Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fangyan Xu, Yaoyu Huang, Ming Zeng, Lina Zhang, Wenkai Ren, Hanyang Qian, Ying Cui, Guang Yang, Wenbin Zhou, Shui Wang, Hui Huang, Huimin Chen, Yujie Xiao, Xueyan Gao, Zhanhui Gao, Jing Wang, Cuiping Liu, Jing Zhang, Baiqiao Zhao, Anning Bian, Fan Li, Huiting Wan, Changying Xing, Xiaoming Zha, Ningning Wang
Summary: This study demonstrates the risk of residual cervicothoracic parathyroids causing SHPT in patients with chronic kidney disease undergoing PTX. The intraoperative reduction percentages of plasma (1-84) PTH levels are more accurate in predicting the success of PTX surgery than iPTH.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Sanchita Agarwal, Donald J. McMahon, Juliet Chen, Aiden V. Brossfield, Jason Fernando, John P. Bilezikian, Natalie E. Cusano, Mishaela R. Rubin
Summary: Hypoparathyroidism is a disorder characterized by low calcium levels, reduced parathyroid hormone, decreased bone remodeling, and increased bone density. Long-term treatment with PTH can reduce the need for calcium and active vitamin D supplements, maintain normal calcium levels, but lead to a decrease in bone mass.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Tatsuki Urakawa, Shinichiro Sano, Sayaka Kawashima, Akie Nakamura, Hirohito Shima, Motoki Ohta, Yuki Yamada, Ai Nishida, Hiromune Narusawa, Yoshiaki Ohtsu, Keiko Matsubara, Sumito Dateki, Yoshihiro Maruo, Maki Fukami, Tsutomu Ogata, Masayo Kagami
Summary: This study aimed to investigate the clinical characteristics of pseudohypoparathyroidism type 1B (PHP1B). Patients were classified into different groups based on the methylation defects and etiologies, and their clinical findings were compared. The study found that patients in Group 2 (G2) had a younger age at diagnosis and higher levels of intact parathyroid hormone. They were more likely to experience seizures or loss of consciousness. Additionally, some patients also had neurodevelopmental disorders.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Elisabeth Laurer, Johanna Gruenberger, Uvistra Naidoo, Roland Lanzersdorfer, Marlene Wimleitner, Katharina Tischlinger, Wolfgang Hoegler
Summary: Full-length recombinant human parathyroid hormone (rhPTH[1-84]) is effective in treating hypoparathyroidism, especially in patients refractory to conventional therapy. Dose optimization based on serum ionized calcium, urinary calcium-to-creatinine ratio, and 24-hour urinary calcium excretion is crucial for successful treatment.
Review
Cell Biology
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan
Summary: This article reviews the effects of PTH, PTHrP, and PTH1R signaling on MSCs in the orofacial region, as well as the potential therapeutic applications for dental and bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Sofia Ish-Shalom, Yoseph Caraco, Nariman Saba Khazen, Michal Gershinsky, Auryan Szalat, Phillip Schwartz, Ehud Arbit, Hillel Galitzer, Jonathan C. Y. Tang, Gregory Burshtein, Ariel Rothner, Arthur Raskin, Miriam Blum, William D. Fraser
Summary: Oral hPTH(1-34) treatment as an adjunct to standard therapy in adult patients with hypoparathyroidism was found to be safe and effective, allowing for a reduction in exogenous calcium supplementation while maintaining normocalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Urology & Nephrology
Xiaoling Zhou, Yidan Guo, Yang Luo
Summary: The study found an association between serum intact parathyroid hormone levels and mortality in hemodialysis patients, showing a U-shaped curve of this relationship. The optimal range of serum iPTH levels conferring the lowest risk of all-cause and cardiovascular mortality may range from 150 pg/mL to 450 pg/mL in this group of incident HD patients.
Article
Multidisciplinary Sciences
Takahisa Hiramitsu, Toshihide Tomosugi, Manabu Okada, Kenta Futamura, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Yoshihiro Tominaga, Toshihiro Ichimori
Summary: This study proposes a method utilizing intact PTH ratio to predict the localization of causative parathyroid glands for re-parathyroidectomy, avoiding the risks of pain and nerve damage that traditional methods may pose.
