Review
Cell Biology
Theodoros Rizopoulos, Martha Assimakopoulou
Summary: TRPs play a crucial role in the pathogenesis of colorectal cancer and could serve as potential therapeutic targets and prognostic biomarkers.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhenghao Zhang, Xuan Sun, Yinghao Ding, Xiangyang Zhang, Yiming Zhang, Tianxiao Zhang, Jie Li, Ling Wang, Zhimou Yang, Zhi-Wen Hu
Summary: A self-assembling peptide N-pGE11 can mobilize extracellular Ca2+ reservoir for Ca2+ overload therapy by promoting the formation of EGFR-specific nanofibers and indirectly stimulating TRP channels, effectively inhibiting tumor growth and enhancing therapeutic efficacy through extracellular Ca2+ calcification.
Article
Agriculture, Dairy & Animal Science
Karina Lezama-Garcia, Daniel Mota-Rojas, Alfredo M. F. Pereira, Julio Martinez-Burnes, Marcelo Ghezzi, Adriana Dominguez, Jocelyn Gomez, Ana de Mira Geraldo, Pamela Lendez, Ismael Hernandez-Avalos, Isabel Falcon, Adriana Olmos-Hernandez, Dehua Wang
Summary: This review discusses recent discoveries about transient receptor potential and their role in thermoregulatory mechanisms of animals, emphasizing the importance of understanding how these receptors are activated and the pathways they use to recognize specific thermal sensations. Ongoing research aims to develop therapeutic approaches targeting these receptors to improve non-human animals' quality of life. The review presents and analyzes findings on TRP structure, physiology, and neurotransmission in thermoregulation, highlighting the need for further studies to advance our understanding of these mechanisms and control thermoregulatory disorders.
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Joris Vriens, Katrien De Clercq
Summary: Calcium ions play a critical role in cell function, with transient receptor potential (TRP) channels serving as a type of ion channel that can convey various stimuli and potentially participate in cellular responses to changing environments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Felix Yang, Andy Sivils, Victoria Cegielski, Som Singh, Xiang-Ping Chu
Summary: Pharmacomodulation of membrane channels is a crucial field in understanding physiological conditions and diseases. Transient receptor potential (TRP) channels, especially TRPM, TRPV, and TRPC, have been shown to mediate pain sensation, neuropsychiatric disorders, and epilepsy, providing potential therapeutic targets. This review emphasizes the importance of these TRP channels and their potential for future clinical treatments, giving patients hope for improved care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Joris Vriens
Summary: EMT is a tightly regulated process essential for normal development but can also lead to fibrosis and cancer progression. Calcium is a key player in translating molecular messages during EMT, and calcium-permeable ion channels play a significant role in influencing cellular phenotype. TRP channels, as cellular sensors, are important proteins involved in decoding physical and chemical stimuli, making them ideal candidates to study in the context of phenotypic transitions like EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Christine Haewon Park, Jinsung Kim, Jung Eun Lee, Misun Kwak, Insuk So
Summary: This study focuses on the pore region of TRPC1 and TRPC4 as a determinant of the characteristics of a heteromeric TRPC1/4 channel. Mutants and chimeras were used to investigate the effects of changes in the pore region on calcium permeability and current-voltage curve.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dae Ki Hong, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Bo Young Choi, Sang Won Suh
Summary: Maintaining the correct ionic gradient is crucial for cellular homeostasis, and the TRP channel family and zinc play important roles in brain disease. Dysregulation of ionic gradients in diseases like ischemic stroke and traumatic brain injury leads to excessive release of zinc, causing cell damage. Regulating zinc homeostasis and blocking zinc translocation via TRP channels can protect against brain damage. These findings suggest that targeting zinc and TRP channels could be a potential strategy for treating brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jianxiong Jiang, Ying Yu
Summary: Epilepsy is a prevalent and disabling brain disorder characterized by spontaneous seizures. The current medications for epilepsy are not effective for over 30% of patients and have significant adverse effects. Identifying novel drug targets, such as TRP channels, can lead to new therapies for epilepsy.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Dermatology
Kieran B. Garbutcheon-Singh, Saxon D. Smith
Summary: With the recent interest in medical marijuana, research into cannabinoids is regaining wider attention. Cannabinoids are known to modulate cutaneous inflammation, pain, and itch by acting on different receptors. Rosacea may be associated with transient receptor potential ion channels, and cannabinoids may play a potential role in treating rosacea by affecting these pathways.
DERMATOLOGIC THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Gang-Fan Zong, Rui Deng, Su-Yun Yu, Ai-Yun Wang, Zhong-Hong Wei, Yang Zhao, Yin Lu
Summary: This paper summarizes the existing literature on the changes in thermo-TRP protein expression that are associated with the incidence and progression of gastric cancer (GC). The elucidation of the mechanisms underlying the response of thermo-TRPs to physiological stimuli or drugs is crucial for advancements in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Tao Pan, Yueying Gao, Gang Xu, Ping Zhou, Si Li, Jing Guo, Haozhe Zou, Qi Xu, Xiaoyan Huang, Juan Xu, Yongsheng Li
Summary: The study comprehensively characterized the genetic and transcriptomic alterations of TRP genes in cancer, revealing the association between these alterations and cancer development and prognosis. It provided a valuable resource for analyzing cancer-related pathways and developing targeted therapies.
