Article
Biochemistry & Molecular Biology
Essam N. Ads, Syed Hassan, Saravanan Rajendrasozhan, Mona H. Hetta, Shaza H. Aly, Mohamed A. Ali
Summary: This study isolates and identifies two new compounds from the stem bark of Ziziphus spina-christi, demonstrating their potential antimicrobial properties in pharmaceutical and clinical applications.
Article
Plant Sciences
Paul Thomas, Emmanuel Essien, Anwanabasi Udoh, Bright Archibong, Ofonasaha Akpan, Emediong Etukudo, Marinella De Leo, Olorunfemi Eseyin, Guido Flamini, Kola Ajibesin
Summary: The study evaluated the anti-inflammatory, analgesic, and antioxidant activities of Uapaca staudtii stem bark extract and fractions, and isolated protocatechuic acid and betulinic acid as bioactive compounds. The results demonstrated significant medicinal value of Uapaca staudtii stem bark in treating pain and inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saeedeh Gilani, Ghasem Najafpour
Summary: This study optimized the extraction of cinnamic acid and cinnamaldehyde from cinnamon bark, investigating the impact of different solvent types, temperature, process time, solid: solvent portion, and particle size on the yield. The obtained extraction samples were analyzed by HPLC with a UV detector.
PROCESS BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Martina S. Savova, Liliya V. Vasileva, Saveta G. Mladenova, Kristiana M. Amirova, Claudio Ferrante, Giustino Orlando, Martin Wabitsch, Milen Georgiev
Summary: The study showed that Ziziphus jujuba Mill. leaf extract and its components, apigenin, betulinic acid, and maslinic acid, inhibited adipocyte differentiation by targeting the PI3K/AKT pathway. Among them, betulinic acid exhibited the most promising anti-adipogenic activity. This suggests that ZJL extract could be a potential source for new bioactive compounds in obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Adithya Sridhar, Vijay Vaishampayan, P. Senthil Kumar, Muthamilselvi Ponnuchamy, Ashish Kapoor
Summary: This review evaluates the key parameters affecting the extraction of targeted components and highlights the importance of extraction technologies and process parameters. The findings suggest that extraction processes vary depending on the category of food and its structure. Optimization of process parameters and the synergistic combination of multiple extraction processes can enhance efficiency.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Somayeh Mirnezhad, Mousa Sadeghi-Kiakhani, Elaheh Hashemi
Summary: Considering the importance of natural colorants and sustainable products, researchers focused on new color resources, identification, and standardization of natural dyes. They extracted natural colorants from Ziziphus bark using ultrasound technique and applied them to wool yarn to produce antioxidant and antibacterial fibers. The optimum conditions for extraction were determined, and the effects of temperature, dye concentration, dyeing time, pH, and L.R ratio on the wool yarn were investigated. The Ziziphus dye showed a significant reduction in Gram-negative and Gram-positive bacteria and exhibited antioxidant properties on the wool yarn.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Chemical
Ivo S. Azenha, Jose P. S. Aniceto, Diogo P. Ribeiro, Adelio Mendes, Carlos M. Silva
Summary: This study focused on the reversed-phase chromatographic separation of betulinic and oleanolic acids using a C30 stationary phase. The method of moments was used to determine the equilibrium constants and coefficients of the acids, which were validated by breakthrough curve modeling. The study also found that adding water to methanol/acetonitrile mixtures can efficiently precipitate the TTAs.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Piotr Kaminski, Katarzyna Tyskiewicz, Zygmunt Fekner, Marcin Gruba, Zbigniew Kobus
Summary: This study investigated the impact of subcritical water extraction parameters on the content of polyphenols and flavonoids in walnut bark extracts, as well as their antioxidant activity. The study optimized the extraction conditions using response surface methodology and found that the highest content of polyphenols, flavonoids, and antioxidant activity were achieved at a temperature of 131.6 degrees C, a raw material fraction size of 0.9 mm, and a process time of 10 min. The results also indicated that temperature had the greatest impact on the extraction yield, while the raw material fraction size and process time had a secondary impact.
APPLIED SCIENCES-BASEL
(2022)
Review
Agricultural Engineering
Sabrina Mores, Luciana Porto de Souza Vandenberghe, Antonio Irineudo Magalhaes Junior, Julio Cesar de Carvalho, Ariane Fatima Murawski de Mello, Ashok Pandey, Carlos Ricardo Soccol
Summary: The review highlights the challenges in CA bioproduction, emphasizing the potential of reactive extraction and adsorption for industrial applications. While adsorption, extraction, and membrane separation have lower environmental impacts than precipitation, their technological maturity remains limited. New processes combining these techniques for CA recovery and purification still hold promise for further exploration.
