Article
Cell Biology
Jia Chen, Yuhan Chen, Xue Du, Guojun Liu, Xiaowei Fei, Jian Ru Peng, Xing Zhang, Fengjun Xiao, Xue Wang, Xiao Yang, Zhichun Feng
Summary: CB-MNCs and UC-MSCs show efficacy in alleviating BPD, with CB-MNCs having more pronounced effects in restoring lung function. Through analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks, it was found that therapeutic effects are related to regulation of GTPase activity, ERK signaling cascade, chromosome regulation, and cell cycle control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Guilian Liao, Yan Liao, Duanduan Li, Zeqin Fu, Shiduo Wu, Danling Cheng, Qiuxing Ouyang, Zan Tang, Guifang Zeng, Xiao Liang, Shaokun Xu, Junyuan Hu, Muyun Liu
Summary: Culture supplement of human platelet lysate (hPL) enhances the growth and differentiation potential of umbilical cord-derived mesenchymal stromal cells (UC-MSCs), leading to improved therapeutic efficacy for newborn bronchopulmonary dysplasia (BPD) in preclinical models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pediatrics
Wai Kit Chia, Fook Choe Cheah, Nor Haslinda Abdul Aziz, Nirmala Chandralega Kampan, Salwati Shuib, Teck Yee Khong, Geok Chin Tan, Yin Ping Wong
Summary: Bronchopulmonary dysplasia (BPD) is a devastating lung disorder in preterm infants caused by abnormal reparative response, and current treatment strategies have limited success. Stem cell therapy, particularly using placenta-derived and umbilical cord-derived stem cells, shows potential in mitigating BPD, but further research and clinical trials are needed to confirm its effectiveness.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cell Biology
Xin-qi Zhong, Qin Yan, Zhuang-gui Chen, Chun-hong Jia, Xiu-hong Li, Zi-yan Liang, Jian Gu, Hui-ling Wei, Chang-yu Lian, Jing Zheng, Qi-liang Cui
Summary: Exosomes derived from umbilical cord blood of BPD infants impair angiogenesis, possibly via differentially expressed EXO-miRNAs, which might contribute to the development of BPD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pediatrics
Yu Wang, Xuan Wang, Qiushi Xu, Jiao Yin, Huaiyan Wang, Lin Zhang
Summary: This study detected the expression profiles of circRNAs, lncRNAs, and mRNAs in umbilical cord blood-derived exosomes of infants with BPD and identified differentially expressed circRNAs and lncRNAs. The results suggested that these exosomal RNAs may play important roles in the development of BPD.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cell & Tissue Engineering
Merline Benny, Benjamin Courchia, Sebastian Shrager, Mayank Sharma, Pingping Chen, Joanne Duara, Krystalenia Valasaki, Michael A. Bellio, Andreas Damianos, Jian Huang, Ronald Zambrano, Augusto Schmidt, Shu Wu, Omaida C. Velazquez, Joshua M. Hare, Aisha Khan, Karen C. Young
Summary: This study compared the regenerative effects of MSC obtained from bone marrow (BM) and umbilical cord tissue (UCT) in an experimental BPD model. The results showed that UCT-MSC had better proliferation and expression of anti-inflammatory cytokines, leading to better wound healing and reduced lung macrophage infiltration compared to BM-MSC.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xin-qi Zhong, Ding Wang, Shuang Chen, Jing Zheng, Tao-fang Hao, Xiu-hong Li, Li-hua Luo, Jian Gu, Chang-yu Lian, Xiao-sa Li, Dun-jin Chen
Summary: This study aimed to investigate the effects of umbilical cord blood-derived exosomes (UCB-EXOs) on hyperoxia-induced lung injury and identify potential targets for the treatment of bronchopulmonary dysplasia (BPD). The results showed that UCB-EXO alleviated lung injuries and promoted vascular growth.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, General & Internal
Michelle C. Starr, Russell Griffin, Katja M. Gist, Jeffrey L. Segar, Rupesh Raina, Ronnie Guillet, Saudamini Nesargi, Shina Menon, Nekayla Anderson, David J. Askenazi, David T. Selewski
Summary: This study describes fluid balance patterns in extremely low gestational age neonates and finds that peak fluid balance is associated with mechanical ventilation on postnatal day 14 and severe bronchopulmonary dysplasia (BPD) or death.
