Review
Medical Laboratory Technology
Mary Kathryn Bohn, Shannon Steele, Alexandra Hall, Jasmin Poonia, Benjamin Jung, Khosrow Adeli
Summary: Despite the lack of clinical awareness in pediatrics, there is increasing literature supporting the potential application of cardiac biomarkers in various contexts. These biomarkers are undervalued resources in pediatric populations, showing potential value in the diagnosis and prognosis of myocarditis, congenital heart disease, heart failure, as well as the assessment of severity and cardiac involvement in immune-related and other systemic conditions. Interpretation challenges exist due to age- and sex-specific dynamics, but this should not hinder their use. Future research should focus on establishing evidence-based cut-offs for specific indications using the most current assays.
CLINICAL CHEMISTRY
(2021)
Review
Immunology
Chao Quan, Othmane Belaydi, Jiao Hu, Huihuang Li, Anze Yu, Peihua Liu, Zhenglin Yi, Dongxu Qiu, Wenbiao Ren, Hongzhi Ma, Guanghui Gong, Zhenyu Ou, Minfeng Chen, Yin Sun, Jinbo Chen, Xiongbing Zu
Summary: m(6)A modification plays a crucial role in regulating the expression of oncogenes and tumor suppressor genes, and recent studies have revealed its new role in the anti-tumor immune response. By modulating the fate of targeted RNA, m(6)A affects the activation and infiltration of tumor-associated immune cells in the tumor microenvironment, and it also impacts the efficacy of classical immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Bert Heyrman
Summary: This paper argues for the importance of paying attention to health-related quality of life as a study endpoint in lower-risk MDS patients. Currently, there are limited therapeutic options available for this population, with new treatments mainly being studied in clinical trials. However, data on health-related quality of life during phase III studies are not commonly published, undermining its significance as a treatment goal. The paper suggests that health-related quality of life should be the main treatment goal in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Barbara Bonnesen, Pradeesh Sivapalan, Alexander Jordan, Johannes Wirenfeldt Pedersen, Christina Marisa Bergsoe, Josefin Eklof, Louise Lindhardt Toennesen, Sidse Graff Jensen, Matiullah Naqibullah, Zaigham Saghir, Jens-Ulrik Staehr Jensen
Summary: The aim of this study was to evaluate if patients with asthma-COPD overlap have a higher risk of malignancy than patients with COPD without asthma. The study found that asthma-COPD overlap was not associated with an increased risk of cancer events within 2 years as compared to patients with COPD without asthma.
Article
Physiology
Yang Tian, Luna Liu, Yuchen Li, Xiude Fan, Wanhong Wu, Yingzhou Shi, Jie Jiang, Zinuo Yuan, Hang Dong, Huijie Li, Qiuhui Xuan, Chao Xu
Summary: There is a relationship between metabolic overweight/obesity phenotypes and the risk of unplanned readmission in COPD patients. Overweight/obesity alone has little effect on readmission, but metabolic abnormalities regardless of overweight/obesity are associated with an increased risk. Hyperglycemia and hypertension should be given particular attention. Overweight/obesity and metabolic abnormalities independently exacerbate adverse outcomes in elderly patients (age >= 65).
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Respiratory System
Nirupama Putcha, Antonio R. Anzueto, Peter M. A. Calverley, Bartolome R. Celli, Donald P. Tashkin, Norbert Metzdorf, Achim Mueller, Robert A. Wise
Summary: There is an association between body mass index (BMI) and adverse outcomes in COPD, with underweight individuals having higher mortality and exacerbation risk. Overweight and obese individuals are at lower risk or no additional risk. A holistic management approach is needed to improve the general well-being of COPD patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Felipe V. C. Machado, Martijn A. Spruit, Miriam T. J. Groenen, Sarah Houben-Wilke, Paula P. van Melick, Nidia A. Hernandes, Annemie M. W. J. Schols, Fabio Pitta, Emiel F. M. Wouters, Frits M. E. Franssen
Summary: This study analyzed data from 469 COPD patients and found that over half of overweight and obese patients have low muscle mass when using age-gender-BMI-specific cut-offs. Low muscle mass is associated with worse functional outcomes in overweight and obese COPD patients.