Article
Endocrinology & Metabolism
Tatsuhiko Kuroda, Masataka Shiraki, Toshitaka Nakamura, Hiroaki Suzuki, Kazuki Hiraishi, Toshitsugu Sugimoto, Satoshi Tanaka
Summary: This study reanalyzed data from a previous phase 1 pharmacokinetic study and found that serum sclerostin levels show specific patterns of change at different time points after zoledronic acid injection, with a negative correlation with iPTH levels.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Urology & Nephrology
Miho Murashima, Naohiko Fujii, Shunsuke Goto, Takeshi Hasegawa, Masanori Abe, Norio Hanafusa, Masafumi Fukagawa, Takayuki Hamano
Summary: This study aimed to evaluate the associations between calcium, phosphate, and intact parathyroid hormone (iPTH) levels and outcomes in peritoneal dialysis (PD) patients. The results showed that higher levels of calcium and phosphate were associated with higher mortality, while lower levels of calcium and phosphate were associated with faster decline in urine output and lower incidence of transition to hemodialysis.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Olulade Ayodele, Fan Mu, Richard Berman, Elyse Swallow, Lars Rejnmark, Elvira O. Gosmanova, Sanjiv Kaul
Summary: This study found that treatment with recombinant human parathyroid hormone (1-84) can reduce the risk of cardiovascular disease in patients with chronic hypoparathyroidism. Patients treated with rhPTH(1-84) had a lower risk of cardiovascular events compared to those who did not receive the treatment.
ADVANCES IN THERAPY
(2022)
Article
Engineering, Biomedical
Zhiyuan Zou, Le Wang, Zhifei Zhou, Qing Sun, Delong Liu, Yan Chen, Hao Hu, Yu Cai, Sixiong Lin, Zhengran Yu, Bizhi Tan, Wei Guo, Zemin Ling, Xuenong Zou
Summary: The use of hydrogels containing PTH and nHAP can promote cranial bone regeneration by enhancing the expression of osteogenic-related proteins and facilitating osteogenic differentiation of BMSCs through the Notch signaling pathway. Implantation of the hydrogel into a rat cranial defect model showed efficient bone regeneration compared to using the hydrogel alone or nHAP alone, indicating a promising therapeutic effect of combining nHAP and PTH for bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Endocrinology & Metabolism
Lars Rejnmark, Olulade Ayodele, Angela Lax, Fan Mu, Elyse Swallow, Elvira O. Gosmanova
Summary: This study found that adult patients with chronic hypoparathyroidism treated with rhPTH(1-84) had a significantly lower risk of developing chronic kidney disease (CKD) compared to patients not treated with rhPTH(1-84).
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Olulade Ayodele, Lars Rejnmark, Fan Mu, Angela Lax, Richard Berman, Elyse Swallow, Elvira O. Gosmanova
Summary: This study evaluated the changes in estimated glomerular filtration rate (eGFR) over a 5-year period in patients with chronic hypoparathyroidism treated with rhPTH(1-84). The results showed that long-term treatment with rhPTH(1-84) was associated with stable eGFR compared with a decline in eGFR in the control group. This suggests that rhPTH(1-84) may help preserve renal function and reduce the risk of long-term renal complications in patients with chronic hypoparathyroidism.
ADVANCES IN THERAPY
(2022)
Article
Urology & Nephrology
Masaaki Nagai, Naoto Kobayashi, Naoki Izumi, Takaaki Ohbayashi, Osamu Hotta, Takayuki Hamano
Summary: This study found that in patients with IgA nephropathy, those with severe pre-treatment hematuria or a high percentage of crescents are likely to see an improvement in eGFR after methylprednisolone pulse therapy with tonsillectomy.
JOURNAL OF NEPHROLOGY
(2022)
Article
Transplantation
Takayuki Hamano, Takahiro Imaizumi, Takeshi Hasegawa, Naohiko Fujii, Hirotaka Komaba, Masahiko Ando, Masaomi Nangaku, Kosaku Nitta, Hideki Hirakata, Yoshitaka Isaka, Takashi Wada, Shoichi Maruyama, Masafumi Fukagawa
Summary: The CGA classification is more valuable than the GA classification in predicting kidney disease outcomes, and incorporating a prior biopsy-proven diagnosis significantly improves the accuracy of outcome prediction.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Hematology
Mao Shimizu, Hideki Fujii, Keiji Kono, Kentaro Watanabe, Shunsuke Goto, Kandai Nozu, Kimitoshi Nakamura, Shinichi Nishi
Summary: This study did not identify any Fabry disease patients among male hemodialysis patients in Awaji Island, Japan, despite some patients having a family history of kidney and cardiovascular diseases. Although a few patients had low levels of alpha-galactosidase A activity, none of them tested positive in secondary screening.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Transplantation
Junichi Hoshino, Masanori Abe, Takayuki Hamano, Takeshi Hasegawa, Atsushi Wada, Shigeru Nakai, Norio Hanafusa, Ikuto Masakane, Kosaku Nitta
Summary: The GA/A1c ratio is significantly associated with 3-year mortality, especially infectious and cardiovascular mortality, in dialysis patients with diabetes. This ratio may be a promising new clinical indicator of survival in these patients, independent of their current glycemic control and nutritional markers.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Takahiro Imaizumi, Naohiko Fujii, Takayuki Hamano, Wei Yang, Masataka Taguri, Mayank Kansal, Rupal Mehta, Tariq Shafi, Jonathan Taliercio, Alan Go, Panduranga Rao, L. Lee Hamm, Rajat Deo, Shoichi Maruyama, Masafumi Fukagawa, Harold I. Feldman
Summary: It has been found that patients receiving dialysis therapy in the United States are more prone to cardiovascular disease (CVD) compared to those in Japan. Left ventricular mass index (LVMI) and ejection fraction (EF) showed significant differences between the two cohorts, and low EF and high LVMI were significantly associated with subsequent CVD in both groups. The higher LV mass and lower EF, even within the normal range, were found to be predictive of CVD in chronic kidney disease (CKD) patients.
