期刊
TETRAHEDRON-ASYMMETRY
卷 19, 期 15, 页码 1829-1832出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.06.019
关键词
-
资金
- Conseil Regional Champagne-Ardenne
- Swiss National Science Foundation
The synthesis of a fully deprotected ketimine-type iminosugar is reported, starting from commercial D-mannose diacetonide. An appropriate solvent system was critical for the success of the key tandem addition/cyclization reaction. Reduction of the imine was also achieved to yield the corresponding pyrrolidine in a stereoselective manner. The cyclic sugar imine displayed modest fucosidase inhibitory activity when compared to the saturated analogue. (C) 2008 Elsevier Ltd. All rights reserved.
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