Article
Chemistry, Medicinal
Ana Carolina C. de Sousa, Jill M. Combrinck, Keletso Maepa, Timothy J. Egan
Summary: The study found that both THC and CBD from cannabis inhibit the growth of malaria parasites, with CBD exhibiting milder antimalarial activity. While THC has psychoactive effects, CBD does not, making it a potentially more promising treatment for malaria. The research suggests that cannabinoids could be a new class of chemicals to be explored for malaria treatment, with the aim of reducing psychoactive effects and enhancing antimalarial effects.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Medicine, Legal
A. Scheunemann, K. Elsner, T. Germerott, C. Hess, S. Zoerntlein, J. Roehrich
Summary: This study quantified 16 phytocannabinoids in seized and medical cannabis samples, Sativex® and Dronabinol from two manufacturers, identifying potential distinguishing markers. Sativex® was characterized by a specific cannabidiol/tetrahydrocannabinol ratio and presence of cannabichromene, while Dronabinol consisted mainly of tetrahydrocannabinol but also included minor cannabinoids. Principal component analysis revealed significant differences in cannabinoid contents between certain medical marihuana varieties and seized cannabis samples.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Environmental Sciences
Xingpei Fan, Xiangjuan Wei, Hailong Hu, Boya Zhang, Daqian Yang, Haining Du, Ruijiao Zhu, Xiaotong Sun, Yuri Oh, Ning Gu
Summary: The study found that oral administration of PS-NPs can cause visceral organ injury in mice, with main impacts on liver function and abnormal lipid metabolism. RNA-Seq revealed the effects of PS-NPs on genes related to ROS generation and the PI3K/Akt signaling pathway, leading to increased blood glucose and ROS levels in mice, but without affecting insulin secretion.
Article
Biochemistry & Molecular Biology
Anne Scheunemann, Katrin Elsner, Tanja Germerott, Sergiu Groppa, Cornelius Hess, Isabelle Miederer, Alicia Poplawski, Joerg Roehrich
Summary: This pilot study investigated serum cannabinoid profiles after the use of cannabis-based medicines to identify potential distinguishing markers. Specific cannabinoid ratios and concentrations were found to distinguish Dronabinol and Sativex(R) use. The study also found that recreational and medical cannabis use could not be easily distinguished, except for specific strains with higher concentrations of certain cannabinoids.
Article
Physiology
Victoria L. Vernail, Sarah S. Bingaman, Yuval Silberman, Wesley M. Raup-Konsavage, Kent E. Vrana, Amy C. Arnold
Summary: Cannabigerol, a compound synthesized by Cannabis sativa, has been found to lower blood pressure by activating alpha 2-adrenoreceptors and inhibiting norepinephrine release. These findings suggest that cannabigerol could be potentially used as a therapeutic for hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Henry Miller, Nicholas De Leo, Jeremy Badach, Andrew Lin, John Williamson, Steven Bonawitz, Olga Ostrovsky
Summary: The study demonstrates that cannabinoids can enhance the regenerative capacity of two major sources of stem cells from human and porcine donors, showing that CBD and THC priming can improve stem cell therapies.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Veterinary Sciences
Kelsey Meyer, Kristen Hayman, James Baumgartner, Patrick J. Gorden
Summary: This study describes the pharmacokinetics of CBD in calves and finds that CBD is slowly absorbed and has an extended elimination half-life in cattle compared to other species.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Food Science & Technology
Yasutake Tanaka, Motofumi Kumazoe, Hiroaki Onda, Yoshinori Fujimura, Hirofumi Tachibana
Summary: EGCG, the major catechin in green tea, has various beneficial effects in vivo and its functional effectiveness can be evaluated in the short term through the plasma cGMP levels.
Article
Biochemical Research Methods
Danielle McCartney, Richard C. Kevin, Anastasia S. Suraev, Ayshe Sahinovic, Peter T. Doohan, Miguel A. Bedoya-Perez, Ronald R. Grunstein, Camilla M. Hoyos, Iain S. McGregor
Summary: An increasing number of clinical trials are investigating the therapeutic potential of CBD, a non-intoxicating phytocannabinoid found in cannabis. These trials often use crossover experimental designs and require washout periods. The study found that CBD has a long window of detection in plasma, indicating caution should be exercised when conducting crossover studies involving CBD.
