期刊
TETRAHEDRON-ASYMMETRY
卷 25, 期 6-7, 页码 578-582出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2014.02.008
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资金
- DENOVA, New Delhi, India [ESC 0205]
- Council of Scientific and Industrial Research (CSIR), New Delhi
- [DST-SERB/EMEQ-078/2013]
Lipase Pseudomonas cepacia catalyzed acylation of (+/-)-2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one using vinyl acetate as the acyl donor in acetone gave (-)-(R)-2-acetoxy-2-(methyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one and (+)-(S)-2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one with high enantiomeric excess. Enantiomerically pure 2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one are useful intermediates for the preparation of Ramelteon, an FDA approved drug for the treatment of insomnia. (C) 2014 Elsevier Ltd. All rights reserved.
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