BIORESOURCE TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tania Paul, Abhijit Mondal, Tarun Kanti Bandyopadhyay, Nibedita Mahata, Biswanath Bhunia
Summary: The present study aims to optimize various process parameters during ultrasound-assisted extraction (UAE) to increase the yield of prodigiosin. The Taguchi methodology is used to determine the optimal conditions, which resulted in a significant increase in prodigiosin yield. Additionally, a second-order kinetic model is used to create a batch extractor for commercial extraction of prodigiosin.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
X. Vecino, M. Reig, C. Valderrama, J. L. Cortina
Summary: The study proposed the use of ion-exchange technology for lactic acid recovery, with A100 resin showing the best removal efficiency under specific conditions. The sorption process followed the Langmuir isotherm and a pseudo-second order kinetic model.
Article
Food Science & Technology
Swati Sethi, D. N. Yadav, Sneha Snigdha, Antima Gupta
Summary: Optimizing process parameters can reduce the neurotoxin content in grass pea protein isolates while maintaining high protein extraction rates, resulting in functional properties comparable to other legume protein isolates.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Martina Jakovljevic Kovac, Stela Jokic, Igor Jerkovic, Maja Molnar
Summary: This study extracted gallic acid, ellagic acid, and hydrolyzable tannins (HT) from Alchemilla vulgaris L. plant using different deep eutectic solvents (DESs). Choline chloride:urea (1:2) was found to be the most suitable solvent. Extraction by stirring and heating was the most effective method for obtaining the highest amounts of gallic acid, ellagic acid, and HT.
Article
Computer Science, Interdisciplinary Applications
Maurizio Galetto, Elisa Verna, Gianfranco Genta
Summary: The research uses a Design of Experiments approach to study the effects of FDM process parameters on PLA component production, optimizes response outputs through mathematical models, and verifies the optimizations through experiments.
The results show that different parameter settings can lead to different goals in terms of part quality and process efficiency.
This method can help designers determine the optimal process parameter settings to enhance both part quality and process efficiency.
COMPUTERS & INDUSTRIAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Fatiha Brahmi, Inmaculada Mateos-Aparicio, Alejandra Garcia-Alonso, Nadjet Abaci, Salima Saoudi, Leila Smail-Benazzouz, Hayate Guemghar-Haddadi, Khodir Madani, Lila Boulekbache-Makhlouf
Summary: The aim of this study was to optimize the extraction conditions of phenolic compounds from potato peels and evaluate their effects on the properties and quality of yogurt. The results showed that the highest content of phenolic compounds and antioxidant capacity were achieved with an extraction using 80% ethanol for 150 minutes with a liquid/solid ratio of 1 g/30 mL. Yogurts fortified with the potato peel extract exhibited improved nutritional, antioxidant, and sensory qualities compared to the control yogurt.
Review
Environmental Sciences
M. Sharma, A. Yadav, M. K. Mandal, K. K. Dubey
Summary: Increasing population and globalization have led to an increase in the demand for pharmaceuticals, but their overuse and discharge pose potential threats to the aquatic environment. Photocatalysis is a promising and efficient technique that can completely degrade pharmaceutical pollutants in water, enabling safe reuse of wastewater.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Khushboo, Nirjara Singhvi, Vipin Gupta, Namrata Dhaka, Kashyap Kumar Dubey
Summary: This study examined the presence of Streptomyces strains in a soil sample collected from an industrial area in Bahadurgarh, Haryana, India. Morphological analysis confirmed that the isolated strain belonged to the species Streptomyces, named Streptomyces sp. KD18. Genome sequencing of Streptomyces sp. KD18 was performed using the Illumina Nextseq500 platform, generating 65 contigs with a genome size of 7.2 Mb. The presence of 25 biosynthetic gene clusters, including the lipstatin BGC, was revealed by the AntiSMASH server. The strain KD18 was identified as S. toxytricini based on ANI values. LC-MS analysis confirmed the production of lipstatin. The genome sequence data has been deposited to NCBI under the accession number GCA_014748315.1.
Article
Chemistry, Analytical
Indu Jatain, Ravi Kumar, Kashyap Kumar Dubey, Karuna Yadav, Ram Gopal Nitharwal
Summary: Lipstatin or orlistat is widely used for obesity treatment as an irreversible inhibitor of intestinal lipase. Detection and estimation of lipstatin/orlistat can be done using sophisticated methods, but they are expensive and time-consuming. Here, we present a simple and cost-effective method based on thin-layer chromatography for the detection of lipstatin in Streptomyces toxytricini.