Article
Multidisciplinary Sciences
Yusuke Noguchi, Atsuko Taki, Izumi Honda, Manabu Sugie, Tsunanori Shidei, Kazuyuki Ito, Haruka Iwata, Akira Koyama, Kaoru Okazaki, Masatoshi Kondo, Chikako Morioka, Kenichi Kashimada, Tomohiro Morio
Summary: This study aimed to clarify the fetal programming caused by chorioamnionitis (CAM) using gene expression profiles of umbilical cord mesenchymal stem cells (UCMSCs). The results revealed distinctive changes in UCMSCs from the CAM group, including increased expression levels of myofibroblast-related genes and impaired cellular proliferation. Pathway analysis also showed increased expression of genes related to white fat cell differentiation. These findings provide insights into the long-term outcomes of patients exposed to CAM and highlight the potential of UCMSCs as an in vitro model for studying CAM-induced fetal programming.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chang Hao, Jingyi You, Huijun Qiu, Ou Zhou, Jiang Liu, Wenjing Zou, Ke Yang, Zhou Fu, Lin Zou
Summary: For the treatment of bronchopulmonary dysplasia (BPD), mesenchymal stem cell (MSC) transplantation has emerged as a promising option. However, the low cell survival rate limits its efficacy. This study found that hypoxic preconditioning can improve the survival rate of MSCs and enhance their therapeutic effect on BPD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Respiratory System
Ying-Hua Sun, Yang Du, Jie-Ru Shen, Dan-Yang Ai, Xiang-Yuan Huang, Si-Hao Diao, Sam Bill Lin, Rong Zhang, Lin Yuan, Yi-Pei Yang, Li-Li He, Xiao-Jiao Qin, Jian-Guo Zhou, Chao Chen
Summary: This study suggests that a new method based on lung ultrasound scoring can better evaluate the severity of bronchopulmonary dysplasia (BPD) and assess short-term clinical outcomes in preterm infants.
BMC PULMONARY MEDICINE
(2022)
Article
Cell Biology
Xuan Wang, Yijun Liu, Dongshan Han, Junyan Zhong, Chuanzhong Yang, Xueyu Chen
Summary: This study investigates the immunomodulatory function of metformin in human macrophages and finds that low-dose metformin promotes the expansion of anti-inflammatory macrophages, while high-dose treatment exacerbates inflammation.
CELLULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Andre Gie, Yannick Regin, Arianna Mersanne, Jaan Toelen
Summary: Intratracheal drug delivery provides a direct way to deliver pharmaceutical substances to the lungs of premature animals, with the transcutaneous technique being simple and effective. This method is well tolerated by newborn pups and can be repeated for multiple consecutive days without affecting survival.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Pediatrics
Jing Xiong, Qing Ai, Lei Bao, Yuanshan Gan, Xiaoyu Dai, Mei Han, Yuan Shi
Summary: This study aims to assess the effects of different doses of human umbilical cord-derived MSCs (hUC-MSCs) on a hyperoxia-induced bronchopulmonary dysplasia (BPD) model in newborn rats. The results show that intraperitoneal administration of a high dose of hUC-MSCs (1 x 107 cells) can effectively treat hyperoxia-induced BPD in neonatal rats.
