Article
Infectious Diseases
Ruth Gil-Prieto, Nizar Allouch, Isabel Jimeno, Valentin Hernandez-Barrera, Raquel Arguedas-Sanz, Angel Gil-de-Miguel
Summary: Pneumococcal infection in Spain has a high impact on health, with 253,899 hospitalizations occurring from 2016 to 2020. The average age of patients was 67 years old and the average length of hospitalization was 12.72 days. The annual hospitalization rate was 10.84 per 10,000 population, increasing with age and reaching 65.75 per 10,000 population in individuals aged over 85. The case-fatality rate was 14.07%, with the highest rates seen in sepsis. The annual cost of hospitalizations exceeded EUR 359 million.
Article
Immunology
Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van 't Veer, Tom van der Poll, Alex F. de Vos
Summary: The research indicates that besides regulating B cell-mediated immunity, Btk is critical for the regulation of myeloid cell-mediated, and particularly neutrophil-mediated, innate host defense against S. pneumoniae in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliu, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Summary: Intestinal dysbiosis increases susceptibility to infection due to metabolic profile changes, resulting in increased morbidity. The study found that ZIP8, a type of zinc transporter, is important for myeloid cells in maintaining host defense against bacterial pneumonia. Furthermore, a common variant of ZIP8 is closely associated with inflammation-based disorders and bacterial infection. The researchers developed a new model to study the effects of ZIP8-mediated intestinal dysbiosis on pulmonary host defense, independent of genetic factors. The results showed that the intestinal microbiota, regardless of host genetics, play a crucial role in regulating host defense in the lung against infection. These findings support future microbiome-based intervention studies, considering the high prevalence of zinc deficiency and the rs13107325 allele in humans.
Article
Immunology
Flavia Rayssa Braga Martins, Maycon Douglas de Oliveira, Jessica Amanda Marques Souza, Celso Martins Queiroz-Junior, Francisco Pereira Lobo, Mauro Martins Teixeira, Nathalia Luisa Malacco, Frederico Marianetti Soriani
Summary: This study aimed to investigate the inflammatory mechanisms involved in pneumococcal pneumonia associated with chronic ethanol exposure. The results showed that alcohol-fed mice produced higher levels of nitric oxide and CXCL1 during pneumonia, exhibited reduced leukocyte infiltration and less severe lung inflammation, but no changes in survival after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Lena Ostermann, Benjamin Seeliger, Sascha David, Carolin Flasche, Regina Maus, Marieke S. Reinboth, Martin Christmann, Konstantin Neumann, Korbinian Brand, Stephan Seltmann, Frank Buehling, James C. Paton, Johannes Roth, Thomas Vogl, Dorothee Viemann, Tobias Welte, Ulrich A. Maus
Summary: S100A9 plays important immunomodulatory roles in antibacterial defense, and its increased levels are associated with bacterial pneumonia. Deficiency in S100A9 leads to elevated Zn2+ levels in the lungs, resulting in bacterial outgrowth and reduced survival. S100A9 appears to be a promising biomarker for distinguishing bacterial pneumonia from viral pneumonia.
Article
Medical Laboratory Technology
Chunmei Zhang, Yuan Yuan, Jie Song, Xiaohui Li, Jinxiang Wang
Summary: The study found that MRP8/14, TNF-alpha, and IL-1 ss levels in the serum of AECOPD patients were significantly higher than in the control group, with positive correlations between MRP8/14 and TNF-alpha, IL-1 ss, and negative correlation with FEV1 % pred. Serum MRP8/14 levels were higher in GOLD 3-4 patients compared to GOLD 1-2 patients, and higher in mMRC 3-4 patients compared to mMRC 0-2 patients. ROC analysis showed that serum MRP8/14 could differentiate AECOPD patients from healthy controls.
CLINICAL LABORATORY
(2021)
Article
Plant Sciences
Magdalena Miklaszewska, Krzysztof Zienkiewicz, Ewa Klugier-Borowska, Marcin Rygielski, Ivo Feussner, Agnieszka Zienkiewicz
Summary: This study provides new insights into the microautophagy-mediated degradation mechanism of lipid droplets (LDs) during Arabidopsis seed germination. The researchers discovered how LDs enter the central vacuole and undergo degradation there, as well as the interaction between LD proteins and AUTOPHAGY-RELATED PROTEIN 8. These findings reveal the mechanism of LD degradation during seed germination and highlight the role of structural LD proteins in this process.
