Article
Oncology
Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Lijun Zhu, Huining Lian, Minfeng Liu, Zhaoze Guo, Jingyun Guo, Changsheng Ye, Yunjiu Cheng, Jianyu Dong
Summary: This study utilized data from the ARIC study and found that combined cardiovascular risk factors are associated with increased risk of breast cancer, especially in postmenopausal Black women.
Article
Biochemistry & Molecular Biology
Rong-zhu Huang, Jing-fei Ma, Si Chen, Yu-ming Chen, Ai-ping Fang, Xiao-ting Lu, Zi-hui Huang, Hui-lian Zhu, Bi-xia Huang
Summary: The impact of betaine on hypertension development and the association between serum betaine and blood pressure were investigated using data from a community-based study in China. The results showed that higher levels of serum betaine were associated with lower systolic blood pressure, diastolic blood pressure, and pulse pressure. Additionally, a nonlinear association was found between serum betaine and the risk of hypertension, with higher betaine levels linked to lower hypertension risk in individuals with relatively low betaine concentrations.
Article
Peripheral Vascular Disease
William B. Earle, Jordan K. Kondo, Karla N. Kendrick, Ruth-Alma Turkson-Ocran, Long Ngo, Jennifer L. Cluett, Kenneth J. Mukamal, Natalie Daya Malek, Elizabeth Selvin, Pamela L. Lutsey, Josef Coresh, Stephen P. Juraschek
Summary: This study compares the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults.
Article
Cardiac & Cardiovascular Systems
H. Holm, M. Magnusson, A. Jujic, Nicola Riccardo Pugliese, E. Bozec, Z. Lamiral, O. Huttin, F. Zannad, P. Rossignol, N. Girerd
Summary: This study explored normal values of ventricular-arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular factors. The results showed that pulse wave velocity (PWV)/Global longitudinal strain (GLS) were positively associated with age and cardiovascular risk factors, while arterial elastance (Ea)/end-systolic elastance (Ees) were negatively associated.
Article
Nutrition & Dietetics
Xinting Jiang, Liang Cui, Lin Huang, Yihan Guo, Gaozhong Huang, Qihao Guo
Summary: This study examines the relationship between beverage consumption and cognitive impairment. It shows that the consumption of green tea, coffee, and pure milk can protect cognitive function, while low water intake increases the risk of cognitive impairment. These associations are influenced by baseline cognitive status, gender, and A beta deposition.
Article
Endocrinology & Metabolism
Trasias Mukama, Theron Johnson, Verena Katzke, Rudolf Kaaks
Summary: In this large population-based study, a J-shaped association was observed between dehydroepiandrosterone sulfate (DHEAS) and mortality. Both low and high levels of DHEAS were associated with higher risks of mortality from cancer, cardiovascular disease, and all causes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
M. Wang, F. Wu, M. L. Callisaya, G. Jones, T. Winzenberg
Summary: This study found that falls are a major issue in middle-aged women, a group that has been largely overlooked in fall prevention efforts. Those at higher risk of falls, especially in middle-aged women, should be targeted for fall prevention strategies. Further research is needed to identify risk factors for falls in this population in order to develop effective prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Jiaqi Wang, He Dai, Chong Chen, Ganling Ding, Yongqing Zhang, Yu Qin, Yuqing Zhang, Quanyong Xiang
Summary: Hypertension, especially when combined with restrictive lung function impairment, is independently associated with major adverse cardiovascular events (MACEs). Additionally, obstructive and mixed lung function impairments also show associations with MACEs when combined with hypertension.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Fernandez-Labandera, Eva Calvo-Bonacho, Pedro Valdivielso, Luis Quevedo-Aguado, Paloma Martinez-Munoz, Carlos Catalina-Romero, Luis M. Ruilope, Miguel A. Sanchez-Chaparro
Summary: The study aimed to improve risk assessment for fatal and non-fatal cardiovascular events in a young and healthy working population. The new model IberScore showed superior performance compared to SCORE in predicting cardiovascular risk over a 10-year follow-up, with higher true positive rate and better clinical utility.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Behavioral Sciences
Xingyao Tang, Wei Zhao, Ming Lu, Xin Zhang, Ping Zhang, Zhong Xin, Ran Sun, Wei Tian, Marly Augusto Cardoso, Jinkui Yang, Rafael Sim, Jian-Bo Zhou, Coen D. A. Stehouwer
Summary: The study found a higher waist circumference to be associated with an increased risk of cognitive impairment and dementia, especially in individuals over the age of 65.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, General & Internal
Olga E. Titova, John A. Baron, Karl Michaelsson, Susanna C. Larsson
Summary: This study found that the use of Swedish snus was not significantly associated with majority of cardiovascular diseases and CVD mortality in a middle-aged and elderly Swedish population, but was linked to an increased risk of stroke in never smokers.
