Article
Chemistry, Multidisciplinary
Minjae Kim, Bohyun Park, Minkyeong Shin, Suyeon Kim, Junghoon Kim, Mu-Hyun Baik, Seung Hwan Cho
Summary: A copper-catalyzed enatiotopic-group-selective allylation of gem-diborylalkanes with allyl bromides was reported in this study. The combination of copper(I) bromide and H-8-BINOL derived phosphoramidite ligand proved to be the most effective catalytic system, providing various enantioenriched homoallylic boronate esters under mild conditions. Experimental and theoretical studies elucidated the reaction mechanism and revealed the enatiotopic-group-selective trans-metalation of gem-diborylalkanes with chiral copper complex.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Yuan Zhou, Tong Xiong, Li-Yan Zhou, Hong-Yan Li, You-Cai Xiao, Fen-Er Chen
Summary: This paper reports the catalytic asymmetric synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins. Chiral 3-hydroxyoxindoles bearing two contiguous stereogenic centers were produced with high stereoselectivity and demonstrated synthetic utility through transformations of the boryl moiety.
Article
Chemistry, Multidisciplinary
Man Tang, Wenyan Zhu, Huaxing Sun, Jing Wang, Su Jing, Minyan Wang, Zhuangzhi Shi, Jiefeng Hu
Summary: Efficient synthesis methods for organosilanes are important in the fields of synthetic chemistry and materials science. In this study, an alkoxide base-promoted deborylative silylation reaction was developed, providing straightforward access to valuable organosilanes. This method demonstrates operational simplicity, broad substrate scope, excellent functional group compatibility, and convenient scalability, making it an effective and complementary platform for generating diversified benzyl silanes and silylboronates. Detailed experimental results and mechanistic studies revealed unique features of the C-Si bond formation.
Article
Chemistry, Multidisciplinary
Chaohuang Chen, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker
Summary: The synthesis of element-carbon double bonds is described in this passage, focusing on the reactions with various molecules to form annulated heterocycles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Crystallography
Dipendu Mandal, Georgina M. Rosair
Summary: The metalation of a thallium salt with nickel fragments resulted in the formation of bis(nickelated) products, which were characterized and identified as different stereospecific species. The study also demonstrated the achievement of new structures by utilizing different nickel fragments in the metalation process.
Article
Chemistry, Multidisciplinary
Bingbing Wang, Xiangyu Zhang, Yangmin Cao, Long Zou, Xiaotian Qi, Qingquan Lu
Summary: This report describes the unprecedented electrooxidation of a solvent (e.g., DMF)-ligated B(2)cat(2) complex, leading to the formation of a solvent-stabilized boryl radical through the cleavage of the B-B bond. Experimental and theoretical evidence supports this novel B-B bond activation strategy. Additionally, an electrochemical gem-diborylation strategy for gem-bromides is developed, providing versatile gem-diborylalkanes without the need for transition metals or external activators.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Yulan Dai, Zhewei Li, Min Pu, Ming Lei
Summary: The reaction mechanism of synthesizing 1,1-diborylalkanes from alkenes and borane was investigated using density functional theory (DFT). The role of reducing reagents in the equilibrium of self-contradictory reactivity was elaborated. The use of H-2 as a reducing agent was found to be more advantageous and the & sigma;-bond metathesis was identified as the rate-determining step.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Kanak Kanti Das, Debraj Ghorai, Somenath Mahato, Santanu Panda
Summary: Gem-diborylalkanes, as valuable synthons in diverse C-C bond-forming reactions, have been studied. A Pd-catalysed hydrogenation method for the synthesis of gem-diborylalkanes from gem-diborylalkenes has been reported.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Multidisciplinary
Liuzhou Gao, Xinyi Liang, Linke He, Guoao Li, Shengda Chen, Jia Cao, Jing Ma, Guoqiang Wang, Shuhua Li
Summary: The effect of tBuOK on benzylic boronates in solution phase was investigated using NMR analysis and DFT calculations. It was found that using excess tBuOK leads to the complete deborylation of benzylic boronates, resulting in the formation of free benzyl potassium species. These insights were utilized for the synthesis of beta-silyl/boryl functionalized 1,1-diarylalkanes from aromatic alkenes through a combination of base-mediated silylboration or diborylation reactions and nucleophilic reactions with various electrophiles. Machine-learning-assisted screening expanded the scope of electrophiles to challenging aromatic heterocycles. Late-stage functionalization of drug-relevant molecules yielded valuable 1,1-diaryl frameworks.
