Article
Medicine, General & Internal
Inwu Yu, Tae-Jin Song, Bum Joon Kim, Sung Hyuk Heo, Jin-Man Jung, Kyung-Mi Oh, Chi Kyung Kim, Sungwook Yu, Kwang Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon-Tae Kim, Yang-Ha Hwang, Jong-Won Chung, Oh Young Bang, Geong-Moon Kim, Yong-Jae Kim, Seonwoo Kim, Sook Young Woo, Hyun Cho, Woo-Keun Seo
Summary: The performance of scoring systems for risk stratification in patients with atrial fibrillation (AF) was not well validated in patients with stroke. Among stroke patients with AF, CHADS(2), CHA(2)DS(2)-VASc, ATRIA, and Essen stroke risk scores were not associated with recurrent ischemic stroke and any stroke, but were correlated with death and major adverse cerebrovascular and cardiovascular events (MACEs), particularly in the group treated with oral anticoagulants (OACs). A new risk stratification scheme specific to secondary stroke prevention in the AF population is needed.
Article
Cardiac & Cardiovascular Systems
James Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, Jeptha P. Curtis
Summary: This study evaluated the postprocedure care patterns and compared the risk of adverse events for different discharge antithrombotic strategies after left atrial appendage occlusion (LAAO) with the Watchman device. The study found that practitioners rarely followed the recommended postprocedure treatment protocols and that discharge on warfarin or direct oral anticoagulants (DOACs) without aspirin was associated with a lower risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Gregory Y. H. Lip, Richard R. Murphy, Farhad Sahiar, Timothy J. Ingall, Amol D. Dhamane, Mauricio Ferri, Patrick Hlavacek, Madison T. Preib, Allison Keshishian, Cristina Russ, Lisa Rosenblatt, Huseyin Yuce, Steven Deitelzweig
Summary: This study evaluated the incidence of adverse outcomes among patients with nonvalvular atrial fibrillation receiving oral anticoagulants based on the CHA(2)DS(2)-VASc risk score, thromboembolic event history, and age group. The results provide insights into the importance of specific risk score range, thromboembolic event history, and age group strata in clinical decision-making, research, and policy.
Article
Multidisciplinary Sciences
Gernot Wagner, Michael Smeikal, Christoph Gisinger, Deddo Moertl, Stephan Nopp, Gerald Gartlehner, Ingrid Pabinger, Gerald Ohrenberger, Cihan Ay
Summary: This study aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in long-term care hospital patients. The study found a high burden of AF, but only half of the patients received oral anticoagulation therapy.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Hui-Jin Lee, So-Ryoung Lee, Eue-Keun Choi, Sang-Hyun Park, Jae-Wook Chung, Jung-Min Choi, Min-Ju Han, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: The findings of this cohort study suggest that all types of smoking were associated with a significantly higher risk of dementia in patients with new-onset AF. Smoking cessation after AF diagnosis was associated with a lower risk of dementia than among current smokers.
Article
Cardiac & Cardiovascular Systems
Mariam Anjum, Inger Ariansen, Vidar Hjellvik, Randi Selmer, Lars J. Kjerpeseth, Eva Skovlund, Marius Myrstad, Hanne Ellekjaer, Ingrid E. Christophersen, Arnljot Tveit, Trygve Berge
Summary: In patients with atrial fibrillation (AF) at intermediate risk of stroke, oral anticoagulant use was associated with overall favorable clinical outcomes. Non-anticoagulated AF patients had a higher risk of ischemic stroke compared to individuals without AF but with the same risk profile.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Christina J-Y Lee, Anne Pernille Toft-Petersen, Brice Ozenne, Matthew Phelps, Jonas Bjerring Olesen, Patrick T. Ellinor, Gunnar Gislason, Gregory Y. H. Lip, Christian Torp-Pedersen, Thomas Alexander Gerds
Summary: This study aimed to evaluate the risk of stroke and thromboembolism in patients with atrial fibrillation using the CHA(2)DS(2)-VASc score. The research found personalized risk predictions varied widely within each score, highlighting the importance of individualized risk estimation. The development of the Calculator of Absolute Stroke Risk (CARS) can assist in evidence-based decision-making regarding oral anticoagulation therapy.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Pascal B. Meyre, Steffen Blum, Elisa Hennings, Stefanie Aeschbacher, Tobias Reichlin, Nicolas Rodondi, Jurg H. Beer, Annina Stauber, Andreas Mueller, Tim Sinnecker, Elisavet Moutzouri, Rebecca E. Paladini, Giorgio Moschovitis, Giulio Conte, Angelo Auricchio, Alexandra Ramadani, Matthias Schwenkglenks, Leo H. Bonati, Michael Kuehne, Stefan Osswald, David Conen