SEPARATION SCIENCE PLUS
(2023)
Article
Chemistry, Analytical
Karuna Yadav, Indu Jatain, Kashyap Kumar Dubey, Ram Gopal Nitharwal, Inderjeet Kaur
Summary: In this study, a thin-layer chromatography method was developed for the rapid detection of coenzyme Q(10) extracted from Agrobacterium tumefaciens. Methanol and ethyl acetate (8:2, v/v) were found to be the optimum mobile phase for thin-layer chromatography. The results were similar to those obtained from high-performance liquid chromatography, indicating that the developed method is simple and cost-effective for the commercial production of coenzyme Q(10).
SEPARATION SCIENCE PLUS
(2023)
Article
Biochemistry & Molecular Biology
Khushboo, Kashyap Kumar Dubey
Summary: Lipstatin, a natural inhibitor of pancreatic lipase, produced by Streptomyces toxytricini, has been used as an anti-obesity drug. Chemical mutagenesis using N-methyl-N '-nitro-N-nitrosoguanidine (NTG) was performed to improve the strain for higher lipstatin yield. The bioreactor study showed that the NTG mutation significantly increased the lipstatin production from 2.4 g/L to 5.35 g/L, but resulted in lower Dry Cell Weight (DCW) and noticeable morphological differences.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Environmental Sciences
Ankush Yadav, Eldon R. Rene, Manisha Sharma, Vinod Kumar, Mrinal Kanti Mandal, Kashyap Kumar Dubey
Summary: The review article aims to address the gaps in the literature regarding cancer incidence, antineoplastic drug consumption, environmental persistence, and toxicity assessment. It highlights the adverse effects of the presence of antineoplastic drugs in water bodies on the environment and human health. The review also emphasizes the importance of understanding the risk and difficulties associated with the emergence of anticancer medications.
CURRENT POLLUTION REPORTS
(2023)
Review
Pharmacology & Pharmacy
Mony Thakur, Yatin Khushboo, Yatin Kumar, Vinod Yadav, Avijit Pramanik, Kashyap Kumar Dubey
Summary: Pseudomonas aeruginosa has various virulence factors that contribute to host infection and persistence. These factors allow the bacteria to cause severe infections in immunocompromised individuals. P. aeruginosa is a nosocomial pathogen that is typically resistant to available antibiotics. Biofilm formation by P. aeruginosa is a major concern in hospitals and can lead to chronic infection and increased mortality risk. Therefore, it is crucial to develop new strategies to disrupt biofilm formation and improve antibiotic efficacy for the treatment of P. aeruginosa infections. Inhibition of quorum sensing and biofilm formation through pharmacological approaches, such as phytochemicals and essential oils, has shown promising results in laboratory studies. LasR, a regulatory protein, plays a key role in quorum sensing signaling, and designing an antagonist molecule that mimics the natural autoinducer could be the best approach for LasR inhibition. In this review, we discuss antibiotic resistance mechanisms and alternative approaches to combat the pathogenicity of P. aeruginosa.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Deepanshi Rajput, Anshu Baldia, Akshay Kumar, Vinod Kumar, Gunda Mohanakrishna, Kashyap Kumar Dubey
Summary: Nitrogen is crucial for life and food production, but the loss of unused nitrogen in wastewater, air, freshwater, and oceans has led to nitrogen pollution, impacting the environment and causing eutrophication, climate change, biodiversity loss, and ozone depletion. It also affects human health by causing cardio respiratory issues. Anthropogenic activities like food processing, fertilizer production, and mining have disrupted the global nitrogen cycle. Autotrophic ammonia-oxidizing microbial communities, such as AOA, AOB, and AnAOB, are widely used to remove nitrogen. New strategies, such as Anammox, Feammox, and Comammox, are being developed to reduce carbon footprint and improve nitrogen removal efficiency. This review explores the applications of autotrophic ammonia oxidizers in agriculture, wastewater treatment plants, and engineered ecosystems, as well as the stress impacts on these organisms.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Environmental
Deepti Agrawal, Kelvin Awani, Seyed Ali Nabavi, Venkatesh Balan, Mingjie Jin, Tejraj M. Aminabhavi, Kashyap Kumar Dubey, Vinod Kumar
Summary: This article discusses the importance of the fermentation industry as a sustainable solution for decarbonizing the chemical sector. It explores different types of fermentation processes and their impact on carbon release and decarbonization. The advantages of bio-based products over their fossil-based competitors, especially from an environmental perspective, are highlighted. Additionally, the benefits of biogenic CO2 from the fermentation industry and CO2 removal as a platform for carbon offsetting are covered.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Kashyap Kumar Dubey, Deepanshi Rajput, Anshu Baldia, Akshay Kumar, Vinod Kumar, Ankush Yadav, Shikha Rao, Yogendra Kumar Mishra
