Article
Biochemistry & Molecular Biology
Raphael S. Pinto, Carlos A. Minanni, Aecio Lopes de Araujo Lira, Marisa Passarelli
Summary: This review focuses on the role of advanced glycation end products (AGEs) in cardiovascular disease (CVD). Clinical trials and experimental evidence are used to revisit the mechanisms by which AGEs contribute to CVD, including enhanced oxidative stress, inflammation, endoplasmic reticulum stress, and impairment in reverse cholesterol transport (RCT). AGEs promote cholesterol accumulation in the arterial wall through these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Agnieszka Zawada, Alicja Machowiak, Anna Maria Rychter, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: The formation of advanced glycation end-products (AGE) in tissues is a physiological process, but excessive production and storage can lead to inflammation. A sedentary lifestyle, hypercaloric and high-fructose diet, and increased intake of processed food contribute to the excessive production of AGE. Accumulation of AGE increases oxidative stress and initiates various diseases.
Article
Biochemistry & Molecular Biology
Mirko Luketin, Maja Mizdrak, Dijana Boric-Skaro, Dinko Martinovic, Daria Tokic, Marino Vilovic, Daniela Supe-Domic, Tina Ticinovic Kurir, Josko Bozic
Summary: The study revealed significantly higher plasma CST levels in HD patients compared to healthy controls, with a significant positive correlation between CST and AGEs. Additionally, there were positive correlations between plasma CST levels, Dialysis Malnutrition Score, and Malnutrition-Inflammation Score.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Chemistry, Applied
Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li
Summary: Advanced glycation end products (AGEs) are formed through chemical reactions of amino acids, peptides, proteins, and ketones at normal or heated non-enzymatic conditions. The intake of dietary AGEs is linked to the development of various chronic diseases, and their safety and health risks have garnered significant attention. This review provides an overview of the production, bio-transport, detection technologies, and physiological toxicity of dietary AGEs, as well as discusses strategies to inhibit their generation. Future opportunities and challenges in the detection, toxicity, and inhibition of dietary AGEs are also highlighted.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Yi Wu, Minhua Zong, Zhenhui Zhang, Yongtai Wu, Lin Li, Xia Zhang, Hong Wu, Bing Li
Summary: This study identifies the selective transmembrane transport of different modification types of AGEs and their effects on cellular energy homeostasis. The results show that only certain types of free and peptide-bound AGEs can easily cross the cell membrane and exert their effects. Mechanistically, free AGEs interfere with mitochondrial function and energy production through the thymidine phosphorylase and AMPK-SIRT6 signaling pathways.
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Integrative & Complementary Medicine
Yoko Uchiyama-Tanaka
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2018)
Article
Medicine, Research & Experimental
Yoko Uchiyama-Tanaka
BIOMEDICAL RESEARCH-TOKYO
(2009)
Article
Integrative & Complementary Medicine
Yoko Uchiyama-Tanaka
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2014)
Article
Hematology
Yoko Uchiyama-Tanaka, Yasukiyo Mori
THERAPEUTIC APHERESIS AND DIALYSIS
(2010)
Article
Cardiac & Cardiovascular Systems
Yoko Uchiyama-Tanaka
CARDIOLOGY AND THERAPY
(2012)
Article
Urology & Nephrology
Y Uchiyama-Tanaka, Y Mori, T Kimura, K Sonomura, S Umemura, N Kishimoto, A Nose, T Tokoro, Y Kijima, H Yamahara, T Nagata, H Masaki, Y Umeda, K Okazaki, T Iwasaka
AMERICAN JOURNAL OF KIDNEY DISEASES
(2004)
Article
Urology & Nephrology
Y Uchiyama-Tanaka, H Matsubara, Y Mori, A Kosaki, N Kishimoto, K Amano, S Higashiyama, T Iwasaka
KIDNEY INTERNATIONAL
(2002)
Article
Urology & Nephrology
Y Uchiyama-Tanaka, H Matsubara, Y Nozawa, S Murasawa, Y Mori, A Kosaki, K Maruyama, H Masaki, Y Shibasaki, S Fujiyama, A Nose, O Iba, T Hasagawa, E Tateishi, S Higashiyama, T Iwasaka
KIDNEY INTERNATIONAL
(2001)
Article
Medicine, General & Internal
Yoko Uchiyama-Tanaka, Yasukiyo Mori
Article
Physiology
Y Uchiyama-Tanaka, Y Mori, N Kishimoto, M Fukui, A Nose, Y Kijima, H Yamahara, T Hasegawa, A Kosaki, H Matsubara, T Iwasaka
KIDNEY & BLOOD PRESSURE RESEARCH
(2005)