FRONTIERS IN PEDIATRICS
(2023)
Article
Physiology
Andrea Porzionato, Patrizia Zaramella, Arben Dedja, Diego Guidolin, Luca Bonadies, Veronica Macchi, Michela Pozzobon, Marcin Jurga, Giorgio Perilongo, Raffaele De Caro, Eugenio Baraldi, Maurizio Muraca
Summary: The study demonstrated the protective effects of intratracheally-administered extracellular vesicles secreted by mesenchymal stem cells in a rat model of bronchopulmonary dysplasia, with prevention of morphometric changes induced by hyperoxia exposure in the long term. The findings further support the potential of intratracheally-administered EVs as an effective approach to prevent/treat BPD, with a possible role of M2 macrophage polarization.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Beatrice L. Crippa, Stefano Ghirardello, Lorenzo Colombo, Francesca Tel, Lidia Zanotta, Dario Consonni, Patrizia Salice, Silvia Ghiglia, Fabio Mosca, Gianluigi Ardissino
Summary: This study compared two groups of newborns and found that newborns with fathers who had hypertension had significantly higher levels of cystatin C at birth, which was associated with nephron endowment and implied a relationship between reduced nephron number and familial hypertension pathogenesis.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Nursing
Domenica Mallardi, Pasqua Piemontese, Nadia Liotto, Rosaria M. Colombo, Antonella Dodaro, Antonella Schiavello, Chiara Tabasso, Laura Plevani, Elena Bezze, Camilla Menis, Paola Roggero, Fabio Mosca
JOURNAL OF HUMAN LACTATION
(2022)
Review
Pediatrics
Maria Elena Cavicchiolo, Daniele Trevisanuto, Elena Priante, Laura Moschino, Fabio Mosca, Eugenio Baraldi
Summary: This review summarizes all published papers related to neonatal COVID-19 management in Italy, providing useful insights for managing the mother-neonate dyad during future waves of SARS-CoV-2. Italian neonatologists have actively contributed to producing guidelines and data that have enhanced neonatal care in the pandemic. A joint European action plan is essential for increasing awareness and effectively addressing COVID-19 in neonates.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Ilaria Amodeo, Irene Borzani, Giulia Corsani, Nicola Pesenti, Genny Raffaeli, Francesco Macchini, Valentina Condo, Nicola Persico, Stefano Ghirardello, Mariarosa Colnaghi, Fabio Mosca, Giacomo Cavallaro
Summary: In newborns with congenital diaphragmatic hernia, the degree of mediastinal shift assessed by fetal MRI is inversely correlated with total fetal lung volume and may be associated with higher respiratory and cardiocirculatory impairment, leading to increased pharmacological treatments, mechanical ventilation, and hospitalization duration in survivors. Further studies are required to confirm these findings.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Flavia Indrio, Alessia Salatto, Orsola Amato, Fabio Bartoli, Letizia Capasso, Luigi Corvaglia, Gianfranco Maffei, Fabio Mosca, Massimo Pettoello Mantovani, Francesco Raimondi, Matteo Rinaldi, Paola Roggero, Arianna Aceti
Summary: The study found that implementing COVID-19-related NICU hygiene policies is likely to significantly reduce the incidence of late-onset sepsis in high-risk settings.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Jole Costanza, Margherita Camanni, Maria Maddalena Ferrari, Valentina De Cosmi, Silvia Tabano, Laura Fontana, Tatjana Radaelli, Giulia Privitera, Daniela Alberico, Patrizia Colapietro, Silvia Motta, Silvia Sirchia, Tamara Stampalija, Chiara Tabasso, Paola Roggero, Fabio Parazzini, Fabio Mosca, Enrico Ferrazzi, Silvano Bosari, Monica Miozzo, Carlo Agostoni
Summary: In a study of 503 women with uncomplicated pregnancies, maternal pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and placental weight were found to be independently correlated with neonatal birth weight. However, maternal nutrition during pregnancy was not found to be associated with birth weight.
