Article
Public, Environmental & Occupational Health
Chiara Celine Bruck, Frank J. Wolters, M. Arfan Ikram, Inge M. C. M. de Kok
Summary: Accurate projections of future dementia burden are important for healthcare systems and policymakers. Using a dementia microsimulation model, we found that changes in age-specific dementia incidence have a significant impact on the future burden of dementia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Jonviea D. Chamberlain, Anais Rouanet, Bruno Dubois, Florence Pasquier, Olivier Hanon, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Yannick Bejot, Olivier Godefroy, David Wallon, Armelle Gentric, Genevieve Chene, Carole Dufouil
Summary: The study found that incident cancer was associated with a reduced risk of dementia, suggesting a protective relationship between cancer and dementia. Further investigations are encouraged to understand potential underlying mechanisms.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Anders Wimo, Katrin Seeher, Rodrigo Cataldi, Eva Cyhlarova, Joseph L. Dielemann, Oskar Frisell, Maelenn Guerchet, Linus Jonsson, Angeladine Kenne Malaha, Emma Nichols, Paola Pedroza, Martin Prince, Martin Knapp, Tarun Dua
Summary: Dementia is a major cause of death and disability worldwide. A global cost model was constructed to estimate the total societal costs of dementia, including direct and indirect economic costs. In 2019, the annual global societal costs of dementia were estimated to be $1313.4 billion, with the highest costs seen in high-income countries.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Christopher Kruse, Franziska Maier, Annika Spottke, Jan-Philipp Bach, Claudia Bartels, Katharina Buerger, Andreas Fellgiebel, Klaus Fliessbach, Lutz Frolich, Lucrezia Hausner, Martin Hellmich, Stefan Kloppel, Arne Klostermann, Johannes Kornhuber, Christoph Laske, Oliver Peters, Josef Priller, Tanja Richter-Schmidinger, Anja Schneider, Kija Shah-Hosseini, Stefan Teipel, Christine A. F. von Arnim, Jens Wiltfang, Hendrik van der Wurp, Richard Dodel, Frank Jessen
Summary: This study analyzed the influence of apathy on resource utilization in patients with dementia of the Alzheimer's type. The findings suggest that apathy is a significant factor driving costs in mild to moderate dementia. Effective treatment of apathy may lead to reduced overall costs in Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Cell Biology
Julian M. Carosi, Timothy J. Sargeant
Summary: The potential use of rapamycin for treating Alzheimer's disease has been studied, suggesting promise for early prevention but limited effectiveness in resolving existing pathology. The impact of lysosomal degradative capacity on rapamycin's effectiveness in Alzheimer's treatment needs further investigation.
Review
Medicine, General & Internal
Flavia Mayer, Giulia Remoli, Ilaria Bacigalupo, Ilaria Palazzesi, Paola Piscopo, Guido Bellomo, Marco Canevelli, Massimo Corbo, Nicola Vanacore, Eleonora Lacorte
Summary: Population ageing is a global social phenomenon where the risk of dementia may be changing in certain countries and areas. This systematic review examined recent observations of a possible decrease in dementia frequency in some Western countries between 1977 and 2014. The studies included had heterogeneity in clinical criteria and methodological quality.
Article
Medicine, General & Internal
Xingzhong Gu, Zhihong Shi, Shuai Liu, Yalin Guan, Hui Lu, Ying Zhang, Meilin Zhang, Shuling Liu, Wei Yue, Hao Wu, Xiaodan Wang, Yajing Zhang, Yong Ji
Summary: The study found a higher incidence of dementia in rural China than previously reported, with rates increasing with age and AD being the most common type of dementia. Poor education was associated with increased risk of VaD and AD, while engagement in social activities was identified as an independent protective factor for VaD.
