Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Jie Lian, Guanqun Ju, Xueyao Cai, Yuchen Cai, Chun Li, Sunxiang Ma, Yi Cao
Summary: Hydrogen sulfide and endothelial progenitor cells have been shown to enhance wound healing, and a novel drug carrier nanofibrous membrane has been developed for effective release of H2S and improved therapeutic effects of EPCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ting-Ting Chang, Ching Chen, Liang-Yu Lin, Jaw-Wen Chen
Summary: This study found that the increased level of CCL4 in diabetes patients is associated with non-healing wounds. Inhibiting CCL4 can restore cell function and accelerate wound healing in diabetic patients. These findings provide a new therapeutic option for clinical treatment of diabetic wounds.
Article
Physiology
Huiya Huang, Linlin Wang, Fanyu Qian, Xiong Chen, Haiping Zhu, Mei Yang, Chunxiang Zhang, Maoping Chu, Xiaorong Wang, Xiaozhong Huang
Summary: Lira has a significant inhibitory effect on hyperglycemia-induced endothelial dysfunction and angiogenesis disturbance, promoting diabetic wound healing by restoring impaired AMPK signaling pathway activity. The protective and pro-angiogenic effects of Lira are regulated by AMPK, with the promotion of diabetic wound healing dependent on the Hif-1 alpha-HO-1 axis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Biochemistry & Molecular Biology
Iman M. Ahmad, Alicia J. Dafferner, Ramia J. Salloom, Maher Y. Abdalla
Summary: This study explored new strategies that could lead to the development of less toxic and more effective therapies against PDAC by combining increased cellular stress and targeting autophagy.
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Modar Kassan, Youngin Kwon, Undral Munkhsaikhan, Amal M. Sahyoun, Tauheed Ishrat, Maria Galan, Alexis A. Gonzalez, Ammaar H. Abidi, Adam Kassan, Karima Ait-Aissa
Summary: In this study, the in vitro effect of short-chain fatty acids (SCFAs) on cerebrovascular endothelial cells and mitochondrial function after angiotensin II (Ang-II) treatment was investigated. The results showed that SCFAs restored the oxidative damage induced by Ang-II and exerted their beneficial effects through heme oxygenase 2 (HO-2). These findings provide new insights into the effect of the SCFAs/HO-2 axis on cerebrovascular diseases induced by hypertension and obesity.
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Endocrinology & Metabolism
Antonietta Maio, Maria Ida Maiorino, Miriam Longo, Lorenzo Scappaticcio, Vlenia Pernice, Paolo Cirillo, Paola Caruso, Vanda Amoresano Paglionico, Giuseppe Bellastella, Katherine Esposito
Summary: The study compared the levels of EPCs and sexual function changes during the menstrual cycle in women with T1DM and healthy women, finding lower EPCs levels and sexual function scores in diabetic women, particularly in the ovulatory phase.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Ermelindo Carreira Leal, Eugenia Carvalho
Summary: A diabetic foot ulcer is a major complication of diabetes with impaired wound healing. The enzyme heme oxygenase-1 plays a crucial role in wound healing due to its antioxidant and anti-inflammatory properties, among others. Therapeutic strategies targeting heme oxygenase-1 are important in treating diabetic foot ulcers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Pharmacology & Pharmacy
Hengyue Song, Kewa Gao, Dake Hao, Andrew Li, Ruiwu Liu, Bryan Anggito, Boyan Yin, Qianyu Jin, Vanessa Dartora, Kit S. Lam, Lucas R. Smith, Alyssa Panitch, Jianda Zhou, Diana L. Farmer, Aijun Wang
Summary: The lack of vascularization associated with deep burns delays wound healing, increases infection risks, and leads to hypertrophic scars or disfigurement. To address this challenge, a multi-functional pro-angiogenic molecule, LXW7-DS-SILY (LDS), was fabricated and used to functionalize collagen-based Integra scaffolds. In a mouse burn wound model, LDS-modified Integra scaffolds loaded with endothelial cells (ECs) accelerated wound healing rate, re-epithelialization, vascularization, and collagen deposition. These scaffolds have the potential to reduce morbidity associated with open burn wounds and the need for autografting in patients with limited areas of harvestable skin.