NPJ GENOMIC MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Hannah Yang, Luana Tenorio Lopes, Nicole O. Barioni, Jamie Roeske, Anthony Incognito, Jacquie Baker, Satish R. Raj, Richard J. A. Wilson
Summary: The autonomic nervous system plays a crucial role in maintaining homeostasis of various organ systems, including the cardiovascular system. Mechanosensors within the body are important for blood pressure regulation, but their precise molecular identity is still unclear. Understanding these mechanosensors is essential for the development of therapies for conditions involving impaired baroreflex function.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Katrien De Clercq, Vicente Perez-Garcia, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens
Summary: TRP channels play important roles in ion homeostasis by controlling cation influx. Specific TRP channels are highly expressed in trophoblasts and may be involved in regulating placental development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Danila Bobkov, Svetlana Semenova
Summary: This review examines the role of lipid rafts in regulating TRP channel activity, with a focus on the interaction between the channels and cholesterol. Understanding the mechanisms behind these interactions would enhance our understanding of TRP channel regulation and allow for better control of cellular responses to environmental stimuli.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Rene P. Schellart, Sandra E. Zwolsman, Jean-Philippe Lucot, Dirk J. M. K. de Ridder, Marcel G. W. Dijkgraaf, Jan-Paul W. R. Roovers
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2018)
Review
Oncology
Thomas Gevaert, Rodolfo Montironi, Antonio Lopez-Beltran, Geert Van Leenders, Yves Allory, Dirk De Ridder, Frank Claessens, Mark Kockx, Murat Akand, Steven Joniau, George Netto, Louis Libbrecht
SEMINARS IN CANCER BIOLOGY
(2018)
Article
Biochemical Research Methods
Ehsan Motazedi, Dick de Ridder, Richard Finkers, Samantha Baldwin, Susan Thomson, Katrina Monaghan, Chris Maliepaard
Review
Urology & Nephrology
Manuela Tutolo, Enrico Ammirati, John Heesakkers, Thomas M. Kessler, Kenneth M. Peters, Tina Rashid, Karl-Dietrich Sievert, Michele Spinelli, Giacomo Novara, Frank Van der Aa, Dirk De Ridder
Editorial Material
Urology & Nephrology
Frank Van der Aa, Dirk De Ridder
Article
Cell Biology
Clara Steiner, Thomas Gevaert, Roman Ganzer, Dirk De Ridder, Jochen Neuhaus
HISTOCHEMISTRY AND CELL BIOLOGY
(2018)
Article
Urology & Nephrology
Emmanuel Weyne, Johanna L. Hannan, Thomas Gevaert, Mohammad Ayodhia Soebadi, Hotaka Matsui, Fabio Castiglione, Koenraad van Renterghem, Dirk De Ridder, Frank Van der Aa, Trinity J. Bivalacqua, Maarten Albersen
JOURNAL OF SEXUAL MEDICINE
(2018)
Article
Urology & Nephrology
Emmanuel Weyne, Karel Dewulf, Yves Deruyer, Roma Rietjens, Wouter Everaerts, Trinity J. Bivalacqua, Dirk De Ridder, Frank Van der Aa, Maarten Albersen
NEUROUROLOGY AND URODYNAMICS
(2018)
Article
Urology & Nephrology
Haixia Ye, Francois Haab, Dirk de Bidder, Philippe Chauveau, Armin Becker, Pedro Arano, Olivier Haillot, Hakim Fassi-Fehri
Article
Oncology
Valerie Fonteyne, Elke Rammant, Piet Ost, Yolande Lievens, Bart De Troyer, Sylvie Rottey, Gert De Meerleer, Daan De Maeseneer, Dirk De Ridder, Karel Decaestecker
CLINICAL GENITOURINARY CANCER
(2018)
Editorial Material
Urology & Nephrology
Paul Abrams, Karl-Erik Andersson, Apostolos Apostolidis, Lori Birder, Donna Bliss, Linda Brubaker, Linda Cardozo, David Castro-Diaz, P. R. O'Connell, Alan Cottenden, Nikki Cotterill, Dirk de Ridder, Roger Dmochowski, Chantal Dumoulin, Mandy Fader, Christopher Fry, Howard Goldman, Philip Hanno, Yukio Homma, Vik Khullar, Chris Maher, Ian Milsom, Diane Newman, Rien J. M. Nijman, Kevin Rademakers, Dudley Robinson, Peter Rosier, Eric Rovner, Stefano Salvatore, Masayuki Takeda, Adrian Wagg, Todd Wagner, Alan Wein
NEUROUROLOGY AND URODYNAMICS
(2018)
Article
Multidisciplinary Sciences
Thomas Gevaert, Yves-Remi Van Eycke, Thomas Vanden Broeck, Hein Van Poppel, Isabelle Salmon, Sandrine Rorive, Frank Claessens, Dirk De Ridder, Christine Decaestecker, Steven Joniau
SCIENTIFIC REPORTS
(2018)
Article
Medicine, General & Internal
Fabio Castiglione, Petter Hedlund, Emanuel Weyne, Lukman Hakim, Francesco Montorsi, Trinity J. Bivalacqua, Dirk De Ridder, Uros Milenkovic, David Ralph, Giulio Garaffa, Asif Muneer, Steven Joniau
Article
Urology & Nephrology
Fabio Castiglione, Petter Hedlund, Emmanuel Weyne, Lukman Hakim, Francesco Montorsi, Andrea Salonia, Trinity J. Bivalacqua, Dirk De Ridder, Uros Milenkovic, David Ralph, Giulio Garaffa, Asif Muneer, Steven Joniau, Maarten Albersen
Review
Urology & Nephrology
Mauro Gacci, Arcangelo Sebastianelli, Pietro Spatafora, Giovanni Corona, Sergio Serni, Dirk De Ridder, Stavros Gravas, Paul Abrams
THERAPEUTIC ADVANCES IN UROLOGY
(2018)
