期刊
TETRAHEDRON-ASYMMETRY
卷 24, 期 17, 页码 990-994出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2013.07.017
关键词
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资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21780070, 24688010, 22658027, 23248014]
- Grants-in-Aid for Scientific Research [23248014, 21780070, 24688010, 22658027] Funding Source: KAKEN
Asymmetric sulfoxidation of sulfur-containing L-amino acids was successfully achieved through bioconversion using IDO, which is an Fe(II)/alpha-ketoglutarate-dependent dioxygenase previously found in Bacillus thuringiensis strain 2e2. The IDO catalyzed sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine into the corresponding (S)-configured sulfoxides such as (+)-methiin and (+)-alliin, which are responsible for valuable physiological activities in mammals, and have high stereoselectivity. Herein we have established an effective preparative laboratory scale production method to obtain enantiomerically pure chiral sulfoxides using an IDO biocatalyst. (C) 2013 Elsevier Ltd. All rights reserved.
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