Article
Immunology
Gary P. Wormser, Adriana Marques, Charles S. Pavia, Ira Schwartz, Henry M. Feder, Andrew R. Pachner
Summary: This article discusses the potential role of microorganisms in the development of Alzheimer's disease, focusing on whether Lyme disease is a cause of Alzheimer's disease or Lewy body dementia. The paper concludes that there is no convincing evidence supporting a causal relationship between Lyme disease and either Alzheimer's disease or Lewy body dementia.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Julia G. Burgdorf, Tracy M. Mroz, Jennifer M. Reckrey, Yolanda Barron, Miriam Ryvicker
Summary: Home health (HH) is an important source of care for early-stage/undiagnosed Alzheimer's Disease and Related Dementias (ADRD) patients. This study aims to investigate the prevalence and predictors of incident ADRD diagnosis following HH. The results show that 10% of HH patients without diagnosed ADRD received an incident diagnosis within 1 year. Furthermore, HH patients with impaired overall cognition and community-referred patients were more likely to receive an incident ADRD diagnosis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pharmacology & Pharmacy
Manuel Enrique Machado-Duque, Luis Fernando Valladales-Restrepo, Juan Alberto Ospina-Cano, Maria Jose Londono-Serna, Jorge Enrique Machado-Alba
Summary: Dementias are neurodegenerative diseases, with over one-third of patients with dementia receiving antipsychotic prescriptions, which may be considered inappropriate as they can exacerbate cognitive decline and lead to adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Tatsushi Toda, Atsushi Iwata, Takeshi Iwatsubo
Summary: Through vector-autoregression modeling, this study evaluates the efficacy and cost-effectiveness of different promotion methods for the Japanese Trial-Ready Cohort web study. Results indicate that initial press releases and newspaper advertisements were the most effective promotion methods, significantly impacting daily visitors and registrants.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Jesper Qvist Thomassen, Janne S. Tolstrup, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: The study found that low and high plasma magnesium concentrations were associated with high risk of vascular-related non-Alzheimer dementia, with the lowest risk observed at a concentration of 2.07mg/dL. No association was observed for Alzheimer dementia. Mediation analysis suggested that diabetes may be in the causal pathway between low plasma magnesium concentrations and high risk of non-Alzheimer dementia.
CLINICAL CHEMISTRY
(2021)
Article
Clinical Neurology
Prashanthi Vemuri, Charles Decarli, Marco Duering
Summary: This focused review provides an update on current magnetic resonance imaging methods for measuring cerebrovascular disease lesions and early cerebrovascular disease-related brain injury. It discusses the clinical implications and relevance of these imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer's disease and related dementias. The review also presents the outlook and challenges in the field.
Article
Clinical Neurology
Robert S. Wilson, Tianhao Wang, Lei Yu, Francine Grodstein, David A. Bennett, Patricia A. Boyle
Summary: The study suggests that engaging in cognitive activities in old age could delay the onset of dementia in Alzheimer's disease by up to 5 years.
Article
Chemistry, Analytical
Andreia Carona, Joana Bicker, Rui Silva, Ana Silva, Isabel Santana, Francisco Sales, Amilcar Falcao, Ana Fortuna
Summary: Epilepsy affects approximately 1% of the world population, and despite the availability of many antiepileptic drugs, a significant number of patients do not respond to treatment or show high pharmacokinetic variability, emphasizing the importance of therapeutic drug monitoring (TDM). A novel HPLC-DAD technique was developed in this study to quantify multiple antiepileptic drugs in human saliva, demonstrating sensitive drug quantification and a potential new approach for individualized treatment monitoring and assessing patient adherence.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Clinical Neurology
Andreia Adriao, Isabel Santana, Carolina Ribeiro, M. Leonor Cancela, Natercia Conceicao, Manuela Grazina
Summary: This study identified a heterozygous deletion of 13 nucleotides in the 5' UTR region of the MEF2C gene in a FTLD patient, indicating its potential contribution to the disease phenotype. The mutation may affect mRNA secondary structure and stability, thus potentially influencing MEF2C protein levels.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Marisa Lima, Elia Baeta, Diana Duro, Miguel Tabuas-Pereira, Daniela Valerio, Sandra Freitas, Mario R. Simoes, Isabel Santana
Summary: The Toulouse-Pieron Cancelation Test (TP) is a classic psychometric tool used for assessing selective/sustained attention, processing speed, and visuo-perceptual abilities. This study provides normative scores for the TP in a sample of Portuguese healthy adults, finding that education is a major predictor of TP-WE and TP-DI.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Clinical Neurology
Anuschka Silva-Spinola, Marisa Lima, Maria Joao Leitao, Joao Duraes, Miguel Tabuas-Pereira, Maria Rosario Almeida, Isabel Santana, Ines Baldeiras
Summary: The study on FTD and its subtypes found that levels of NfL in CSF and serum can serve as biomarkers for the disease and are associated with cognitive decline. Genetic cases, especially FTD-GRN, have higher NfL levels. These findings suggest that NfL may have potential value in evaluating disease severity and developing therapies for FTD.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Jillian McCarthy, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Chris Butler, Alex Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Lize C. Jiskoot, Harro Seelaar, John C. van Swieten, Jonathan D. Rohrer, Yasser Iturria-Medina, Simon Ducharme
Summary: Frontotemporal dementia in genetic forms is highly heterogeneous and begins many years prior to symptom onset. This study used an unsupervised machine learning algorithm, cTI, to analyze large-scale population datasets and obtained individual scores of disease stage based on MRI metrics. The results suggest that cTI can identify data-driven disease stages in genetic forms of frontotemporal dementia.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Daniela Valerio, Jorge Almeida, Nele Demeyere, Marisa Lima, Joana Nogueira, Isabel Santana
Summary: In Portugal, there is a lack of gold standard tests to assess acute stroke patients in hospitals. Cognitive deficits are common after stroke and have a negative impact on a patient's quality of life and rehabilitation. This study aimed to adapt the Oxford Cognitive Screening to European Portuguese speakers (OCS-Pt), establish normative data cut-offs, and evaluate the psychometric properties of OCS-Pt. Results showed that OCS-Pt is a promising cognitive screening tool for acute stroke survivors in Portugal.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Willemijn J. Jansen, Olin Janssen, Betty M. Tijms, Stephanie J. B. Vos, Rik Ossenkoppele, Pieter Jelle Visser
Summary: This study aims to estimate the prevalence of amyloid abnormality in individuals with different cognitive statuses and examine the factors that may affect these estimates. The results show that CSF-based estimates using adjusted data-driven cutoffs were higher than PET-based estimates in individuals without dementia, suggesting that preclinical and prodromal AD may be more prevalent than previously estimated. This finding has important implications for clinical trial recruitment strategies and healthcare planning policies.
