Article
Pediatrics
Lu-Jie Liu, Yu-Rong Kang, Yan-Feng Xiao
Summary: The study found that serum asprosin levels were significantly elevated in obese children, especially in those with NAFLD, and were positively correlated with body mass index, waist to height ratio, fasting blood glucose, alanine aminotransferase and tumor necrosis factor-alpha. Furthermore, asprosin was independently associated with NAFLD in binary logistic regression analysis.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kei Kuroe, Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita
Summary: The study found that a higher clinical attachment level (CAL) was associated with the incidence of liver fibrosis in obese adults with NAFL, but not in non-obese participants.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuling Xing, Yunfeng Zhen, Liqun Yang, Lijing Huo, Huijuan Ma
Summary: This study aimed to explore the association between hemoglobin glycation index (HGI) and non-alcoholic fatty liver disease (NAFLD), and to provide new methods for identifying high-risk patients for NAFLD. The results showed a positive correlation between HGI levels and NAFLD occurrence. Body mass index (BMI) partly mediated the impact of HGI on NAFLD. Subgroup analyses indicated that HGI significantly correlated with NAFLD in certain patient populations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yamei Duan, Jiayou Luo, Xiongfeng Pan, Jia Wei, Xiang Xiao, Jingya Li, Miyang Luo
Summary: This study evaluated the association between inflammatory markers and NAFLD in obese children. The findings indicated that levels of IL-1 beta, IL-6, and IL-17 were significantly associated with NAFLD, suggesting that these inflammatory cytokines may serve as non-invasive markers for the development of NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Alba Garcia-Galey, Malika Tami, Pilar del Pino, Isabel Carmona, Soledad Lopez, Gonzalo Alba, Victor Sanchez-Margalet
Summary: NAFLD affects a quarter of the global population and poses a significant health and economic burden across all countries. The lack of approved pharmacotherapy and well-established diagnostic strategies for this disease highlights the urgency for further research and management efforts. Studies have shown a strong relationship between the hormone leptin and the development of NAFLD, suggesting potential advancements in disease management through further investigation of its role.
Review
Medicine, General & Internal
Zahra Namkhah, Fatemeh Naeini, Alireza Ostadrahimi, Helda Tutunchi, Mohammad Javad Hosseinzadeh-Attar
Summary: The study suggests that ZAG may have a protective effect against NAFLD by enhancing fatty acid oxidation, improving hepatic steatosis, regulating energy balance and glucose homeostasis, and inhibiting inflammatory responses. Further research is needed to confirm the beneficial effects of ZAG in prospective cohort studies.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
C. Zusi, A. Morandi, A. Maguolo, M. Corradi, S. Costantini, A. Mosca, A. Crudele, A. Mantovani, A. Alisi, E. Miraglia del Giudice, G. Targher, C. Maffeis
Summary: The study on Italian overweight/obese children did not find a significant association between the MBOAT7 rs641738 polymorphism and NAFL or NASH.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Wenbo Gu, Tianshu Han, Changhao Sun
Summary: This study aimed to investigate the association between 24-hour behavior rhythm and non-alcoholic fatty liver disease (NAFLD). The findings showed that higher relative amplitude and average activity during the least active continuous 5-hour period were associated with a lower risk of NAFLD. Additionally, longer fasting duration and higher feeding rhythm score were associated with a lower risk of NAFLD. The study concluded that there is a significant association between 24-hour behavior rhythm and NAFLD in overweight/obese American adults.
