Article
Oncology
Long Bai, Ze-Yu Lin, Yun-Xin Lu, Qin Chen, Han Zhou, Qi Meng, Chun-Ping Lin, Wan-Lan Huang, Yun-Le Wan, Zhi-Zhong Pan, De-Shen Wang
Summary: The study demonstrates that serum LDH is a reliable and independent laboratory biomarker for predicting the clinical outcome of curative-intent surgery for CRLM. Combining LDH with the Fong score could be a potential stratification tool for CRLM resection.
Article
Multidisciplinary Sciences
Jose Jesus Blanco-Perez, Sara Blanco-Dorado, Javier Rodriguez-Garcia, M. Elena Gonzalez-Bello, Angel Salgado-Barreira, Adriana Carolina Caldera-Diaz, Abel Pallares-Sanmartin, Alberto Fernandez-Villar, Francisco Javier Gonzalez-Barcala
Summary: Silicosis is a lung disease caused by sustained inhalation of silica, leading to pulmonary fibrosis mediated by cytokines. This study aimed to determine the clinical significance of biomarkers in silicosis, assess their association with disease development and severity, and identify determinants of disease progression. The results indicated a potential role of IL-8 as a biomarker for silicosis presence and mortality prediction.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Valente Maldonado, Claudia Hernandez-Ramirez, Eniel Alonso Oliva-Perez, Cesar Omar Sanchez-Martinez, Jorge Fabian Pimentel-Gonzalez, Jose Raul Molina-Sanchez, Yeimmy Zuyenn Jimenez-Villalba, Jaime Chavez-Alderete, Marco A. Loza-Mejia
Summary: Pentoxifylline treatment was associated with an increase in lymphocyte count and a decrease in serum LDH levels among COVID-19 patients. Although there were some favorable trends, no significant differences were found in parameters such as days of hospitalization, mortality, and proportion of patients requiring intubation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michele Mannelli, Tania Gamberi, Francesca Magherini, Tania Fiaschi
Summary: This study demonstrates that cachexia induction in myotubes is associated with a metabolic shift towards fermentation, and inhibiting lactate formation can prevent cachexia. The findings suggest lactate dehydrogenase as a possible new tool for counteracting the onset of this pathology.
Article
Medicine, General & Internal
Murat Yilmaz, Beliz Oztok Tekten
Summary: This study aimed to determine the potential role of postictal serum LDH activities in differentiating epileptic seizures from non-epileptic seizures. The results showed significantly higher LDH activities in patients with epileptic seizures compared to those with non-epileptic seizures, suggesting the potential use of LDH activities as a diagnostic tool in distinguishing between seizure types.
Article
Oncology
Laurent Dercle, Samy Ammari, Elvire Roblin, Amelie Bigorgne, Stephane Champiat, Lokmane Taihi, Athena Plaian, Sophie Hans, Sara Lakiss, Lambros Tselikas, Mathieu Rouanne, Eric Deutsch, Lawrence H. Schwartz, Mithat Gonen, Jessica Flynn, Christophe Massard, Jean-Charles Soria, Caroline Robert, Aurelien Marabelle
Summary: Using machine learning algorithms and multivariate analyses, this study found that serum lactate dehydrogenase and liver metastases are key indicators for predicting the survival rate of patients receiving PD-(L)1 immunotherapies. For some patients, PD-(L)1 monotherapies are ineffective, and additional screening methods and treatment approaches are needed.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Jihyun Kim, Yong Won Kim, Tae-Youn Kim
Summary: This study aimed to assess the accuracy of serum lactate dehydrogenase (LDH) values at initial presentation in the emergency department (ED) in predicting clinical outcomes in patients with out-of-hospital cardiac arrest (OHCA). The results showed that patients with lower LDH levels had better outcomes in terms of sustained return of spontaneous circulation (ROSC) and survival to discharge. Therefore, serum LDH levels may serve as a predictive marker for clinical outcomes in OHCA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Fahad Dakilallah Aljohani, Amin Khattab, Hossein M. Elbadawy, Aisha Alhaddad, Ziab Alahmadey, Yaser Alahmadi, Heba M. Eltahir, Heba M. H. Matar, Hanaa Wanas