Article
Chemistry, Multidisciplinary
Liuzhou Gao, Xinyi Liang, Linke He, Guoao Li, Shengda Chen, Jia Cao, Jing Ma, Guoqiang Wang, Shuhua Li
Summary: The effect of tBuOK on benzylic boronates in solution has been investigated, revealing the full deborylation of benzylic boronates to benzyl potassium species with an excess of tBuOK. This insight has been used for the construction of beta-silyl/boryl functionalized 1,1-diarylalkanes from aromatic alkenes through base-mediated reactions with electrophiles, including challenging aromatic heterocycles.
Review
Chemistry, Multidisciplinary
Wei Sun, Yue Hu, Chungu Xia, Chao Liu
Summary: Gem-borylsilylalkanes have emerged as powerful reagents in synthetic chemistry due to their versatile transforming ability, and efforts have been made to access these motifs from easily accessible chemical feedstocks. Compared with gem-diborylalkane analogues, gem-borylsilylalkanes can be chemoselectively converted into various functionalized molecules through selective C-Si and C-B bond transformation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Paulson Varghese, E. Vetrivendan, B. R. Vaishnavi Krupa, Prabhat Kumar Shukla, Ram Kishor Gupta, E. Hemant Rao, Ganesh Puppala, S. Ningshen
Summary: This study investigates the impact of Laser Surface Remelting on plasma-sprayed TBCs to mitigate molten sodium corrosion. The remelted layer initially retains structural integrity but eventually leads to corrosive damage due to vertical cracks infiltrating molten sodium into non-remelted layers.
Article
Chemistry, Multidisciplinary
Mustapha Hamdaoui, Fan Liu, Yann Cornaton, Xingyu Lu, Xiaohuo Shi, Huan Zhang, Jiyong Liu, Bernhard Spingler, Jean-Pierre Djukic, Simon Duttwyler
Summary: This study reports on the activation of hydroborane by a new iridium boron cluster complex, leading to the formation of a stable boron cation. The reaction involves an unconventional intramolecular B center dot center dot center dot H interaction, and a mechanism is proposed based on theoretical methods and noncovalent interactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Multidisciplinary
Ashkan Ali Madadi, Berkin Dortdivanlioglu
Summary: In this paper, an efficient and stable mixed B-spline material point method (MPM) is proposed for modeling large deformations of quasi-compressible polymeric materials. By introducing a subdivision-stabilization technique based on the two-scale relation of B-splines, numerically stable and oscillation-free nodal solutions with optimal regularity are obtained. The proposed MPM is tested through various models and examples, demonstrating its capabilities for modeling practical soft material applications.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ming-Zhong Guo, Mei-Jin Mou, Zhuo Chen, Shao-Fei Ni, Ming Li, Li-Rong Wen, Lin-Bao Zhang
Summary: A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported. The study demonstrated the tolerance of various functional groups and the potential applications of this methodology through scaled-up experiments.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Haritha R. Chileveru, Shion A. Lim, Phoom Chairatana, Andrew J. Wommack, I-Ling Chiang, Elizabeth M. Nolan
Article
Chemistry, Multidisciplinary
Toshiki G. Nakashige, Jules R. Stephan, Lisa S. Cunden, Megan Brunjes Brophy, Andrew J. Wommack, Brenna C. Keegan, Jason M. Shearer, Elizabeth M. Nolan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Multidisciplinary Sciences
Mohammed Shabab, Markus F. F. Arnold, Jon Penterman, Andrew J. Wommack, Hartmut T. Bocker, Paul A. Price, Joel S. Griffitts, Elizabeth M. Nolan, Graham C. Walker
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biotechnology & Applied Microbiology
G. Hayes, N. Wright, S. L. Gardner, C. L. Telzrow, A. J. Wommack, P. A. Vigueira
