期刊
THEORETICAL POPULATION BIOLOGY
卷 78, 期 1, 页码 36-45出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2010.04.001
关键词
Selective sweep; Fixation probability; Interference
资金
- [EPSRC/GR/T19537]
Suppose that a beneficial mutation is undergoing a selective sweep when another beneficial mutation arises at a linked locus. We study the fixation probability of the double mutant, i.e., one (produced by recombination) that carries both mutations. Previous analysis works well for the case where the earlier beneficial mutation confers a greater selective advantage than the later mutation, but not so well in the opposite case. We present an approach to approximating the fixation probability in the case where the later mutation confers a greater selective advantage. (C) 2010 Elsevier Inc. All rights reserved.
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