Article
Oncology
Tom Jansen, Nike Stikkelbroeck, Annenienke van de Ven, Ilse van Engen-van Grunsven, Marcel Janssen, Han Bonenkamp, Martin Gotthardt, Romana T. Netea-Maier
Summary: Thyroid nodules can be visible, palpable or symptomatic nodules, as well as incidental findings on imaging techniques. The majority are benign, but recognizing clinically relevant nodules remains a challenge. A retrospective observational study found that incidentalomas have a significantly lower risk of malignancy compared to FDG-PET-incidentalomas and non-incidentalomas. Incidentalomas are also significantly smaller than non-incidentalomas. These findings support the current recommendations to prioritize additional analysis for non-incidentalomas, FDG-PET incidentalomas, and clinically relevant non-PET-incidentalomas.
Review
Endocrinology & Metabolism
Je Ern Chooi, Abiramie Ravindiran, Saba P. Balasubramanian
Summary: The impact of incidentally detected thyroid nodules on malignancy risk and prognosis may not be as significant as previously thought, suggesting that management should not be influenced by the mode of detection.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
K. G. Claeys, V. Goosens
Summary: This study investigated the prevalence and outcomes of incidentalomas in whole-body muscle MRI in a large cohort of patients with muscle symptoms. It was found that incidental findings occurred frequently, with most being benign. However, timely detection of incidentalomas can lead to early treatment and impact prognosis.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael T. Corwin, Mohamed Badawy, Elaine M. Caoili, Benjamin W. Carney, Ceylan Colak, Khaled M. Elsayes, Rosalind Gerson, Sergio P. Klimkowski, Rachel McPhedran, Amit Pandya, Matthew E. Pouw, Nicola Schieda, Julie H. Song, Erick M. Remer
Summary: This study aimed to compare the prevalence of malignancy in incidental adrenal nodules with unenhanced attenuation more than 10 HU in patients without a known malignancy history. The results showed that in nodules smaller than 4 cm, the prevalence of malignancy did not significantly differ between those with and without washout of 60% or more, and washout of 60% or more had suboptimal performance for characterizing nodules as benign.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Tiziana Caspanello, Marisa Masucci, Diego Iannelli, Nicola Maria Iannelli, Massimo De Majo
Summary: Computed tomography (CT) is an advanced imaging technique that may lead to detect incidentalomas, unexpected asymptomatic lesions found during unrelated examinations. This study is a retrospective analysis that aims to investigate incidentalomas in CT exams and to describe their prevalence, location, types and follow-up, their correlations and associations with the species, breed, sex, and age of patients examined and with the kind and number of sites scanned. The reports of 561 CT scans performed in 512 dogs and 49 cats in a veterinary facility over six years were reviewed and compared to the clinical records of the patients. Eighty incidentalomas were found in 57 dogs and four cats. A significant positive correlation was found in dogs between age and the prevalence of incidentalomas. In dogs, the prevalence of incidentalomas was significantly higher in Boxers and in neck, thoracic, and abdominal scans. Spinal incidentalomas were the most common typologies in dogs. This study can represent a tool that allows clinicians to acquire greater awareness about incidentalomas and to carry out the evidence-based clinical management of them.
Review
Clinical Neurology
Divya Elizabeth Sunny, Michael Amoo, Maryam Al Breiki, Elite Dong Wen Teng, Jack Henry, Mohsen Javadpour
Summary: Incidental findings are common in brain MRI, especially vascular abnormalities and neoplastic abnormalities. These incidental findings may result in substantial resource expenditure and patient anxiety but are often of little clinical significance.