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study examined the outcomes of a combination of peritoneal dialysis (PD) and once-weekly haemodialysis (PD + HD) compared to thrice-weekly haemodialysis (HD) in terms of mortality. The results showed that PD + HD therapy was associated with similar or potentially lower mortality compared to thrice-weekly HD. This suggests that PD + HD therapy could be a good option.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka
Summary: Obesity is a significant risk factor for end-stage kidney disease. Lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease. However, the regulatory factors involved in countering renal lipotoxicity are largely unknown.
Article
Urology & Nephrology
Minoru Murakami, Naohiko Fujii, Eiichiro Kanda, Kan Kikuchi, Atsushi Wada, Takayuki Hamano, Ikuto Masakane
Summary: This nationwide cohort study in Japan aimed to evaluate the association between arterial superficialization (AS) and mortality in maintenance hemodialysis patients. The study found that the usage of AS may be associated with a lower risk of all-cause mortality, as well as better survival rates compared to the usage of tunneled and cuffed central venous catheter (TC-CVC) in patients who are not suitable for arteriovenous fistula (AVF) or arteriovenous graft (AVG).
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Shunsuke Goto, Hideki Fujii, Kentaro Watanabe, Mao Shimizu, Hidehisa Okamoto, Kazuo Sakamoto, Keiji Kono, Shinichi Nishi
Summary: This study suggests that astragalus root can slow the progression of chronic kidney disease by suppressing oxidative stress and the renin-angiotensin system.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Surgery
Shuhei Ueno, Miho Murashima, Ryo Ogawa, Masaki Saito, Sunao Ito, Shunsuke Hayakawa, Tomotaka Okubo, Hiroyuki Sagawa, Tatsuya Tanaka, Hiroki Takahashi, Yoichi Matsuo, Akira Mitsui, Masahiro Kimura, Takayuki Hamano, Shuji Takiguchi
Summary: This study investigates the association between cisplatin-induced acute kidney injury (c-AKI) after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. The results show that c-AKI is significantly associated with a higher incidence of postoperative complications and longer hospital stays.
Article
Medicine, General & Internal
Masao Iwagami, Yuka Kanemura, Naru Morita, Toshitaka Yajima, Masafumi Fukagawa, Shuzo Kobayashi
Summary: This study examined hemodialysis patients in Japan with dyskalemia and analyzed their characteristics and clinical outcomes. The study found that dyskalemia was associated with adverse outcomes such as increased mortality and major adverse cardiovascular events. Older age and malnutrition were associated with hypokalemia, while a longer duration of dialysis was associated with hyperkalemia. Optimizing serum potassium levels is important for hemodialysis patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nobumichi Saito, Masao Toyoda, Masumi Kondo, Makiko Abe, Noriyuki Sanechika, Moritsugu Kimura, Kaichiro Sawada, Masafumi Fukagawa
Summary: This study reveals that phosphorylation of β1-integrin inhibits the expression of renin, while dephosphorylation promotes its expression. Knockdown of β1-integrin and connexin-40 both enhance the expression of renin. Pneumatic pressurization and hypotonic medium culture decrease renin expression, which can be restored by β1-integrin knockdown.
Article
Urology & Nephrology
Shunsuke Goto, Hideki Fujii, Makiko Mieno, Takashi Yagisawa, Masanori Abe, Kosaku Nitta, Shinichi Nishi
Summary: This study found that living donor kidney transplantation (LKT) is associated with a lower risk of mortality and an increase in life expectancy compared to hemodialysis (HD), with larger benefits observed in female and older patients.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Transplantation
Shunsuke Goto, Takayuki Hamano, Hideki Fujii, Masatomo Taniguchi, Masanori Abe, Kosaku Nitta, Shinichi Nishi
Summary: This study investigated the association between serum calcium levels and cardiovascular mortality in calcimimetics users using a nationwide Japanese registry for dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Maki Hiratsuka, Katsushi Koyama, Makoto Ito, Ryo Sato, Kodai Suzuki, Yuki Ito, Tomoko Namba-Hamano, Takayuki Hamano
Summary: The patient in this case study was a female with Fabry disease who experienced various severe complications at a young age, ultimately leading to her death at 44 years old due to cerebral hemorrhage. Autopsy findings revealed significant globotriaosylceramide accumulation in major organs and their vascular smooth muscle cells. FD can cause vascular thickening and atherosclerosis, while also being influenced by lifestyle factors such as obesity.