RESPIRATORY RESEARCH
(2021)
Review
Immunology
Xiurong Cai, Frank Tacke, Adrien Guillot, Hanyang Liu
Summary: Biliary epithelial cells, also known as cholangiocytes, form a barrier between intra- and extrahepatic bile ducts and modulate bile composition and transportation. In hepatobiliary diseases, bile duct injury leads to alterations in cholangiocyte phenotypes and their release of cytokines, which contribute to ductular cell proliferation, inflammation, fibrosis, and carcinogenesis. This review summarizes recent insights into the role of cholangiocytes in liver injury-regeneration, inflammation, fibrosis, and malignant transformation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vojko Kanic, Maja Vollrath, Barbara Frank, Zlatka Kanic
Summary: The study found an inverse J-shaped relationship between BMI and long-term mortality in patients with MI who underwent PCI. Both lower and higher BMI values were found to be harmful, and an obesity paradox was observed.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Agriculture, Dairy & Animal Science
W. Nipuna U. Perera, M. Reza Abdollahi, Faegheh Zaefarian, Timothy J. Wester, Velmurugu Ravindran
Summary: The supply of conventional cereal grains, especially maize, is a significant constraint to the poultry industry's future growth. Alternative feed ingredients, such as barley, are being tested to replace maize in poultry diets. However, the use of barley in poultry diets is limited due to its low metabolisable energy and the presence of anti-nutritive substances and soluble non-starch polysaccharides, as well as the inter-cultivar variability. Inconsistent research methodologies have also contributed to the lack of understanding of barley's nutritional value for poultry. Accurate nutrient profiles and tailored feed processing conditions are crucial for increasing the inclusion of barley in poultry diets.
Article
Geriatrics & Gerontology
Tong Ji, Yun Li, Lina Ma
Summary: Sarcopenic obesity (SO) in older adults is associated with a range of health issues including frailty, falls, disability, increased morbidity, and mortality. Understanding the core mechanism of SO is crucial for implementing effective prevention and treatment strategies to reduce adverse clinical outcomes.
Article
Forestry
Markus Didion, Meinrad Abegg
Summary: This study demonstrates the significant contribution of stumps to the dead wood pool based on the detailed stump inventory in the Swiss National Forest Inventory.
ANNALS OF FOREST SCIENCE
(2022)
Article
Psychology, Developmental
Filippo Muratori, Sara Calderoni, Valeria Bizzari
Summary: George Frankl played a significant role in the early history of autism, with his innovative views on the condition influencing its definition. He proposed that autism could cover a spectrum of conditions, is not necessarily abnormal, and is primarily a neurobiological condition that requires understanding from others.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Review
Nutrition & Dietetics
Marianna Pellegrini, Chiara D'Eusebio, Valentina Ponzo, Luca Tonella, Concetta Finocchiaro, Maria Teresa Fierro, Pietro Quaglino, Simona Bo
Summary: Melanoma is an aggressive skin cancer with risk factors including genetics, environment, and lifestyle. New treatments have revolutionized melanoma therapy, but the potential link between obesity and melanoma etiology remains controversial.
Review
Biochemistry & Molecular Biology
Joana Domingues, Fernanda Delgado, Jose Carlos Goncalves, Monica Zuzarte, Ana Paula Duarte
Summary: Globally, climate change and wildfires are endangering endemic species. Lavandula species in the Mediterranean region have high economic value in pharmaceutical, flavor, fragrance, and food industries. Their essential oils are rich in compounds such as 1,8-cineole, camphor, fenchone, and trans-alpha-necrodyl acetate. Lavenders also contain phenolic compounds and flavonoids with pharmacological potential. Despite the promising bioactivity, a systematic and updated review of their chemical profile is lacking.
