Article
Physiology
Ramon Paniagua, Elvia Garcia-Lopez, Marcela Avila-Diaz, Maria-de-Jesus Ventura, Oscar Orihuela, Maria-del-Carmen Prado-Uribe, Juan-Manuel Gallardo-Montoya, Bengt Lindholm
Summary: During peritoneal dialysis treatment with icodextrin solutions, females show higher levels of icodextrin metabolites in serum, which may lead to an increase in blood volume and blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Jose Emilio Sanchez, Catalina Ulloa, Carmen Merino Bueno, Elena Astudillo, Carmen Rodriguez-Suarez
Summary: The aim of this study was to evaluate the impact of PD strategy on technique and patient survival. The results showed that the use of APD and APD/icodextrin had a positive impact on patient survival, while age and Charlson Index had a negative impact. Age and early peritoneal infection also significantly impacted technique survival.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
David A. Jaques, Andrew Davenport
Summary: The study found that factors such as fast transport type, serum sodium levels, and diabetes were positively associated with sodium to water clearance, while PD mode and the use of 2.27% glucose dialysate were negatively associated. This indicates that CAPD, fast transport, and high serum sodium levels may allow more sodium to be removed compared to water.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Gordon Chun Kau Chan, Win Hlaing Than, Bonnie Ching Ha Kwan, Ka Bik Lai, Ronald Cheong Kin Chan, Jeremy Yuen Chun Teoh, Jack Kit Chung Ng, Kai Ming Chow, Phyllis Mei Shan Cheng, Man Ching Law, Chi Bon Leung, Philip Kam Tao Li, Cheuk Chun Szeto
Summary: This study found that miR-221 and miR-222 are associated with the progression of obesity, insulin resistance, and new onset diabetes mellitus (NODM) after peritoneal dialysis (PD).
Article
Cell Biology
Rebecca Herzog, Juan Manuel Sacnun, Guadalupe Gonzalez-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J. Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucia Pascual-Anton, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel Lopez-Cabrera, Seth L. Alper, Christoph Aufricht, Klaus Kratochwill
Summary: Adding lithium chloride to peritoneal dialysis fluid can improve mesothelial cell survival, reduce angiogenesis and fibrosis, and provide a translatable intervention to counteract peritoneal membrane deterioration during PD therapy. This study identified a potential therapeutic strategy in repurposing LiCl as a cytoprotective PDF additive to combat PD-induced mesothelial cytotoxicity.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chi-Chong Tang, Jen-Pi Tsai, Yi-Hsin Chen, Szu-Chun Hung, Yu-Li Lin, Bang-Gee Hsu
Summary: Disruptions in glucose metabolism are common among peritoneal dialysis (PD) patients, and impaired fasting glucose, insulin resistance, and PD glucose load are closely associated with aortic stiffness in PD patients without diabetes mellitus (DM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qi Guo, Shicheng Cao, Xiaohong Wang
Summary: Exercise can improve the pathogenic changes in adiponectin and betatrophin levels in insulin-resistant mice. This effect is achieved by increasing adiponectin levels and reducing betatrophin levels through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Emily Blaine, Robin Tumlinson, Marion Colvin, Tyler Haynes, Heather P. Whitley
Summary: Chronically uncontrolled hyperglycemia is a common factor in end stage kidney disease (ESKD) that requires dialysis. However, there is a lack of clear clinical recommendations for adjusting insulin dosing during the transition to hemodialysis (HD) or peritoneal dialysis (PD).
Review
Hematology
Guido Filler, Aaron Haig, Neil Merritt, Ana Catalina Alvarez-Elias, Chia Wei Teoh, Timm Joachim Filler, Maria Esther Diaz-Gonzalez de Ferris
Summary: Peritoneal biopsies in pediatrics with long-term PD using physiological solutions showed significant histopathological changes, indicating that avoiding pH trauma may not completely ameliorate the effects of glucose exposure.
BLOOD PURIFICATION
(2022)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Dopytalska, Malgorzata Kalisz, Anna Litwiniuk, Irena Walecka, Wojciech Bik, Agnieszka Baranowska-Bik
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis in the skin and internal organs. This study examined the levels of omentin-1 and adiponectin in SSc patients to understand their role in the development of the disease. The results showed that omentin-1 levels were significantly higher in SSc patients, especially in those with longer disease duration, suggesting its involvement in the pathogenesis of SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Daniel Antonio de Luis Roman, David Primo, Olatz IZaola, Emilia Gomez, Juan Jose Lopez
Summary: The ADIPOQ gene variant rs3774261 combined with a high polyunsaturated fat hypocaloric diet is associated with a significant increase in serum adiponectin levels and adiponectin/leptin ratio, as well as a decrease in lipid profile and C-reactive protein concentration.
Article
Neurosciences
Wanling Xu, Junfeng Li, Chang Ji, Danwei Fang, Lulu Yao, Nenggui Xu, Wei Yi
Summary: This study provides mechanistic insights into how electroacupuncture (EA) improves insulin resistance (IR) through the response of Pro-opiomelanocortin (POMC) neurons to adiponectin (Adipo).
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Lorena Orostica, Isis Astorga, Francisca Plaza-Parrochia, Cristian Poblete, Rodrigo Carvajal, Victor Garcia, Carmen Romero, Margarita Vega
Summary: PCOS is an endocrine/metabolic disorder associated with insulin resistance and obesity. This study found that MTF can improve insulin and adiponectin signaling in endometrial tissues, independent of PCOS. This suggests that MTF may help improve insulin action and reproductive issues in women with obesity/PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Romulo Sperduto Dezonne, Claudia Maria Pereira, Cyro Jose de Moraes Martins, Virginia Genelhu de Abreu, Emilio Antonio Francischetti
Summary: Dementia, including Alzheimer's Disease, is a global public health problem related to metabolic dysfunction. Adiponectin plays an important and contradictory role in the development of Alzheimer's Disease, known as the adiponectin paradox. Alzheimer's Disease and type 2 diabetes mellitus share common features, including brain insulin resistance. The evolvability of amyloidogenic proteins is also important in the development of Alzheimer's Disease.
METABOLIC BRAIN DISEASE
(2023)