F. Barrette, S. David, E. V. Khankin, M. A. Adams, B. A. Croy
Article
Obstetrics & Gynecology
Eliyahu V. Khankin, Michele R. Hacker, Carolyn M. Zelop, S. Ananth Karumanchi, Sarosh Rana
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2012)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)