Summary: This study found that lymphopenia, prolonged aPTT, high INR, high D. dimer, and high CK are valuable predictors of disease severity in COVID-19 patients upon admission to hospital, helping determine the final outcome. It is recommended to conduct these tests on moderate to severe COVID-19 patients for improved case management and reduced mortality.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Chunxia Zhang, Zhouwei Zhan, Yunxiang Fang, Yuanyuan Ruan, Mingan Lin, Zhisen Dai, Yanping Zhang, Shanshan Yang, Shuxiang Xiao, Bijuan Chen
Summary: This study suggests that PNI and LDH could be valuable predictors of prognosis for non-metastatic NPC patients, and the combination of PNI and LDH can enhance prognostic accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Qiaowei Lin, Zhengwang Sun, Lin Yu, Qifeng Wang, Ping Zhu, Yihan Jiang, Yangbai Sun, Wangjun Yan
Summary: The study aimed to investigate the relationship between preoperative serum lactate dehydrogenase (LDH) and prognosis in undifferentiated pleomorphic sarcoma (UPS) patients. The findings showed that preoperative serum LDH was an independent factor for overall survival (OS) in UPS patients, and it was correlated with future surgical margin.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Xiaoyu Wei, Yumeng Chai, Zhouyue Li, Xuanyan Che, Yong Zhang, Zhongbao Zhou, Xiang Wang
Summary: This study conducted a meta-analysis and found that serum lactate dehydrogenase (LDH) level is significantly associated with the prognosis of bladder cancer (BC) patients. High levels of serum LDH are associated with inferior overall survival (OS) in BC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wanyong Jin, Mo Zhu, Yang Zheng, Yuanyuan Wu, Xu Ding, Heming Wu, Jinhai Ye, Yunong Wu, Zaiou Zhu, Xiaomeng Song
Summary: A nomogram based on PNI, LDH, GLO, and NA was developed to predict the risk of neck occult metastasis in early OSCC patients. It demonstrated good predictive ability in both the training and validation cohorts.
Article
Chemistry, Analytical
Justyna Glowacka, Agnieszka Wisniewska, Robert Koncki, Kamil Strzelak
Summary: In this study, two modifications of the routine LDH activity assay based on the use of reducing properties of NADH were compared. A fully-mechanized MCFA-PEDD system was developed for accurate measurement of LDH activity in serum samples. The linear ranges obtained for Fe-ferrozine and NBT methods were 6.0-200.0 U L-1 and 10.0-250.0 U L-1 with estimated detection limits at 0.2 U L-1 and 4.5 U L-1, respectively. The Fe-ferrozine method showed higher selectivity for LDH activity in the presence of glucose, ascorbic acid, albumin, bilirubin, copper and calcium ions.
Article
Medicine, General & Internal
Shu-Hsien Hsu, Po-Hsuan Kao, Tsung-Chien Lu, Chih-Hung Wang, Cheng-Chung Fang, Wei-Tien Chang, Chien-Hua Huang, Chu-Lin Tsai
Summary: This study aimed to evaluate the role of serum lactate in predicting in-hospital cardiac arrest in the emergency department. The study found that elevated lactate levels and poor lactate clearance were strongly associated with a higher risk of in-hospital cardiac arrest in the emergency department.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Ashekul Islam, Dhiman Chowdhury, Pulak Kanti Palit, Md Sohel, Md. Mozibullah, Mohammod Johirul Islam, Abdullah Al Mamun, Joyonti Datta, Annanya Dev, Pradip Kumar Nath, Md Faisal Fahad Chowdhury, Sabuj Kanti Nath, Abu Syed Mohammed Mujib
Summary: This study investigated the correlation between serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) levels and the severity of acute organophosphorus compound (OPC) poisoning. The results showed that serum CPK level strongly correlated with the degree of OPC poisoning and could be used as a predictor for clinical intervention approaches.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)