Article
Endocrinology & Metabolism
Ayesha Fawad, Andreas Bergmann, Janin Schulte, Zahra A. Butt, Peter M. Nilsson, Louise Bennet, Marju Orho-Melander, Olle Melander
Summary: This study found that high levels of proneurotensin are associated with increased mortality risk in middle-aged individuals, particularly for deaths related to cardiovascular disease, digestive tract disease, mental and behavioral disease, and unspecific causes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Yaqiong Yan, Benchao Li, Fengping Li, Xiaoqi Zhou, Tingting Li, Yuanyuan Li, Changshu Liu, Sai Wang, Yang Cong, Yan Deng, Ziping Wang, Jin Zhou, Shuang Rong
Summary: This study aimed to examine the associations of mushroom consumption with cognitive function and mild cognitive impairment (MCI) among middle-aged and older adults. The study found that higher mushroom consumption was associated with better cognitive function and lower risk of MCI.
Article
Environmental Sciences
Shiyun Lv, Yadi Shi, Yongxi Xue, Yaoyu Hu, Meiling Hu, Shuting Li, Wenhan Xie, Yuan Li, Yixin Ouyang, Zhiwei Li, Mengmeng Liu, Jing Wei, Xiuhua Guo, Xiangtong Liu
Summary: This study aimed to investigate the long-term effects of particulate matter (PM) on cardiovascular diseases (CVD) in China. The results showed that long-term exposure to PM1, PM2.5, and PM10 was associated with an increased incidence of CVD, with PM1 having the strongest impact.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Taoming Qian, Xiaomeng Sheng, Pengyu Shen, Yuting Fang, Yao Deng, Guoliang Zou
Summary: This study aimed to explore the association between Mets-IR and cardiovascular disease (CVD), and investigate the potential mediating role of low-density lipoprotein cholesterol (LDL-C). The results showed that increasing Mets-IR raised the risk of CVD, and LDL-C mediated the association between Mets-IR and stroke. Improving insulin sensitivity and lipid regulation may be effective preventive measures for cardiovascular events.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Respiratory System
Andre F. S. Amaral, Peter G. J. Burney, Jaymini Patel, Cosetta Minelli, Filip Mejza, David M. Mannino, Terence A. R. Seemungal, Padukudru Anand Mahesh, Li Cher Lo, Christer Janson, Sanjay Juvekar, Meriam Denguezli, Imed Harrabi, Emiel F. M. Wouters, Hamid Cherkaski, Kevin Mortimer, Rain Jogi, Eric D. Bateman, Elaine Fuertes, Mohammed Al Ghobain, Wan Tan, Daniel O. Obaseki, Asma El Sony, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E. Erhabor, Thorarinn Gislason, Tobias Welte, Amund Gulsvik, Rune Nielsen, Louisa Gnatiuc, Ali Kocabas, Guy B. Marks, Talant Sooronbaev, Bertrand Hugo Mbatchou Ngahane, Cristina Barbara, A. Sonia Buist
Summary: Smoking was strongly associated with the prevalence of CAO, while poverty also played a role. However, there was no independent association between CAO prevalence and PM2.5 levels. Therefore, prioritizing tobacco control efforts and enhancing understanding of the relationship between CAO and poverty are crucial.
