期刊
SCIENTIFIC WORLD JOURNAL
卷 -, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/712303
关键词
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资金
- Fostering program of regionally specialized industries through Korea Institute for Advancement of Technology (KIAT)
- Jeju Institute for Regional Program Evaluation
- Ministry of Trade, Industry and Energy [2013-R0002288]
During our ongoing screening program designed to determine the anti-inflammatory potential of natural compounds, we isolated sargachromenol from Sargassum micracanthum. In the present study, we investigated the anti-inflammatory effects of sargachromenol on lipopolysaccharide (LPS)-induced inflammation in murine RAW 264.7 macrophage cells and the underlying mechanisms. Sargachromenol significantly inhibited the LPS-induced production of nitric oxide (NO) and prostaglandin E 2 (PGE 2) in a dose-dependent manner. It also significantly inhibited the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner in LPS-stimulated macrophage cells. Further analyses showed that sargachromenol decreased the cytoplasmic loss of inhibitor.kappa B alpha (I kappa B alpha) protein. These results suggest that sargachromenol may exert its anti-inflammatory effects on LPS-stimulated macrophage cells by inhibiting the activation of theNF-.. B signaling pathway. In conclusion, to our knowledge, this is the first study to show that sargachromenol isolated from S. micracanthum has an effective anti-inflammatory activity. Therefore, sargachromenol might be useful for cosmetic, food, or medical applications requiring antiinflammatory properties.
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