Summary: The direct discharge of human urine into the environment without recycling, despite its economic potential as a fertilizer, is a major concern. Train coaches contribute significantly to the generation of urine waste. Adopting a circular economy approach can lead to synergistic water usage after nutrient recovery from urine. Advanced decentralized treatment systems such as electrochemical, bioelectrical, or reverse osmosis are effective in treating and recovering nutrients from urine waste/wastewater. The sustainable removal of nutrients like N, P, and K from human urine presents a challenge, but the recovered nutrients can be reused as fertilizers and in biodiesel production through microalgae cultivation. The commercial potential of reusing urine waste remains unexplored, but artificial intelligence may soon offer sustainable approaches for urine separation and recycling.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2023)
Review
Materials Science, Multidisciplinary
Ritika Sharma, Shikha Jyoti Borah, Bhawna, Sanjeev Kumar, Akanksha Gupta, Vandana Kumari, Ravinder Kumar, Kashyap Kumar Dubey, Vinod Kumar
Summary: Diabetes mellitus is a disease characterized by blood sugar imbalance, and the mortality rates associated with diabetes are increasing daily in developed countries. Currently, there is no effective treatment and management options available, which highlights the urgent need for inexpensive nano-based antidiabetic therapeutics. Nanocarriers or nanomaterials, with their characteristics of enhanced bioavailability, specificity, absorption, and biocompatibility, are the preferred choice. This study focuses on the functionalization and therapeutic implications of nano-based drugs, exploring the synthesis of nanoparticles commonly used in diabetes therapy and their functionalization with organic or inorganic molecules, plant extracts, and other moieties. The study also demonstrates the therapeutic potential of these functionalized nanoparticles, including nano therapy, nano sensors for monitoring and detection of diabetes, and treatment of diabetic complications such as wound healing.
MATERIALS ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Karuna Yadav, Devender Arora, Indu Jatain, Kashyap Kumar Dubey, Namrata Dhaka, Inderjeet Kaur, Nidhi Adlakha
Summary: This study provides a comprehensive understanding of the biosynthetic pathway of CoQ(10) in A. tumefaciens, including the roles of key precursors and enzymes. Pathway inhibitors were found to decrease CoQ(10) production, while enhancers increased CoQ(10) production.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Environmental Sciences
Puja Bhattacharyya, Prathu Raja Parmar, Sanchari Basak, Kashyap Kumar Dubey, Soumyaditya Sutradhar, Dipankar Bandyopadhyay, Sandip Chakrabarti
Summary: The absence of efficient antibiotic removal processes in conventional waste water treatment methods has increased the threat of antibiotic contamination to humanity. We report the synthesis of coral-like Co@Co3O4/C nanohybrids for the remediation of three different classes of antibiotics. These nanohybrids exhibit attractive porous structure and superior magnetic responses, achieving a high removal efficiency of 99.98% for nalidixic acid within 120 minutes. The adsorbent also shows reusability for four cycles without significant change in removal efficiency, indicating its potential for wide range antibiotic removal and hassle-free magnetic separation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Shikha Jyoti Borah, Akanksha Gupta, Kashyap Kumar Dubey, Vinod Kumar
Summary: This study demonstrates the potential of spherical SnO2 nanoparticles as nano-adsorbents for the removal of toxic organic pollutants. The nanoparticles show high efficiency in removing anionic dyes from aqueous solutions, with electrostatic attraction and hydrogen bonding as the primary driving forces. Metal leaching is addressed through encapsulation of the nanoparticles in sodium alginate crosslinked by CaCl2.
MATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Shikha Jyoti Borah, Akanksha Gupta, Kashyap Kumar Dubey, Vinod Kumar
Summary: Nano-adsorbents are potential candidates for removing toxic organic pollutants, and spherical SnO2 nanoparticles synthesized through a hydrothermal method show high removal efficiency for anionic dyes. The adsorption process is mainly driven by electrostatic attraction and hydrogen bonding, and the presence of oxygen vacancies contributes to the high adsorption efficiency. The SnO2 nanoparticles can be encapsulated within sodium alginate to prevent metal leaching. Overall, this study demonstrates the potential of SnO2 NPs as a sustainable and economical nano-adsorbent for treating toxic effluents.
MATERIALS ADVANCES
(2023)
