Article
Endocrinology & Metabolism
Pieter Evenepoel, Hanne Skou Jorgensen, Hirotaka Komaba, Sandro Mazzaferro, Marc Vervloet, Etienne Cavalier, Masafumi Fukagawa
Summary: This study found that Japanese patients receiving HD have lower bone turnover than their European counterparts, even at similar PTH levels. Male sex, obesity, and hyperphosphatemia were the main determinants of the bone turnover marker/PTH ratios.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Anju Murayama, Kohki Yamada, Makoto Yoshida, Yudai Kaneda, Hiroaki Saito, Toyoaki Sawano, Sunil Shrestha, Rajeev Shrestha, Tetsuya Tanimoto, Akihiko Ozaki
Summary: This study examined the financial and nonfinancial conflicts of interest among authors of CKD guidelines in Japan and found that most of the recommendations were based on low-quality evidence tied to pharmaceutical companies. The study also revealed the lack of rigorous and transparent conflict of interest policies for nephrology guideline authors.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
Akitsugu Takada, Tomohisa Shibata, Takanori Shiga, Dorien Groenendaal-van de Meent, Kanji Komatsu
Summary: The study developed a population PK model to describe roxadustat plasma concentrations in Japanese DD-CKD patients and identified age and phosphate binders as key factors affecting roxadustat clearance and bioavailability.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sherif Bayoumy, Iida Martiskainen, Taina Heikkila, Carita Rautanen, Pirjo Hedberg, Heidi Hyytia, Saara Wittfooth, Kim Pettersson
Summary: The study presents a new approach utilizing UCNP-LFIA technology for quantifying cTnI with minimized plasma interference, demonstrating good performance in clinical plasma samples. The method has the potential to provide a simple and rapid assay for point-of-care testing in emergency department settings for diagnosing acute myocardial infarction.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Michelle S. Keller, Christine Mavilian, Keaton L. Altom, Kevin F. Erickson, Laura M. Drudi, Karen Woo
Summary: The updated guidelines recommend the individualized end-stage kidney disease (ESKD) Life-Plan (LP) for each patient, which is a dramatic shift from previous recommendations. This study aims to examine the barriers and facilitators to implementing the LP among key stakeholders, including patients, care partners, and clinicians.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Hirofumi Sakuma, Minori Ikeda, Shiori Nakao, Reina Suetsugu, Motoki Matsuki, Naoyuki Hasebe, Naoki Nakagawa
Summary: This study investigates the relationship between pre-dialysis systolic blood pressure (SBP) and underlying disease in Japanese patients undergoing dialysis, and finds a positive correlation between pre-dialysis SBP and cardiovascular disease (CVD) mortality rate. The results suggest that optimal blood pressure management at the prefectural level may reduce CVD mortality rates.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Smita S. Divyaveer, Raja Ramachandran, Manisha Sahay, Dibya Singh Shah, Fazal Akhtar, Aminu K. Bello, Arpana Iyengar, David W. Johnson, David C. H. Harris, Adeera Levin, Meaghan Lunney, Muhibur Rahman, Harun-Ur Rashid, Syed Saad, Deenaz Zaidi, Mohamed A. Osman, Santosh Varughese, Eranga S. Wijewickrama, Maryam Khan, Feng Ye, Marcello Tonelli, Ikechi G. Okpechi, Vivekanand Jha
Summary: The prevalence of chronic kidney disease is relatively high in South Asia, with diabetes and hypertension being the major causes. Treatment options include hemodialysis, peritoneal dialysis, and kidney transplantation. However, there is a shortage of healthcare personnel and inadequate financial support mechanisms in these countries.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Review
Nutrition & Dietetics
Carlo Garofalo, Chiara Ruotolo, Claudia Annoiato, Maria Elena Liberti, Roberto Minutolo, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
Summary: A systematic review and meta-analysis revealed that approximately 1.5% of patients undergoing maintenance dialysis experience recovery of kidney function unrelated to acute kidney injury. The prevalence of recovery is higher in the United States compared to other countries.
