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Synthesis of novel chiral oxazoline-Schiff base ligands for the catalytic asymmetric chlorination of β-keto esters

期刊

TETRAHEDRON-ASYMMETRY
卷 21, 期 2, 页码 247-253

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.02.003

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资金

  1. Shanghai Municipal Committee of Science and Technology [06XD14005, 08dj1400100-2]
  2. National Basic Research Program of China [(973)-2010CB833302]
  3. National Natural Science Foundation of China [20902019, 20872162, 20672127, 20821002, 20732008, 20702059]

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A series of novel monooxazoline-Schiff base ligands 1 has been successfully synthesized. The Cu(I)-1a complex showed excellent catalytic activities with up to 83% ee for the asymmetric a-chlorination of beta-keto esters. (C) 2010 Elsevier Ltd. All rights reserved.

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