Article
Clinical Neurology
Xin Liu, Gehang Ju, Xinyi Huang, Wenyu Yang, Lulu Chen, Chao Li, Qingfeng He, Nuo Xu, Xiao Zhu, Dongsheng Ouyang
Summary: This study aimed to develop a popPK model characterizing the disposition of SCIT in the Chinese population and proposed remedial strategies for non-adherence scenarios. Significant covariates impacting SCIT exposure were identified, and recommendations for dosage adjustments in different scenarios were provided based on CYP2C19 phenotypes. The study highlighted the importance of personalized medication based on patient characteristics and the utilization of popPK repository for precision dosing.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Pharmacology & Pharmacy
Shujing Liu, Tao Xiao, Shanqing Huang, Xiaolin Li, Wan Kong, Ye Yang, Zi Zhang, Xiaojia Ni, Haoyang Lu, Ming Zhang, Dewei Shang, Yuguan Wen
Summary: This study aimed to establish a population pharmacokinetic model of escitalopram in Chinese psychiatric patients, identify factors influencing drug exposure, and compare the results with the therapeutic reference range through simulation. The study revealed the impact of age and CYP2C19 genotype on drug clearance. The findings suggest the need for cautious dosing regimens, especially for older patients who are poor metabolizers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Hristo Y. Ivanov, Denitsa Grigorova, Volker M. Lauschke, Branimir Velinov, Kaloyan Stoychev, Gergana Kyosovska, Peter Shopov
Summary: CYP2D6 and CYP2C19 are important enzymes that affect the pharmacokinetics of commonly used psychiatric medications. Variations in these genes can impact the safety and efficacy of treatment. In Bulgaria, a high prevalence of genetic variability in these enzymes was found among psychiatric patients, which has significant implications for precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Kine Eide Kvitne, Veronica Krogstad, Christine Wegler, Line Kristin Johnson, Marianne K. Kringen, Markus Herberg Hovd, Jens K. Hertel, Maria Heijer, Rune Sandbu, Eva Skovlund, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Joran Hjelmesaeth, Anders Asberg, Rasmus Jansson-Lofmark, Hege Christensen, Ida Robertsen
Summary: The study suggests that CYP2C19 activity is lower in obese patients and increases after weight loss, which may have implications for drug dosing. No clinically significant effect on CYP1A2 and CYP2C9 activities was observed.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
SiChan Li, SanLan Wu, WeiJing Gong, Peng Cao, Xin Chen, Wanyu Liu, Liping Xiang, Yang Wang, JianGeng Huang
Summary: The joint population pharmacokinetic model of voriconazole and its metabolite was established in immunocompromised patients. The study found that pharmacokinetics of voriconazole was influenced by CYP2C19 genetic variations and recommended dosage regimens might need adjustment for different CYP2C19 genotypes. The proposed maintenance dose regimens could improve clinical outcomes and minimize drug-related toxicities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Meng Fu, Lin Luo, Sheng Feng, Hongda Lin, Zekun Lu, Fei Gu, Yang Fan, Bing Wu, Jianying Huang, Kai Shen
Summary: This study evaluated the effects of SHR0302 on the pharmacokinetics of cytochrome P450 (CYP) probe substrates. The results demonstrated that co-administration of SHR0302 did not have a clinically meaningful effect on the exposure of drugs metabolized by CYP3A4, CYP2C8, CYP2C9 and CYP2C19 in healthy subjects.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying C. Ou, Zhiyu Tang, William Novotny, Manal Tawashi, Ta-Kai Li, Hugh A. Coleman, Srikumar Sahasranaman
Summary: Zanubrutinib at a total daily dose of 320 mg had minimal or no effect on the activity of CYP2C9, BCRP, and P-gp, but decreased the systemic exposure of CYP3A and CYP2C19 substrates with mean reduction less than 50%.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, Jose A. G. Agundez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, Andrea Gaedigk
Summary: This article introduces the star (*) allele nomenclature for the polymorphic human CYP2C19 gene catalogued by PharmVar, and highlights the impact of CYP2C19 genetic variation on drug metabolism, as well as how haplotype information compiled by PharmVar is utilized by CPIC.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, Jose A. G. Agundez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, Andrea Gaedigk
Summary: Genetic variation in the CYP2C19 gene impacts the metabolism of many drugs and is associated with efficacy and safety issues for several commonly prescribed medications. The PharmVar catalogued haplotype information is utilized by the Pharmacogenomics Knowledgebase and CPIC.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Julia Carolin Stingl, Jason Radermacher, Justyna Wozniak, Roberto Viviani
Summary: Pharmacogenetic variability in drug metabolism can affect patient vulnerability to side effects and therapeutic failure. This study introduces a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in pharmacogenetic subgroups. The methodology addresses the challenges of sparse data, incomplete information on phenotypic groups, and heterogeneity of study design. The results demonstrate the effectiveness of the modeling approach in predicting dose adjustments and considering uncertainty.
