Article
Environmental Sciences
Narayanan Shyam-Sundar, Sengodan Karthi, Sengottayan Senthil-Nathan, Kilapavoor Raman Narayanan, Balasubramanian Santoshkumar, Haridoss Sivanesh, Kanagaraj Muthu-Pandian Chanthini, Vethamonickam Stanley-Raja, Ramakrishnan Ramasubramanian, Ahmed Abdel-Megeed, Guilherme Malafaia
Summary: The use of Desmostachya bipinnata for the biosynthesis of TiO2NPs has been explored in this study. These nanoparticles have larvicidal and pupicidal effects on mosquitoes and agricultural pests, while showing lower toxicity to non-target organisms. The study provides pioneering evidence for the potential use of D. bipinnata-mediated TiO2NPs for mosquito and pest control.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Article
Biochemistry & Molecular Biology
Wangta Liu, Li-Ching Lin, Pei-Ju Wang, Yan-Ning Chen, Sheng-Chieh Wang, Ya-Ting Chuang, I-Hsuan Tsai, Szu-Yin Yu, Fang-Rong Chang, Yuan-Bin Cheng, Li-Chen Huang, Ming-Yii Huang, Hsueh-Wei Chang
Summary: The study evaluated the antioxidant properties and antiproliferative impact of Nepenthes ethyl acetate extract (EANT) on leukemia cells. EANT demonstrated oxidative stress-dependent anti-leukemia ability associated with apoptosis and DNA damage in HL-60 cells. This suggests the potential of EANT as a therapeutic agent for leukemia treatment.
Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Safura Bibi, Muhammad Sajid Aqeel Ahmad, Mansoor Hameed, Farooq Ahmad, Ambreen Khadija Alvi, Ali Kamal
Summary: This study evaluated the response of Desmostachya bipinnata L. populations from arid regions to adaptability to aridity through the analysis of morpho-physiological and leaf surface attributes, as well as antioxidant potential. The results showed that the plant exhibited reduced vegetative growth and increased root growth in response to increased aridity. Additionally, degradation of chlorophyll a and reduced carotenoid content were observed, along with increased activities of antioxidant enzymes. The concentration of Na+ in the shoot increased, while K+ and Mg2+ concentration decreased.
ARID LAND RESEARCH AND MANAGEMENT
(2022)
Article
Pharmacology & Pharmacy
Alexandru Nicolescu, Mihai Babota, Maria Ilea, Maria Ines Dias, Ricardo C. Calhelha, Laura Gavrilas, Gabriele Rocchetti, Gianina Crisan, Andrei Mocan, Lillian Barros, Alina Elena Parvu
Summary: This study found that extracts of Salvia glutinosa exhibit antioxidant and anti-inflammatory activity, as well as a modest cytotoxic effect on HepG2 cell line. These findings are consistent with the traditional use of the plant in Romanian folk medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ali Acar, Divya Singh
Summary: The present study aimed to explore the toxicity of penoxsulam and the protective effects of blueberry extract in roots of Allium cepa L. Penoxsulam exposure inhibited cell division, rooting percentage, growth rate, root length, and weight gain, and induced chromosomal anomalies and DNA strand breaks. Blueberry extracts reduced penoxsulam toxicity in a concentration-dependent manner and showed positive effects on cytological, morphological, and oxidative stress parameters.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Vijakhana Pilaisangsuree, Kanitha Supdensong, Pimpimon Lumpa, Jintana Pankam, Apinun Limmongkon
Summary: Pre-treatment with methyl jasmonate and methyl-beta-cyclodextrin followed by cadmium induced the highest ferric reducing antioxidant power in peanut hairy root culture. Crude extracts showed DNA-protective activity at low concentrations, but exhibited pro-oxidant activity at higher concentrations. The bioactive compounds in hairy root extracts have the potential to serve as health-promoting or cancer chemotherapeutic agents, with both antioxidant and pro-oxidant activities in a concentration-dependent manner.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Biophysics
Ana Julia F. Dalcin, Isabel Roggia, Sabrina Felin, Bruno S. Vizzotto, Montserrat Mitjans, Maria Pilar Vinardell, Andre P. Schuch, Aline F. Ourique, Patricia Gomes
Summary: The study found that cationic nanocapsules containing DMY flavonoids can be safely used topically to protect the skin from UV-induced DNA damage. The formulation remained stable at 4 degrees Celsius, demonstrated skin safety, and provided significant photoprotection and antioxidant potential.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Plant Sciences
Stefania Lamponi, Maria Camilla Baratto, Elisabetta Miraldi, Giulia Baini, Marco Biagi
Summary: This study characterized the chemical profile and in vitro bioactivity of an ethanolic extract of Tuscan Rosmarinus officinalis, which demonstrated antioxidant activity, hydrogen peroxide scavenging capability, and influence on cell viability. The extract also showed anti-coagulating effect and lack of genotoxicity in Ames test, with biological activities correlated to its rich phytochemical profile.
