Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Matthew R. Woeste, Rejeena Shrestha, Anne E. Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A. Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M. McMasters, Robert C. G. Martin, Jun Yan
Summary: This study investigates the combination therapy of IRE and beta-glucan in the treatment of pancreatic cancer, and finds that this combination can enhance immune response, reduce tumor burden, and prolong survival in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Szymczak, Margery G. H. Pelletier, James M. Mackay, DeAnne Reid, Peter C. W. Gaines
Summary: Neutrophils are important regulators of innate immunity, and a small molecule antagonist called RIST4721 can effectively inhibit their chemotaxis in ex vivo-cultured mouse bone marrow cells stimulated by KC. RIST4721-treated neutrophils exhibited enhanced phagocytosis and reactive oxygen species production, confirming the specificity of the drug. These findings suggest that RIST4721 could be a potential treatment for various inflammatory conditions mediated by neutrophils.
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Clinical Neurology
Che-Feng Chang, Brittany A. Goods, Michael H. Askenase, Hannah E. Beatty, Artem Osherov, Jonathan H. DeLong, Matthew D. Hammond, Jordan Massey, Margaret Landreneau, J. Christopher Love, Lauren H. Sansing
Summary: Our study shows that microglia and MDMs have distinct functional properties in the brain after ICH, with MDMs exhibiting higher phagocytic activity, erythrophagocytosis, and antigen-presenting capabilities compared to microglia. This suggests that the different origins of microglia and MDMs lead to divergent responses and functions in the inflamed brain following ICH.
Article
Oncology
Yan Wang, Haiqing Ni, Shuaixiang Zhou, Kaijie He, Yarong Gao, Weiwei Wu, Min Wu, Zhihai Wu, Xuan Qiu, Ying Zhou, Bingliang Chen, Donghui Pan, Chenrong Huang, Mingzhu Li, Yicong Bian, Min Yang, Liyan Miao, Junjian Liu
Summary: The newly designed CD47/PD-L1 bispecific antibody, IBI322, effectively inhibits CD47-SIRP alpha signal, promotes tumor cell phagocytosis, accumulates in PD-L1-positive tumors, shows synergistic therapeutic effects, and has minimal impact on red blood cells, making it a promising option for cancer treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
Shir Eliachar, Grace Ann Snyder, Shany Klara Barkan, Shani Talice, Aner Otolenghi, Adrian Jaimes-Becerra, Ton Sharoni, Eliya Sultan, Uzi Hadad, Oren Levy, Yehu Moran, Orly Gershoni-Yahalom, Nikki Traylor-Knowles, Benyamin Rosental
Summary: Climate change-induced heat stress leads to increased coral bleaching events. This study explored the immune response during heat stress using two sea anemone models. The results showed enhanced immune cell activity during heat stress, which was not influenced by the presence of algal symbionts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Tariq A. Bhat, Suresh G. Kalathil, Maciej L. Goniewicz, Alan Hutson, Yasmin Thanavala
Summary: Inhaling CBD vapor leads to more severe inflammatory response, lung damage, oxidative stress, and cytotoxicity compared to nicotine vapor.
Article
Cell Biology
Melissa Parny, Jose Bernad, Melissa Prat, Marie Salon, Agnes Aubouy, Elsa Bonnafe, Agnes Coste, Bernard Pipy, Michel Treilhou
Summary: Ziram affects macrophage functions and polarization, increasing phagocytosis and inducing oxidative stress which leads to the expression of antioxidant genes. Ziram modulates macrophages to M2-like anti-inflammatory phenotype through zinc, potentially associated with various diseases.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Fisheries
Chen-Yang Lin, Wen-Bin Xu, Bang-Ze Li, Miao-An Shu, Yan-Mei Zhang
Summary: A homolog of cPLA2, PccPLA2, was identified and characterized in red swamp crayfish and was found to play a role in both cellular and humoral immune responses, influencing the expression of antimicrobial peptides and the phagocytic ability of cells.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
David S. Phelps, Vernon M. Chinchilli, Xuesheng Zhang, Debra Shearer, Judith Weisz, Joanna Floros
Summary: The study investigated the molecular phenotypes of alveolar macrophages using the toponome imaging system and observed changes in phenotype in SP-A knockout mice following infection. The results showed a decrease in infection-specific phenotypes in KO mice, potentially contributing to their susceptibility to infection; however, there were more unique phenotypes in both KO groups compared to the corresponding WT groups, indicating a vigorous effort to compensate for deficits caused by the absence of SP-A. Shared phenotypes across groups suggest that certain phenotypes are regulated independently of infection or the presence of SP-A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Naomi L. P. Keehnen, Lisa Fors, Peter Jarver, Anna-Lena Spetz, Soren Nylin, Ulrich Theopold, Christopher W. Wheat
Summary: Insects rely on their innate immune system to interact with their microbiota, with populations of butterflies found to differ in phagocytic capability and genetic variation related to phagocytosis. Enrichment analysis identified genes involved in glutamine metabolism as potentially underlying these phenotypic differences.
Review
Chemistry, Applied
Darshan M. Sivaloganathan, Mark P. Brynildsen
Summary: The interactions between phagosomes and bacteria play a crucial role in infection outcomes and are potential targets for next-generation antibiotics. Understanding these interactions can be achieved through top down or bottom up approaches, which can increase knowledge for developing effective therapies. Interdisciplinary collaboration between immunology, microbiology, and engineering can enhance understanding in this area.