Article
Pharmacology & Pharmacy
Junichi Nakagawa, Takahiko Kinjo, Naoya Aiuchi, Kayo Ueno, Hirofumi Tomita, Takenori Niioka
Summary: This study examined the impact of gene polymorphisms on the plasma concentration of apixaban. The results showed that decreased creatinine clearance and the PXR*1B/*1B haplotype were associated with increased plasma concentration of apixaban, while the presence of the POR*28 allele was associated with decreased plasma concentration of apixaban.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lin Zhang, Hongbin Sun, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yong-guo Li, Yang He, Eric Y. Zhang, Xiaoyu Yan
Summary: This study developed a semi-mechanistic population pharmacokinetic model to characterize the pharmacokinetic profile of M15-2, the active metabolite of vicagrel and clopidogrel. It was found that the bioactivation of vicagrel is more efficient and less dependent on CYP2C19 than that of clopidogrel, suggesting that vicagrel may reduce the complexity of currently recommended CYP2C19-based dosage adjustment for clopidogrel.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Win Lee Edwin Wong, Chiara Fabbri, Benjamin Laplace, Danyang Li, Roos van Westrhenen, Cathryn M. Lewis, Gavin Stewart Dawe, Allan H. Young
Summary: This study suggests that CYP2C19 genotypes, and consequently metabolic phenotypes, may play a role in determining clinical responses to SSRIs, particularly escitalopram and citalopram. However, further investigation is needed to better understand this relationship.
Article
Chemistry, Physical
R. Raveesha, K. Yogesh Kumar, M. S. Raghu, S. B. Benaka Prasad, Ali Alsalme, Prakash Krishnaiah, M. K. Prashanth
Summary: Two new series of pyrazine derivatives were synthesized and evaluated for their antioxidant, anticonvulsant, and neurotoxicity properties. Compounds 2a, 2b, and 2e showed good anticonvulsant activity and minimal neurotoxicity. Computational analysis revealed strong binding interactions of these compounds in the binding pocket of a specific protein. The results suggest that compounds 2a, 2b, and 2e have potential as safer and more effective anticonvulsant drugs with neuroprotective properties.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Woo-Yul Lee, Dong-Woo Chae, Choon-Ok Kim, Sang-Eun Lee, Yee-Gyung Kwak, Joon-Sup Yeom, Kyung-Soo Park
Summary: The study aimed to develop a population pharmacokinetic model of primaquine and its metabolite, and found that body weight and CYP2D6 activity significantly impact primaquine pharmacokinetics. The results showed that weight and enzyme activity play crucial roles in drug metabolism and can influence drug exposure levels.