Article
Plant Sciences
Xiudong Yang, Zi-Fan Bai, Yan Zhang, Hao Cui, Hong-Li Zhou
Summary: The study demonstrated that flavonoids-rich extract from Bidens bipinnata exhibited protective effects on H2O2-induced pancreatic beta cell damage by influencing the expression of apoptosis-related proteins and regulating cell signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Fany Renata Aguilera-Rodriguez, Ana Lourdes Zamora-Perez, Clara Luz Galvan-Moreno, Rosalinda Gutierrez-Hernandez, Claudia Araceli Reyes Estrada, Edgar L. Esparza-Ibarra, Blanca Patricia Lazalde-Ramos
Summary: The cytotoxicity and genotoxicity of aqueous and hydroalcoholic leaf and bark extracts of Crataegus oxyacantha were evaluated using the micronucleus test in a murine model. Results showed genotoxic effects for both leaf and bark extracts, while only the aqueous leaf extract exhibited cytotoxic effects.
Article
Multidisciplinary Sciences
Nazanin Danaei, Heibatollah Sadeghi, Arash Asfarm, Davoud Rostamzadeh, Esmaeel Panahi Kokhdan, Hossein Sadeghi, Negin Rahimi
Summary: This study found that Daphne oleoides and Betulin can prevent bleomycin-induced lung fibrosis in rats by reducing inflammatory and antioxidant markers. Therefore, Daphne oleoides has the potential to be used therapeutically to treat pulmonary fibrosis.
Article
Veterinary Sciences
Roberta Salaroli, Giulia Andreani, Chiara Bernardini, Augusta Zannoni, Debora La Mantia, Michele Protti, Monica Forni, Laura Mercolini, Gloria Isani
Summary: This study evaluated the cytotoxic effects of Artemisia annua extract on canine osteosarcoma cell lines and found its potential involvement in ferroptosis. The results showed that the extract exhibited anticancer activity on canine osteosarcoma cells and may be useful in treating drug resistant canine osteosarcomas.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Food Science & Technology
Hao Guo, Chang Liu, Qi Tang, Deyu Li, Yinsheng Wan, Jiu-Hong Li, Xing-Hua Gao, Navindra P. Seeram, Hang Ma, Hong-Duo Chen
Summary: The study found that pomegranate extract and its polyphenols can protect DNA integrity, reduce the toxicity induced by MGO, and improve cell functions.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Oncology
Upendarrao Golla, Swati Swagatika, Sakshi Chauhan, Raghuvir Singh Tomar
Article
Biochemistry & Molecular Biology
Pilendra K. Thakre, S. Athira, Upendarrao Golla, Sakshi Chauhan, Raghuvir S. Tomar
Article
Chemistry, Medicinal
Pilendra Kumar Thakre, Upendarrao Golla, Ashis Biswas, Raghuvir Singh Tomar
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Rout George Kerry, Gitishree Das, Upendarrao Golla, Maria del Pilar Rodriguez-Torres, Han-Seung Shin, Jayanta Kumar Patra
Summary: Nutritional supplementations, also known as nutraceuticals, are extracted from edible sources and have medical benefits as well as primary nutritional values. They can alter gut microbiota, prevent chronic non-communicable degenerative diseases, and alleviate complications in preterm babies. The molecular pathways in these diseases can be regulated or modulated by nutraceutical supplementations. Advanced genome-editing techniques and delivery systems can also be applied in therapeutic activities.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Meeting Abstract
Hematology
Melanie Ehudin, Upendarrao Golla, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Dhimant Desai, David F. Claxton, Sinisa Dovat, Arati Sharma
Article
Oncology
Upendarrao Golla, Melanie A. Ehudin, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Abhijit A. Date, Irina Elcheva, Arthur Berg, Shantu Amin, Thomas P. Loughran, Mark Kester, Dhimant Desai, Sinisa Dovat, David Claxton, Arati Sharma
Summary: The ROCK inhibitor DJ4 shows therapeutic efficacy in acute myeloid leukemia, enhancing survival rates and demonstrating cytotoxic effects on AML cells, while sparing normal hematopoietic cells.
Review
Biochemistry & Molecular Biology
Melanie A. Ehudin, Upendarrao Golla, Devnah Trivedi, Shobha D. Potlakayala, Sairam Rudrabhatla, Dhimant Desai, Sinisa Dovat, David Claxton, Arati Sharma
Summary: Supplementing chemotherapy and radiotherapy with selenium has shown beneficial effects against various cancers and can alleviate side effects while improving patients' quality of life. Selenium levels have been correlated with different cancers and can serve as diagnostic markers for tracking treatment efficiency and determining the relationship between selenium levels and the disease. This review provides an overview of the significant impact of selenium in different cancers, discussing its anti-cancer mechanisms and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andrei Khokhlatchev, Arati Sharma, Tye G. Deering, Jeremy J. P. Shaw, Pedro Costa-Pinheiro, Upendarrao Golla, Charyguly Annageldiyev, Myles C. Cabot, Mark R. Conaway, Su-Fern Tan, Johnson Ung, David J. Feith, Thomas P. Loughran, David F. Claxton, Todd E. Fox, Mark Kester
Summary: Research has shown that using a nanoscale delivery system for ceramide (CNL) can enhance the efficacy of venetoclax/cytarabine treatment in acute myeloid leukemia (AML) by reducing drug-resistant signaling pathways and increasing cell death.
