Article
Psychiatry
Adam Wysokinski, Elzbieta Kozlowska, Ewa Szczepocka, Anna Lucka, Justyna Agier, Ewa Brzezinska-Blaszczyk, Katarzyna Sobierajska
Summary: Schizophrenia patients exhibit a distinctive mRNA expression profile of dopamine and serotonin receptors in peripheral blood mononuclear cells. This expression is minimally affected by antipsychotic treatment, suggesting it may serve as a useful diagnostic biomarker for schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Gal Warhaftig, Chaya Mushka Sokolik, Khen Khermesh, Yehuda Lichtenstein, Michal Barak, Tzofnat Bareli, Erez Y. Levanon, Gal Yadid
Summary: The study found changes in the RNA editing machinery in the central amygdala associated with PTSD, and deamination of the 5-HT2C serotonin receptor may help alleviate PTSD-like behaviors. This research provides a new avenue for understanding PTSD regulation.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Dmitrii S. Traktirov, Ilya R. Nazarov, Valeria S. Artemova, Raul R. Gainetdinov, Nina S. Pestereva, Marina N. Karpenko
Summary: This article explores the roles of dopamine and serotonin in the central nervous system and the impact of knockout of the DAT gene on neurotransmission. The study reveals that excessive dopamine leads to dysregulation of neurotransmission in multiple brain regions and significant effects on the serotonin system. These findings highlight the importance of considering these factors in drug therapies.
Article
Biochemistry & Molecular Biology
Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschytz
Summary: There is growing interest in the therapeutic potential of psilocybin. This study examined the role of different serotonergic receptors and TAAR1 in modulating the head twitch response induced by 5-HTP and psilocybin in mice. The findings suggest that compounds that modulate psychedelic-induced head twitch response may have important therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Julian B. Wilson, Ma'ayan Epstein, Briana Lopez, Amira K. Brown, Kabirullah Lutfy, Theodore C. Friedman
Summary: Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues, with high co-occurrence rates. This review explores how T2DM and depression interact through shared molecular pathways, affecting brain structure, function, and reward. Treating the symptoms of T2DM without addressing these underlying pathways may not be effective, and targeting immune system, stress circuit, melatonin, and other alterations could offer more promising approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Henry K. Karlsson, Lauri Tuominen, Semi Helin, Paulina Salminen, Pirjo Nuutila, Lauri Nummenmaa
Summary: Bariatric surgery is the most effective method for treating morbid obesity, with significant individual variability in postoperative weight outcomes. Brain receptor systems such as MOR may play a key role in predicting weight development post-surgery, offering new potential for treatment possibilities.
Article
Pharmacology & Pharmacy
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong
Summary: This study found that activation of AMPA receptors in the lateral habenula can reduce anxiety-like behaviors and increase dopamine and serotonin levels in the basolateral amygdala. Conversely, blocking AMPA receptors in the LHb may induce anxiety-like effects and decrease dopamine and serotonin levels in the BLA.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nina K. Popova, Anton S. Tsybko, Vladimir S. Naumenko
Summary: This article reviews the neurobiological links between aggression, depression, and suicidal behavior, focusing on the involvement of different types of 5-HT receptors. It provides evidence that specific 5-HT receptors are associated with depression-related and aggression-related behaviors, and highlights the potential of targeting these receptors for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Heloisa H. Vilela-Costa, Jhonatan Christian Maraschin, Plinio C. Casarotto, Ana Beatriz Sant'Ana, Valquiria C. de Bortoli, Maria Adrielle Vicente, Alline Cristina Campos, Francisco S. Guimaraes, Helio Zangrossi Jr
Summary: Antidepressant drugs are effective in treating panic disorder, with facilitation of 5-HT1A receptors in the dPAG implicated in panic relief. The panicolytic effect caused by chronic administration of ADs may be related to 5-HT1A receptor-mediated neurotransmission, while the anxiogenic effect of short-term treatment with these drugs may not depend on 5-HT2C receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Rina Kwag, Jieon Lee, Doyoung Kim, Haeun Lee, Miyoung Yeom, Jiwan Woo, Yakdol Cho, Hak Joong Kim, Jeongjin Kim, Gyochang Keum, Byungsun Jeon, Hyunah Choo
Summary: By designing and synthesizing a series of compounds and evaluating their activities and selectivities, it was found that one compound showed good binding affinity and selectivity for 5-HT7R, exhibiting a G protein-biased antagonistic effect. The compound demonstrated inhibitory effects on self-grooming behavior in transgenic mice, indicating that 5-HT7R may be a potential therapeutic target for treating stereotypical behaviors in autism spectrum disorder.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Fei Huang, Xiaojun Wu
Summary: Researches show that gut microbiota play a crucial role in neurotransmitter modulation in the brain, which is closely related to the pathophysiology of anxiety and depression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Behavioral Sciences
Rhayra Xavier do Carmo Silva, Bianca Gomes do Nascimento, Gabriela Cristini Vidal Gomes, Nadyme Assad Holanda da Silva, Jessica Souza Pinheiro, Suianny Nayara da Silva Chaves, Ana Flavia Nogueira Pimentel, Bruna Patricia Dutra Costa, Anderson Manoel Herculano, Monica Lima-Maximino, Caio Maximino
Summary: The role of serotonin (5-HT) receptors in vertebrates in response to aversive stimuli remains unclear due to the existence of multiple specific receptors. Different aversive stimuli elicit responses at various threat levels, such as exploration, defensive behaviors, and freezing reactions. Exposure of adult zebrafish to a conspecific alarm substance showed that agnostic and antagonist of the 5-HT2C receptor had different effects on responses to different levels of threat.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Huma Ikram, Shehnaz Abdul Sheikh, Darakhshan Jabeen Haleem, Mario Ganau, Adnan Maqsood Choudhry
Summary: Diabetic patients have a higher risk of depression, and pioglitazone, a drug commonly used to treat diabetes, may have antidepressant effects but also exhibit anxiogenic and sedative effects in animal studies. Furthermore, pioglitazone may alter neurotransmitter metabolism, potentially leading to increased sensitivity to CNS depressants in diabetic patients.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)