FRONTIERS IN PHARMACOLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
Jerzy Kotlinowski, Anna Grochot-Przeczek, Hevidar Taha, Magdalena Kozakowska, Bartosz Pilecki, Klaudia Skrzypek, Jakub Zimoch, Aleksandra Bartelik, Rafal Derlacz, Anton J. G. Horrevoets, Attila Pap, Laszlo Nagy, Jozef Dulak, Alicja Jozkowicz
CARDIOVASCULAR DIABETOLOGY
(2015)
Letter
Cardiac & Cardiovascular Systems
Agnieszka Loboda, Urszula Florczyk, Agnieszka Jazwa, Anna Grochot-Przeczek, Witold Nowak, Alicja Jozkowicz, Jozef Dulak
CIRCULATION RESEARCH
(2015)
Review
Biochemistry & Molecular Biology
Agata Szade, Anna Grochot-Przeczek, Urszula Florczyk, Alicja Jozkowicz, Jozef Dulak
Article
Cell & Tissue Engineering
Magdalena Kozakowska, Jerzy Kotlinowski, Anna Grochot-Przeczek, Maciej Ciesla, Bartosz Pilecki, Rafal Derlacz, Jozef Dulak, Alicja Jozkowicz
STEM CELL RESEARCH & THERAPY
(2015)
Review
Pharmacology & Pharmacy
Agnieszka Jazwa, Urszula Florczyk, Anna Grochot-Przeczek, Bart Krist, Agnieszka Loboda, Alicja Jozkowicz, Jozef Dulak
VASCULAR PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Witold Norbert Nowak, Hevidar Taha, Neli Kachamakova-Trojanowska, Jacek Stepniewski, Joanna Agata Markiewicz, Anna Kusienicka, Krzysztof Szade, Agata Szade, Karolina Bukowska-Strakova, Karolina Hajduk, Damian Kloska, Aleksandra Kopacz, Anna Grochot-Przeczek, Kathrin Barthenheier, Camille Cauvin, Jozef Dulak, Alicja Jozkowicz
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Cell Biology
Aleksandra Piechota-Polanczyk, Aleksandra Kopacz, Damian Kloska, Branislav Zagrapan, Christoph Neumayer, Anna Grochot-Przeczek, Ihor Huk, Christine Brostjan, Jozef Dulak, Alicja Jozkowicz
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Biochemistry & Molecular Biology
Anna Grochot-Przeczek, Jerzy Kotlinowski, Magdalena Kozakowska, Katarzyna Starowicz, Jolanta Jagodzinska, Anna Stachurska, Oscar L. Volger, Karolina Bukowska-Strakova, Urszula Florczyk, Magdalena Tertil, Agnieszka Jazwa, Krzysztof Szade, Jacek Stepniewski, Agnieszka Loboda, Anton J. G. Horrevoets, Jozef Dulak, Alicja Jozkowicz
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Biochemistry & Molecular Biology
Urszula Florczyk, Agnieszka Jazwa, Monika Maleszewska, Mateusz Mendel, Krzysztof Szade, Magdalena Kozakowska, Anna Grochot-Przeczek, Monika Viscardi, Szymon Czauderna, Karolina Bukowska-Strakova, Jerzy Kotlinowski, Alicja Jozkowicz, Agnieszka Loboda, Jozef Dulak
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Biochemistry & Molecular Biology
Damian Kloska, Aleksandra Kopacz, Dominik Cysewski, Martin Aepfelbacher, Jozef Dulak, Alicja Jozkowicz, Anna Grochot-Przeczek
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Cardiac & Cardiovascular Systems
Jerzy Kotlinowski, Anna Grochot-Przeczek, Hevidar Taha, Magdalena Kozakowska, Bartosz Pilecki, Klaudia Skrzypek, Aleksandra Bartelik, Rafal Derlacz, Anton J. G. Horrevoets, Attila Pap, Laszlo Nagy, Jozef Dulak, Alicja Jozkowicz
CARDIOVASCULAR DIABETOLOGY
(2014)
Review
Pharmacology & Pharmacy
Damian Kloska, Aleksandra Kopacz, Aleksandra Piechota-Polanczyk, Witold N. Nowak, Jozef Dulak, Alicia Jozkowicz, Anna Grochot-Przeczek
VASCULAR PHARMACOLOGY
(2019)
Article
Cell Biology
Aleksandra Kopacz, Damian Kloska, Ewa Werner, Karolina Hajduk, Anna Grochot-Przeczek, Alicja Jozkowicz, Aleksandra Piechota-Polanczyk
Summary: In normolipidemic mice, the deficiency of HO-1 can slow down the development of AAA, but exacerbate the condition of formed AAA. This dual role is not associated with enhanced inflammatory response or oxidative stress, but with an increase in regulators of aortic remodeling and angiotensin receptor-2 expression, significant medial thickening, and delayed blood pressure elevation in response to AngII.
Article
Biochemistry & Molecular Biology
Wojciech Krzeptowski, Patryk Chudy, Grzegorz Sokolowski, Monika Zukowska, Anna Kusienicka, Agnieszka Seretny, Agata Kalita, Alicja Czmoczek, Jakub Gubala, Sonia Baran, Damian Kloska, Mateusz Jez, Jacek Stepniewski, Krzysztof Szade, Agata Szade, Anna Grochot-Przeczek, Alicja Jozkowicz, Witold N. Nowak
Summary: G-quadruplexes are nucleic acid structures stabilized by heme, influencing DNA replication and gene transcription. The accumulation of G-quadruplexes is affected by heme oxygenase-1 expression in a cell-type-specific manner. Cellular co-localization of G-quadruplexes with helicases and HMOX1 can be detected using the proximity ligation assay, providing insights into potential roles of HMOX1 in G4 modifications.
Review
Biochemistry & Molecular Biology
Aleksandra Kopacz, Ana Rojo, Chinmai Patibandla, Diego Lastra-Martinez, Aleksandra Piechota-Polanczyk, Damian Kloska, Alicja Jozkowicz, Calum Sutherland, Antonio Cuadrado, Anna Grochot-Przeczek
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