Article
Oncology
Kelsey H. Fisher-Wellman, Miki Kassai, James T. Hagen, P. Darrell Neufer, Mark Kester, Thomas P. Loughran Jr., Charles E. Chalfant, David J. Feith, Su-Fern Tan, Todd E. Fox, Johnson Ung, Gemma Fabrias, Jose' Luis Abad, Arati Sharma, Upendarrao Golla, David F. Claxton, Jeremy J. P. Shaw, Debajit Bhowmick, Myles C. Cabot
Summary: This study investigates the effects of blocking ceramide clearance in drug-resistant acute myeloid leukemia (AML), a major obstacle in successful treatment. By employing agents that inhibit ceramide hydrolysis and glycosylation, the study demonstrates elevated intracellular ceramide levels, impaired mitochondrial function, enhanced caspase activation, and cell death in drug-resistant AML models. The findings suggest that targeting sphingolipid metabolic pathways could enhance vulnerability of leukemia cells in the drug-resistant setting, providing a novel therapeutic strategy for difficult-to-treat cancers.
Review
Cell Biology
Naresh Kumar Manda, Upendarrao Golla, Kishore Sesham, Parth Desai, Shrushti Joshi, Satyam Patel, Sharada Nalla, Susmitha Kondam, Lakhwinder Singh, Deepak Dewansh, Hemalatha Manda, Namita Rokana
Summary: The organization of eukaryotic genome in the nucleus is complex and dynamic, and its morphology and size have significant impact on nuclear mechanics, chromatin organization, gene expression, cell functionality, and disease development. Abnormal nuclear envelope morphologies are implicated in human disorders. However, our knowledge about the molecular mechanisms regulating nuclear morphology and cell functionality during health and illness is limited. This review discusses the essential components governing nuclear organization and the functional consequences associated with nuclear morphometric aberrations, as well as recent developments with diagnostic and therapeutic implications for nuclear morphology.
Article
Chemistry, Medicinal
Vijay Pralhad Kale, Jeremy A. Hengst, Arati K. Sharma, Upendarrao Golla, Sinisa Dovat, Shantu G. Amin, Jong K. Yun, Dhimant H. Desai
Summary: This study characterized the anti-proliferative and apoptotic effects of a novel small molecule DJ4 in non-small cell lung cancer and triple-negative breast cancer cells. Structural modifications led to the discovery of four active analogs with enhanced ROCK/MRCK inhibitory potency. These active analogs showed anti-proliferative and anti-migratory effects in various cancer cell lines.
Meeting Abstract
Oncology
Satyam Patel, Upendarrao Golla, Arati Sharma, David Claxton
Meeting Abstract
Oncology
Upendarrao Golla, Satyam Patel, Diwakar B. Tukaramrao, Jeremy Hengst, Juliana Restrepo, Shantu Amin, Dhimant Desai, Sinisa Dovat, David Claxton, Arati Sharma
Review
Biochemistry & Molecular Biology
Upendarrao Golla, Kishore Sesham, Siva Dallavalasa, Naresh Kumar Manda, Sambamoorthy Unnam, Arun Kumar Sanapala, Sharada Nalla, Susmitha Kondam, Rajesh Kumar
Summary: The aberrant expression of lncRNA ABHD11-AS1 has been linked to the development and progression of various cancers, with its high expression observed in gastric, lung, breast, colorectal, thyroid, pancreas, ovary, endometrium, cervix, and bladder cancers. It has clinical significance in prognosis, diagnosis, prediction of cancer progression stage, and treatment response. ABHD11-AS1 exerts oncogenic effects by altering various mechanisms and has prognostic potential in certain cancers. However, further research is needed to elucidate the specific role of ABHD11-AS1 in tumor development, prognosis, progression, and treatment.
Article
Cell & Tissue Engineering
Nathaniel A. Long, Upendarrao Golla, Arati Sharma, David F. Claxton
Summary: This article reviews the biology of leukemia stem cells (LSCs) in acute myeloid leukemia (AML), focusing on their relationship with the heterogeneous nature of AML and its high relapse rate. The defining functional and phenotypic features of LSCs are discussed, including their surface and metabolic phenotypes that differentiate them from normal hematopoietic stem cells (HSCs). The potential for using this information to improve therapy and address clinical needs is highlighted, as well as the current gaps in the scientific understanding of LSCs.
STEM CELL REVIEWS AND REPORTS
(2022)
