Article
Critical Care Medicine
Jean-Louis Pepin, Ognian Georgiev, Rumen Tiholov, Valerie Attali, Johan Verbraecken, Bertien Buyse, Markku Partinen, Ingo Fietze, Georgi Belev, Dejan Dokic, Renaud Tamisier, Patrick Levy, Isabelle Lecomte, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Yves Dauvilliers
Summary: In individuals with moderate to severe OSA adhering to CPAP treatment but experiencing residual EDS, Pitolisant significantly reduced daytime sleepiness and improved participant-reported outcomes and physician-reported disease severity. Adverse events, mainly headache and insomnia, were higher with Pitolisant compared to placebo, but no significant safety concerns were reported.
Article
Critical Care Medicine
Sara Q. C. Giampa, Sofia F. Furlan, Lunara S. Freitas, Thiago A. Macedo, Adriana Lebkuchen, Karina H. M. Cardozo, Valdemir M. Carvalho, Franco C. Martins, Indira F. B. Azam, Valeria Costa-Hong, Heno F. Lopes, Mariana L. Baptista, Carlos E. Rochitte, Luiz A. Bortolotto, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: Despite an improved reversibility rate, most patients still retained the diagnosis of metabolic syndrome after CPAP treatment. CPAP treatment did not significantly affect adiposity biomarkers and deposits, indicating a modest role of OSA in modulating metabolic syndrome.
Article
Clinical Neurology
Tsai-Yu Wang, Yu-Chen Huang, Ting-Yu Lin, Yung-Lun Ni, Yu-Lun Lo
Summary: This study compared the difference between drug-induced sleep endoscopy (DISE)-guided continuous positive airway pressure (CPAP) titration and conventional sleep center (CSC) CPAP titration in patients with obstructive sleep apnea (OSA). The results showed that both modalities were comparable in terms of establishing the pressure settings required to treat patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Lea Tischmann, Tanja C. Adam, Ronald P. Mensink, Peter J. Joris
Summary: This study investigated the longer-term effects of soy nut consumption on vascular function and cardiometabolic risk markers in healthy older adults. The results showed that long-term soy nut intake improved endothelial function, reduced LDL-cholesterol concentrations, and lowered mean arterial pressure.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Ioana Madalina Zota, Radu Andy Sascau, Cristian Statescu, Grigore Tinica, Maria Magdalena Leon Constantin, Mihai Roca, Daniela Boisteanu, Larisa Anghel, Ovidiu Mitu, Florin Mitu
Summary: Obstructive sleep apnea (OSA) is commonly associated with cardiovascular comorbidities. Short-term CPAP treatment can improve ventricular function, particularly left ventricular global longitudinal strain, in patients with moderate to severe OSA, with benefits dependent on CPAP adherence.
Review
Medicine, General & Internal
Klaudia Brozyna-Tkaczyk, Wojciech Myslinski, Jerzy Mosiewicz
Summary: Patients with obstructive sleep apnea (OSA) exhibit microcirculation dysfunction due to oxidative stress and impaired nitric oxide secretion. Continuous positive airway pressure (CPAP) treatment significantly improves endothelial function and microvascular blood flow, reducing inflammatory mediator levels.
MEDICINA-LITHUANIA
(2021)
Article
Multidisciplinary Sciences
Ryutaro Shirahama, Takeshi Tanigawa, Yoshifumi Ida, Kento Fukuhisa, Rika Tanaka, Kiyohide Tomooka, Fan-Yun Lan, Ai Ikeda, Hiroo Wada, Stefanos N. Kales
Summary: The study found that good long-term adherence to CPAP therapy was associated with lower diastolic blood pressure without significant weight loss.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Peter A. Dargaville, C. Omar F. Kamlin, Francesca Orsini, Xiaofang Wang, Antonio G. De Paoli, H. Gozde Kanmaz Kutman, Merih Cetinkaya, Lilijana Kornhauser-Cerar, Matthew Derrick, Hilal Ozkan, Christian Hulzebos, Georg M. Schmolzer, Ajit Aiyappan, Brigitte Lemyre, Sheree Kuo, Victor S. Rajadurai, Joyce O'Shea, Manoj Biniwale, Rangasamy Ramanathan, Alla Kushnir, David Bader, Mark R. Thomas, Mallinath Chakraborty, Mariam J. Buksh, Risha Bhatia, Carol L. Sullivan, Eric S. Shinwell, Amanda Dyson, David P. Barker, Amir Kugelman, Tim J. Donovan, Markus K. Tauscher, Vadivelam Murthy, Sanoj K. M. Ali, Pete Yossuck, Howard W. Clark, Roger F. Soll, John B. Carlin, Peter G. Davis
Summary: This study aimed to examine the effect of selective application of minimally invasive surfactant therapy on preterm infants with respiratory distress syndrome. The results showed that while there was no significant difference between the MIST group and the control group in terms of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age, the incidence of BPD in survivors was lower in the MIST group.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Mushari Alharbi, Martina Chiurazzi, Gilda Nasti, Espedita Muscariello, Teresa Mastantuono, Christina Koechl, Blossom C. M. Stephan, Oliver M. Shannon, Antonio Colantuoni, Mario Siervo
Summary: This pilot study investigates the combined effects of caloric restriction and dietary nitrate supplementation on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. The findings suggest that combining caloric restriction with dietary nitrate supplementation could lead to greater improvements in vascular and cognitive functions.
