Article
Biochemistry & Molecular Biology
Javier Modrego, Adriana Ortega-Hernandez, Josebe Goirigolzarri, Maria Alejandra Restrepo-Cordoba, Christine Bauerl, Erika Cortes-Macias, Silvia Sanchez-Gonzalez, Alberto Esteban-Fernandez, Julian Perez-Villacastin, Maria Carmen Collado, Dulcenombre Gomez-Garre
Summary: A longitudinal study found that after 12 months of the initial heart failure episode, patients showed improved clinical parameters, reduced inflammation, and endothelial dysfunction, which were associated with the reversal of gut microbiota dysbiosis and increased production of the short-chain fatty acid butyrate. This suggests that restoring butyrate levels or promoting the growth of butyrate-producing bacteria could serve as a complementary treatment for heart failure patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Nikolai Pakhomov, John A. Baugh
Summary: Heart failure is a major cause of mortality and morbidity in the modern world, with increasing prevalence of HFpEF being of particular concern. Pressure overload caused by hypertension is the predominant driver of HFpEF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Debora Maria Soares de Souza, Maria Claudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lucio, Nivia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Joao Santana Silva, Andre Talvani
Summary: The study showed that tissue from mice subjected to a lard diet was more favorable for the growth of T. cruzi parasites, supporting the hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Adam Oesterle, Petra Buzkova, Cara N. Pellegrini, Calvin Hirsch, Russell P. Tracy, David S. Siscovick, Luc Djousse, Ken J. Mukamal, Jorge R. Kizer
Summary: Glucose, both fasting and post-load, is associated with incident heart failure, while non-esterified fatty acids (NEFA) are not. The association is particularly strong for post-load glucose, suggesting potential targets for HF prevention.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Beatriz Burger, Roberta Nicolli Sagiorato, Jessica Rondoni Silva, Thamiris Candreva, Mariana R. Pacheco, Daniel White, Bianca G. Castelucci, Lais P. Pral, Helena L. Fisk, Izadora L. Rabelo, Jefferson Elias-Oliveira, Wislei Riuper Osorio, Silvio Roberto Consonni, Alessandro dos Santos Farias, Marco Aurelio Ramirez Vinolo, Claudiana Lameu, Daniela Carlos, Barbara A. Fielding, Martin Brunel Whyte, Fernando O. Martinez, Philip C. Calder, Hosana Gomes Rodrigues
Summary: Research has shown that supplementation with fish oil, which is rich in omega-3 fatty acids, may have a detrimental effect on wound healing in diabetes, leading to delayed closure and impaired tissue quality. This effect is PPAR-γ-dependent and involves the modulation of inflammatory and non-inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Liang Yu, Huaji Shen, Xiaohan Ren, Anqi Wang, Shu Zhu, Yafeng Zheng, Xiuli Wang
Summary: In this study, 129 differentially expressed genes (DEGs) were identified in EMs, of which 78 were up-regulated and 51 were down-regulated. Through GO functional enrichment analysis, it was found that the DEGs are mainly enriched in cell adhesion, extracellular matrix remodeling, chemokine regulation, angiogenesis regulation, epithelial cell proliferation, etc. In Hallmark pathway enrichment analysis, the coagulation pathway showed great significance, including central complement factors. Additionally, the genes were dominating in the PPI network.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Raquel Guillamat-Prats
Summary: MSCs play a vital role in controlling various phases in response to injuries, immune reactions, wound healing, and regeneration. They can regulate coagulation pathways, trigger platelet production, and contribute to platelet activation. Proper characterization of MSCs is important to prevent adverse coagulation events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Jussara J. Simao, Maysa M. Cruz, Fernanda M. Abdala, Andressa Bolsoni-Lopes, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
Summary: The study demonstrates that palmitoleic acid (n7) can alleviate or prevent low-grade chronic inflammation caused by obesity by inducing adipocyte differentiation and reducing the expression of inflammatory cytokines.