Article
Clinical Neurology
Victor S. van Dam, Britta D. P. J. Maas, Tjard R. Schermer, Peter-Paul G. van Benthem, Tjasse D. Bruintjes
Summary: This prospective cohort study identified that a short duration of dizziness spells and dizziness provoked by rolling over in bed are the most reliable predictors for BPPV in patient history. Elderly patients with BPPV not only perceive dizziness as vertigo, but also as a feeling of instability.
FRONTIERS IN NEUROLOGY
(2021)
Article
Anesthesiology
C. Warnar, E. Faber, P. A. Katinakis, T. Schermer, P. E. Spronk
Summary: This study aimed to evaluate the safety of detecting and adjusting citrate accumulation and electrolyte imbalances in critically ill patients receiving continuous venovenous hemodialysis. The results suggest that a blood sample frequency every 6 hours is safe and effective in preventing serious electrolyte disturbances in ICU patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Cardiac & Cardiovascular Systems
L. Cozijnsen, R. L. Braam, M. Bakker-de Boo, A. M. Otten, J. G. Post, T. Schermer, B. J. Bouma, B. J. M. Mulder
Summary: This study aimed to determine the prevalence of undiagnosed BAV and isolated aortic dilatation in first-degree relatives of patients with isolated BAV, resulting in 14% new cases. Different subgroups of probands showed varying risks of BAV in their first-degree relatives, with a trend towards increased risk observed in probands with previous AVS and decreased risk in probands with associated aortic dilatation.
NETHERLANDS HEART JOURNAL
(2022)
Article
Clinical Neurology
Lise A. J. Hanskamp, Tjard R. Schermer, Roeland B. van Leeuwen
Summary: This study explores the long-term prognosis of vestibular paroxysmia (VP) patients, showing unfavorable outcomes in terms of vertigo attacks and health-related quality of life limitations. Follow-up is recommended after the initial diagnosis to monitor clinical outcomes in these patients.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Hanna Maria Koppelaar-van Eijsden, Tjard Roland Schermer, Tjasse Doewe Bruintjes
Summary: This study critically evaluated and summarized the measurement properties of the Dizziness Handicap Inventory (DHI) in adult patients with complaints of dizziness. The results showed that the content validity of the DHI was lacking or limited, there was inconsistent structural validity, sufficient construct validity, and borderline sufficient responsiveness. However, there was low evidence for sufficient reliability of the DHI due to its multidimensionality and a lack of information on measurement error.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Roeland B. van Leeuwen, Carla Colijn, Babette F. F. van Esch, Tjard R. Schermer
Summary: This study compared the course of vertigo attacks in patients with BRV, MD, and VM over a 3-year follow-up period. The results showed no significant differences in attack-free rates among the three groups, with 67-70% of patients being free of vertigo attacks after the follow-up. MD patients had higher HADS scores compared to BRV patients. The findings suggest that BRV may be a milder variant of VM and MD rather than a separate disease entity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Fieke K. Oussoren, Louise N. F. Poulsen, Joost J. Kardux, Tjard R. Schermer, Tjasse D. Bruintjes, Roeland B. van Leeuwen
Summary: Through a comparative study of elderly patients with vestibular neuritis and a control group, we found a positive correlation between white matter hyperintensities and vestibular neuritis, supporting the hypothesis of vascular involvement in the pathophysiology of vestibular neuritis in elderly patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Esteban Garcia-Gallo, Laura Merson, Kalynn Kennon, Sadie Kelly, Barbara Wanjiru Citarella, Daniel Vidali Fryer, Sally Shrapnel, James Lee, Sara Duque, Yuli V. Fuentes, Valeria Balan, Sue Smith, Jia Wei, Bronner P. Goncalves, Clark D. Russell, Louise Sigfrid, Andrew Dagens, Piero L. Olliaro, Joaquin Baruch, Christiana Kartsonaki, Jake Dunning, Amanda Rojek, Aasiyah Rashan, Abi Beane, Srinivas Murthy, Luis Felipe Reyes
Summary: The ISARIC COVID-19 dataset is one of the largest international databases of clinical data on hospitalized COVID-19 patients. It includes data from hospitals worldwide and provides comprehensive information on patient characteristics and treatments.
