Stereoselective synthesis of GABOB, carnitine and statine phosphonates analogues

gamma-Amino acids such as GABA. GABOB, statine and carnitine have attracted considerable attention as biologically active compounds. Over the last few years, significant interest in the stereoselective synthesis of gamma-aminophosphonic acids GABOB(P), phosphocarnitine, phosphostatine and derivatives has been observed. An overview of synthetic approaches of gamma-aminophosphonic acids and derivatives is presented. Data on the practical applications of the gamma-aminophosphonic acids are also discussed. (C) 2010 Elsevier Ltd. All rights reserved.