Article
Urology & Nephrology
Fidelis Oguejiofor, Daniel S. Kiggundu, Aminu K. Bello, Charles R. Swanepoel, Gloria Ashuntantang, Vivekanand Jha, David C. H. Harris, Adeera Levin, Marcello Tonelli, Abdou Niang, Nicola Wearne, Mothusi Walter Moloi, Ifeoma Ulasi, Fatiu A. Arogundade, Syed Saad, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Meaghan Lunney, Timothy O. Olanrewaju, Udeme Ekrikpo, Theophilus Umeizudike, Aliyu Abdu, Aisha M. Nalado, Muhammad Aliyu Makusidi, Hamidu M. Liman, Aminu Sakajiki, Hassane M. Diongole, Maryam Khan, Mohammed Benghanem Gharbi, David W. Johnson, Ikechi G. Okpechi
Summary: Despite positive developments in Africa's economy, democracy, and reduction in regional conflicts, challenges such as poverty, inadequate infrastructure, and communicable diseases persist. The continent faces significant gaps in kidney care, including workforce shortages, insufficient government funding, and limitations in the availability and quality of kidney replacement therapy. Urgent action is needed to address these gaps and improve kidney care in Africa.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Article
Urology & Nephrology
Atefeh Amouzegar, Ali K. Abu-Alfa, Mona N. Alrukhaimi, Aminu K. Bello, Mohammad A. Ghnaimat, David W. Johnson, Vivekanand Jha, David C. H. Harris, Adeera Levin, Marcello Tonelli, Meaghan Lunney, Syed Saad, Maryam Khan, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Ikechi G. Okpechi, Shahrzad Ossareh
Summary: The Middle East region has a high burden of kidney disease and requires cost-effective measures through effective health care funding to improve kidney care in the region. Additionally, well-designed and sustainable health information systems are needed to address the current gaps in kidney care in the region.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Article
Urology & Nephrology
Elena Zakharova, Abduzhappar Gaipov, Aminu K. Bello, David W. Johnson, Vivekanand Jha, David C. H. Harris, Adeera Levin, Syed Saad, Maryam Khan, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Meaghan Lunney, Marcello Tonelli, Ikechi G. Okpechi, Alexander Zemchenkov, Irma Tchokhonelidze
Summary: The ISN Global Kidney Health Atlas studied the kidney care in the Newly Independent States and Russia, revealing challenges such as shortage of KF care providers and essential medications, low reporting of quality indicators for KF replacement therapy, and financial issues. The region requires strategic support for fundamental changes in funding structures and collaborations for establishment of universal health care systems for KF management.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Article
Hematology
Barbara Bain, Yvonne Daniel, Joan Henthorn, Barbara de la Salle, Amanda Hogan, Noemi B. A. Roy, Ciaran Mooney, Lisa C. Langabeer, David Rees, BSH Comm
Summary: Antenatal screening/testing should follow the guidelines of the NHS Sickle Cell and Thalassaemia Screening Programme. Newborn screening and necessary follow-up testing should also adhere to these guidelines. All babies under 1 year old entering the UK should be offered sickle cell disease screening. Preoperative screening is required for patients from ethnic groups with a high prevalence of the disease. Emergency screening using a sickle solubility test must always be followed by definitive analysis. Laboratories performing antenatal screening should use methods capable of detecting significant variants and quantitating haemoglobins A(2) and F according to the national programme's criteria. A provisional report must be provided to antenatal patients within three working days.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Urology & Nephrology
Aminu K. Bello, Mark McIsaac, Ikechi G. Okpechi, David W. Johnson, Vivekanand Jha, David C. H. Harris, Syed Saad, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Meaghan Lunney, Kailash Jindal, Scott Klarenbach, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy, Rulan S. Parekh, Bhanu Prasad, Maryam Khan, Parnian Riaz, Marcello Tonelli, Myles Wolf, Adeera Levin
Summary: The North America and Caribbean region has better infrastructure and funding for health care, with higher availability of essential medicines. Although dialysis is widely available, shortages of nephrologists and other health care workers are reported in some countries. Economic factors are the major barriers to optimal kidney failure care in the Caribbean countries.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Review
Urology & Nephrology
Debasish Banerjee, Peter Winocour, Tahseen A. Chowdhury, Parijat De, Mona Wahba, Rosa Montero, Damian Fogarty, Andrew Frankel, Gabrielle Goldet, Janaka Karalliedde, Patrick B. Mark, Dipesh Patel, Ana Pokrajac, Adnan Sharif, Sagen Zac-Varghese, Stephen Bain, Indranil Dasgupta
