期刊
TETRAHEDRON LETTERS
卷 55, 期 18, 页码 2977-2981出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.03.112
关键词
Multi-component reactions; E-factor and atom economy; Indoles; Mannich reaction; Catalyst free
资金
- DU-PURSUE grant, New Delhi, India
- University of Delhi, Delhi, India
- UGC [41-202/2012]
A highly efficient and sustainable approach for the multi-component synthesis of biologically important 3-amino alkylated indoles has been investigated via Mannich-type reaction under catalyst-free, ethylene glycol as a recyclable promoting medium. The wide applicability of the present method was examined with various substrates viz substituted aldehydes, indoles and secondary amines. This method will be useful for a large scale synthesis of 3-amino alkylated indoles without the use of column chromatography. The present method provides higher environmental compatibility and sustainability factors such as smaller E-factor (0.433) and higher atom-economy (AE = 93.3%). (C) 2014 Elsevier Ltd. All rights reserved.
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