Article
Chemistry, Organic
Kiran Chinthapally, Brian S. J. Blagg, Brandon L. Ashfeld
Summary: Significant achievements have been made in organic chemistry in recent years, leading to the discovery of new drugs and biologically active molecules. This article describes a practical and efficient approach to synthesizing enantiomerically pure and diverse lysobisphosphatidic acid analogues. The key feature of the synthesis is a one-pot, sequential phosphorylation and oxidation reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Kiran Chinthapally, Brian S. J. Blagg, Brandon L. Ashfeld
Summary: Recent years have seen significant achievements in organic chemistry, leading to the discovery of new drugs and biologically interesting molecules. This study presents a practical and efficient method for synthesizing enantiomerically pure and diverse lysobisphosphatidic acid analogues, featuring a one-pot sequential phosphorylation and oxidation of protected sn-2-O-oleoyl glycerol or sn-3-O-oleoyl glycerol using 2-cyanoethyl N,N-diisopropylchlorophosphoramidite.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Tyll Freese, Lukas J. Patalag, J. Luca Merz, Peter G. Jones, Daniel B. Werz
Summary: This study reports an improved direct access to red-emitting BOIMPY fluorophores, starting from easily available benzimidazole-2-carboxylic acids, which greatly enhances yields and saves costs, facilitating the synthesis of novel unsymmetrical BOIMPY motifs. As a result, the BOIMPY scaffolds derived from the BODIPY core become more accessible for applications as fluorophores at the appealing red edge of the visible spectrum.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Hua-Wei Liu, Yong-Jiu Hao, Zhong-Jian Cai, Shun-Jun Ji
Summary: This article describes a copper-catalyzed photoinduced [3+3] cycloaddition reaction of α-acidic isocyanides with 2,5-diaryltetrazoles. The reaction proceeded smoothly with high regioselectivity, affording a range of important 1,2,4-triazines under mild conditions. The obtained 1,2,4-triazines were easily converted into triazine alcohol, Weinreb amide, and triazinone, demonstrating the utility of this [3+3] cycloaddition process.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Jimin Guo, Jianjian Zha, Tao Zhang, Chang-Hua Ding, Qitao Tan, Bin Xu
Summary: Unsymmetrical disulfides can be prepared effectively through thiol exchange with symmetrical disulfides using a simple PdCl2/DMSO catalytic system. The method demonstrates excellent functional group tolerance, a broad substrate scope, and operational simplicity. This reaction is particularly valuable for late-stage functionalization of bioactive scaffolds such as peptides and pharmaceuticals.
Article
Chemistry, Organic
Jakub Szyling, Aleksandra Szymanska, Adrian Franczyk, Jedrzej Walkowiak
Summary: A simple, efficient, and selective method for the preparation of boryl-functionalized enynes or dienes via catalytic diboration has been developed. The method was proven to be effective and was applied in advanced organic transformations.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jivan Shinde, Prakash Bhimrao Patil, Veerababurao Kavala, Ching-Fa Yao
Summary: This article introduces a greener and safer method for the synthesis of unsymmetrical urea derivatives catalyzed by copper in ethyl acetate. This method minimizes the use of toxic reagents and successfully achieves high yields and gram-scale synthesis of urea.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Raziyeh Hosseini, Reza Ranjbar-Karimi, Kazem Mohammadiannejad
Summary: This study evaluated a novel N,N-bidentate TRAM-based ligand in Suzuki-Miyaura cross-coupling reactions, showing promising activity as an alternative to traditional phosphine ligands. The in-situ generated complex of this ligand with CuI exhibited excellent activity in the cross-coupling of aryl bromides with 4-formylphenyl boronic acid, resulting in good yields of a pre-selected library of compounds.
Article
Thermodynamics
Dhanup S. Pillai, J. Prasanth Ram, Veronika Shabunko, Young-Jin Kim
Summary: A new PV array reconfiguration technique is proposed, which can be applied globally and involves rearranging PV modules diagonally within the smallest rectangle formed using squares. This technique aims to maximize power generation under partial shading conditions. Compared to existing methods, this approach significantly reduces the number of relocations and is applicable to a wide range of PV arrays.
Article
Chemistry, Multidisciplinary
Puhui Xie, Ying Zhou, Xiaochuan Li, Xiaojing Liu, Lijie Liu, Zhanqi Cao, Jianji Wang, Xin Zheng
Summary: A novel derivative of thiazolothiazole-bridged imidazole was discovered to exhibit blue fluorescence in gaseous state or in methanol and yellow fluorescence in solid state. The N-alkylation of imidazole sub-unit(s) generated highly water-soluble alkylated imidazolium salts with strong emission in solution. By replacing the counter-anion, the salts achieved strong emission and good water solubility in solid state and in solution, attributed to their twisted and rigid structures induced by interionic C-H···F hydrogen bonding.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
James A. Isaac, Gisele Gellon, Florian Molton, Christian Philouze, Nicolas Le Poul, Catherine Belle, Aurore Thibon-Pourret
Summary: This study explores the synthesis and spectroscopic characterizations of copper-oxygen adducts, which are key active species for the oxidation of C-H bonds in copper enzymes and their synthetic models. The results show that the reaction of dicopper(I) complexes with O2 leads to the formation of a peroxido species, while the reaction of these species with 2,4-di-tert-butyl-phenolate results in the formation of a C-C coupling product. In addition, the synthesis of dinuclear Cu(II) bis-mu-hydroxido complexes generates (CuCuIII)-Cu-II oxygen species.
Review
Chemistry, Organic
Swagata Paul, Kanak Kanti Das, Debasis Aich, Samir Manna, Santanu Panda
Summary: This review summarizes the recent development of enantioselective synthesis of gem-diborylalkanes and their application in asymmetric synthesis.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Ming Zeng, Zi-Xin Yuan, Lin-Fei Wen, Dengzhao Jiang, Hui Lu, Wenbo Liu, Jun Dai, Shen-Xin Zeng
Summary: We have reported an efficient copper-catalyzed dehydrogenation method for the synthesis of aroyl triazines from arylmethyl triazines using water as the sole oxidant and hydrogen as the by-product. Moderate to good yields were obtained using substrates with both electron-donating and electron-withdrawing groups. The use of liquid chromatography-mass spectrometry, O-18-labeled-water reactions, and hydrogen capture experiments confirmed the role of water as the oxygen donor. This oxidation strategy provides a new approach for synthesizing aroyl triazines with a wide range of substrates.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hande Pekbelgin Karaoglu, Ozgul Saglam, Sadin Ozdemir, Serpil Gonca, Makbule Burkut Kocak
Summary: A new fluorinated phthalonitrile compound and phthalocyanine derivatives were synthesized and characterized. The compounds showed potential biological activities including antioxidant, DNA cleavage, antimicrobial, biofilm inhibition, and bacterial viability inhibition. The results indicated effective activities in different assays, highlighting the potential applications of these compounds in various fields.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Physical
Fengxi Li, Chunyu Wang, Yaning Xu, Zixian Zhao, Jiali Su, Chenhan Luo, Yujie Ning, Zhengqiang Li, Chen Li, Lei Wang
Summary: The research introduces a green and efficient method for the synthesis of unsymmetrical trisubstituted 1,3,5-triazines from isothiocyanate, amidines, and 1,1,3,3-tetramethylguanidine, achieving high yields under optimal conditions with Hemoglobin from rabbit blood as the catalyst. This enzymatic approach demonstrates the potential for extending the application of enzyme catalytic promiscuity in organic synthesis.
MOLECULAR CATALYSIS
(2021)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