ACTA NEUROCHIRURGICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark M. Hammer, Chung Yin Kong
Summary: In this study, a simulation model was used to evaluate the cost-effectiveness of follow-up strategies for incidentally detected thyroid nodules on CT. The results suggest that follow-up ultrasound may not be cost-effective for older patients, while it may be cost-effective for younger patients with thyroid nodules.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Reginald F. Munden, William C. Black, Thomas E. Hartman, Heber MacMahon, Jane P. Ko, Debra S. Dyer, David Naidich, Santiago E. Rossi, H. Page McAdams, Eric M. Goodman, Kathleen Brown, Michael Kent, Brett W. Carter, Caroline Chiles, Ann N. Leung, Phillip M. Boiselle, Ella A. Kazerooni, Lincoln L. Berland, Pari Pandharipande
Summary: The ACR Incidental Findings Committee aims to improve the quality of care by providing recommendations for managing incidentally detected lung findings on thoracic CT scans.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ji Ye Lee, Jung Hwan Baek, Eun Ju Ha, Jin Yong Sung, Jung Hee Shin, Ji-hoon Kim, Min Kyoung Lee, So Lyung Jung, Young Hen Lee, Hye Shin Ahn, Jung Hyun Yoon, Yoon Jung Choi, Jeong Seon Park, Yoo Jin Lee, Miyoung Choi, Dong Gyu Na
Summary: The guidelines aim to assist physicians in making informed decisions in the diagnosis of thyroid diseases, reducing unnecessary examinations, supplementing insufficient or equivocal evidence with expert opinion, and assessing the appropriateness of imaging for specific clinical situations.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jing Zhang, Minghao Li, Yingxian Pang, Cikui Wang, Jingjing Wu, Ziyun Cheng, Xiaomu Li, Zhiqiang Lu, Yujun Liu, Jianming Guo, Xiang Chen, Yao He, Xiao Guan, Xiaowen Xu, Yong Wang, Jiahao Liu, Wei Guo, Yingyong Hou, Longfei Liu, Jingjing Jiang, Xin Gao
Summary: More than half of patients with incidental PPGLs had mutations in common susceptibility genes. The search for susceptibility genes should take both the mode of discovery and tumor location into consideration.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Emine Ayca Cimbek, Recep Polat, Bircan Sonmez, Nazim Ercument Beyhun, Hasan Dinc, Haluk Saruhan, Gulay Karaguzel
Summary: This retrospective study analyzed the clinical, laboratory, and ultrasound findings of 102 children and adolescents with thyroid nodules between 2007 and 2019. The study revealed a higher proportion of malignancy in children compared to adults, with 4.9% of patients diagnosed with thyroid carcinoma, a rate below previous literature descriptions.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Chandler A. A. Annesi, Stephanie D. D. Talutis, Anna L. L. Goldman, Ellen Childs, Philip E. E. Knapp, David McAneny, Frederick Thurston Drake
Summary: This study investigated the management of incidental masses by primary care providers. The results showed that when clinical guidelines were available, doctors were more likely to make appropriate decisions, reducing errors and improving patient safety.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Wen Yan, Dong-Ya Li, Wang-Yi Jin, Chao-Ran Huang, Sheng Pan, Da-Lin Peng, Xing-Chen Zhang, Yong Pang, Kai-Jin Guo, Xin Zheng
Summary: This study found that incidental thyroid abnormalities are common in patients with degenerative cervical spondylosis (DCS) who undergo cervical spine magnetic resonance imaging (MRI). The prevalence of incidental thyroid abnormalities in this population was 7.5%, with thyroid nodules being the most frequent abnormality. Age and sex were found to have a significant impact on the presence of incidental thyroid abnormalities in DCS patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael T. Corwin, Nicola Schieda, Erick M. Remer, Elaine M. Caoili
Summary: This study investigated the practice patterns of abdominal radiologists regarding the interpretation and management of adrenal incidentalomas and found wide variability among radiologists. Further standardization of guidelines and education of radiologists is needed.
ABDOMINAL RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Siqiong Yao, Pengcheng Shen, Tongwei Dai, Fang Dai, Yun Wang, Weituo Zhang, Hui Lu
Summary: Artificial intelligence (AI) enables accurate diagnosis of thyroid cancer but lacks explanation. This study developed TiNet, a human understandable AI report system for thyroid cancer prediction. TiNet uses deep learning to extract features of thyroid nodules and provides quantitative explanations. Compared to clinical reports, TiNet reports were significantly easier to understand and can enhance collaboration between AI and clinicians.