Summary: Anticoagulated patients with atrial fibrillation who experience new bleeding events have an increased risk of subsequent adverse clinical outcomes, especially with major bleeding. Long-term follow-up is important for these patients.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Mette F. Hindsholm, Dorte Damgaard, M. Edip Gurol, David Gaist, Claus Z. Simonsen
Summary: Atrial fibrillation is a significant risk factor for ischemic stroke and oral anticoagulation can reduce the risk but also increase bleeding risk. AF-related strokes have worse outcomes compared to non-AF strokes. The management of AF-related strokes is challenging and requires considering individual risks and benefits in treatment and prevention strategies. This review summarizes the current knowledge and implications for the acute and long-term management of ischemic and hemorrhagic stroke in patients with AF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wern Yew Ding, Jose Miguel Rivera-Caravaca, Francisco Marin, Christian Torp-Pedersen, Vanessa Roldan, Gregory Y. H. Lip
Summary: The study investigated the use of a modified version of the Calculator of Absolute Stroke Risk (mCARS) to assess residual stroke risk in anticoagulated atrial fibrillation (AF) patients. By analyzing patient-level data from real-world and clinical trial cohorts, it was found that mCARS could accurately estimate stroke risk, providing a more personalized risk assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Christopher Wallenhorst, Carlos Martinez, Ben Freedman
Summary: The study found that the risk of ischemic stroke in patients with incidentally detected AA-AF in primary care is not lower than clinically presented AF patients, highlighting the importance of identifying previously undetected AF through opportunistic screening and implementing stroke prevention measures.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Adenike R. Adelakun, Ricky D. Turgeon, Mary A. De Vera, Kimberlyn McGrail, Peter S. Loewen
Summary: The study aims to examine the phenomenon of oral anticoagulant (OAC) switching in patients with atrial fibrillation. The results show that OAC switching is common, with varying types and frequencies. However, there is limited research on switching from direct-acting OACs (DOACs).
Article
Clinical Neurology
Anjali Bhatla, Yuliya Borovskiy, Ronit Katz, Matthew C. Hyman, Parin J. Patel, Jeffrey Arkles, David J. Callans, Neel Chokshi, Sanjay Dixit, Andrew E. Epstein, David S. Frankel, Fermin C. Garcia, Ramanan Kumareswaran, Jackson J. Liang, David Lin, Steven R. Messe, Saman Nazarian, Michael P. Riley, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, Scott E. Kasner, Francis Marchlinski, Rajat Deo
Summary: This study assessed the prognosis of patients with ischemic stroke based on the timing of AF diagnosis. The findings indicated that patients diagnosed with AF after stroke within <= 6 months had the highest risk of death.
Article
Cardiac & Cardiovascular Systems
Mu Chen, Jian Sun, Qun-Shan Wang, Peng-Pai Zhang, Wei Li, Rui Zhang, Bin-Feng Mo, Yi-Chi Yu, Xingxing Cai, Mei Yang, Xiao-Ming Lian, Yan Zhao, Changqi Gong, Yi Yu, Bo Liu, Xiangfei Feng, Qiufen Lu, Yi-Gang Li
Summary: This study evaluated the procedural safety and long-term outcome of the combined procedure of catheter ablation and left atrial appendage closure in patients with atrial fibrillation. The results showed that the combined procedure was safe and effective in controlling heart rhythm and reducing the risk of strokes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Danilo Menichelli, Angela Sciacqua, Roberto Cangemi, Paola Andreozzi, Francesco Del Sole, Francesco Violi, Pasquale Pignatelli, Daniele Pastori
Summary: The study investigated the impact of left atrial diameter (LAd) on cardiovascular outcomes in different types of atrial fibrillation (AF) patients. Results showed that patients with LAd above the median had higher risks of cardiovascular events, major adverse cardiac events, and cardiovascular death, regardless of AF pattern.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