PEDIATRIC RESEARCH
(2022)
Correction
Nursing
Elena Nicoletta Bezze, Daniela Morniroli, Martina Farneti, Patrizio Sannino, Roberto Marinello, Maria Enrica Bettinelli, Germana Santini, Laura Plevani, Paola Marchisio, Fabio Mosca, Maria Lorella Gianni
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
(2022)
Article
Clinical Neurology
Sarah Treit, Julia N. Rickard, Emily Stolz, Kevin Solar, Peter Seres, Derek Emery, Christian Beaulieu
Summary: The goal of this study was to create a normative brain MRI database for comparisons with various neurological disorders across the lifespan. A sample of 378 neurotypical controls completed brain MRI and other assessments, providing valuable insight into healthy brain development and aging.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Giusy Ranucci, Claudia Della Corte, Daniele Alberti, Maria Pia Bondioni, Giovanni Boroni, Pier Luigi Calvo, Mara Cananzi, Manila Candusso, Maria Grazia Clemente, Lorenzo D'Antiga, Irene Degrassi, Jean De Ville De Goyet, Fabiola Di Dato, Angelo Di Giorgio, Carlo Dionisi Vici, Federica Ferrari, Paola Francalanci, Maurizio Fuoti, Fabio Fusaro, Paola Gaio, Chiara Grimaldi, Maria Iascone, Giuseppe Indolfi, Raffaele Iorio, Giuseppe Maggiore, Claudia Mandato, Lorenza Matarazzo, Lidia Monti, Fabio Mosca, Gabriella Nebbia, Federica Nuti, Giulia Paolella, Michele Pinon, Paola Roggero, Marco Sciveres, Daniele Serranti, Marco Spada, Pietro Vajro, Emanuel Nicastro
Summary: Neonatal and infantile cholestasis can be corrected by surgery or treated medically. Timely recognition and identification of the underlying etiology are crucial for improving outcomes. An expert working group was formed to formulate evidence-based positions on the diagnosis of NIC, defining the best-evidence diagnostic approach.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Pediatrics
Alessandra Consales, Jacopo Cerasani, Gabriele Sorrentino, Daniela Morniroli, Lorenzo Colombo, Fabio Mosca, Maria Lorella Gianni
Summary: Human milk microbiome (HMM), which includes bacteria, viruses, fungi, and yeasts, may impact the infant's gut microbiome and immune system, and may have evolutionary significance. Understanding the origin, determinants, and impact of HMM on infant health is crucial.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Nicola Pozzi, Paola Cogo, Corrado Moretti, Paolo Biban, Tiziana Fedeli, Luigi Orfeo, Eloisa Gitto, Fabio Mosca
Summary: Studies have shown that mortality rates for critically ill infants and toddlers are lower in paediatric intensive care units (PICUs) compared to adult ICUs. Some neonatal ICUs (NICUs) have begun managing critically ill infants and toddlers due to the lack of PICUs, while others have established extended NICUs. Neonatologists play a key role in the management of these patients, but they require specific training in paediatric critical care medicine (PCCM). Scientific societies should promote awareness and training, and collaborate with governmental bodies to establish standards for extended NICUs.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashmita De, Hongfu Sun, Derek J. Emery, Kenneth S. Butcher, Alan H. Wilman
Summary: The purpose of this study was to optimize quantitative susceptibility-weighted imaging for strong susceptibility sources like hemorrhage and compare it to standard susceptibility-weighted imaging and quantitative susceptibility mapping. The results showed that quantitative susceptibility-weighted imaging minimized blooming effects and phase wrap artifacts observed in susceptibility-weighted imaging. However, it requires an altered upper threshold for best hemorrhage depiction.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Pediatrics
Maria Pierro, Roberto Chioma, Consuelo Benincasa, Giacomo Gagliardi, Lorenzo Amabili, Francesca Lelli, Giovanni De Luca, Enrico Storti
Summary: This retrospective pilot analysis investigated cardiopulmonary ultrasound patterns in term and late preterm infants with transient respiratory distress. Seven potential sonographic phenotypes were identified, including signs of increased pulmonary vascular resistance and irregular atelectasis. The findings suggest that these infants may have mild forms of persistent pulmonary hypertension of the newborn and mild meconium aspiration syndrome. CPUS evaluation could improve accuracy in diagnosing acute respiratory distress and have important epidemiological consequences.
Article
Biophysics
Diana Valdes Cabrera, Gregg Blevins, Penelope Smyth, Derek Emery, Kevin Grant Solar, Christian Beaulieu
Summary: High-resolution DTI and T2 mapping revealed abnormalities in the hippocampus of patients with multiple sclerosis. In patients with cognitive impairment, higher MD and T2 values and lower FA and volume were observed. These abnormalities may be associated with demyelination, neuron loss, and/or inflammation.
NMR IN BIOMEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Valeria Peli, Mario Barilani, Araceli Rivera-Ordaz, Paolo Manzini, Francesco Rusconi, Cristiana Lavazza, Silvia Cimoni, Lorenza Lazzari
Summary: This study validated an image cytometer-based method for determining the viability of human induced pluripotent stem cells (hiPSCs) and demonstrated its feasibility as a quality control test during large-scale GMP hiPSC expansion.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)