Letter
Acoustics
Franklin N. Tessler, William D. Middleton, Edward G. Grant, Jenny K. Hoang
JOURNAL OF CLINICAL ULTRASOUND
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jenny K. Hoang, Andrew R. Menard
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jenny K. Hoang, William D. Middleton, Franklin N. Tessler
Summary: The ACR TI-RADS is an ultrasound-based risk stratification system for thyroid nodules that has been shown to have higher specificity and reduce unnecessary biopsies compared to other systems. It also mitigates the risk of missing significant cancers through follow-up recommendations for nodules that do not meet biopsy criteria. Practices implementing ACR TI-RADS must engage their radiologists to address overdiagnosis and unnecessary surgeries by reducing unnecessary biopsies.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Editorial Material
Otorhinolaryngology
Javad R. Azadi, Jenny K. Hoang
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Jenny K. Hoang, William D. Middleton, Franklin N. Tessler
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Naykky Singh Ospina, Natalia Genere, Jenny K. Hoang, Juan P. Brito
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jenny K. Hoang, William D. Middleton, Jill E. Langer, Kendall Schmidt, Laura B. Gillis, Sujith Surendran Nair, Jay A. Watts, Randall W. Snyder, Rachita Khot, Upma Rawal, Franklin N. Tessler
Summary: This study compared the recommendation rates for fine-needle aspiration of thyroid nodules under different guidelines, with ACR TI-RADS suggesting 25% to 50% fewer biopsies compared to other standards.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Article
Oncology
Anna Rodrigues, Kelly Loman, Jeff Nawrocki, Jenny K. Hoang, Zheng Chang, Yvonne M. Mowery, Taofik Oyekunle, Donna Niedzwiecki, David M. Brizel, Oana Craciunescu
Summary: This study aimed to evaluate the baseline variability of histogram and texture features derived from ADC maps in HNSCC patients undergoing definitive chemoradiation, and to identify early treatment-induced changes to these features. The study found that some features had excellent repeatability, and early treatment induced significant changes in four features.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Zander, Paul M. Bunch, Bruno Policeni, Amy F. Juliano, Denise Carneiro-Pla, Prachi Dubey, Maria K. Gule-Monroe, Mari Hagiwara, Jenny K. Hoang, Vikas Jain, Lawrence T. Kim, Gul Moonis, Matthew S. Parsons, Tanya J. Rath, Carmen C. Solorzano, Rathan M. Subramaniam, M. Reza Taheri, Kate DuChene Thoma, Andrew T. Trout, Mark E. Zafereo, Amanda S. Corey
Summary: Hyperparathyroidism is diagnosed through biochemical testing, with imaging playing a crucial role in preoperative localization and surgical treatment. Imaging can help accurately locate lesions, such as single parathyroid adenomas, and impact surgical outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vivek Yedavalli, Jenny K. Hoang, Christine Glastonbury, David Yousem, Haris Sair
Summary: Visiting Professorships have significant benefits but can be costly. The COVID-19 pandemic has led to the redesign of VPs, using virtual platforms to improve collaboration and communication.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2022)
Article
Endocrinology & Metabolism
Nydia Burgos, Jing Zhao, Juan P. Brito, Jenny K. Hoang, Fabian Pitoia, Spyridoula Maraka, M. Regina Castro, Ji-Hyun Lee, Naykky Singh Ospina
Summary: This study found high variation in judgments about thyroid nodule risk categories and individual features, which poses potential challenges for the widescale implementation of thyroid nodule risk stratification.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jenny K. Hoang, Shadi Asadollahi, Cosimo Durante, Laszlo Hegedus, Enrico Papini, Franklin N. Tessler
Summary: Multiple ultrasound-based risk stratification systems for thyroid nodules are used worldwide, causing confusion. Medical specialty and geographic region are strongly associated with the choice of risk stratification system. About one third of respondents use more than one system, and a similar proportion do not use any due to various reasons.
Editorial Material
Endocrinology & Metabolism
Benjamin Wildman-Tobriner, Jenny K. Hoang
Article
Oncology
Andrew R. Carey, Govind Warrier, Jenny K. Hoang, Megan D. Schollenberger, Evan J. Lipson, Nicholas R. Mahoney
Summary: This study investigated tumor response and cranial nerve function outcomes in patients with cutaneous squamous cell carcinoma (CSCC) treated with anti-PD-1. The results showed that all patients experienced objective anti-tumor responses to anti-PD-1, and there were improvements in ocular motility deficits and pain.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Andrew R. Carey, Govind Warrier, Jenny K. Hoang, Megan D. Schollenberger, Evan J. Lipson, Nicholas R. Mahoney
Summary: In patients with cutaneous squamous cell carcinoma (CSCC) with perineural spread extending into the cavernous sinus, administration of anti-PD-1 therapy resulted in durable anti-tumor regressions and restoration of cranial nerve function, without the morbidity associated with surgical resection or radiotherapy. These findings contribute to the growing literature supporting the use of this treatment approach for this specific patient population.
JOURNAL OF NEURO-ONCOLOGY
(2023)