期刊
TETRAHEDRON-ASYMMETRY
卷 23, 期 3-4, 页码 245-251出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2012.02.016
关键词
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资金
- Chinese Academy of Science
- National Sciences Foundation of China [225013]
- Opening Foundation of Zhejiang Provincial Top Key Discipline
The first successful enantioselective intermolecular bromoesterification was realized by using a chiral phosphoric acid as a catalyst. The reaction was optimized after screening 2-aminopyridine based basic catalysts. cinchona alkaloid based basic catalysts, and binol backbone based Bronsted acid catalysts. Up to 70% ee and a moderate yield were achieved under the optimized condition. An ion-pair mechanism has been suggested in order to explain the reaction results. (C) 2012 Elsevier Ltd. All rights reserved.
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