Article
Cell Biology
Waltraud Cornelia Schrottmaier, Julia Barbara Kral-Pointner, Manuel Salzmann, Marion Mussbacher, Anna Schmuckenschlager, Anita Pirabe, Laura Brunnthaler, Mario Kuttke, Barbara Maier, Stefan Heber, Hannes Datler, Yasemin Ekici, Birgit Niederreiter, Ulrike Heber, Bo Blomgren, Anna-Dorothea Gorki, Cecilia Soederberg-Naucler, Bernard Payrastre, Marie-Pierre Gratacap, Sylvia Knapp, Gernot Schabbauer, Alice Assinger
Summary: Phosphatidylinositol 3-kinase catalytic subunit p110 beta plays a role in tumorigenesis and hemostasis. This study investigates the role of p110 beta in platelet-mediated immune responses and finds that its dysfunction exacerbates infection by impeding leukocyte functions. These findings provide important insights into the immunomodulatory potential of PI3K inhibitors in bacterial infection.
Article
Oncology
Yuanming Cheng, Wei Xie, Brian F. Pickering, Karen L. Chu, Angela M. Savino, Xuejing Yang, Hanzhi Luo, Diu Tt Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas M. Rohwetter, Dinshaw J. Patel, Samie R. Jaffrey, Michael G. Kharas
Summary: The study revealed the crucial role of m(6)A in myeloid leukemia, where it maintains cell survival and the undifferentiated state necessary for leukemia maintenance through the formation of nuclear YTHDC1-m(6)A condensates.
Article
Chemistry, Physical
Han Liu, Shaolan Zou, Sirui Dai, Jinli Zhang, Wei Li
Summary: Dopamine increases the solubility of lysozyme and promotes crystal nucleation, leading to a shape change from a block to a rod. The growth rates of neighboring crystal planes are altered, resulting in anisotropic crystal growth.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Developmental Biology
Yun-Ling Hsiao, Hui -Wen Chen, Kuan-Han Chen, Bertrand Chin -Ming Tan, Chia -Hsiang Chen, Haiwei Pi
Summary: Neurogenesis is initiated by basic helix-loop-helix proneural proteins. Actin-related protein 6(Arp6) and H2A.Z play crucial roles in the efficient onset of proneural protein target gene expression. ARP6 and H2A.Z are involved in the activation of proneural protein target genes, enabling rapid neural differentiation.
Article
Biochemistry & Molecular Biology
Yingying Xing, Ning Xu, Deepak D. Bhandari, Dmitry Lapin, Xinhua Sun, Xuming Luo, Yeqiong Wang, Jidong Cao, Hongbin Wang, Gitta Coaker, Jane E. Parker, Jun Liu
Summary: The pathogen targets the plant iron sensor protein BRUTUS through the effector protein AvrRps4 to facilitate iron uptake and pathogen proliferation in Arabidopsis thaliana. AvrRps4 inhibits the degradation of iron regulatory proteins and enhances the accumulation of immune proteins, contributing to immune responses mediated by RPS4/EDS1.
Article
Oncology
Zhihong Zeng, Abhishek Maiti, Shelley Herbrich, Tianyu Cai, Antonio Cavazos, Taylor Manzella, Helen Ma, Kala Hayes, Jairo Matthews, Courtney D. D. DiNardo, Naval G. G. Daver, Marina Y. Y. Konopleva
Summary: The study shows that targeting PD-1 for immune modulation enhances the therapeutic effect of combining HMA and venetoclax in patients with AML.
Article
Cell Biology
Ping Yin, Dan Li, Qi Zhao, Mingming Cai, Zhenru Wu, Yujun Shi, Li Su
Summary: The research showed that fluctuations in Gs alpha levels may play a crucial role in the development of heart failure, with loss of Gs alpha function leading to cardiac deterioration and remodeling by inhibiting the CREB1 and Bmp10 signaling pathways.
CELL DEATH DISCOVERY
(2021)
Article
Environmental Sciences
Jianyu He, Mengxue Jia, Jianxin Wang, Ziqi Wu, Shuai Shao, Yutang He, Xiaolin Zhang, Isabella Buttino, Zhi Liao, Xiaojun Yan
Summary: Research has found that Mytilus coruscus farming has a significant impact on the microbiota of surrounding seawater, increasing bacterial diversity and promoting the growth of aerobic anoxygenic photoheterotrophic bacteria. Furthermore, the presence of M. coruscus consistently affects the bacterial community composition in seawater, and the tissue composition of M. coruscus differs from that of seawater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Respiratory System
Pouline M. P. van Oort, Tamara M. Nijsen, Iain R. White, Hugo H. Knobel, Timothy Felton, Nicholas Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas, Pedro R. Povoa, Ignacio Martin-Loeches, Hans Weda, Royston Goodacre, Marcus J. Schultz, Paul M. Dark, Stephen J. Fowler, Lieuwe D. Bos
Summary: The study found that exhaled breath analysis can effectively distinguish patients suspected of ventilator-associated lower respiratory tract infections, with high sensitivity and negative predictive value.