Article
Neurosciences
Daniel Agostinho, Francisco Caramelo, Ana Paula Moreira, Isabel Santana, Antero Abrunhosa, Miguel Castelo-Branco
Summary: This study investigated whether the combination of T1 Weighted MRI and diffusion tensor imaging (DTI) can achieve comparable performance to the combination of quantitative structural MRI (sMRI) with amyloid-PET. Results showed that the combination of sMRI and DTI had similar performance to sMRI and amyloid PET, indicating the importance of white matter changes in Alzheimer's Disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Rheumatology
Goncalo Durao-Carvalho, Raquel Fernandez-Gonzalez, Bethan Goulden, Filipa Farinha, David Isenberg
Summary: The study found that patients with white ethnicity, older age at diagnosis, absence of renal involvement, and no antiphospholipid syndrome (APS) were more likely to achieve sustained complete remission (CR) in systemic lupus erythematosus (SLE). Patients who did not achieve any kind of sustained remission had a higher risk of early mortality.
Article
Rheumatology
Weike Luo, Filipa Farinha, David A. Isenberg, Anisur Rahman
Summary: In this study, non-Caucasian ethnicity and younger age at diagnosis are associated with the risk of developing LN in SLE patients. There is evidence of improvement in survival among SLE patients over time.
Article
Rheumatology
Jyoti Bakshi, Sara C. Croca, Maura Griffin, Filipa Farinha, David A. Isenberg, Andrew Nicolaides, Anisur Rahman
Summary: The total burden and location of plaque in patients with SLE may be valuable in assessing the risk of developing CVD.
Article
Health Care Sciences & Services
Rui Martins, Bruno de Sousa, Thomas Kneib, Maike Hohberg, Nadja Klein, Elisa Duarte, Vitor Rodrigues
Summary: Due to conflicting results in current research, this study investigates whether age at menopause is increasing or decreasing in Western countries and explores methods for handling missing data. The study finds that imputing missing menopause ages can recover the trend and reduce bias caused by excluding the younger generation cohort.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Multidisciplinary Sciences
Rui Martins, Bruno de Sousa, Vitor Rodrigues
Summary: This study aims to study the spatio-temporal evolution of the age at menopause in central Portugal since the early twentieth century. By analyzing 320,444 women who had reached menopause between 1990 and 2018 in a free breast cancer screening program, it was found that the median age at menopause has been increasing and there are regional differences among different percentile ranges.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Daniela Marinho, Ildete Luisa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Summary: This study evaluates the efficacy of inhibiting or reducing histone deacetylases (HDACs) in Alzheimer's disease (AD) models by modifying gene transcription. The results show that inhibiting class I HDACs can ameliorate ER-mitochondria cross-talk in AD by normalizing calcium signaling between the two organelles. The selective HDAC inhibitor, Tacedinaline (Tac), counteracted the impaired ER-mitochondria communication and reduced amyloid beta levels in AD cells and animal models. These findings suggest that transcriptional regulation of ER-mitochondria communication could be a promising target for innovative therapeutics in AD.
Article
Genetics & Heredity
Miguel Tabuas-Pereira, Rita Guerreiro, Celia Kun-Rodrigues, Maria Rosario Almeida, Jose Bras, Isabel Santana
Summary: This article reports a case of a patient with parkinsonism and Lewy body dementia carrying mutations in PSEN1 and ATP7B genes. The case highlights the importance of considering ATP7B gene mutations and supports the pathogenicity of the p.Ile408Thr variant in PSEN1.