Article
Respiratory System
Vanessa Bironneau, Pierre Ingrand, Sandrine Pontier, Carmen Iamandi, Laurent Portel, Francis Martin, Anne Mallart, Lionel Lerousseau, Didier Alfandary, Virginie Levrat, Florence Portier, Renaud Tamisier, Frederic Goutorbe, Claudio Rabec, Francois Codron, Guy Auregan, Magalie Mercy, Valerie Attali, Frank Soyez, Claire Launois, Didier Recart, Marie-Francoise Vecchierini, Frederic Gagnadoux, Jean-Claude Meurice, REDIVARIUS Grp
Summary: The aim of this study was to evaluate the efficacy of CPAP used in fixed CPAP or APAP mode for the treatment of severe obstructive sleep apnoea (OSA) over a three-month period. The study found no difference in efficacy between the two modes, with similar rates of residual apnea hypopnea index (AHI) and adherence. Tolerance, quality of life, and blood pressure were also similar between the two groups.
Article
Food Science & Technology
Rosa M. Valls, Anna Pedret, Lorena Calderon-Perez, Elisabet Llaurado, Laura Pla-Paga, Judit Companys, Ana Moragas, Francisco Martin-Lujan, Yolanda Ortega, Montse Giralt, Laura Rubio, Nuria Canela, Francesc Puiggros, Antoni Caimari, Josep M. Del Bas, Lluis Arola, Rosa Sola
Summary: After 12 weeks of sustained consumption, orange juice enriched with hesperidin significantly increased ischaemic reactive hyperemia, improved endothelial function, reduced systemic inflammatory levels, and affected transcriptomic levels, suggesting a potential mechanism for the observed increase in IRH.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Letter
Cardiac & Cardiovascular Systems
Chinthaka B. B. Samaranayake, Christopher Turnbull, Stefan Neubauer, Ilias Kylintireas, John Stradling, Sonya Craig, Colm McCabe
Summary: The effects of continuous positive airway pressure (CPAP) on right ventricular (RV) function in patients with untreated mild-to-moderate obstructive sleep apnea (OSA) are uncertain. In this exploratory analysis of patients from a randomized control trial, no significant impact of CPAP on RV function was observed. However, in patients with lower RV ejection fraction and higher RV end-diastolic volume, CPAP treatment appeared to improve RV function with a significant reduction in both RV end-diastolic volume and RV end-systolic volume. Further research with a larger sample size and a wider range of RV dysfunction is recommended.
PULMONARY CIRCULATION
(2023)
Article
Medicine, General & Internal
Maria Perticone, Raffaele Maio, Paola Elisa Scarpino, Luana Mancuso, Mara Volpentesta, Benedetto Caroleo, Edoardo Suraci, Angela Sciacqua, Giorgio Sesti, Francesco Perticone
Summary: Obese patients with OSAS have lower e-GFR values compared to non-OSAS patients, and CPAP therapy can significantly improve e-GFR values in these patients. Delta AHIa is the main independent predictor of Delta e-GFR after CPAP therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jae Min Cho, Seul-Ki Park, Oh Sung Kwon, D. Taylor La Salle, James Cerbie, Caitlin C. Fermoyle, David Morgan, Ashley Nelson, Amber Bledsoe, Leena P. Bharath, Megan Tandar, Satya P. Kunapuli, Russell S. Richardson, Pon Velayutham Anandh Babu, Sohom Mookherjee, Bellamkonda K. Kishore, Fei Wang, Tianxin Yang, Sihem Boudina, Joel D. Trinity, J. David Symons
Summary: This study explores the importance of endothelial cell autophagy in maintaining vascular homeostasis and its role in nitric oxide generation. The findings suggest that autophagy is necessary for glycolysis-dependent purinergic signaling to eNOS, and impaired autophagy leads to arterial dysfunction. The activation of P2Y(1)-Rs improves arterial function in cases of compromised autophagy.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell & Tissue Engineering
Liping Su, Xiaocen Kong, Szejie Loo, Yu Gao, Bingli Liu, Xiaofei Su, Rinkoo Dalan, Jianhua Ma, Lei Ye
Summary: This study aimed to evaluate the effect of thymosin beta-4 (Tb-4) on endothelial function using diabetic human induced pluripotent stem cell derived endothelial cells (dia-hiPSC-ECs) as a model. The results showed that Tb-4 improved endothelial dysfunction by enhancing cell viability, reducing senescence and endothelin-1 production, and improving angiogenic potency in diabetes.
STEM CELL RESEARCH & THERAPY
(2022)