Article
Gastroenterology & Hepatology
Marianna G. Mavilia, George Y. Wu
Summary: Adiponectin levels are lower in NAFLD patients compared to controls in both serum and liver tissue. Liver adiponectin levels were significantly lower in the HS group than in the NASH and HC groups, indicating a potential relationship between adiponectin and liver inflammation in the pathogenesis of NAFLD.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Gastroenterology & Hepatology
Ruifang Li, Jie Liu, Ping Han, Ruifang Shi, Lili Zhao, Jia Li
Summary: This study aims to explore the associations between various abdominal obesity indices and the pathological features of NAFLD. The results show that Chinese VAI (CVAI) is significantly associated with the pathological features of NAFLD, and it has the most superior efficacy in diagnosing fibrosis among these indices.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biology
Mengyao Wu, Tak-Ho Lo, Liping Li, Jia Sun, Chujun Deng, Ka-Ying Chan, Xiang Li, Steve Ting-Yuan Yeh, Jimmy Tsz Hang Lee, Pauline Po Yee Lui, Aimin Xu, Chi-Ming Wong
Summary: This study found that adhesion G protein-coupled receptor F1 (Adgrf1) regulates hepatic lipid metabolism by controlling the expression of stearoyl-coA desaturase 1 (Scd1). The downregulation of Adgrf1 expression in the livers of obese subjects may serve as a protective mechanism to prevent the excessive accumulation of fat. These findings not only reveal a new mechanism for the progression of non-alcoholic fatty liver disease (NAFLD), but also propose a novel therapeutic approach to combat NAFLD by targeting Adgrf1.
Article
Immunology
Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Hydar El Jamaly, Guy D. Eslick, Martin Weltman
Summary: This meta-analysis provides evidence showing a significant association between NAFLD and maternal diabetic and hypertensive complications, as well as multiple adverse fetal outcomes.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sailimai Man, Jun Lv, Canqing Yu, Yuhan Deng, Jianchun Yin, Bo Wang, Liming Li, Hui Liu
Summary: This study found that metabolically healthy obesity individuals were significantly associated with higher risks of NAFLD and its fibrosis progression. MHO individuals might still benefit from lifestyle interventions aimed at body weight and waist circumference maintenance for NAFLD prevention.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Eunice Xiang-Xuan Tan, Jonathan Wei-Jie Lee, Nur Halisah Jumat, Wah-Kheong Chan, Sombat Treeprasertsuk, George Boon-Bee Goh, Jian-Gao Fan, Myeong Jun Song, Phunchai Charatcharoenwitthaya, Ajay Duseja, Kento Imajo, Atsushi Nakajima, Yosuke Seki, Kazunori Kasama, Satoru Kakizaki, Laurentius A. Lesmana, Kenneth Zheng, Ming-Hua Zheng, Calvin J. Koh, Khek-Yu Ho, Khean-Lee Goh, Vincent Wai-Sun Wong, Yock-Young Dan
Summary: A significant proportion of non-obese NAFLD patients have NASH or advanced fibrosis. FIB-4 outperforms NFS in identifying non-obese NAFLD patients with advanced liver disease. Additionally, serum GGT, cholesterol, haemoglobin, and waist circumference are important biomarkers for advanced liver disease in non-obese patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Genetics & Heredity
Victoria E. J. M. Palasantzas, Isabel Tamargo-Rubio, Kieu Le, Jelle Slager, Cisca Wijmenga, Iris H. Jonkers, Vinod Kumar, Jingyuan Fu, Sebo Withoff
Summary: Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex genetic diseases and drug efficacy. However, functional characterization of these variants is challenging due to the lack of human model systems. Organ-on-a-chip (OoC) platforms, enabled by advances in molecular and nanotechnology, provide personalized platforms for studying the impact of genetics and environment on organ physiology. This review highlights the technology and showcases the potential of OoCs in disease modeling and pharmacogenetic research.
TRENDS IN GENETICS
(2023)
Article
Pathology
Cedric Peleman, Winnok H. De Vos, Isabel Pintelon, Ann Driessen, Annelies Van Eyck, Christophe Van Steenkiste, Luisa Vonghia, Joris De Man, Benedicte Y. De Winter, Tom Vanden Berghe, Sven M. Francque, Wilhelmus J. Kwanten
Summary: A new image analysis method was used to quantify the differences between liver lobule zones in NAFLD. The results showed that this method accurately measured the distribution of hypoxia markers in the steatotic liver and overcame the impact of steatosis on pathologists' interpretation.