Summary: Diabetic kidney disease (DKD) is a common type of chronic kidney disease (CKD) globally, with hypertension being a major risk factor for its progression. Controlling blood pressure is crucial for slowing down the progression of DKD and reducing cardiovascular risk. The target blood pressure varies in different clinical trials for different types of diabetes and stages of DKD. Renin-angiotensin blocking agents have shown effectiveness in reducing DKD progression and cardiovascular events, while there is emerging evidence for the benefit of sodium glucose cotransporter 2, nonsteroidal selective mineralocorticoid antagonists, and endothelin-A receptor antagonists.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Marina Wainstein, Aminu K. Bello, Vivekanand Jha, David C. H. Harris, Adeera Levin, Maria C. Gonzalez-Bedat, Guillermo J. Rosa-Diez, Alejandro Ferreiro Fuentes, Laura Sola, Roberto Pecoits-Filho, Rolando Claure-Del Granado, Magdalena Madero, Mohamed A. Osman, Syed Saad, Deenaz Zaidi, Meaghan Lunney, Feng Ye, Ivor J. Katz, Maryam Khan, Sally Shrapnel, Marcello Tonelli, Ikechi G. Okpechi, David W. Johnson
Summary: Latin America's widely variable socioeconomic landscape faces challenges with chronic kidney disease and kidney failure, with uncertainty remaining regarding the capacity, accessibility, and quality of kidney failure care in the region. Most countries rely on public and private funding for kidney replacement therapy, while lacking chronic kidney disease registries or targeted detection programs.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Correction
Endocrinology & Metabolism
Moritsugu Kimura, Masao Toyoda, Nobumichi Saito, Noriko Kaneyama, Han Miyatake, Eitaro Tanaka, Hirotaka Komaba, Masanori Hara, Masafumi Fukagawa
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Urology & Nephrology
Suguru Yamamoto, Douglas S. Fuller, Hirotaka Komaba, Takanobu Nomura, Ziad A. Massy, Brian Bieber, Bruce Robinson, Ronald Pisoni, Masafumi Fukagawa
Summary: In this study, serum total IS level was found to be positively associated with all-cause mortality and infectious events in hemodialysis patients.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Suguru Yamamoto, Brian A. Bieber, Hirotaka Komaba, Norio Hanafusa, Hiroki Kitabayashi, Takanobu Nomura, Aleix Cases, Christian Combe, Ronald L. Pisoni, Bruce M. Robinson, Masafumi Fukagawa
Summary: This study investigated the association between medical director's practice of recommending an increase in dietary protein intake and outcomes in hemodialysis patients. It found that this practice was associated with lower mortality and higher serum creatinine levels.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yosuke Nakagawa, Hirotaka Komaba, Naoto Hamano, Hisae Tanaka, Takehiko Wada, Hiroaki Ishida, Michio Nakamura, Hiroo Takahashi, Yuichiro Takahashi, Toru Hyodo, Miho Hida, Takao Suga, Takatoshi Kakuta, Masafumi Fukagawa
Summary: Elevated levels of sclerostin in hemodialysis patients are associated with increased bone density, decreased PTH levels, and decreased levels of bone turnover markers. However, the effects of PTH on bone turnover markers appear to be primarily direct rather than mediated by sclerostin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Hirotaka Komaba, Junhui Zhao, Suguru Yamamoto, Takanobu Nomura, Douglas S. Fuller, Keith P. McCullough, Pieter Evenepoel, Anders Christensson, Xinju Zhao, Mona Alrukhaimi, Fadwa Al-Ali, Eric W. Young, Bruce M. Robinson, Masafumi Fukagawa
Summary: The study found that secondary hyperparathyroidism may be a novel mechanism of wasting, corroborated by experimental data, and in chronic dialysis patients, this pathway may be a mediator between elevated PTH levels and mortality. Future research should determine whether PTH-lowering therapy can limit weight loss and improve longer term dialysis outcomes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Editorial Material
Urology & Nephrology
Hirotaka Komaba, Masafumi Fukagawa
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Hirotaka Komaba, Takayuki Hamano, Naohiko Fujii, Kensuke Moriwaki, Atsushi Wada, Ikuto Masakane, Kosaku Nitta, Masafumi Fukagawa
Summary: This study compared the risk of mortality between parathyroidectomy (PTx) and cinacalcet treatment in hemodialysis patients. The results showed that PTx resulted in greater reductions in intact PTH, calcium, and phosphorus levels compared with cinacalcet. PTx was associated with a lower risk of mortality, particularly among patients with severe secondary hyperparathyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Urology & Nephrology
Hirotaka Komaba
Summary: Growth differentiation factor 15 has been identified as a potential renoprotective factor that is induced at the proximal tubular site following kidney injury. It has been found that growth differentiation factor 15 not only exhibits a protective effect against different types of kidney injury but also stimulates the expression of another renoprotective factor called Klotho in the kidney. The enhanced expression of Klotho in the proximal tubule suggests a cooperative action between these two renoprotective factors at this vulnerable site.