Review
Nutrition & Dietetics
Peng Zhao, Suhong Zhao, Jinwei Tian, Xinxin Liu
Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Jeneen Panezai, Thomas van Dyke
Summary: Polyunsaturated fatty acids (PUFAs) are diverse molecules that play significant roles in human physiology as sources of fuel, cellular structural components, and substrates for bioactive metabolites. They have been found to be involved in inflammation, particularly in the context of polymicrobial biofilms contributing to periodontitis pathology. The immunologic implications of PUFAs in modulating immuno-inflammatory reactions in periodontitis are still being uncovered as research progresses.
Review
Cell Biology
Tongtong Hu, Qingqing Wu, Qi Yao, Kebing Jiang, Jiabin Yu, Qizhu Tang
Summary: This article summarizes the role of short-chain fatty acids in cardiovascular diseases and highlights the positive effects of most short-chain fatty acids in regulating related diseases through mechanisms such as inflammation modulation, immune system regulation, and G protein-coupled receptors.
AGEING RESEARCH REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Yi Yu, Chunna Jin, Chengchen Zhao, Shiyu Zhu, Simin Meng, Hong Ma, Jian'an Wang, Meixiang Xiang
Summary: This study found that serum FFA levels in AHF patients were associated with an increased risk of adverse outcomes, independent of insulin resistance. Each SD higher FFAs was associated with a 26% higher risk of death or HF rehospitalization. Additional studies are needed to determine the causal-effect relationship between FFAs and acute cardiac dysfunction and whether FFAs could be a potential target for AHF management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Simona Mattioli, Elisa Angelucci, Alessandro Dal Bosco, Cinzia Signorini, Lakamy Sylla, Luigia Bosa, Giulia Collodel, Thierry Durand, Jean-Marie Galano, Camille Oger, Cesare Castellini
Summary: Dietary factors can affect sperm traits, and diets rich in pro-oxidant and pro-atherogenic substances may lead to a decline in sperm kinetics and viability.
Article
Nutrition & Dietetics
Erin D. Clarke, Jordan Stanford, Jessica J. A. Ferguson, Lisa G. Wood, Clare E. Collins
Summary: This study investigates the relationship between fatty acids, diet quality scores, and inflammatory markers. The results indicate a positive association between saturated fat and inflammation, while monounsaturated fatty acids, polyunsaturated fatty acids, and the Mediterranean diet are inversely associated with inflammation.
Article
Surgery
Daniela Branzan, Antonia Geisler, Sabine Steiner, Markus Doss, Manuela Matschuck, Dierk Scheinert, Andrej Schmidt
Summary: Preemptive embolization of aneurysm sac side branches is effective in preventing Type II endoleak after EVAR, with a low rate of occurrence. Most patients experienced shrinkage of the aneurysm sac after the procedure. The number of remaining patent side branches post-embolization is a crucial factor in predicting the occurrence of Type II endoleak.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Daniela Branzan, Antonia Geisler, Ronny Grunert, Sabine Steiner, Yvonne Bausback, Ines Gockel, Dierk Scheinert, Andrej Schmidt
Summary: This study aimed to describe the outcomes of high risk patients with symptomatic or contained rupture of pararenal and thoraco-abdominal aortic aneurysms who underwent fenestrated endovascular aneurysm repair using physician modified stent grafts planned with 3D image analysis software and 3D printed aortic models. The results showed that this approach was feasible and safe, with high success rates and low complication rates.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Sabine Steiner
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Peripheral Vascular Disease
Daniela Branzan, Antonia Geisler, Sabine Steiner, Tina Lautenschlaeger, Markus Doss, Manuela Matschuck, Dierk Scheinert, Andrej Schmidt
Summary: The study aimed to determine the rate of ischemic stroke following TEVAR with de-airing of thoracic stentgrafts with high-volume of 0.9% heparinized saline solution. Results showed that this method is safe and effective in reducing in-hospital rates of ischemic stroke and spinal cord ischemia, with no further in-hospital events observed.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Georg Semmler, Fabian Barbieri, Karin Thudt, Paul Vock, Deddo Moertl, Harald Mayr, Christian Georg Wollmann, Agne Adukauskaite, Bernhard Pfeifer, Thomas Senoner, Wolfgang Dichtl
Summary: The study revealed a surprisingly high rate of technical issues with the Osypka QT-5(R) ventricular lead during long-term follow-up, including an increase in pacing threshold and a significant decline in impedance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Gernot Wagner, Deddo Moertl, Anna Glechner, Verena Mayr, Irma Klerings, Casey Zachariah, Miriam Van den Nest, Gerald Gartlehner, Birgit Willinger
Summary: Paracoccidioidomycosis is a systemic mycosis endemic to Central and South America, with cases imported to Europe through migration and travel. A systematic review identified 83 cases of paracoccidioidomycosis diagnosed in 11 European countries, highlighting challenges in diagnosing the disease in individuals returning or immigrating from endemic areas, given the varied age of patients and time of symptom onset.