Article
Multidisciplinary Sciences
Koen F. Dekkers, Roderick C. Slieker, Andreea Ioan-Facsinay, Maarten van Iterson, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Jan H. Veldink, Lude Franke, Dorret I. Boomsma, P. Eline Slagboom, J. Wouter Jukema, Bastiaan T. Heijmans
Summary: Circulating lipids can alter immune cell function, which may be relevant to lipid-associated inflammatory diseases. Through transcriptome-wide association analysis and Mendelian randomization analysis, we identified genes that are affected by blood triglycerides and HDL cholesterol, and found that triglycerides downregulate lipid metabolism and allergic response. Additionally, these genes were found to affect the incidence of allergic diseases. This highlights the interplay between triglycerides and immune cells in allergic disease.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
James Elste, Angelica Chan, Chandrashekhar Patil, Vinisha Tripathi, Daniel M. Shadrack, Dinesh Jaishankar, Andrew Hawkey, Michelle Swanson Mungerson, Deepak Shukla, Vaibhav Tiwari
Summary: The structural diversity of heparan sulfate (HS) in various vertebrates and invertebrates is remarkably preserved and plays a key role in ligand binding and virus entry. The interaction between glycoprotein D (gD) from herpes simplex virus (HSV) and 3-O sulfated HS leads to virus-cell fusion and HSV entry. HSV-1, which infects a large number of people worldwide, can also cause severe diseases in both primates and non-primates. The enzymatic modification of HS by 3-O sulfotransferase-3 (3-OST-3) enhances HSV-1 infectivity and suggests a possible role of HS in cross-species transmission.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Annemarie J. F. Westheim, Lara M. Stoffels, Ludwig J. Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, Ronit Shiri-Sverdlov, Jan Theys
Summary: Cancer burden is increasing rapidly globally, with lifestyle factors such as unhealthy diet being major contributors. The specific fatty acids that contribute to a healthy and balanced diet in terms of cancer risk and prognosis are still unclear. This review explores the associations between intake of different fatty acids and cancer risk, as well as the effects of specific fatty acids on tumor cells and inflammation-induced cancer progression, highlighting challenges and opportunities for fatty acid tailored nutritional interventions.
Article
Chemistry, Analytical
P. Vangeenderhuysen, J. Van Arnhem, B. Pomian, M. De Graeve, L. De Commer, G. Falony, J. Raes, A. Zhernakova, J. Fu, L. Y. Hemeryck, L. Vanhaecke
Summary: In recent years, feces has emerged as the ideal matrix for studying the connection between the gut microbiome and health due to its non-invasive sampling and ability to reflect an individual's lifestyle. To facilitate large cohort studies with limited availability, there is a need for high-throughput analyses that require minimal sample and resources. This study presents a workflow that combines fecal extraction and ultra high performance liquid chromatography-high resolution-quadrupole-orbitrap-mass spectrometry (UHPLC-HR-Q-Orbitrap-MS) to enable targeted and untargeted metabolome and lipidome analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Floranne Boulogne, Laura R. Claus, Henry Wiersma, Roy Oelen, Floor Schukking, Niek de Klein, Shuang Li, Harm-Jan Westra, Bert van der Zwaag, Franka van Reekum, Dana Sierks, Ria Schoenauer, Zhigui Li, Emilia K. Bijlsma, Willem Jan W. Bos, Jan Halbritter, Nine V. A. M. Knoers, Whitney Besse, Patrick Deelen, Lude Franke, Albertien M. van Eerde
Summary: Researchers have developed KidneyNetwork, a method that utilizes tissue-specific expression to prioritize candidate genes for kidney diseases. By integrating kidney RNA-sequencing co-expression network with a multi-tissue network, KidneyNetwork predicts genes related to kidney disease phenotypes using expression patterns and gene-phenotype associations. Applying KidneyNetwork to patients with undiagnosed kidney disease, it accurately predicts kidney-specific gene functions and identifies ALG6 as a plausible candidate gene for kidney and liver cysts.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Victoria Pascal Andreu, Hannah E. E. Augustijn, Lianmin Chen, Alexandra Zhernakova, Jingyuan Fu, Michael A. A. Fischbach, Dylan Dodd, Marnix H. H. Medema
Summary: Profile hidden Markov models are used to identify taxon-specific primary metabolic pathways. The gut microbiota produce various small molecules that modulate host physiology. The gutSMASH algorithm is introduced to identify primary metabolic gene clusters in high-quality microbial genomes, revealing marked differences in pathway distribution among phyla and indicating a characteristic metabolic niche for each taxon. The study also highlights the crucial role of pathway-specific gene regulation and metabolite flux in microbiome-derived metabolites.