KIDNEY INTERNATIONAL
(2022)
Article
Transplantation
Takayuki Hamano, Takahiro Imaizumi, Takeshi Hasegawa, Naohiko Fujii, Hirotaka Komaba, Masahiko Ando, Masaomi Nangaku, Kosaku Nitta, Hideki Hirakata, Yoshitaka Isaka, Takashi Wada, Shoichi Maruyama, Masafumi Fukagawa
Summary: The CGA classification is more valuable than the GA classification in predicting kidney disease outcomes, and incorporating a prior biopsy-proven diagnosis significantly improves the accuracy of outcome prediction.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Pieter Evenepoel, Hanne Skou Jorgensen, Hirotaka Komaba, Sandro Mazzaferro, Marc Vervloet, Etienne Cavalier, Masafumi Fukagawa
Summary: This study found that Japanese patients receiving HD have lower bone turnover than their European counterparts, even at similar PTH levels. Male sex, obesity, and hyperphosphatemia were the main determinants of the bone turnover marker/PTH ratios.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Yosuke Nakagawa, Hirotaka Komaba, Takehiko Wada, Hiroo Takahashi, Yuichiro Takahashi, Toru Hyodo, Miho Hida, Takao Suga, Takatoshi Kakuta, Masafumi Fukagawa
Summary: This study aimed to investigate the association between serum sclerostin levels and mortality in hemodialysis patients. The results showed that there was no significant correlation between serum sclerostin levels and mortality, even after adjusting for potential confounders. Therefore, further research is needed to determine the role of sclerostin in vascular calcification and cardiovascular disease in kidney failure.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Pediatrics
Mai Kubota, Yuko Hamasaki, Junya Hashimoto, Yujiro Aoki, Takeshi Kawamura, Akinobu Saito, Rena Yuasa, Masaki Muramatsu, Hirotaka Komaba, Masao Toyoda, Masafumi Fukagawa, Seichiro Shishido, Ken Sakai
Summary: This study aimed to investigate the relationship between fibroblast growth factor 23 (FGF23) levels and mineral metabolism in pediatric kidney transplant patients. The results showed that FGF23 levels decreased rapidly after transplantation and were associated with hypophosphatemia and increased phosphorus excretion. Alpha Klotho levels were initially low but tended to increase after transplantation. Pre-transplant FGF23 and alpha Klotho were not significantly associated with post-transplant parameters.
PEDIATRIC TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Hirotaka Komaba
Summary: Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) play crucial roles in the development of chronic kidney disease-mineral and bone disorder (CKD-MBD). As kidney function declines, both hormones increase to maintain normal phosphate balance. However, when patients reach kidney failure, PTH and FGF23 fail to regulate phosphorus levels properly, leading to hyperphosphatemia. Elevated PTH and FGF23 are associated with mortality, and lowering PTH has been shown to improve survival.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce M. Robinson, Masafumi Fukagawa
Summary: This study analyzed the association between the prescription of active vitamin D and fracture incidence in hemodialysis patients. The results suggested that active vitamin D does not have a PTH-independent benefit in fracture prevention, supporting the current guideline of using active vitamin D only in patients with elevated or rising PTH.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Urology & Nephrology
Chiaki Kawabata, Hirotaka Komaba, Hiroaki Ishida, Yosuke Nakagawa, Naoto Hamano, Masahiro Koizumi, Genta Kanai, Takehiko Wada, Michio Nakamura, Masafumi Fukagawa