Article
Cell Biology
Wiwat Chancharoenthana, Asada Leelahavanichkul, Marcus J. Schultz, Arjen M. Dondorp
Summary: Leptospirosis is a global zoonotic and waterborne disease that poses a significant public health problem. It is often difficult to diagnose due to its similarity to other tropical diseases, and there is increasing evidence of chronic symptoms that can go unrecognized. Kidney involvement is common in leptospirosis, and early recognition of severe cases is crucial for reducing morbidity and mortality. This review highlights the spectrum of characteristics seen in leptospirosis kidney disease, as well as the diagnostic and treatment methods.
Article
Respiratory System
F. D. Simonis, S. Einav, A. Serpa Neto, S. N. Hemmes, P. Pelosi, M. Gama de Abreu, M. J. Schultz
Summary: This study found that postoperative ventilation in the ICU did not differ significantly from that in the operating room. However, there is room for improvement in the use of low tidal volume ventilation. The development of postoperative pulmonary complications is associated with mortality.
Article
Medicine, General & Internal
Anna Geke Algera, Charalampos Pierrakos, Michela Botta, Claudio Zimatore, Luigi Pisani, Pieter-Roel Tuinman, Lieuwe D. J. Bos, Wim K. Lagrand, Marcello Gama de Abreu, Paolo Pelosi, Ary Serpa Neto, Marcus J. Schultz, Thomas G. Cherpanath, Frederique Paulus
Summary: The study found that lower PEEP did not have beneficial effects on right ventricular MPI in patients without ARDS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Kirsten Daniels, Marc B. V. Rouppe van der Voort, Douwe H. Biesma, Paul B. van der Nat
Summary: This study explores the hindering and supporting factors in the implementation of value-based quality improvement (VBQI) teams in hospital care. A qualitative study was conducted with semi-structured interviews, revealing nine main factors in the areas of organization, culture, and practice. The study provides practical insights on how to implement VBQI in a hospital setting.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Medicine, General & Internal
Charalampos Pierrakos, Fleur L. I. M. van der Ven, Marry R. Smit, Laura A. Hagens, Frederique Paulus, Marcus J. Schultz, Lieuwe D. J. Bos
Summary: The study found that prone positioning can reduce inhomogeneity, increase lung volumes, and improve dorsal compliance in spontaneously breathing invasively ventilated COVID-19 patients.
Article
Medicine, General & Internal
Willemke Stilma, Christel M. A. Valk, David M. P. van Meenen, Luis Morales, Daantje Remmelzwaal, Sheila N. Myatra, Antonio Artigas, Ary Serpa Neto, Frederique Paulus, Marcus J. Schultz
Summary: This study describes the use of awake prone positioning in patients with COVID-19 acute hypoxemic respiratory failure and its association with outcomes. The study found that about 16.1% of patients received awake prone positioning treatment. Treatment failure occurred more often in patients who received prone positioning in the unmatched analysis, but there was no significant difference in the matched analysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Anesthesiology
Marcelo Gama de Abreu, Marcus J. Schultz, Ary Serpa Neto
Summary: Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Critical Care Medicine
Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Summary: This study examines the argumentative practices of doctors and families in making decisions about life-sustaining treatment in ICUs. The research identifies the arguments used by both parties and explores how they structure their arguments during conversations. The study reveals that there is limited and brief exchange of arguments, although the types of arguments presented by doctors and families largely overlap.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Editorial Material
Respiratory System
M. J. Schultza, P. J. van Oostena, L. Hol
Article
Biochemistry & Molecular Biology
Luis Enrique Olmedilla Arnal, Oscar Diaz Cambronero, Guido Mazzinari, Jose Maria Perez Pena, Jaime Zorrilla Ortuzar, Marcos Rodriguez Martin, Maria Vila J. Montanes, Marcus Schultz, Lucas Rovira, Maria Pilar Argente Navarro
Summary: High intra-abdominal pressure during laparoscopic surgery is associated with reduced splanchnic blood flow. This study found that an individualized low-pneumoperitoneum-pressure strategy may prevent a reduction in liver perfusion.
Article
Medicine, General & Internal
Liselotte J. Hol, Marcus Schultz, Ignacio Martin-Loeches, David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus
Summary: The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to COVID-19 between the first and second wave in the Netherlands. The study found that patients in the second wave were sicker, had more comorbidities, and had worse oxygenation parameters. Changes in ventilation management were observed, such as lower positive end-expiratory pressure and higher fraction inspired oxygen. Duration of ventilation was shorter, but mortality rates were similar.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)