NATURE BIOTECHNOLOGY
(2023)
Article
Genetics & Heredity
Niek de Klein, Ellen A. Tsai, Martijn Vochteloo, Denis Baird, Yunfeng Huang, Chia-Yen Chen, Sipko van Dam, Roy Oelen, Patrick Deelen, Olivier B. Bakker, Omar El Garwany, Zhengyu Ouyang, Eric E. Marshall, Maria I. Zavodszky, Wouter van Rheenen, Mark K. Bakker, Jan Veldink, Tom R. Gaunt, Heiko Runz, Lude Franke, Harm-Jan Westra
Summary: This study utilized RNA-sequencing samples from multiple brain datasets to identify cis- and trans-expression quantitative trait loci (eQTLs) and potential drivers for brain-related diseases.
Article
Multidisciplinary Sciences
Qile Dai, Geyu Zhou, Hongyu Zhao, Urmo Vosa, Lude Franke, Alexis Battle, Alexander Teumer, Terho Lehtimaki, Olli T. Raitakari, Tonu Esko, Michael P. Epstein, Jingjing Yang
Summary: Most TWAS tools require individual-level eQTL reference data, making them not suitable for summary-level reference eQTL datasets. Hence, the development of TWAS methods that can utilize summary-level reference data is valuable. In this study, a TWAS framework called OTTERS is introduced, which adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level data and performs omnibus TWAS. Both simulations and application studies demonstrate the practicality and power of OTTERS as a TWAS tool.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Collins K. Boahen, Roy Oelen, Kieu Le, Mihai G. Netea, Lude Franke, Monique G. P. van der Wijst, Vinod Kumar
Summary: Both gene expression and protein concentrations are regulated by genetic variants. Exploring the regulation of eQTLs and pQTLs simultaneously in a context- and cell-type dependent manner may help unravel the mechanistic basis for genetic regulation of pQTLs. By conducting meta-analysis of Candida albicans-induced pQTLs from two population-based cohorts and intersecting the results with Candida-induced cell-type specific expression association data (eQTL), we found systematic differences between pQTLs and eQTLs, indicating the limitation of using eQTLs as a proxy for pQTLs. Additionally, our study identified SNPs affecting protein networks and implicated specific genomic loci through colocalization of pQTLs and eQTLs signals.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Shixian Hu, J. Casper Swarte, Yanni Li, Johannes Bjork, Ranko Gacesa, Arnau Vich Vila, Rianne Douwes, Valerie Collij, Alexander Kurilshikov, Aadrian Post, Marjolein A. Y. Klaassen, Michele F. Eisenga, Antonio W. Gomes-Neto, Daan Kremer, Bernadien H. Jansen, Tim J. Knobbe, Stefan P. Berger, Jan-Stephan F. Sanders, M. Rebecca Heiner-Fokkema, Robert J. Porte, Frans J. C. Cuperus, Vincent E. Demeijer, Cisca Wijmenga, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Hans Blokzijl, Stephan J. L. Bakker, Rinse Weersma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Ecology
Johanne E. Spreckels, Asier Fernandez-Pato, Marloes Kruk, Alexander Kurilshikov, Sanzhima Garmaeva, Trishla Sinha, Hiren Ghosh, Hermie Harmsen, Jingyuan Fu, Ranko Gacesa, Alexandra Zhernakova
Summary: This study aims to find a method to study milk bacteria and assess bacterial sharing between maternal and infant microbiota. The results show that DNA isolation using the PS or MX kits followed by 16S rRNA gene sequencing reliably characterizes human milk microbiota. Additionally, the use of 16S-ITS-23S rRNA gene sequencing enables the study of bacterial transmission in low-biomass samples.
ISME COMMUNICATIONS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Cedric Peleman, Ine Koeken, Geraldine Veeckmans, Astrid Van den Branden, Emily Van San, Behrouz Hassannia, Luc Van Nassauw, Els Goeman, Ann Driessen, Lieve Vits, Annelies Van Eyck, Wilhelmus Kwanten, Luisa Vonghia, Joris De Man, Benedicte De Winter, Christophe Van Steenkiste, Tom Vanden Berghe, Sven Francque
JOURNAL OF HEPATOLOGY
(2023)