Article
Surgery
Olaf Bakker, Yvonne Bausback, Tim Wittig, Daniela Branzan, Sabine Steiner, Axel Fischer, Manuela Konert, Sandra Duesing, Ursula Banning-Eichenseer, Dierk Scheinert, Andrej Schmidt
Summary: The study evaluated the use of the GoBack-catheter in complex revascularizations in lower limb arteries and found that the device has a high technical success rate and low complication rate in recanalization of chronic total occlusions.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Medicine, General & Internal
Sabine Steiner, Andrej Schmidt
Summary: Successful revascularization of PAD patients requires understanding of risk population and treatment options. Endovascular techniques have evolved rapidly and can successfully treat complex lesions. Bypass surgery remains an important option for advanced diseases. The use of paclitaxel-coated balloons and stents can reduce restenosis rates.
Article
Cardiac & Cardiovascular Systems
Sabine Steiner, Benjamin Honton, Ralf Langhoff, Roberto Chiesa, Andrea Kahlberg, Marcus Thieme, Thomas Zeller, Philippe Garot, Philippe Commeau, Alberto Cremonesi, Enrico Maria Marone, Antoine Sauguet, Dierk Scheinert
Summary: This study assessed the 24-month efficacy and safety of a novel drug-eluting stent for femoropopliteal interventions. The stent has an innovative design and abluminal reservoir technology for efficient drug transfer and optimized release kinetics.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Surgery
Tim Wittig, Andrej Schmidt, Maria Kabelitz, Martin Hukauf, Toni Pflug, Dierk Scheinert, Sabine Steiner
Summary: This study investigated the safety and efficacy of paclitaxel coated balloons (PCBs) for below knee (BTK) interventions. Results showed that PCBs were safe with a trend towards lower amputation rates, but no significant benefit for repeat revascularization was observed.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schroeder, Wulf Euringer, Corneliu Popescu, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Ulrich Beschorner, Tim Wittig, Dierk Scheinert
Summary: This study compares the efficacy and safety of low-dose and high-dose paclitaxel-coated balloons (PCBs) with different coating technologies for femoropopliteal interventions. The 2-year results show no significant difference in treatment effects between the two types of balloons, and both provide sustained treatment benefits.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Medicine, General & Internal
Gernot Wagner, Anna Glechner, Emma Persad, Irma Klerings, Gerald Gartlehner, Deddo Moertl, Sabine Steiner
Summary: The aim of this systematic review was to summarize the comparative evidence on the risk of contrast-associated acute kidney injury (CA-AKI) with CO2 or iodinated contrast medium (ICM) for peripheral vascular interventions. The review found that the use of CO2 reduces the risk of CA-AKI compared to ICM. However, other risk factors for kidney injury should be considered in patients undergoing peripheral vascular interventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tim Wittig, Arsen Sabanov, Andrej Schmidt, Dierk Scheinert, Sabine Steiner, Daniela Branzan
Summary: This study reviewed the feasibility and safety of percutaneous axillary artery approach for complex endovascular repair. The results showed that this method is feasible and safe, especially when the maximum diameter of the axillary artery is >= 5 mm.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
S. Kaser, M. Huelsmann, P. Siostrzonek, M. Clodi, D. Moertl, H. Sourij, K. Huber
Summary: The position paper aims to raise awareness of the close relationship between chronic heart failure and diabetes, summarizing relevant diagnostic procedures and therapeutic approaches for daily clinical practice.
JOURNAL FUR KARDIOLOGIE
(2021)