LETTERS IN APPLIED MICROBIOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Andrew J. Wommack, Joshua J. Ziarek, Jill Tomaras, Haritha R. Chileveru, Yunfei Zhang, Gerhard Wagner, Elizabeth M. Nolan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Multidisciplinary Sciences
Brianna K. Bruggeman, Katharine E. Storo, Haley M. Fair, Andrew J. Wommack, Colin R. Carriker, James M. Smoliga
Article
Plant Sciences
Tessa B. Moyer, Lilian R. Heil, Christine L. Kirkpatrick, Dennis Goldfarb, William A. Lefever, Nicole C. Parsley, Andrew J. Wommack, Leslie M. Hicks
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Biodiversity Conservation
Nicole M. Hughes, Giana M. Gigantino, Mary H. Grace, Kevin M. Hoffman, Mary Ann Lila, Brooke N. Willans, Andrew J. Wommack
SOUTHEASTERN NATURALIST
(2019)
Article
Plant Sciences
Anthony A. Iannetta, Holden T. Rogers, Thualfeqar Al-Mohanna, Juliana N. O'Brien, Andrew J. Wommack, Sorina C. Popescu, Leslie M. Hicks
Summary: Protein homeostasis plays a critical role in maintaining cellular functions and plant interactions with the environment, particularly in response to stress signals and pathogens. Study of thimet oligopeptidases TOP1 and TOP2 in Arabidopsis revealed their involvement in processes beyond defense signaling.
Article
Biochemistry & Molecular Biology
Nicole M. Hughes, Michaela K. Connors, Mary H. Grace, Mary Ann Lila, Brooke N. Willans, Andrew J. Wommack
Summary: In this study, the histological and chemical structures of anthocyanins associated with different leaf color patterns in the terrestrial orchid Tipularia discolor were characterized, revealing that different colors in leaves were a result of the anthocyanins being located in different anatomical positions. This highlights the importance of both phylogenetic inertia and natural selection in determining anthocyanin chemical structure and anatomical location in plants.
Article
Microbiology
Tessa B. Moyer, Ashleigh L. Purvis, Andrew J. Wommack, Leslie M. Hicks
Summary: This study demonstrates the antibacterial activity of Atr-DEF2(G39-C54) against two Gram-negative human bacterial pathogens, with proteomic changes in E. coli indicating membrane lysis as an important mechanism of action. Additionally, the study highlights the potential multifaceted mechanism of action of plant defensin analogs beyond membrane disruption, including metal sequestration as a contributing factor.
Article
Biochemistry & Molecular Biology
Martina J. Krone, Caroline N. Rivera, Madison E. Rivera, Rachel M. Watne, Sarah E. Lemonds, Andrew J. Wommack, Roger A. Vaughan
Summary: This study found that supraphysiological concentrations of glutamine have no significant effect on myotube metabolism and insulin signaling, while physiological levels of glutamine can improve metabolism.
Article
Cell Biology
Caroline N. Rivera, Madison M. Kamer, Madison E. Rivera, Rachel M. Watne, Trent C. Macgowan, Andrew J. Wommack, Roger A. Vaughan
Summary: Insulin resistance, but not BCAA treatment, promotes extracellular BCAA accumulation independent of changes in LAT1 content, suggesting insulin resistance as a causal agent of extracellular BCAA accumulation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caroline N. Rivera, Carly E. Smith, Lillian V. Draper, Gabriela E. Ochoa, Rachel M. Watne, Andrew J. Wommack, Roger A. Vaughan
Summary: The study found that LAT1 is the primary transporter of BCAA in skeletal muscle, and JPH203 (JPH) is its inhibitor. The results showed that treatment with 1μM JPH increased mitochondrial metabolism and content, and reduced extracellular leucine and valine. However, treatment with 2μM JPH suppressed insulin signaling and increased extracellular accumulation of isoleucine without affecting BCAA metabolic genes.
Meeting Abstract
Cardiac & Cardiovascular Systems
Brianna K. Bruggeman, Katharine E. Storo, Haley M. Fair, Andrew J. Wommack, James M. Smoliga, Colin R. Carriker
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
