Article
Immunology
Weiwei Zhu, Huifang Zhang, Qiming Dong, Hongyong Song, Lin Zhao
Summary: This study reveals the dual wave of neutrophil recruitment during C. albicans infection, emphasizing the importance of early fungal clearance for favorable disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Xiaoxi Sun, Bing Huang, Yuping Pan, Jinhua Fang, Hefeng Wang, Yanru Ji, Yingchen Ling, Pei Guo, Jiangguo Lin, Quhuan Li, Ying Fang, Jianhua Wu
Summary: Activation of integrins is crucial for recruitment of flowing leukocytes to inflammatory or injured vascular sites. We found that integrin activation occurs via different signaling pathways and at different timescales. Under static conditions, activation is mediated by mitogen-activated protein kinase (MAPK) or non-MAPK signaling, and is force-dependent. Under flow conditions, activation requires intracellular Ca2+ release and occurs within minutes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Martin Alexander Schick, Nicolas Schlegel
Summary: Phosphodiesterase 4 inhibitors play an important role in regulating physiological functions and treating diseases, but they also carry significant risks of serious side effects. This review aims to provide a comprehensive overview of the approaches and effects of phosphodiesterase 4 inhibition in different therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ofer Regev, Marina Kizner, Francesco Roncato, Maya Dadiani, Massimo Saini, Francesc Castro-Giner, Olga Yajuk, Stav Kozlovski, Nehora Levi, Yoseph Addadi, Ofra Golani, Shifra Ben-Dor, Zvi Granot, Nicola Aceto, Ronen Alon
Summary: ICAM-1 expressed by breast cancer cells is involved in innate immunity and can inhibit intravascular breast cancer metastasis to lungs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seung-Jin Lee, Dong-Soon Im
Summary: The study demonstrated that activation of GPR55 by O-1602 can promote monocyte adhesion to endothelial cells via induction of the adhesion molecule Mac-1, while blockade of GPR55 using CID16020046 can suppress monocyte adhesion to vascular endothelial cells and protect against the development of atherosclerosis in high-fat diet-induced ApoE(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Victor Pui-Yan Ma, Yuesong Hu, Anna Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, Khalid Salaita
Summary: T cells defend against cancer and viral infections by binding to specific peptide antigens on target cells. It has been found that the forces transmitted through the LFA-1 /ICAM-1 complex can tune T cell signaling and enhance T cell activation and TCR discrimination.
Article
Immunology
Viktoria Szeifert, Ferenc Kolonics, Balazs Bartos, Delaram Khamari, Pal Vagi, Laszlo Barna, Erzsebet Ligeti, Akos M. Lorincz
Summary: The study demonstrates that specific stimulation of Mac-1 integrin can initiate the release of anti-bacterial and pro-inflammatory extracellular vesicles (EVs), but only when neutrophils are activated on ligand coated surfaces. This process involves clustering of Mac-1 molecules and a strong calcium signal, showing that Mac-1 stimulation and clustering are necessary and sufficient for aEV biogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kai Yang, Junping Yin, Xiaoyang Yue, Katja Bieber, Gabriela Riemekasten, Ralf J. Ludwig, Frank Petersen, Xinhua Yu
Summary: This study demonstrates that luteolin peracetate and gossypolone are potential therapeutics for EBA, as they inhibit immune complex-mediated neutrophil activation and tissue damage.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kristoffer H. Johansen, Dominic P. Golec, Julie H. Thomsen, Pamela L. Schwartzberg, Klaus Okkenhaug
Summary: PI3K signaling is crucial for T cell activation, differentiation, and trafficking, with PI3K delta being the dominant isoform in T cells. It regulates T cell functions by controlling adhesion receptors and their interaction with antigen-presenting cells. Understanding the role of PI3K delta in T cell migration and localization is important for potential impacts of PI3K delta inhibitors on T cell redistribution and function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tom McEnery, Michelle M. White, Debananda Gogoi, Orla Coleman, David Bergin, Bakr Jundi, Ryan Flannery, Fatima Abbas T. Alsaif, Sarah A. Landers, Michelle Casey, Danielle Dunlea, Paula Meleady, Noel G. McElvaney, Emer P. Reeves
Summary: This study investigates the increased neutrophil adhesion in alpha-1 antitrypsin deficiency (AATD) and the effect of alpha-1 antitrypsin (AAT) augmentation therapy. It is found that AATD neutrophils have decreased plasma membrane cholesterol content but increased expression of integrins and cytoskeletal adaptor proteins. AAT augmentation therapy increases membrane cholesterol content, decreases neutrophil integrin expression and adhesion, and reduces circulating inflammation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyun-Kyoung Lim, Sungjun Bae, Kayoung Han, Bok-Man Kang, Yoonyi Jeong, Seong-Gi Kim, Minah Suh
Summary: Cerebral hypoperfusion is a potential cause of postictal neurological dysfunction in epilepsy. The reduction in cerebral blood flow (CBF) after a seizure is initially induced by arteriolar constriction, and then prolonged by neutrophil adhesion to brain capillaries, decreased red blood cell (RBC) flow, and elevated ICAM-1 expression. Antibodies against Ly6G and LFA-1 can prevent neutrophil adhesion and restore CBF to normal levels. Seizure-induced neutrophil adhesion via ICAM-1 may contribute to the prolonged hypoperfusion and neurological dysfunction in epilepsy.
Article
Astronomy & Astrophysics
Rahul Bandyopadhyay, Ramkrishna Das, Soumen Mondal
Summary: The characteristics of planetary nebulae MaC 2-1 and Sp 4-1 were studied, revealing low to moderate-excitation levels with different dust and molecular compositions. Estimates of precursor masses and metal-poor environments suggest that they are distant nebulae.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Zhenjie Qi, Simiaomiao Wen, Zhao Liu, Dongfang Jiang
Summary: A synthetic strategy to pyridazin-4(1H)-ones/oxazin-4(1H)-ones has been developed through an oxidative 6-endo-trig cyclization and [2+2] cycloaddition of β,γ-unsaturated hydrazones/ketoximes and diazonium tetrafluoroborates under metal-free conditions. This method demonstrates excellent functional group tolerance and remarkable regioselectivity. Mechanistic studies using O-18 and H-2O-18 labeling confirm the involvement of O-2 as both a reaction component and an oxidant.
Article
Integrative & Complementary Medicine
Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen, Gui-Yuan Lv
Summary: The study demonstrated that luteolin significantly inhibited LPS-induced leukocyte adhesion, hydrogen peroxide production, and mast cell degranulation. It also increased intestinal microcirculation blood flow and ameliorated pathological changes in the mesenteric artery and the small intestine. Furthermore, luteolin inhibited the release of pro-inflammatory cytokines and the expression of related signaling molecules, suggesting its potential in ameliorating microcirculatory disturbance.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Multidisciplinary Sciences
Alexey D. Sereda, Anna S. Kazakova, Viktor V. Dmitrenko, Denis Kolbasov
Summary: This report evaluates the immunobiological properties of a candidate live vaccine against African swine fever (ASF) using two tests. The results demonstrate that attenuated virus strains can modulate the cellular link of protective immunity without negatively affecting the humoral immune response.