DRUG TESTING AND ANALYSIS
(2023)
Article
Veterinary Sciences
Barbara Moroni, Jose Enrique Granados Torres, Jorge Ramon Lopez-Olvera, Jose Espinosa Cerrato, Arian Raez Bravo, Gregorio Mentaberre, Paulino Fandos, Marco Pazzi, Monica Romagnoli, Giulia Gardini, Luca Rossi, Marta Valldeperes, Emmanuel Serrano, Blanca Ramos, Rosangela Odore
Summary: Sarcoptic mange is a major factor causing the decline of Iberian ibex populations. Use of in-feed acaricides as a mass treatment measure lacks evidence on its effectiveness. This study investigates the pharmacokinetics of ivermectin (IVM) in ibexes and suggests that a single in-feed dose may not effectively control sarcoptic mange.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Luigi Bellocchio, Assunta Patano, Alessio Danilo Inchingolo, Francesco Inchingolo, Gianna Dipalma, Ciro Gargiulo Isacco, Elisabetta de Ruvo, Biagio Rapone, Antonio Mancini, Felice Lorusso, Antonio Scarano, Giuseppina Malcangi, Angelo Michele Inchingolo
Summary: The medical use of cannabis has a long history, and Delta 9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabinol (CBN) are the main cannabinoids found in cannabis. CBD does not produce the psychotropic effects associated with cannabis and has gained attention in dentistry. Subjective findings and research evidence suggest therapeutic effects of CBD, although there is conflicting data on its mechanism of action and therapeutic potential. This article provides an overview of the scientific evidence on CBD's action and explores its possible oral benefits in dentistry, highlighting its promising biological features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ashley M. M. Schnakenberg Martin, L. Taylor Flynn, Esra Sefik, Christina Luddy, Jose Cortes-Briones, Patrick D. D. Skosnik, Brian Pittman, Mohini Ranganathan, Deepak Cyril D'Souza
Summary: Alcohol and cannabis have effects on driving ability, and combining both substances results in greater effects. This study found that oral THC and low-dose intravenous ethanol reduced perceived ability to drive, which lasted for approximately 6 hours. Additionally, combining THC and ethanol had synergistic effects on heart rate, increased subjective feelings of intoxication, and resulted in greater lateral position deviations during simulated driving.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Flavia M. Costa, Bruno M. Fonseca, Susana I. Sa
Summary: By targeting the endocannabinoid system, delta-9-tetrahydrocannabinol (THC) modulates female motivated behaviours, influenced by sex hormones. Both medial preoptic nucleus (MPN) and ventromedial nucleus of the hypothalamus (VMN) are involved in the modulation of female sexual responses. This study demonstrates how the possible outcomes of endocannabinoid system instability within hypothalamic neuron connectivity can modify female rat sociosexual behaviour.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Plant Sciences
Jose-Manuel Quintero, German Pulido, Luis-Fernando Giraldo, Marta-Ximena Leon, Luis-Eduardo Diaz, Rosa-Helena Bustos
Summary: The use of cannabis and its compounds for neuropathic pain treatment is a growing field of research. While systemic cannabinoid therapies have shown some side effects, alternative routes of administration may offer better tolerance and safety. However, there is a lack of clinical research on the use of non-oral and non-inhalation routes, calling for further well-designed trials.
Article
Microbiology
Keith A. Rodvold, Mark H. Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss
Summary: This study evaluated the pharmacokinetics and distribution of TBP-PI-HBr in healthy adults, and found that Tebipenem can effectively distribute into the lungs, supporting further evaluation for the treatment of lower respiratory tract bacterial infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Analytical
Dayong Lee, Chris W. Chronister, Jennifer Hoyer, Bruce A. Goldberger
JOURNAL OF ANALYTICAL TOXICOLOGY
(2015)
Article
Chemistry, Analytical
Dayong Lee, Mateus M. Bergamaschi, Garry Milman, Allan J. Barnes, Regina H. C. Queiroz, Ryan Vandrey, Marilyn A. Huestis
JOURNAL OF ANALYTICAL TOXICOLOGY
(2015)
Editorial Material
Medical Laboratory Technology
Thomas Kampfrath, Penny Peng, Valli Vairavan, Dayong Lee
Article
Biochemical Research Methods
Dayong Lee, Timothy J. Garrett, Bruce A. Goldberger, Lindsay A. L. Bazydlo
Editorial Material
Medical Laboratory Technology
Thomas Kampfrath, Penny Peng, Valli Vairavan, Dayong Lee
Article
Chemistry, Analytical
Dayong Lee, Chris W. Chronister, Wilson A. Broussard, Suzanne R. Utley-Bobak, Daniel L. Schultz, Russell S. Vega, Bruce A. Goldberger
JOURNAL OF ANALYTICAL TOXICOLOGY
(2016)
Article
Medicine, Legal
Dayong Lee, Chris Delcher, Mildred M. Maldonado-Molina, Jon R. Thogmartin, Bruce A. Goldberger
JOURNAL OF FORENSIC SCIENCES
(2016)
Article
Biochemical Research Methods
Nathalie A. Desrosiers, Garry Milman, Damodara R. Mendu, Dayong Lee, Allan J. Barnes, David A. Gorelick, Marilyn A. Huestis
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2014)
Article
Medical Laboratory Technology
Nathalie A. Desrosiers, Dayong Lee, Marta Concheiro-Guisan, Karl B. Scheidweiler, David A. Gorelick, Marilyn A. Huestis
CLINICAL CHEMISTRY
(2014)
Review
Biochemical Research Methods
Dayong Lee, Marilyn A. Huestis
DRUG TESTING AND ANALYSIS
(2014)
Article
Biochemical Research Methods
Matthew N. Newmeyer, Nathalie A. Desrosiers, Dayong Lee, Damodara R. Mendu, Allan J. Barnes, David A. Gorelick, Marilyn A. Huestis
DRUG TESTING AND ANALYSIS
(2014)
Article
Biochemical Research Methods
Sebastien Anizan, Mateus M. Bergamaschi, Allan J. Barnes, Garry Milman, Nathalie Desrosiers, Dayong Lee, David A. Gorelick, Marilyn A. Huestis
DRUG TESTING AND ANALYSIS
(2015)
Article
Biochemical Research Methods
Dayong Lee, Ryan Vandrey, Damodara R. Mendu, Jeannie A. Murray, Allan J. Barnes, Marilyn A. Huestis
DRUG TESTING AND ANALYSIS
(2015)
Letter
Anesthesiology
Dayong Lee, Lindsay A. L. Bazydlo, Gary M. Reisfield, Bruce A. Goldberger
Article
Substance Abuse
Dayong Lee, Jennifer R. Schroeder, Erin L. Karschner, Robert S. Goodwin, Jussi Hirvonen, David A. Gorelick, Marilyn A. Huestis
AMERICAN JOURNAL ON ADDICTIONS
(2014)