Article
Psychiatry
Kentaro Oniki, Ryoko Kamihashi, Tetsu Tomita, Masamichi Ishioka, Yuki Yoshimori, Natsumi Osaki, Shoko Tsuchimine, Norio Sugawara, Ayami Kajiwara, Kazunori Morita, Keishi Miyata, Koji Otake, Kazuko Nakagawa, Yasuhiro Ogata, Junji Saruwatari, Norio Yasui-Furukori
PSYCHIATRY RESEARCH
(2016)
Article
Endocrinology & Metabolism
K. Oniki, K. Morita, T. Watanabe, A. Kajiwara, K. Otake, K. Nakagawa, Y. Sasaki, Y. Ogata, J. Saruwatari
NUTRITION & DIABETES
(2016)
Article
Endocrinology & Metabolism
Kazunori Morita, Junji Saruwatari, Takahiro Tanaka, Kentaro Oniki, Ayami Kajiwara, Hiroko Miyazaki, Akira Yoshida, Hideaki Jinnouchi, Kazuko Nakagawa
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2017)
Review
Pharmacology & Pharmacy
Kentaro Oniki, Junji Saruwatari
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2019)
Article
Multidisciplinary Sciences
Junji Saruwatari, Chao Dong, Teruo Utsumi, Masatake Tanaka, Matthew McConnell, Yasuko Iwakiri
SCIENTIFIC REPORTS
(2018)
Article
Nutrition & Dietetics
Yuka Nagase, Takao Satoh, Keiichi Shigetome, Naoto Tokumaru, Erika Matsumoto, Kazunori D. Yamada, Tadashi Imafuku, Hiroshi Watanabe, Toru Maruyama, Yasuhiro Ogata, Minoru Yoshida, Junji Saruwatari, Kentaro Oniki
Summary: This study investigated the association between the overall balance of serum fatty acid composition and MAFLD prevalence. The serum fatty acid composition balance was evaluated using fuzzy c-means clustering, and a specific balance was found to be associated with a higher MAFLD prevalence. The study highlights the importance of focusing on this balance when examining the relationship between MAFLD and serum fatty acids.
Meeting Abstract
Gastroenterology & Hepatology
Masatake Tanaka, Teruo Utsumi, Junji Saruwatari, Pengpeng Zhang, Manuel Morales-Ruiz, Yasuko Iwakiri, Jin-Kyu Park
Article
Pharmacology & Pharmacy
Kentaro Oniki, Takehisa Watanabe, Miku Kudo, Tomoko Izuka, Tatsumasa Ono, Kazuki Matsuda, Yuki Sakamoto, Katsuya Nagaoka, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Junji Saruwatari
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2018)
Meeting Abstract
Respiratory System
Hirofumi Nohara, Shunsuke Kamei, Haruka Fujikawa, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Mary Ann Suico, Naomi Nakagata, Junji Saruwatari, Hirofumi Kai, Tsuyoshi Shuto
EUROPEAN RESPIRATORY JOURNAL
(2017)
Meeting Abstract
Endocrinology & Metabolism
Kentaro Oniki, Yuki Sakamoto, Miku Kudo, Tatsumasa Ono, Kazuki Matsuda, Narumi Muto, Tomoko Izuka, Takehisa Watanabe, Koji Otake, Yasuhiro Ogata, Junji Saruwatari
Meeting Abstract
Endocrinology & Metabolism
Yuki Sakamoto, Kentaro Oniki, Ayami Kajiwara, Akira Yoshida, Kosuke Taharasako, Hiroko Ijima, Fumio Miyamoto, Seigo Sugiyama, Kunio Hiejima, Noboru Kurinami, Tomio Jinnouchi, Keizo Kajihara, Hideaki Jinnouchi, Junji Saruwatari
Article
Cardiac & Cardiovascular Systems
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
IJC HEART & VASCULATURE
(2017)
Review
Pharmacology & Pharmacy
Akihiro Sonoda, Yuki Kondo, Yasuhiro Tsuneyoshi, Yoshitaka Iwashita, Shoji Nakao, Kazuhisa Ishida, Kentaro Oniki, Junji Saruwatari, Tetsumi Irie, Yoichi Ishitsuka
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
(2017)
Meeting Abstract
Pharmacology & Pharmacy
Hirofumi Nohara, Shunsuke Kamei, Haruka Fujikawa, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Mary Ann Suico, Junji Saruwatari, Hirofumi Kai, Tsuyoshi Shuto
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2017)
Meeting Abstract
Pharmacology & Pharmacy
Haruka Fujikawa, Natsuki Masuda, Shunsuke Kamei, Hirofumi Nohara, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Yuka Eto, Kentaro Oniki, Toru Takeo, Naomi Nakagata, Hiroshi Watanabe, Naoko Tomioka-Hara, Makoto Hosoyamada, Mary Ann Suico, Hirofumi Kai, Junji Saruwatari, Tsuyoshi Shuto
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2017)