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 12, 2021
(2021)
Article
Biochemistry & Molecular Biology
Lucy Hezinger, Sarah Bauer, Kornelia Ellwanger, Alban Piotrowsky, Felix Biber, Sascha Venturelli, Thomas A. Kufer
Summary: The study found that the human NOD-like receptor protein NOD1 is involved in cell migration and chemotaxis in cervical cancer cells by regulating cofilin phosphorylation status. Additionally, HAX-1 was identified as a new interacting protein of NOD1, and both proteins act in the same signaling pathway.
Editorial Material
Oncology
Carlotta Costa, Ana Bosch
CLINICAL CANCER RESEARCH
(2018)
Article
Multidisciplinary Sciences
Konstantinos V. Floros, Timothy L. Lochmann, Bin Hu, Carles Monterrubio, Mark T. Hughes, Jason D. Wells, Cristina Bernado Morales, Maninderjit S. Ghotra, Carlotta Costa, Andrew J. Souers, Sosipatros A. Boikos, Joel D. Leverson, Ming Tan, Violeta Serra, Jennifer E. Koblinski, Joaquin Arribas, Aleix Prat, Laia Pare, Todd W. Miller, Mikhail G. Dozmorov, Hisashi Harada, Brad E. Windle, Maurizio Scaltriti, Anthony C. Faber
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Neurosciences
Mara Brancaccio, Flora Pirozzi, Emilio Hirsch, Alessandra Ghigo
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Oncology
Carlotta Costa, Ye Wang, Amy Ly, Yasuyuki Hosono, Ellen Murchie, Charlotte S. Walmsley, Tiffany Huynh, Christopher Healy, Rachel Peterson, Shogo Yanase, Charles T. Jakubik, Laura E. Henderson, Leah J. Damon, Daria Timonina, Ioannis Sanidas, Christopher J. Pinto, Mari Mino-Kenudson, James R. Stone, Nicholas J. Dyson, Leif W. Ellisen, Aditya Bardia, Hiromichi Ebi, Cyril H. Benes, Jeffrey A. Engelman, Dejan Juric
Article
Multidisciplinary Sciences
Braulio Henrique Freire Lima, Pedro Elias Marques, Lindisley Ferreira Gomides, Matheus Silverio Mattos, Lucas Kraemer, Celso M. Queiroz-Junior, Mark Lennon, Emilio Hirsch, Remo Castro Russo, Gustavo Batista Menezes, Edith M. Hessel, Augustin Amour, Mauro Martins Teixeira
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Summary: The study unveiled a new immune modulatory function of SHP2, with inhibition promoting anti-tumor immunity by enhancing T cell cytotoxicity and immune-mediated tumor regression. Additionally, SHP2 inhibition improved responses to anti-PD-1 blockade, suggesting its potential as a promising strategy for cancer immunotherapy.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Biology
Paulin Brosinsky, Julia Bornbaum, Bjorn Warga, Lisa Schulz, Klaus-Dieter Schluter, Alessandra Ghigo, Emilio Hirsch, Rainer Schulz, Gerhild Euler, Jacqueline Heger
Summary: The study demonstrates the involvement of PI3K and ALK5/SMAD pathways in TGF beta(1)-induced cardiomyocyte apoptosis and impaired function, with a partial dependence on PI3K gamma.
Review
Biochemistry & Molecular Biology
Jean Piero Margaria, Lucia Moretta, Jose Carlos Alves-Filho, Emilio Hirsch
Summary: This article summarizes the progress in understanding the role of PI3K/Akt in the development of lung fibrosis and its causative pathological context, including sepsis as well as acute lung injury (ALI) and its consequent acute respiratory distress syndrome (ARDS). Current knowledge about PI3K inhibitors for pulmonary fibrosis treatment, including drugs under development as well as in clinical trials, is further summarized. The discussion also includes how the design of inhaled compounds targeting the PI3K pathways might potentiate efficacy and improve tolerability.
Editorial Material
Cardiac & Cardiovascular Systems
Carlo G. Tocchetti, Alessandra Ghigo, Emilio Hirsch
Summary: This editorial discusses the study conducted by Lu et al. on the protective effect of circular RNA derived from the insulin receptor locus against doxorubicin-induced cardiotoxicity.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Oncology
Emilio Hirsch
JACC: CARDIOONCOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Jean Piero Margaria, Edoardo Ratto, Luca Gozzelino, Huayi Li, Emilio Hirsch
Article
Oncology
Anahita Dastur, Ahyun Choi, Carlotta Costa, Xunqin Yin, August Williams, Joseph McClanaghan, Max Greenberg, Justine Roderick, Neha U. Patel, Jessica Boisvert, Ultan McDermott, Mathew J. Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A. Engelman, Michelle Kelliher, Anthony C. Faber, Cyril H. Benes
CLINICAL CANCER RESEARCH
(2019)
Review
Cardiac & Cardiovascular Systems
Matthew Movsesian, Faiyaz Ahmad, Emilio Hirsch
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2018)
Article
Oncology
Timothy L. Lochmann, Konstantinos V. Floros, Mitra Naseri, Krista M. Powell, Wade Cook, Ryan J. March, Giovanna T. Stein, Patricia Greninger, Yuki Kato Maves, Laura R. Saunders, Scott J. Dylla, Carlotta Costa, Sosipatros A. Boikos, Joel D. Leverson, Andrew J. Souers, Geoffrey W. Krystal, Hisashi Harada, Cyril H. Benes, Anthony C. Faber
CLINICAL CANCER RESEARCH
(2018)