Article
Critical Care Medicine
Jose G. M. Hofhuis, Tjard Schermer, Peter E. Spronk
Summary: Delirium during ICU stay may be related to premorbid mental illness and negatively affect long-term mental quality of life after discharge.
INTENSIVE CARE MEDICINE
(2022)
Article
Primary Health Care
Jelle D. M. Bouwens, Erik W. M. A. Bischoff, Johannes C. C. M. In 't Veen, Tjard R. Schermer
Summary: Spirometry testing enhances the ability of primary care clinicians to differentiate between asthma and COPD, while more advanced diagnostic tests used in hospital care settings do not seem to provide a better overall diagnostic differentiation between the two conditions in primary care patients.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Article
Clinical Neurology
Fieke K. Oussoren, Roeland B. van Leeuwen, Tjard R. Schermer, Louise N. F. Poulsen, Joost J. Kardux, Tjasse D. Bruintjes
Summary: The aim of this study was to compare the presence of CSVD and cardiovascular risk factors in elderly patients with iSSNHL to a control cohort. The results showed that iSSNHL patients did not exhibit more CSVD on MRI than controls. Therefore, a larger prospective analysis is needed to further validate this result.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Primary Health Care
Wendy Schreurs, Tjard Ronald Jacob Schermer, Reinier Peter Akkermans, Erik Wiely Maria Anton Bischoff, Hilde Dymphna Luijks
Summary: Climate change has led to an increase in air temperature in the Netherlands, resulting in longer pollen seasons and potentially impacting seasonal allergic rhinitis (SAR) in general practice. This longitudinal study over 25 years found an increase in the duration of the peak-period of SAR presentations to general practitioners (GPs) and a significant association between air temperature and the peak-period duration. The findings emphasize the importance of further researching the impact of climate change and raising awareness of its tangible effects in healthcare.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Article
Hematology
Heleen P. Eising, Marieke C. Punt, Tjard Schermer, Jaklien C. Leemans, Marlies Y. Bongers
Summary: This study aimed to investigate the postsurgical incidence of amenorrhea, dysmenorrhea, quality of life, re-intervention after endometrial ablation (EA), and ISTH-BAT score in women with heavy menstrual bleeding (HMB). The results showed that an ISTH-BAT score of 6 may be associated with a lower incidence of amenorrhea and a higher rate of dysmenorrhea after EA.
Article
Allergy
Susanne J. van de Hei, Chong H. Kim, Persijn J. Honkoop, Jacob K. Sont, Tjard R. J. Schermer, Elaine MacHale, Richard W. Costello, Janwillem W. H. Kocks, Maarten J. Postma, Job F. M. van Boven
Summary: This study assessed the long-term cost-effectiveness of digital inhaler-based medication adherence management in difficult-to-treat asthma. The findings showed that digital inhalers can lead to cost savings in the long-term by optimizing medication adherence and inhaler technique and reducing add-on biologic prescriptions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Otorhinolaryngology
Eleonore Josephine Propper, Hanna Maria Koppelaar-van Eijsden, Tjard R. Schermer, Tjasse Bruintjes
Summary: The study aims to determine the occurrence of bilateral vestibular hypofunction in a specialized dizziness clinic and assess the causes. The findings indicate that approximately 1% of the patients visiting the clinic have bilateral vestibular hypofunction, with ototoxicity being the most common cause.
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
(2022)