Article
Critical Care Medicine
Peter Burney, Jaymini Patel, Cosetta Minelli, Louisa Gnatiuc, Andre F. S. Amaral, Ali Kocabas, Hamid Hacene Cherkaski, Amund Gulsvik, Rune Nielsen, Eric Bateman, Anamika Jithoo, Kevin Mortimer, Talant M. Sooronbaev, Herve Lawin, Chakib Nejjari, Mohammed Elbiaze, Karima El Rhazi, Jin-Ping Zheng, Pixin Ran, Tobias Welte, Daniel Obaseki, Gregory Erhabor, Asma Elsony, Nada Bakri Osman, Rana Ahmed, Ewa Nizankowska-Mogilnicka, Filip Mejza, David M. Mannino, Cristina Barbara, Emiel F. M. Wouters, Luisito F. Idolor, Li-Cher Loh, Abdul Rashid, Sanjay Juvekar, Thorarinn Gislason, Mohamed Al Ghobain, Michael Studnicka, Imed Harrabi, Meriam Denguezli, Parvaiz A. Koul, Christine Jenkins, Guy Marks, Rain Jogi, Hasan Hafizi, Christer Janson, Wan C. Tan, Althea Aquart-Stewart, Bertrand Mbatchou, Asaad Ahmed Nafees, Kirthi Gunasekera, Terry Seemungal, Mahesh Padukudru Anand, Paul Enright, William M. Vollmer, Marta Blangiardo, Fadlalla G. Elfadaly, A. Sonia Buist
Summary: The study identified smoking and ambient air pollution as major drivers of chronic obstructive pulmonary disease. In addition to smoking, factors such as low education level, dusty occupations, low body mass index, and history of tuberculosis can also increase the risk of chronic airflow obstruction.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Nicola A. Hanania, Scott Caveney, Tedi Soule, Lee Tombs, Sally Lettis, Courtney Crim, David M. Mannino, Hitesh Patel, Isabelle H. Boucot
Summary: Analysis of data from five clinical trials evaluating medications administered using the ELLIPTA dry-powder inhaler showed that treatment with FF/VI, UMEC, or UMEC + FF/VI led to statistically significant and clinically meaningful improvements in trough FEV1 in patients with COPD aged 40 years and older. The results support the use of these medications in both older (>= 65 years) and younger (<65 years) patients with COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Physiology
Byron M. Thomashow, David M. Mannino, Ruth Tal-Singer, James D. Crapo
Summary: World COPD Day aims to raise awareness about the disease, which accounts for a significant number of deaths each year. Research funding for COPD is lacking compared to other major diseases. Early diagnosis and improved therapies are crucial in managing COPD.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Editorial Material
Critical Care Medicine
David M. Mannino
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Benjamin Wu, David Mannino, George Mu, Marjorie Stiegler, Michael Bogart
Summary: This study assessed patient characteristics, exacerbations, and medication history in patients with COPD before initiating single-inhaler triple therapy. The majority of patients experienced exacerbations or used maintenance therapy before initiating triple therapy, in line with treatment guidelines.
Editorial Material
Respiratory System
David M. Mannino, Ruth Tal-Singer
Article
Respiratory System
Roy A. Pleasants, Khosrow Heidari, Jill Ohar, James F. Donohue, Njira L. Lugogo, Sarojini M. Kanotra, Monica Kraft, David M. Mannino, Charlie B. Strange
Summary: This study examines the relationship between respiratory symptoms, associated factors such as smoking, and health impairments among adults in the US. Among the findings, it is noteworthy that many individuals who do not have diagnosed asthma or COPD still experience moderate to severe symptoms. Age, smoking duration, and obesity were identified as significant risk factors for respiratory symptoms.
Editorial Material
Critical Care Medicine
David M. Mannino, Mary C. Townsend
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
David M. Mannino
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Radmila Choate, Kristen E. Holm, Robert A. Sandhaus, David M. Mannino, Charlie Strange
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Vira Pravosud, David M. Mannino, Delia Prieto, Quan Zhang, Radmila Choate, Elisha Malanga, Timothy R. Aksamit
Summary: This study found that patients currently receiving treatment for non-tuberculous mycobacterial lung disease (NTMLD) reported more symptoms associated with their disease, including difficulty walking, fatigue, depression, and breathing difficulties. Further research is needed to explore whether these increased symptoms are related to disease severity or medication effects.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2021)
Article
Respiratory System
Dave Singh, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, Peter Lange, Sally Lettis, David A. Lipson, David Mannino, Neil Martin, Fernando J. Martinez, Bruce E. Miller, Robert Wise, Chang-Qing Zhu, David Lomas
Summary: The study using IMPACT trial data found that in patients with COPD, higher levels of fibrinogen were associated with higher rates and risks of exacerbations. Fibrinogen could serve as a predictive biomarker for exacerbations in COPD, and may be utilized as an enrichment strategy in trials examining exacerbation outcomes.
RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Barbara P. Yawn, Meilan Han, Barry M. Make, David Mannino, Randall W. Brown, Catherine Meldrum, Susan Murray, Cathie Spino, Jacqueline S. Bronicki, Nancy Leidy, Hazel Tapp, Rowena J. Dolor, Min Joo, Lyndee Knox, Linda Zittleman, Byron M. Thomashow, Fernando J. Martinez
Summary: This ongoing study aims to validate and assess the impact of a simple COPD screening tool in primary care, aiming to identify undiagnosed COPD and exacerbation risk with the CAPTURE tool. It aims to improve COPD diagnosis and treatment rates by identifying clinically significant COPD cases.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2021)
Article
Respiratory System
Radmila Choate, David M. Mannino, Kristen E. Holm, Tatsiana Beiko, Bonnie Boyd, Robert A. Sandhaus
Summary: The Step Forward Study aimed to increase exercise activity and improve body mass index among individuals with AATD-associated lung disease. The study found that participants in the intervention group reported more exercise activity and improvements in BMI compared to those in the standard care group.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2021)